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Skin fragility caused by biallelic KRT10 mutations: an intriguing form of self-improving epidermolytic ichthyosis.

Frommherz L, Küsel J, Zimmer A, Fischer J, Has C.

Br J Dermatol. 2019 Jul 6. doi: 10.1111/bjd.18325. [Epub ahead of print]


Multi-Gene Panel Testing of 23,179 Individuals for Hereditary Cancer Risk Identifies Pathogenic Variant Carriers Missed by Current Genetic Testing Guidelines.

Neben CL, Zimmer AD, Stedden W, van den Akker J, O'Connor R, Chan RC, Chen E, Tan Z, Leon A, Ji J, Topper S, Zhou AY.

J Mol Diagn. 2019 Jul;21(4):646-657. doi: 10.1016/j.jmoldx.2019.03.001. Epub 2019 Jun 11.


Evaluating the physiological significance of hypoxic hyperventilation in larval zebrafish (Danio rerio).

Pan YK, Mandic M, Zimmer AM, Perry SF.

J Exp Biol. 2019 Jul 5;222(Pt 13). pii: jeb204800. doi: 10.1242/jeb.204800.


Myocardial maladaptation to pressure overload in CB2 receptor-deficient mice.

Duerr GD, Heinemann JC, Kley J, Eichhorn L, Frede S, Weisheit C, Wehner S, Bindila L, Lutz B, Zimmer A, Dewald O.

J Mol Cell Cardiol. 2019 Aug;133:86-98. doi: 10.1016/j.yjmcc.2019.06.003. Epub 2019 Jun 7.


Investigation of cell culture conditions for optimal foot-and-mouth disease virus production.

Dill V, Zimmer A, Beer M, Eschbaumer M.

BMC Biotechnol. 2019 Jun 7;19(1):33. doi: 10.1186/s12896-019-0527-5.


Cell Density Effects in Different Cell Culture Media and Their Impact on the Propagation of Foot-And-Mouth Disease Virus.

Dill V, Ehret J, Zimmer A, Beer M, Eschbaumer M.

Viruses. 2019 Jun 4;11(6). pii: E511. doi: 10.3390/v11060511.


Natural history of caesarean scar pregnancy.

Pomorski M, Fuchs T, Budny-Winska J, Zimmer A, Zimmer M.

Ginekol Pol. 2019;90(6):351-352. doi: 10.5603/GP.a2019.0054. Epub 2019 Jun 5. No abstract available.


Chronified Pain Following Operative Procedures.

Geil D, Thomas C, Zimmer A, Meissner W.

Dtsch Arztebl Int. 2019 Apr 12;116(15):261-266. doi: 10.3238/arztebl.2019.0261.


A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes.

Yeh YN, Hsin KY, Zimmer A, Lin LY, Hung MS.

Biochem Pharmacol. 2019 Aug;166:203-211. doi: 10.1016/j.bcp.2019.05.022. Epub 2019 May 24.


A review of waste glass as a raw material for whitewares.

Zimmer A, Bragança SR.

J Environ Manage. 2019 Aug 15;244:161-171. doi: 10.1016/j.jenvman.2019.05.038. Epub 2019 May 20. Review.


Noise-precision tradeoff in predicting combinations of mutations and drugs.

Tendler A, Zimmer A, Mayo A, Alon U.

PLoS Comput Biol. 2019 May 22;15(5):e1006956. doi: 10.1371/journal.pcbi.1006956. eCollection 2019 May.


Correlation between the solid state of lipid coating and release profile of API from hot melt coated microcapsules.

Salar-Behzadi S, Corzo C, Schaden L, Laggner P, Zimmer A.

Int J Pharm. 2019 Jun 30;565:569-578. doi: 10.1016/j.ijpharm.2019.05.036. Epub 2019 May 14.


CB2 receptor deletion on myeloid cells enhanced mechanical allodynia in a mouse model of neuropathic pain.

Nent E, Nozaki C, Schmöle AC, Otte D, Zimmer A.

Sci Rep. 2019 May 16;9(1):7468. doi: 10.1038/s41598-019-43858-4.


A monoallelic two-hit mechanism in PLCD1 explains the genetic pathogenesis of hereditary trichilemmal cyst formation.

Hörer S, Marrakchi S, Radner FPW, Zolles G, Heinz L, Eichmann TO, Has C, Salavei P, Mahfoud N, Turki H, Zimmer AD, Fischer J.

J Invest Dermatol. 2019 May 10. pii: S0022-202X(19)31554-4. doi: 10.1016/j.jid.2019.04.015. [Epub ahead of print]


Vancomycin ocular delivery systems based on glycerol monooleate reversed hexagonal and reversed cubic liquid crystalline phases.

