Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 63

1.

Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.

Sperling S, Fiedler P, Lechner M, Pollithy A, Ehrenberg S, Schiefer AI, Kenner L, Feuchtinger A, Kühn R, Swinerd G, Schmidt-Supprian M, Strobl LJ, Zimber-Strobl U.

Blood. 2019 Jun 13;133(24):2597-2609. doi: 10.1182/blood.2018880138. Epub 2019 Apr 8.

PMID:
30962205
2.

PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.

Weber J, de la Rosa J, Grove CS, Schick M, Rad L, Baranov O, Strong A, Pfaus A, Friedrich MJ, Engleitner T, Lersch R, Öllinger R, Grau M, Menendez IG, Martella M, Kohlhofer U, Banerjee R, Turchaninova MA, Scherger A, Hoffman GJ, Hess J, Kuhn LB, Ammon T, Kim J, Schneider G, Unger K, Zimber-Strobl U, Heikenwälder M, Schmidt-Supprian M, Yang F, Saur D, Liu P, Steiger K, Chudakov DM, Lenz G, Quintanilla-Martinez L, Keller U, Vassiliou GS, Cadiñanos J, Bradley A, Rad R.

Nat Commun. 2019 Mar 29;10(1):1415. doi: 10.1038/s41467-019-09180-3.

3.

Reproducing indolent B-cell lymphoma transformation with T-cell immunosuppression in LMP1/CD40-expressing mice.

Vincent-Fabert C, Saintamand A, David A, Alizadeh M, Boyer F, Arnaud N, Zimber-Strobl U, Feuillard J, Faumont N.

Cell Mol Immunol. 2019 Apr;16(4):412-414. doi: 10.1038/s41423-018-0197-6. Epub 2019 Jan 11. No abstract available.

PMID:
30635651
4.

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia.

Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny-Geier G, Klein-Hitpass L, Williamson JC, Lehner PJ, Dürig J, Möllmann M, Rásó-Barnett L, Hughes K, Santoro A, Méndez-Ferrer S, Oostendorp RAJ, Zimber-Strobl U, Peschel C, Hodson DJ, Schmidt-Supprian M, Ringshausen I.

Nat Commun. 2018 Sep 21;9(1):3839. doi: 10.1038/s41467-018-06069-5.

5.

Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.

Huang S, Park J, Qiu C, Chung KW, Li SY, Sirin Y, Han SH, Taylor V, Zimber-Strobl U, Susztak K.

PLoS Biol. 2018 Sep 18;16(9):e2005233. doi: 10.1371/journal.pbio.2005233. eCollection 2018 Sep.

6.

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.

Lino AC, Dang VD, Lampropoulou V, Welle A, Joedicke J, Pohar J, Simon Q, Thalmensi J, Baures A, Flühler V, Sakwa I, Stervbo U, Ries S, Jouneau L, Boudinot P, Tsubata T, Adachi T, Hutloff A, Dörner T, Zimber-Strobl U, de Vos AF, Dahlke K, Loh G, Korniotis S, Goosmann C, Weill JC, Reynaud CA, Kaufmann SHE, Walter J, Fillatreau S.

Immunity. 2018 Jul 17;49(1):120-133.e9. doi: 10.1016/j.immuni.2018.06.007. Epub 2018 Jul 10.

7.

Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone.

Engler A, Rolando C, Giachino C, Saotome I, Erni A, Brien C, Zhang R, Zimber-Strobl U, Radtke F, Artavanis-Tsakonas S, Louvi A, Taylor V.

Cell Rep. 2018 Jan 23;22(4):992-1002. doi: 10.1016/j.celrep.2017.12.094. Epub 2018 Jan 28.

8.

Corrigendum: Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Häger C, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP.

Nat Commun. 2017 May 3;8:15486. doi: 10.1038/ncomms15486. No abstract available.

9.

Erratum: CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.

Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T.

Nat Commun. 2017 Apr 24;8:15439. doi: 10.1038/ncomms15439. No abstract available.

10.

CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.

Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T.

Nat Commun. 2017 Mar 9;8:14715. doi: 10.1038/ncomms14715.

11.

c-Myc dysregulation is a co-transforming event for nuclear factor-κB activated B cells.

David A, Arnaud N, Fradet M, Lascaux H, Ouk-Martin C, Gachard N, Zimber-Strobl U, Feuillard J, Faumont N.

Haematologica. 2017 May;102(5):883-894. doi: 10.3324/haematol.2016.156281. Epub 2017 Feb 23.

