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Items: 1 to 50 of 66

1.

CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors.

Ahmed K, Kren BT, Abedin MJ, Vogel RI, Shaughnessy DP, Nacusi L, Korman VL, Li Y, Dehm SM, Zimmerman CL, Niehans GA, Unger GM, Trembley JH.

Oncotarget. 2016 Sep 20;7(38):61789-61805. doi: 10.18632/oncotarget.11442.

2.

Interrelationships among cortisol, 17-hydroxyprogesterone, and androstenendione exposures in the management of children with congenital adrenal hyperplasia.

Sarafoglou K, Zimmerman CL, Gonzalez-Bolanos MT, Willis BA, Brundage R.

J Investig Med. 2015 Jan;63(1):35-41. doi: 10.1097/JIM.0000000000000121.

PMID:
25386671
3.

Comparison of cortisol exposures and pharmacodynamic adrenal steroid responses to hydrocortisone suspension vs. commercial tablets.

Sarafoglou K, Gonzalez-Bolanos MT, Zimmerman CL, Boonstra T, Yaw Addo O, Brundage R.

J Clin Pharmacol. 2015 Apr;55(4):452-7. doi: 10.1002/jcph.424. Epub 2014 Dec 30.

PMID:
25385533
4.

In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide.

Sharan S, Iwuchukwu OF, Canney DJ, Zimmerman CL, Nagar S.

Drug Metab Dispos. 2012 Oct;40(10):1993-2001. doi: 10.1124/dmd.112.046417. Epub 2012 Jul 17. Erratum in: Drug Metab Dispos. 2012 Dec;40(12):2382.

5.

Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation.

Wang J, Zhong Y, Carmella SG, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami DK, Upadhyaya P, Hecht SS, Zimmerman CL.

J Pharmacol Exp Ther. 2012 Sep;342(3):750-60. doi: 10.1124/jpet.112.194118. Epub 2012 Jun 6.

6.

Formation and distribution of NNK metabolites in an isolated perfused rat lung.

Maertens LA, Upadhyaya P, Hecht SS, Zimmerman CL.

Drug Metab Dispos. 2010 May;38(5):752-60. doi: 10.1124/dmd.109.031492. Epub 2010 Feb 16.

7.

The intestinal absorption of a prodrug of the mGlu2/3 receptor agonist LY354740 is mediated by PEPT1: in situ rat intestinal perfusion studies.

Eriksson AH, Varma MV, Perkins EJ, Zimmerman CL.

J Pharm Sci. 2010 Mar;99(3):1574-81. doi: 10.1002/jps.21917.

PMID:
19780137
9.

Hair cell numbers do not decrease in the crista ampullaris of geriatric gerbils.

Kevetter GA, Zimmerman CL, Leonard RB.

J Neurosci Res. 2005 Apr 15;80(2):279-85.

PMID:
15765526
11.

Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen.

Hecht SS, Murphy SE, Carmella SG, Zimmerman CL, Losey L, Kramarczuk I, Roe MR, Puumala SS, Li YS, Le C, Jensen J, Hatsukami DK.

J Natl Cancer Inst. 2004 Jan 21;96(2):107-15.

PMID:
14734700
12.

Metabolism of opioids is altered in liver microsomes of sickle cell transgenic mice.

Nagar S, Remmel RP, Hebbel RP, Zimmerman CL.

Drug Metab Dispos. 2004 Jan;32(1):98-104.

PMID:
14709626
13.

Disposition and oral bioavailability in rats of an antiviral and antitumor amino acid phosphoramidate prodrug of AZT-monophosphate.

Song H, Johns R, Griesgraber GW, Wagner CR, Zimmerman CL.

Pharm Res. 2003 Mar;20(3):448-51.

PMID:
12669967
14.

Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey.

Upadhyaya P, Zimmerman CL, Hecht SS.

Drug Metab Dispos. 2002 Oct;30(10):1115-22.

PMID:
12228188
15.

Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats.

Song H, Griesgraber GW, Wagner CR, Zimmerman CL.

Antimicrob Agents Chemother. 2002 May;46(5):1357-63.

16.

Intestinal metabolism: the role of enzyme localization in phenol metabolite kinetics.

Kothare PA, Zimmerman CL.

Drug Metab Dispos. 2002 May;30(5):586-94.

PMID:
11950792
17.

Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use.

Hecht SS, Carmella SG, Ye M, Le KA, Jensen JA, Zimmerman CL, Hatsukami DK.

Cancer Res. 2002 Jan 1;62(1):129-34.

19.

Methotrexate accumulates to similar levels in animals transplanted with normal versus drug-resistant transgenic marrow.

Belur LR, Boelk-Galvan D, Diers MD, McIvor RS, Zimmerman CL.

Cancer Res. 2001 Feb 15;61(4):1522-6.

20.

The absorption of retinoic acids from the gastrointestinal tract is dependent upon chemical structure.

Zimmerman CL, Han S, Wiedmann TS.

Cancer Chemother Pharmacol. 2001;47(1):27-33.

PMID:
11221958
21.
22.

First-pass disposition of (-)-6-aminocarbovir in rats: II. Inhibition of intestinal first-pass metabolism.

Zimmerman CL, Wen Y, Remmel RP.

Drug Metab Dispos. 2000 Jun;28(6):672-9.

PMID:
10820140
23.

Synthesis and antiviral activity of amino acid carbamate derivatives of AZT.

Chang SL, Griesgraber G, Abraham TW, Garg T, Song H, Zimmerman CL, Wagner CR.

Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):87-100.

PMID:
10772704
24.

Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol.

Wattenberg LW, Wiedmann TS, Estensen RD, Zimmerman CL, Galbraith AR, Steele VE, Kelloff GJ.

Carcinogenesis. 2000 Feb;21(2):179-82.

