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Structure and Ligand-Binding Properties of the O Antigen ABC Transporter Carbohydrate-Binding Domain.

Bi Y, Zimmer J.

Structure. 2019 Dec 17. pii: S0969-2126(19)30438-1. doi: 10.1016/j.str.2019.11.020. [Epub ahead of print]


Clinically Negligible Pharmacokinetic and Pharmacodynamic Interactions Between Lanabecestat and Dabigatran Etexilate, a Prototypical P-gp Substrate.

Monk SA, Kugler AR, Andersen SW, Ayan-Oshodi MA, James DE, Mullen J, Zimmer JA, Willis BA.

J Clin Pharmacol. 2019 Dec 18. doi: 10.1002/jcph.1558. [Epub ahead of print]


Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials.

Wessels AM, Tariot PN, Zimmer JA, Selzler KJ, Bragg SM, Andersen SW, Landry J, Krull JH, Downing AM, Willis BA, Shcherbinin S, Mullen J, Barker P, Schumi J, Shering C, Matthews BR, Stern RA, Vellas B, Cohen S, MacSweeney E, Boada M, Sims JR.

JAMA Neurol. 2019 Nov 25. doi: 10.1001/jamaneurol.2019.3988. [Epub ahead of print]


Alessandro Moretta and Transporter Associated With Antigen Processing (TAP) Deficiency: On Giant's Shoulders.

Zimmer J.

Front Immunol. 2019 Oct 15;10:2404. doi: 10.3389/fimmu.2019.02404. eCollection 2019.


Long-term results achieved by guideline-based stage-dependent management of anal cancer in a non-HIV population.

Fankhaenel B, Zimmer J, Bleyl D, Puffer E, Schreiber A, Kittner T, Witzigmann H, Stelzner S.

Int J Colorectal Dis. 2019 Nov;34(11):1895-1905. doi: 10.1007/s00384-019-03396-x. Epub 2019 Oct 22.


Validated quantitative cannabis profiling for Canadian regulatory compliance - Cannabinoids, aflatoxins, and terpenes.

Brown AK, Xia Z, Bulloch P, Idowu I, Francisco O, Stetefeld J, Stout J, Zimmer J, Marvin C, Letcher RJ, Tomy G.

Anal Chim Acta. 2019 Dec 11;1088:79-88. doi: 10.1016/j.aca.2019.08.042. Epub 2019 Aug 20.


Validating stability and selectivity in the presence of co-administered compounds.

DeChenne S, Yahvah K, Zimmer J.

Bioanalysis. 2019 Oct;11(20):1819-1821. doi: 10.4155/bio-2019-0150. Epub 2019 Oct 16. No abstract available.


Architecture of the Cellulose Synthase Outer Membrane Channel and Its Association with the Periplasmic TPR Domain.

Acheson JF, Derewenda ZS, Zimmer J.

Structure. 2019 Dec 3;27(12):1855-1861.e3. doi: 10.1016/j.str.2019.09.008. Epub 2019 Oct 8.


GCC Consolidated Feedback to ICH on the 2019 ICH M10 Bioanalytical Method Validation Draft Guideline.

Nehls C, Buonarati M, Cape S, Islam R, Satterwhite C, Briscoe C, Hayes R, Dinan A, Sales K, Anderson S, Vance J, Lindsay J, Zimmer J, Couerbe P, Khadang A, Maasjo S, Bravo O, Lindley K, Moran L, Sangster T, Vija J, Stamatopoulos J, Lin J, Reuschel S, Underberg A, MacNeill R, Matassa L, Spytko A, Garofolo W, Savoie N, Rhyne P, Ambrosius J, Barra V, Dufield D, Luna M, Spriggs F, Fedorov E, Ritzén H, Fatmi S, Kane C, Bouhajib M, DiMarco C, Iordachescu A, Tudoroniu A, Farley E, Stouffer B, Tabler E, McCown S, Bower J, Harrison T, Karnik S, Brown M, Joyce P, DuBey I, Hoffpauir B, Boudreau N, Bergeron J, Wang H, Feng H, Zhou S, Wells E, Pirro J, Fang X, Shi J, Yang C.

Bioanalysis. 2019 Sep 30. doi: 10.4155/bio-2019-0207. [Epub ahead of print]


Procedure related risk of premature delivery and fetal growth reduction following amniocentesis, transcervical and transabdominal chorionic villus sampling: a retrospective study.