12.

HSP90 inhibition overcomes ibrutinib resistance in mantle cell lymphoma.

Jacobson C, Kopp N, Layer JV, Redd RA, Tschuri S, Haebe S, van Bodegom D, Bird L, Christie AL, Christodoulou A, Saur A, Tivey T, Zapf S, Bararia D, Zimber-Strobl U, Rodig SJ, Weigert O, Weinstock DM.

Blood. 2016 Nov 24;128(21):2517-2526. Epub 2016 Oct 14.

13.

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP.

Nat Commun. 2016 Aug 31;7:12597. doi: 10.1038/ncomms12597.

14.

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.

Dutta S, Krause A, Vosberg S, Herold T, Ksienzyk B, Quintanilla-Martinez L, Tizazu B, Chopra M, Graf A, Krebs S, Blum H, Greif PA, Vetter A, Metzeler K, Rothenberg-Thurley M, Schneider MR, Dahlhoff M, Spiekermann K, Zimber-Strobl U, Wolf E, Bohlander SK.

Leukemia. 2016 May;30(5):1166-76. doi: 10.1038/leu.2015.349. Epub 2015 Dec 21.

PMID:
26686248
15.

B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19.

Hojer C, Frankenberger S, Strobl LJ, Feicht S, Djermanovic K, Jagdhuber F, Hömig-Hölzel C, Ferch U, Ruland J, Rajewsky K, Zimber-Strobl U.

Cancer Res. 2014 Aug 15;74(16):4318-28. doi: 10.1158/0008-5472.CAN-13-3274. Epub 2014 Jun 17.

16.

Checkpoint kinase 1 negatively regulates somatic hypermutation.

Frankenberger S, Davari K, Fischer-Burkart S, Böttcher K, Tomi NS, Zimber-Strobl U, Jungnickel B.

Nucleic Acids Res. 2014 Apr;42(6):3666-74. doi: 10.1093/nar/gkt1378. Epub 2014 Jan 13.

17.

An RNAi-based approach to down-regulate a gene family in vivo.

Kim J, Badaloni A, Willert T, Zimber-Strobl U, Kühn R, Wurst W, Kieslinger M.

PLoS One. 2013 Nov 12;8(11):e80312. doi: 10.1371/journal.pone.0080312. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/c8b2e360-b78a-4c2f-a1a3-c53325f18211.

18.

Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1.

Jeliazkova P, Jörs S, Lee M, Zimber-Strobl U, Ferrer J, Schmid RM, Siveke JT, Geisler F.

Hepatology. 2013 Jun;57(6):2469-79. doi: 10.1002/hep.26254. Epub 2013 Apr 17.

PMID:
23315998
19.

Humanized c-Myc mouse.

Lehmann FM, Feicht S, Helm F, Maurberger A, Ladinig C, Zimber-Strobl U, Kühn R, Mautner J, Gerbitz A, Bornkamm GW.

PLoS One. 2012;7(7):e42021. doi: 10.1371/journal.pone.0042021. Epub 2012 Jul 31.

20.

CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling.

Hampel F, Ehrenberg S, Hojer C, Draeseke A, Marschall-Schröter G, Kühn R, Mack B, Gires O, Vahl CJ, Schmidt-Supprian M, Strobl LJ, Zimber-Strobl U.

Blood. 2011 Dec 8;118(24):6321-31. doi: 10.1182/blood-2010-12-325944. Epub 2011 Jul 27.

21.

Programming of marginal zone B-cell fate by basic Kruppel-like factor (BKLF/KLF3).

Turchinovich G, Vu TT, Frommer F, Kranich J, Schmid S, Alles M, Loubert JB, Goulet JP, Zimber-Strobl U, Schneider P, Bachl J, Pearson R, Crossley M, Agenès F, Kirberg J.

Blood. 2011 Apr 7;117(14):3780-92. doi: 10.1182/blood-2010-09-308742. Epub 2011 Feb 4.

22.

High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas.

Köchert K, Ullrich K, Kreher S, Aster JC, Kitagawa M, Jöhrens K, Anagnostopoulos I, Jundt F, Lamprecht B, Zimber-Strobl U, Stein H, Janz M, Dörken B, Mathas S.

Oncogene. 2011 Apr 14;30(15):1831-40. doi: 10.1038/onc.2010.544. Epub 2010 Nov 29.

PMID:
21119597
23.

Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo.

Mazur PK, Grüner BM, Nakhai H, Sipos B, Zimber-Strobl U, Strobl LJ, Radtke F, Schmid RM, Siveke JT.