Milak S, Chemelli A, Glatter O, Zimmer A.

Eur J Pharm Biopharm. 2019 Jun;139:279-290. doi: 10.1016/j.ejpb.2019.04.009. Epub 2019 Apr 16.


Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.

Vetrivel S, Tiso N, Kügler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S; German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Götz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Hölter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Rácz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Östereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Hrabě de Angelis M, Graw J.

Exp Eye Res. 2019 Apr 13. pii: S0014-4835(18)30702-4. doi: 10.1016/j.exer.2019.03.024. [Epub ahead of print]


Loss-of-function approaches in comparative physiology: is there a future for knockdown experiments in the era of genome editing?

Zimmer AM, Pan YK, Chandrapalan T, Kwong RWM, Perry SF.

J Exp Biol. 2019 Apr 4;222(Pt 7). pii: jeb175737. doi: 10.1242/jeb.175737. Review.


Coloration mechanism of electrochromic NaxWO3 thin films.

Zimmer A, Gilliot M, Tresse M, Broch L, Tillous KE, Boulanger C, Stein N, Horwat D.

Opt Lett. 2019 Mar 1;44(5):1104-1107. doi: 10.1364/OL.44.001104.


Vitamins in cell culture media: Stability and stabilization strategies.

Schnellbaecher A, Binder D, Bellmaine S, Zimmer A.

Biotechnol Bioeng. 2019 Jun;116(6):1537-1555. doi: 10.1002/bit.26942. Epub 2019 Feb 21. Review.


A scalable, aggregated genotypic-phenotypic database for human disease variation.

Barrett R, Neben CL, Zimmer AD, Mishne G, McKennon W, Zhou AY, Ginsberg J.

Database (Oxford). 2019 Jan 1;2019. doi: 10.1093/database/baz013.


Total Synthesis of α-Tocopherol through Enantioselective Iridium-Catalyzed Fragmentation of a Spiro-Cyclobutanol Intermediate.

Ratsch F, Schlundt W, Albat D, Zimmer A, Neudörfl JM, Netscher T, Schmalz HG.

Chemistry. 2019 Apr 1;25(19):4941-4945. doi: 10.1002/chem.201900564. Epub 2019 Mar 15.


Psychosocial assessment of the family in the clinical setting.

Nasir A, Zimmer A, Taylor D, Santo J.

BMC Psychol. 2019 Jan 11;7(1):3. doi: 10.1186/s40359-018-0277-5.


Optimal Management of Neutropenic Fever in Patients With Cancer.

Zimmer AJ, Freifeld AG.

J Oncol Pract. 2019 Jan;15(1):19-24. doi: 10.1200/JOP.18.00269.


Comparison of plasma and oral fluid concentrations of mycophenolic acid and its glucuronide metabolite by LC-MS in kidney transplant patients.

Ferreira PCL, Thiesen FV, de Araujo TT, D'Ávila DO, Gadonski G, de Oliveira CSA, Zimmer AR, Fröehlich PE.

Eur J Clin Pharmacol. 2019 Apr;75(4):553-559. doi: 10.1007/s00228-018-02614-9. Epub 2019 Jan 4.


Role of internal convection in respiratory gas transfer and aerobic metabolism in larval zebrafish ( Danio rerio).

Hughes MC, Zimmer AM, Perry SF.

Am J Physiol Regul Integr Comp Physiol. 2019 Mar 1;316(3):R255-R264. doi: 10.1152/ajpregu.00315.2018. Epub 2019 Jan 2.


A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene.

Jensen LR, Garrett L, Hölter SM, Rathkolb B, Rácz I, Adler T, Prehn C, Hans W, Rozman J, Becker L, Aguilar-Pimentel JA, Puk O, Moreth K, Dopatka M, Walther DJ, von Bohlen Und Halbach V, Rath M, Delatycki M, Bert B, Fink H, Blümlein K, Ralser M, Van Dijck A, Kooy F, Stark Z, Müller S, Scherthan H, Gecz J, Wurst W, Wolf E, Zimmer A, Klingenspor M, Graw J, Klopstock T, Busch D, Adamski J, Fuchs H, Gailus-Durner V, de Angelis MH, von Bohlen Und Halbach O, Ropers HH, Kuss AW.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2083-2093. doi: 10.1016/j.bbadis.2018.12.011. Epub 2018 Dec 14.


Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cells.

Ehret J, Zimmermann M, Eichhorn T, Zimmer A.