Zimmer J, Schmitz R, Möllers M, Hammer K, Falkenberg MK, Braun J, Schmidt R, Borowski M, Steinhard J, Köster HA, Klockenbusch W, Oelmeier de Murcia K.

J Perinat Med. 2019 Oct 25;47(8):811-816. doi: 10.1515/jpm-2019-0291.


12th GCC Closed Forum: critical reagents; oligonucleotides; CoA; method transfer; HRMS; flow cytometry; regulatory findings; stability and immunogenicity.

Briscoe C, Hughes N, Hayes R, Islam R, Bennett P, Stouffer B, Cape S, Rhyne P, Beaver C, Charles JS, Kakkanaiah V, Xu A, Caturla MC, Spriggs F, Tayyem R, Barry C, Keyhani A, Zimmer J, Couerbe P, Warren M, Khadang A, Bourdage J, Lindley K, Williams D, Sheldon C, Satterwhite C, Vija J, Yu M, Boulay I, Stamatopoulos J, Lin J, Estdale S, Thomas E, Dinan A, MacNeill R, Xiao YQ, Matassa L, Garofolo W, Savoie N, Hristopoulos G, Xu A, Goodwin L, Awaiye K, Ritzén H, Bouhajib M, Marco CD, Savu SR, Nehls C, Tabler E, Hays A, Karnik S, Brown M, Lowes S, DuBey I, Kulagina N, Lindsay J, Williard C, Wang H, Malone M, Wells E, Fang X, Moussallie M.

Bioanalysis. 2019 Jun;11(12):1129-1138. doi: 10.4155/bio-2019-0131. Epub 2019 Jul 19.


Prognosis in patients with synchronous colorectal cancer metastases after complete resection of the primary tumor and the metastases.

Stelzner S, Radulova-Mauersberger O, Zschuppe E, Kittner T, Abolmaali N, Puffer E, Zimmer J, Witzigmann H.

J Surg Oncol. 2019 Sep;120(3):438-445. doi: 10.1002/jso.25578. Epub 2019 Jun 5.


Recommendations for classification of commercial LBA kits for biomarkers in drug development from the GCC for bioanalysis.

Islam R, Kar S, Ritzén H, Hays A, Tayyem R, Barry C, Keyhani A, Zimmer J, Cruz Caturla M, Couerbe P, Warren M, Khadang A, Bourdage J, Lindley K, Williams D, Hughes N, Sheldon C, Satterwhite C, Vija J, Yu M, Boulay I, Stamatopoulos J, Lin J, Cape S, Estdale S, Thomas E, Dinan A, MacNeill R, Xiao YQ, Garofolo W, Savoie N, Brown M, Rhyne P, Hristopoulos G, Xu A, Goodwin L, Spriggs F, Xu A, Awaiye K, Hayes R, St Charles J, Bouhajib M, DiMarco C, DiMarco L, Savu SR, Bennett P, Kakkanaiah V, Nehls C, Stouffer B, Tabler E, Briscoe C, Karnik S, DuBey I, Kulagina N, Lindsay J, Beaver C, Williard C, Wang H, Feng H, Malone M, Wells E, Fang X, Moussallie M.

Bioanalysis. 2019 Apr;11(7):645-653. doi: 10.4155/bio-2019-0072. Epub 2019 Apr 17.


MicroRNA-496 and Mechanistic Target of Rapamycin Expression are Associated with Type 2 Diabetes Mellitus and Obesity in Elderly People.

Rubie C, Zimmer J, Lammert F, Gross JC, Weber SN, Kruse B, Halajda B, Wagner M, Wagenpfeil S, Glanemann M.

Ann Nutr Metab. 2019;74(4):279-286. doi: 10.1159/000499576. Epub 2019 Apr 2.


Structural features underlying recognition and translocation of extracellular polysaccharides.

Zimmer J.

Interface Focus. 2019 Apr 6;9(2):20180060. doi: 10.1098/rsfs.2018.0060. Epub 2019 Feb 15. Review.


A lipid gating mechanism for the channel-forming O antigen ABC transporter.

Caffalette CA, Corey RA, Sansom MSP, Stansfeld PJ, Zimmer J.

Nat Commun. 2019 Feb 18;10(1):824. doi: 10.1038/s41467-019-08646-8.


Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.

Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Lau YC, Heidemann PH, Strowitzki T.

Hum Reprod. 2019 Apr 1;34(4):770-779. doi: 10.1093/humrep/dez004.


To what extent is the low anterior resection syndrome (LARS) associated with quality of life as measured using the EORTC C30 and CR38 quality of life questionnaires?

Kupsch J, Kuhn M, Matzel KE, Zimmer J, Radulova-Mauersberger O, Sims A, Witzigmann H, Stelzner S.

Int J Colorectal Dis. 2019 Apr;34(4):747-762. doi: 10.1007/s00384-019-03249-7. Epub 2019 Feb 5.


Eye removal following parotid duct transposition surgery: A survey of current practice among veterinary ophthalmologists.

Zimmer JL, Diehl KA, Myrna KE.

Vet Ophthalmol. 2019 Mar;22(2):213-217. doi: 10.1111/vop.12639. Epub 2019 Feb 4.


Expression of Nitric Oxide Synthase Interacting Protein (NOSIP) is Decreased in the Pulmonary Vasculature of Nitrofen-Induced Congenital Diaphragmatic Hernia.

Nakamura H, Zimmer J, Friedmacher F, Puri P.

Eur J Pediatr Surg. 2019 Feb;29(1):102-107. doi: 10.1055/s-0038-1675772. Epub 2018 Dec 10.


Ephrin-B1, -B2, and -B4 Expression is Decreased in Developing Diaphragms and Lungs of Fetal Rats with Nitrofen-Induced Congenital Diaphragmatic Hernia.

Takahashi T, Friedmacher F, Zimmer J, Puri P.

Eur J Pediatr Surg. 2019 Feb;29(1):113-119. doi: 10.1055/s-0038-1675774. Epub 2018 Nov 23.


Prenatal treatment with rosiglitazone attenuates vascular remodeling and pulmonary monocyte influx in experimental congenital diaphragmatic hernia.

Gosemann JH, Friedmacher F, Hofmann A, Zimmer J, Kuebler JF, Rittinghausen S, Suttkus A, Lacher M, Alvarez L, Corcionivoschi N, Puri P.

PLoS One. 2018 Nov 12;13(11):e0206975. doi: 10.1371/journal.pone.0206975. eCollection 2018.


Expression of dispatched RND transporter family member 1 is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia.

Takahashi T, Friedmacher F, Zimmer J, Puri P.

Pediatr Surg Int. 2019 Jan;35(1):35-40. doi: 10.1007/s00383-018-4374-6. Epub 2018 Oct 31.


Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes.

García-García A, Korn C, García-Fernández M, Domingues O, Villadiego J, Martín-Pérez D, Isern J, Bejarano-García JA, Zimmer J, Pérez-Simón JA, Toledo-Aral JJ, Michel T, Airaksinen MS, Méndez-Ferrer S.

Blood. 2019 Jan 17;133(3):224-236. doi: 10.1182/blood-2018-08-867648. Epub 2018 Oct 25.


Danazol as a second-line treatment for immune thrombocytopenic purpura.

Zimmer J.

Eur J Haematol. 2019 Jan;102(1):97-98. doi: 10.1111/ejh.13184. Epub 2018 Nov 9. No abstract available.


State of Play: Eight Decades of Surgery for Esophageal Atresia.

Zimmer J, Eaton S, Murchison LE, De Coppi P, Ure BM, Dingemann C.

Eur J Pediatr Surg. 2019 Feb;29(1):39-48. doi: 10.1055/s-0038-1668150. Epub 2018 Aug 15. Review.


[Perioperative safety of intraperitoneal aerosol chemotherapy : Analysis of our first 111 pressurized intraperitoneal aerosol chemotherapy (PIPAC) procedures].

Jansen-Winkeln B, Thieme R, Haase L, Niebisch S, Pommer C, Lyros O, Zimmer J, Lordick F, Remane Y, Frontini R, Gockel I.

Chirurg. 2019 Feb;90(2):137-145. doi: 10.1007/s00104-018-0667-5. German.


The ubiquitin-protein ligase E6AP/UBE3A supports early encephalomyocarditis virus replication.

Carmody M, Zimmer JT, Cushman CH, Nguyen T, Lawson TG.

Virus Res. 2018 Jul 2;252:48-57. doi: 10.1016/j.virusres.2018.05.016. Epub 2018 May 18.