PLoS One. 2010 Oct 22;5(10):e13578. doi: 10.1371/journal.pone.0013578.

24.

Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain.

Lückerath K, Kirkin V, Melzer IM, Thalheimer FB, Siele D, Milani W, Adler T, Aguilar-Pimentel A, Horsch M, Michel G, Beckers J, Busch DH, Ollert M, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Staal FJ, Rajalingam K, Hueber AO, Strobl LJ, Zimber-Strobl U, Zörnig M.

Blood. 2011 Jan 13;117(2):519-29. doi: 10.1182/blood-2010-07-292722. Epub 2010 Oct 22.

25.

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma.

Mazur PK, Einwächter H, Lee M, Sipos B, Nakhai H, Rad R, Zimber-Strobl U, Strobl LJ, Radtke F, Klöppel G, Schmid RM, Siveke JT.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13438-43. doi: 10.1073/pnas.1002423107. Epub 2010 Jul 12.

26.

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.

Pechloff K, Holch J, Ferch U, Schweneker M, Brunner K, Kremer M, Sparwasser T, Quintanilla-Martinez L, Zimber-Strobl U, Streubel B, Gewies A, Peschel C, Ruland J.

J Exp Med. 2010 May 10;207(5):1031-44. doi: 10.1084/jem.20092042. Epub 2010 May 3.

27.

Asymmetric Arginine dimethylation of Epstein-Barr virus nuclear antigen 2 promotes DNA targeting.

Gross H, Barth S, Palermo RD, Mamiani A, Hennard C, Zimber-Strobl U, West MJ, Kremmer E, Grässer FA.

Virology. 2010 Feb 20;397(2):299-310. doi: 10.1016/j.virol.2009.11.023. Epub 2009 Dec 6.

28.

Notch1, Notch2, and Epstein-Barr virus-encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus-infected B cells.

Kohlhof H, Hampel F, Hoffmann R, Burtscher H, Weidle UH, Hölzel M, Eick D, Zimber-Strobl U, Strobl LJ.

Blood. 2009 May 28;113(22):5506-15. doi: 10.1182/blood-2008-11-190090. Epub 2009 Apr 1.

29.

Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice.

Geisler F, Nagl F, Mazur PK, Lee M, Zimber-Strobl U, Strobl LJ, Radtke F, Schmid RM, Siveke JT.

Hepatology. 2008 Aug;48(2):607-16. doi: 10.1002/hep.22381.

PMID:
18666240
30.

Conditional ablation of Notch signaling in pancreatic development.

Nakhai H, Siveke JT, Klein B, Mendoza-Torres L, Mazur PK, Algül H, Radtke F, Strobl L, Zimber-Strobl U, Schmid RM.

Development. 2008 Aug;135(16):2757-65. doi: 10.1242/dev.013722. Epub 2008 Jul 17.

31.

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.

Hömig-Hölzel C, Hojer C, Rastelli J, Casola S, Strobl LJ, Müller W, Quintanilla-Martinez L, Gewies A, Ruland J, Rajewsky K, Zimber-Strobl U.

J Exp Med. 2008 Jun 9;205(6):1317-29. doi: 10.1084/jem.20080238. Epub 2008 May 19.

32.

Molecular basis of cytotoxicity of Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) in EBV latency III B cells: LMP1 induces type II ligand-independent autoactivation of CD95/Fas with caspase 8-mediated apoptosis.

Le Clorennec C, Ouk TS, Youlyouz-Marfak I, Panteix S, Martin CC, Rastelli J, Adriaenssens E, Zimber-Strobl U, Coll J, Feuillard J, Jayat-Vignoles C.

J Virol. 2008 Jul;82(13):6721-33. doi: 10.1128/JVI.02250-07. Epub 2008 Apr 30.

33.

Restricted expression of Epstein-Barr virus latent genes in murine B cells derived from embryonic stem cells.

Zychlinska M, Herrmann H, Zimber-Strobl U, Hammerschmidt W.

PLoS One. 2008 Apr 16;3(4):e1996. doi: 10.1371/journal.pone.0001996.

34.

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

Riccio O, van Gijn ME, Bezdek AC, Pellegrinet L, van Es JH, Zimber-Strobl U, Strobl LJ, Honjo T, Clevers H, Radtke F.

EMBO Rep. 2008 Apr;9(4):377-83. doi: 10.1038/embor.2008.7. Epub 2008 Feb 15.