Biotechnol Bioeng. 2019 Apr;116(4):816-830. doi: 10.1002/bit.26904. Epub 2019 Jan 21.


Innate immune response in the pathogenesis of heart failure in survivors of myocardial infarction.

Zimmer A, Bagchi AK, Vinayak K, Bello-Klein A, Singal PK.

Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H435-H445. doi: 10.1152/ajpheart.00597.2018. Epub 2018 Dec 7.


Mechanisms of Ca2+ uptake in freshwater and seawater-acclimated killifish, Fundulus heteroclitus, and their response to acute salinity transfer.

Zimmer AM, Brix KV, Wood CM.

J Comp Physiol B. 2019 Feb;189(1):47-60. doi: 10.1007/s00360-018-1192-z. Epub 2018 Dec 4.


Rapid tools to gain insights into the interaction dynamics of new 8-hydroxyquinolines with few fungal lines.

Joaquim AR, Pippi B, de Cesare MA, Rocha DA, Boff RT, Staudt KJ, Ruaro TC, Zimmer AR, de Araújo BV, Silveira GP, Martins AF, Teixeira ML, Dos Santos FP, Fuentefria AM, de Andrade SF.

Chem Biol Drug Des. 2018 Nov 19. doi: 10.1111/cbdd.13435. [Epub ahead of print]


CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion.

Duerr GD, Feißt A, Halbach K, Verfuerth L, Gestrich C, Wenzel D, Zimmer A, Breuer J, Dewald O.

Life Sci. 2018 Dec 15;215:96-105. doi: 10.1016/j.lfs.2018.11.003. Epub 2018 Nov 4.


Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray.

Chen YH, Lee HJ, Lee MT, Wu YT, Lee YH, Hwang LL, Hung MS, Zimmer A, Mackie K, Chiou LC.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10720-E10729. doi: 10.1073/pnas.1807991115. Epub 2018 Oct 22.


Cascade Genetic Testing of Relatives for Hereditary Cancer Risk: Results of an Online Initiative.

Caswell-Jin JL, Zimmer AD, Stedden W, Kingham KE, Zhou AY, Kurian AW.

J Natl Cancer Inst. 2019 Jan 1;111(1):95-98. doi: 10.1093/jnci/djy147.


Chronic nicotine administration restores brain region specific upregulation of oxytocin receptor binding levels in a G72 mouse model of schizophrenia.

Zanos P, Keyworth H, Georgiou P, Hambsch B, Otte DM, Kitchen I, Zimmer A, Bailey A.

Eur J Neurosci. 2018 Sep 15. doi: 10.1111/ejn.14155. [Epub ahead of print]


Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity.

Ativie F, Komorowska JA, Beins E, Albayram Ö, Zimmer T, Zimmer A, Tejera D, Heneka M, Bilkei-Gorzo A.

Front Mol Neurosci. 2018 Aug 28;11:295. doi: 10.3389/fnmol.2018.00295. eCollection 2018.


Stilbenoid pterostilbene complexed with cyclodextrin preserves left ventricular function after myocardial infarction in rats: possible involvement of thiol proteins and modulation of phosphorylated GSK-3β.

Lacerda D, Ortiz V, Türck P, Campos-Carraro C, Zimmer A, Teixeira R, Bianchi S, de Castro AL, Schenkel PC, Belló-Klein A, Bassani VL, da Rosa Araujo AS.

Free Radic Res. 2018 Sep;52(9):988-999. doi: 10.1080/10715762.2018.1506115. Epub 2018 Sep 11.


Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents.

Völker LA, Maar BA, Pulido Guevara BA, Bilkei-Gorzo A, Zimmer A, Brönneke H, Dafinger C, Bertsch S, Wagener JR, Schweizer H, Schermer B, Benzing T, Hoehne M.

Genes Brain Behav. 2018 Nov;17(8):e12516. doi: 10.1111/gbb.12516. Epub 2018 Sep 14.


Homozygous intronic MITF mutation causes severe Waardenburg syndrome type 2A.

Rauschendorf MA, Zimmer AD, Laut A, Demmer P, Rösler B, Happle R, Sartori S, Fischer J.

Pigment Cell Melanoma Res. 2019 Jan;32(1):85-91. doi: 10.1111/pcmr.12733. Epub 2018 Sep 6. No abstract available.


Cannabinoid 1 receptor signaling on GABAergic neurons influences astrocytes in the ageing brain.

Bilkei-Gorzo A, Albayram O, Ativie F, Chasan S, Zimmer T, Bach K, Zimmer A.

PLoS One. 2018 Aug 16;13(8):e0202566. doi: 10.1371/journal.pone.0202566. eCollection 2018.