PMID:
10657955
25.

Antiviral nucleoside drug delivery via amino acid phosphoramidates.

Wagner CR, Chang SL, Griesgraber GW, Song H, McIntee EJ, Zimmerman CL.

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):913-9.

PMID:
10432709
26.

Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation.

Hecht SS, Carmella SG, Chen M, Dor Koch JF, Miller AT, Murphy SE, Jensen JA, Zimmerman CL, Hatsukami DK.

Cancer Res. 1999 Feb 1;59(3):590-6.

27.

First-pass disposition of (-)-6-aminocarbovir in rats. I. Prodrug activation may be limited by access to enzyme.

Wen Y, Remmel RP, Zimmerman CL.

Drug Metab Dispos. 1999 Jan;27(1):113-21.

PMID:
9884319
28.

Evaluation of gastrointestinal absorption and metabolism.

Zimmerman CL, Wen Y, Soria I, Pithavala YK.

Drug Metab Rev. 1997 Nov;29(4):957-75. Review. No abstract available.

PMID:
9421681
29.

Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice.

Wattenberg LW, Wiedmann TS, Estensen RD, Zimmerman CL, Steele VE, Kelloff GJ.

Cancer Res. 1997 Dec 15;57(24):5489-92.

30.

Use of the deconvolution principle in the estimation of absorption and pre-systemic intestinal elimination of drugs.

Pithavala YK, Soria I, Zimmerman CL.

Drug Metab Dispos. 1997 Nov;25(11):1260-5.

PMID:
9351902
31.

The validation of the intestinal permeability approach to predict oral fraction of dose absorbed in humans and rats.

Soria I, Zimmerman CL.

Biopharm Drug Dispos. 1996 Dec;17(9):817-8. No abstract available.

PMID:
8968533
32.

Lack of effect of catheterization on the pharmacokinetics of (-)-carbovir in rats.

Zimmerman CL, Ha KJ, Huang SH.

Pharm Res. 1996 Sep;13(9):1417-8. No abstract available.

PMID:
8893285
33.

Solubilization of retinoids by bile salt/phospholipid aggregates.

Li CY, Zimmerman CL, Wiedmann TS.

Pharm Res. 1996 Jun;13(6):907-13.

PMID:
8792431
34.

Diffusivity of bile salt/phospholipid aggregates in mucin.

Li CY, Zimmerman CL, Wiedmann TS.

Pharm Res. 1996 Apr;13(4):535-41.

PMID:
8710742
35.

In vivo bioavailability predictions from perfused intestine studies.

Soria I, Zimmerman CL.

Int J Clin Pharmacol Ther. 1996 Feb;34(2):90-1. No abstract available.

PMID:
8929754
36.

Retinoid absorption from simple and mixed micelles in the rat intestine.

Pithavala YK, Odishaw JL, Han S, Wiedmann TS, Zimmerman CL.

J Pharm Sci. 1995 Nov;84(11):1360-5. Erratum in: J Pharm Sci 1997 Feb;86(2):267.

PMID:
8587056
37.

Comparative brain exposure to (-)-carbovir after (-)-carbovir or (-)-6-aminocarbovir intravenous infusion in rats.

Wen YD, Remmel RP, Pham PT, Vince R, Zimmerman CL.

Pharm Res. 1995 Jun;12(6):911-5.

PMID:
7667200
39.

Pharmacokinetics and hepatic first-pass effect of (-)-carbovir in the anesthetized rat.

Soria I, Zimmerman CL.

Biopharm Drug Dispos. 1995 May;16(4):313-8.

PMID:
7548780
40.

Intestinal absorption of (-)-carbovir in the rat.

Soria I, Zimmerman CL.

Pharm Res. 1994 Feb;11(2):267-71.

PMID:
8165186
41.
42.

Disposition of (-)carbovir in the in situ perfused rat liver and intestinal vasculature preparations.

Soria I, Zimmerman CL.

Drug Metab Dispos. 1993 Jul-Aug;21(4):724-9.

PMID:
8104134
43.

Pharmacokinetic evaluation of (-)-6-aminocarbovir as a prodrug for (-)-carbovir in rats.

Zimmerman CL, Remmel RP, Ibrahim SS, Beers SA, Vince R.

Drug Metab Dispos. 1992 Jan-Feb;20(1):47-51.

PMID:
1346995
44.

The bioavailability and nonlinear clearance of (-)-carbovir in the rat.

Huang SH, Remmel RP, Zimmerman CL.

Pharm Res. 1991 Jun;8(6):739-43.

PMID:
2062804
46.

Methotrexate disposition following disruption of the blood-brain barrier.

Markowsky SJ, Zimmerman CL, Tholl D, Soria I, Castillo R.

Ther Drug Monit. 1991 Jan;13(1):24-31.

PMID:
2057988
47.

Etretinate absorption in the in situ perfused intestinal lumen: preliminary studies in the rat.

Zimmerman CL, Johnson KE.

Biopharm Drug Dispos. 1991 Jan-Feb;12(1):49-57.

PMID:
1828179
48.

Improved fluorometric high-performance liquid chromatographic assay for (-)-carbovir in rat blood and urine.

Remmel RP, Huang SH, Hoff D, Zimmerman CL.

J Chromatogr. 1990 Dec 14;534:109-18.

PMID:
2094697
49.

The disposition of cytosine arabinoside and its metabolite after single doses to rabbits.

Zimmerman CL.

Biopharm Drug Dispos. 1990 Mar;11(2):121-9.

PMID:
2328297
50.

The effects of urine pH modification on the pharmacokinetics and pharmacodynamics of phenylpropanolamine.

Zimmerman CL, O'Connell MB, Soria I.

Pharm Res. 1990 Jan;7(1):96-102.

PMID:
2300545

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