35.

LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1.

Rastelli J, Hömig-Hölzel C, Seagal J, Müller W, Hermann AC, Rajewsky K, Zimber-Strobl U.

Blood. 2008 Feb 1;111(3):1448-55. Epub 2007 Nov 15.

36.

B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance.

Geisberger R, Kiermayer C, Hömig C, Conrad M, Schmidt J, Zimber-Strobl U, Brielmeier M.

Biol Chem. 2007 Oct;388(10):1083-90.

PMID:
17937622
37.

Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.

Besseyrias V, Fiorini E, Strobl LJ, Zimber-Strobl U, Dumortier A, Koch U, Arcangeli ML, Ezine S, Macdonald HR, Radtke F.

J Exp Med. 2007 Feb 19;204(2):331-43. Epub 2007 Jan 29.

38.

Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner.

Schouwey K, Delmas V, Larue L, Zimber-Strobl U, Strobl LJ, Radtke F, Beermann F.

Dev Dyn. 2007 Jan;236(1):282-9.

39.

Control of Epstein-Barr virus reactivation by activated CD40 and viral latent membrane protein 1.

Adler B, Schaadt E, Kempkes B, Zimber-Strobl U, Baier B, Bornkamm GW.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):437-42. Epub 2001 Dec 18.

40.

EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes.

Zimber-Strobl U, Strobl LJ.

Semin Cancer Biol. 2001 Dec;11(6):423-34. Review.

PMID:
11669604
41.

Magnetic DNA affinity purification of a cellular transcription factor.

Strobl LJ, Zimber-Strobl U.

Methods Mol Biol. 2001;174:271-7. No abstract available.

PMID:
11357654
42.

Activated Notch1 can transiently substitute for EBNA2 in the maintenance of proliferation of LMP1-expressing immortalized B cells.

Höfelmayr H, Strobl LJ, Marschall G, Bornkamm GW, Zimber-Strobl U.

J Virol. 2001 Mar;75(5):2033-40.

43.

Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2.

Strobl LJ, Höfelmayr H, Marschall G, Brielmeier M, Bornkamm GW, Zimber-Strobl U.

J Virol. 2000 Feb;74(4):1727-35.

44.

EBNA2 and c-myc in B cell immortalization by Epstein-Barr virus and in the pathogenesis of Burkitt's lymphoma.

Zimber-Strobl U, Strobl L, Höfelmayr H, Kempkes B, Staege MS, Laux G, Christoph B, Polack A, Bornkamm GW.

Curr Top Microbiol Immunol. 1999;246:315-20; discussion 321. Review. No abstract available.

PMID:
10396071
45.

Activated mouse Notch1 transactivates Epstein-Barr virus nuclear antigen 2-regulated viral promoters.

Höfelmayr H, Strobl LJ, Stein C, Laux G, Marschall G, Bornkamm GW, Zimber-Strobl U.

J Virol. 1999 Apr;73(4):2770-80.

46.

Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2.

Sakai T, Taniguchi Y, Tamura K, Minoguchi S, Fukuhara T, Strobl LJ, Zimber-Strobl U, Bornkamm GW, Honjo T.

J Virol. 1998 Jul;72(7):6034-9.

47.

Both Epstein-Barr viral nuclear antigen 2 (EBNA2) and activated Notch1 transactivate genes by interacting with the cellular protein RBP-J kappa.

Strobl LJ, Höfelmayr H, Stein C, Marschall G, Brielmeier M, Laux G, Bornkamm GW, Zimber-Strobl U.

Immunobiology. 1997 Dec;198(1-3):299-306. Review.

PMID:
9442401
48.

Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.

Gires O, Zimber-Strobl U, Gonnella R, Ueffing M, Marschall G, Zeidler R, Pich D, Hammerschmidt W.

EMBO J. 1997 Oct 15;16(20):6131-40.

49.

RBP-L, a transcription factor related to RBP-Jkappa.

Minoguchi S, Taniguchi Y, Kato H, Okazaki T, Strobl LJ, Zimber-Strobl U, Bornkamm GW, Honjo T.

Mol Cell Biol. 1997 May;17(5):2679-87.

50.

Epstein-Barr virus latent membrane protein (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival.

Zimber-Strobl U, Kempkes B, Marschall G, Zeidler R, Van Kooten C, Banchereau J, Bornkamm GW, Hammerschmidt W.

EMBO J. 1996 Dec 16;15(24):7070-8.

Supplemental Content

Loading ...
Support Center