The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies.

Rolvering C, Zimmer AD, Ginolhac A, Margue C, Kirchmeyer M, Servais F, Hermanns HM, Hergovits S, Nazarov PV, Nicot N, Kreis S, Haan S, Behrmann I, Haan C.

J Leukoc Biol. 2018 Nov;104(5):969-985. doi: 10.1002/JLB.MA1217-495R. Epub 2018 Jul 24.


Mosaicism due to postzygotic mutations in women with focal dermal hypoplasia.

Heinz L, Bourrat E, Vabres P, Thevenon J, Hotz A, Hörer S, Küsel J, Zimmer AD, Alter S, Happle R, Fischer J.

Br J Dermatol. 2019 Mar;180(3):657-661. doi: 10.1111/bjd.17024. Epub 2018 Sep 30.


Involvement of leptin signaling in the development of cannabinoid CB2 receptor-dependent mirror image pain.

Nozaki C, Nent E, Bilkei-Gorzo A, Zimmer A.

Sci Rep. 2018 Jul 17;8(1):10827. doi: 10.1038/s41598-018-28507-6.


Mutation update for CYP4F22 variants associated with autosomal recessive congenital ichthyosis.

Hotz A, Bourrat E, Küsel J, Oji V, Alter S, Hake L, Korbi M, Ott H, Hausser I, Zimmer AD, Fischer J.

Hum Mutat. 2018 Oct;39(10):1305-1313. doi: 10.1002/humu.23594. Epub 2018 Aug 7.


Role of WNT5A receptors FZD5 and RYK in prostate cancer cells.

Thiele S, Zimmer A, Göbel A, Rachner TD, Rother S, Fuessel S, Froehner M, Wirth MP, Muders MH, Baretton GB, Jakob F, Rauner M, Hofbauer LC.

Oncotarget. 2018 Jun 5;9(43):27293-27304. doi: 10.18632/oncotarget.25551. eCollection 2018 Jun 5.


GeNets: a unified web platform for network-based genomic analyses.

Li T, Kim A, Rosenbluh J, Horn H, Greenfeld L, An D, Zimmer A, Liberzon A, Bistline J, Natoli T, Li Y, Tsherniak A, Narayan R, Subramanian A, Liefeld T, Wong B, Thompson D, Calvo S, Carr S, Boehm J, Jaffe J, Mesirov J, Hacohen N, Regev A, Lage K.

Nat Methods. 2018 Jul;15(7):543-546. doi: 10.1038/s41592-018-0039-6. Epub 2018 Jun 18.


Assessing the role of the acid-sensing ion channel ASIC4b in sodium uptake by larval zebrafish.

Zimmer AM, Dymowska AK, Kumai Y, Goss GG, Perry SF, Kwong RWM.

Comp Biochem Physiol A Mol Integr Physiol. 2018 Dec;226:1-10. doi: 10.1016/j.cbpa.2018.06.012. Epub 2018 Jun 15.


Cannabinoid Receptor 2-Deficiency Ameliorates Disease Symptoms in a Mouse Model with Alzheimer's Disease-Like Pathology.

Schmöle AC, Lundt R, Toporowski G, Hansen JN, Beins E, Halle A, Zimmer A.

J Alzheimers Dis. 2018;64(2):379-392. doi: 10.3233/JAD-180230.


Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice.

Jehle J, Schöne B, Bagheri S, Avraamidou E, Danisch M, Frank I, Pfeifer P, Bindila L, Lutz B, Lütjohann D, Zimmer A, Nickenig G.

PLoS One. 2018 May 29;13(5):e0197751. doi: 10.1371/journal.pone.0197751. eCollection 2018.


Limited fibrosis accompanies triple-negative breast cancer metastasis in multiple model systems and is not a preventive target.

Brooks D, Zimmer A, Wakefield L, Lyle LT, Difilippantonio S, Tucci FC, Illiano S, Annunziata CM, Steeg PS.

Oncotarget. 2018 May 4;9(34):23462-23481. doi: 10.18632/oncotarget.25231. eCollection 2018 May 4.


The PERIOPTER syndrome (periorificial and ptychotropic erythrokeratoderma): a new Mendelian disorder of cornification.

Bursztejn AC, Happle R, Charbit L, Küsel J, Leclerc-Mercier S, Hadj-Rabia S, Fraitag S, Zimmer A, Fischer J.

J Eur Acad Dermatol Venereol. 2019 Jan;33(1):e1-e3. doi: 10.1111/jdv.15089. Epub 2018 Jun 13. No abstract available.


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