Computing diffusivities from particle models out of equilibrium.

Embacher P, Dirr N, Zimmer J, Reina C.

Proc Math Phys Eng Sci. 2018 Apr;474(2212):20170694. doi: 10.1098/rspa.2017.0694. Epub 2018 Apr 11.


11th GCC Closed Forum: cumulative stability; matrix stability; immunogenicity assays; laboratory manuals; biosimilars; chiral methods; hybrid LBA/LCMS assays; fit-for-purpose validation; China Food and Drug Administration bioanalytical method validation.

Islam R, Briscoe C, Bower J, Cape S, Arnold M, Hayes R, Warren M, Karnik S, Stouffer B, Xiao YQ, van der Strate B, Sikkema D, Fang X, Tudoroniu A, Tayyem R, Brant A, Spriggs F, Barry C, Khan M, Keyhani A, Zimmer J, Caturla MC, Couerbe P, Khadang A, Bourdage J, Datin J, Zemo J, Hughes N, Fatmi S, Sheldon C, Fountain S, Satterwhite C, Colletti K, Vija J, Yu M, Stamatopoulos J, Lin J, Wilfahrt J, Dinan A, Ohorodnik S, Hulse J, Patel V, Garofolo W, Savoie N, Brown M, Papac D, Buonarati M, Hristopoulos G, Beaver C, Boudreau N, Williard C, Liu Y, Ray G, Warrino D, Xu A, Green R, Hayward-Sewell J, Marcelletti J, Sanchez C, Kennedy M, Charles JS, Bouhajib M, Nehls C, Tabler E, Tu J, Joyce P, Iordachescu A, DuBey I, Lindsay J, Yamashita J, Wells E.

Bioanalysis. 2018 Apr 1;10(7):433-444. doi: 10.4155/bio-2018-0014. Epub 2018 Apr 27.


Pathology in Practice.

Zimmer JL, McLean NJ, Craig LE.

J Am Vet Med Assoc. 2018 Apr 15;252(8):937-939. doi: 10.2460/javma.252.8.937. No abstract available.


Outcome of bowel function following anterior resection for rectal cancer-an analysis using the low anterior resection syndrome (LARS) score.

Kupsch J, Jackisch T, Matzel KE, Zimmer J, Schreiber A, Sims A, Witzigmann H, Stelzner S.

Int J Colorectal Dis. 2018 Jun;33(6):787-798. doi: 10.1007/s00384-018-3006-x. Epub 2018 Mar 15.


Gastrointestinal Tolerance and Glycemic Response of Isomaltooligosaccharides in Healthy Adults.

Gourineni V, Stewart ML, Icoz D, Zimmer JP.

Nutrients. 2018 Mar 3;10(3). pii: E301. doi: 10.3390/nu10030301.


Revisiting the Functional Impact of NK Cells.

Poli A, Michel T, Patil N, Zimmer J.

Trends Immunol. 2018 Jun;39(6):460-472. doi: 10.1016/ Epub 2018 Feb 26. Review.


Architecture of a channel-forming O-antigen polysaccharide ABC transporter.

Bi Y, Mann E, Whitfield C, Zimmer J.

Nature. 2018 Jan 18;553(7688):361-365. doi: 10.1038/nature25190. Epub 2018 Jan 10.


Canonical Structure and Orthogonality of Forces and Currents in Irreversible Markov Chains.

Kaiser M, Jack RL, Zimmer J.

J Stat Phys. 2018;170(6):1019-1050. doi: 10.1007/s10955-018-1986-0. Epub 2018 Feb 15.


Topical Mitomycin C Application in Pediatric Patients with Recurrent Esophageal Strictures-Report on Unfavorable Results.

Madadi-Sanjani O, Zimmer J, Gosemann JH, Ure BM, Lacher M, Boehm R.

Eur J Pediatr Surg. 2018 Dec;28(6):539-546. doi: 10.1055/s-0037-1615278. Epub 2017 Dec 21.


Gata-6 expression is decreased in diaphragmatic and pulmonary mesenchyme of fetal rats with nitrofen-induced congenital diaphragmatic hernia.

Takahashi T, Friedmacher F, Zimmer J, Puri P.

Pediatr Surg Int. 2018 Mar;34(3):315-321. doi: 10.1007/s00383-017-4219-8. Epub 2017 Dec 2.


