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Items: 11


Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential.

Buys ES, Zimmer DP, Chickering J, Graul R, Chien YT, Profy A, Hadcock JR, Masferrer JL, Milne GT.

Nitric Oxide. 2018 May 31;78:72-80. doi: 10.1016/j.niox.2018.05.009. [Epub ahead of print] Review.


Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease.

Tobin JV, Zimmer DP, Shea C, Germano P, Bernier SG, Liu G, Long K, Miyashiro J, Ranganath S, Jacobson S, Tang K, Im GJ, Sheppeck J 2nd, Moore JD, Sykes K, Wakefield J, Sarno R, Banijamali AR, Profy AT, Milne GT, Currie MG, Masferrer JL.

J Pharmacol Exp Ther. 2018 Jun;365(3):664-675. doi: 10.1124/jpet.117.247429. Epub 2018 Apr 11.


Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans.

Nakai T, Perl NR, Barden TC, Carvalho A, Fretzen A, Germano P, Im GY, Jin H, Kim C, Lee TW, Long K, Moore J, Rohde JM, Sarno R, Segal C, Solberg EO, Tobin J, Zimmer DP, Currie MG.

ACS Med Chem Lett. 2016 Feb 24;7(5):465-9. doi: 10.1021/acsmedchemlett.5b00479. eCollection 2016 May 12.


The natriuretic peptide uroguanylin elicits physiologic actions through 2 distinct topoisomers.

Moss NG, Riguera DA, Solinga RM, Kessler MM, Zimmer DP, Arendshorst WJ, Currie MG, Goy MF.

Hypertension. 2009 May;53(5):867-76. doi: 10.1161/HYPERTENSIONAHA.108.128264. Epub 2009 Mar 16.


Genome image programs: visualization and interpretation of Escherichia coli microarray experiments.

Zimmer DP, Paliy O, Thomas B, Gyaneshwar P, Kustu S.

Genetics. 2004 Aug;167(4):2111-9.


Escherichia coli spotted double-strand DNA microarrays: RNA extraction, labeling, hybridization, quality control, and data management.

Khodursky AB, Bernstein JA, Peter BJ, Rhodius V, Wendisch VF, Zimmer DP.

Methods Mol Biol. 2003;224:61-78. No abstract available.


Structural origins of adenine-tract bending.

Barbic A, Zimmer DP, Crothers DM.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2369-73. Epub 2003 Feb 13.


Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains.

Askenazi M, Driggers EM, Holtzman DA, Norman TC, Iverson S, Zimmer DP, Boers ME, Blomquist PR, Martinez EJ, Monreal AW, Feibelman TP, Mayorga ME, Maxon ME, Sykes K, Tobin JV, Cordero E, Salama SR, Trueheart J, Royer JC, Madden KT.

Nat Biotechnol. 2003 Feb;21(2):150-6. Epub 2003 Jan 21.


Isolation of Escherichia coli mRNA and comparison of expression using mRNA and total RNA on DNA microarrays.

Wendisch VF, Zimmer DP, Khodursky A, Peter B, Cozzarelli N, Kustu S.

Anal Biochem. 2001 Mar;290(2):205-13.


Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation.

Zimmer DP, Soupene E, Lee HL, Wendisch VF, Khodursky AB, Peter BJ, Bender RA, Kustu S.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14674-9.


NMR of enzymatically synthesized uniformly 13C15N-labeled DNA oligonucleotides.

Zimmer DP, Crothers DM.

Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3091-5.

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