Distinct reaction mechanisms for hyaluronan biosynthesis in different kingdoms of life.

Blackburn MR, Hubbard C, Kiessling V, Bi Y, Kloss B, Tamm LK, Zimmer J.

Glycobiology. 2018 Feb 1;28(2):108-121. doi: 10.1093/glycob/cwx096.


Development Review of the BACE1 Inhibitor Lanabecestat (AZD3293/LY3314814).

Sims JR, Selzler KJ, Downing AM, Willis BA, Aluise CD, Zimmer J, Bragg S, Andersen S, Ayan-Oshodi M, Liffick E, Eads J, Wessels AM, Monk S, Schumi J, Mullen J.

J Prev Alzheimers Dis. 2017;4(4):247-254. doi: 10.14283/jpad.2017.38. Review.


Validation of ELISA methods for quantification of the major birch allergen Bet v 1 (BSP090).

Kaul S, Zimmer J, Dehus O, Constanzo A, Daas A, Buchheit KH, Asturias J, Arilla MC, Barber D, Bertocchi A, Brunetto B, Carnes JA, Chapman M, Chaudemanche G, Dayan-Kenigsberg J, Döring S, Führer F, Gallego MT, Iacovacci P, Hanschmann KM, Holzhauser T, Hrabina M, Ledesma A, Moingeon P, Nony E, Pini C, Plunkett G, Raulf M, Reese G, Sandberg E, Sander I, Smith B, Strecker D, Valerio C, van Ree R, Weber B, Vieths S.

Pharmeur Bio Sci Notes. 2017;2017:69-87.


Quality requirements for allergen extracts and allergoids for allergen immunotherapy.

Zimmer J, Bonertz A, Vieths S.

Allergol Immunopathol (Madr). 2017 Dec;45 Suppl 1:4-11. doi: 10.1016/j.aller.2017.09.002. Epub 2017 Nov 9. Review.


Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells.

Lai X, Broderick R, Bergoglio V, Zimmer J, Badie S, Niedzwiedz W, Hoffmann JS, Tarsounas M.

Nat Commun. 2017 Oct 26;8:16171. doi: 10.1038/ncomms16171.


Automatic processing of emotional facial expressions as a function of social anhedonia.

Günther V, Zimmer J, Kersting A, Hoffmann KT, Lobsien D, Suslow T.

Psychiatry Res Neuroimaging. 2017 Dec 30;270:46-53. doi: 10.1016/j.pscychresns.2017.10.002. Epub 2017 Oct 10.


Increased CaSR and TRPC6 pulmonary vascular expression in the nitrofen-induced model of congenital diaphragmatic hernia.

Nakamura H, Zimmer J, Lim T, Puri P.

Pediatr Surg Int. 2018 Feb;34(2):211-215. doi: 10.1007/s00383-017-4191-3. Epub 2017 Oct 5.


Synthesis and Self-Assembly of Cellulose Microfibrils from Reconstituted Cellulose Synthase.

Cho SH, Purushotham P, Fang C, Maranas C, Díaz-Moreno SM, Bulone V, Zimmer J, Kumar M, Nixon BT.

Plant Physiol. 2017 Sep;175(1):146-156. doi: 10.1104/pp.17.00619. Epub 2017 Aug 2.


MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells.

Lai X, Broderick R, Bergoglio V, Zimmer J, Badie S, Niedzwiedz W, Hoffmann JS, Tarsounas M.

Nat Commun. 2017 Jul 17;8:15983. doi: 10.1038/ncomms15983. Erratum in: Nat Commun. 2017 Oct 26;8:16171.


Downregulated Elastin Microfibril Interfacer 1 Expression in the Pulmonary Vasculature of Experimental Congenital Diaphragmatic Hernia.

Zimmer J, Takahashi T, Hofmann AD, Puri P.

Eur J Pediatr Surg. 2018 Feb;28(1):115-119. doi: 10.1055/s-0037-1604026. Epub 2017 Jul 12.


Decreased Expression of Integrin Subunits α3, α6, and α8 in the Branching Airway Mesenchyme of Nitrofen-Induced Hypoplastic Lungs.

Takahashi T, Friedmacher F, Zimmer J, Puri P.

Eur J Pediatr Surg. 2018 Feb;28(1):109-114. doi: 10.1055/s-0037-1604022. Epub 2017 Jul 12.


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