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Items: 21


Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node.

Kim MS, Maltsev AV, Monfredi O, Maltseva LA, Wirth A, Florio MC, Tsutsui K, Riordon DR, Parsons SP, Tagirova S, Ziman BD, Stern MD, Lakatta EG, Maltsev VA.

Cell Calcium. 2018 Sep;74:168-179. doi: 10.1016/j.ceca.2018.07.002. Epub 2018 Jul 10.


A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells.

Tsutsui K, Monfredi OJ, Sirenko-Tagirova SG, Maltseva LA, Bychkov R, Kim MS, Ziman BD, Tarasov KV, Tarasova YS, Zhang J, Wang M, Maltsev AV, Brennan JA, Efimov IR, Stern MD, Maltsev VA, Lakatta EG.

Sci Signal. 2018 Jun 12;11(534). pii: eaap7608. doi: 10.1126/scisignal.aap7608.


Mammalian γ2 AMPK regulates intrinsic heart rate.

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H.

Nat Commun. 2017 Nov 2;8(1):1258. doi: 10.1038/s41467-017-01342-5.


Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells.

Yaniv Y, Ganesan A, Yang D, Ziman BD, Lyashkov AE, Levchenko A, Zhang J, Lakatta EG.

J Mol Cell Cardiol. 2015 Sep;86:168-78. doi: 10.1016/j.yjmcc.2015.07.024. Epub 2015 Aug 1.


Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells.

Yaniv Y, Lyashkov AE, Sirenko S, Okamoto Y, Guiriba TR, Ziman BD, Morrell CH, Lakatta EG.

J Mol Cell Cardiol. 2014 Dec;77:1-10. doi: 10.1016/j.yjmcc.2014.09.008. Epub 2014 Sep 22.


Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals.

Yaniv Y, Ahmet I, Liu J, Lyashkov AE, Guiriba TR, Okamoto Y, Ziman BD, Lakatta EG.

Heart Rhythm. 2014 Jul;11(7):1210-9. doi: 10.1016/j.hrthm.2014.03.049. Epub 2014 Apr 5.


New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.

Yaniv Y, Sirenko S, Ziman BD, Spurgeon HA, Maltsev VA, Lakatta EG.

J Mol Cell Cardiol. 2013 Sep;62:80-9. doi: 10.1016/j.yjmcc.2013.04.026. Epub 2013 May 5.


Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand.

Yaniv Y, Spurgeon HA, Ziman BD, Lyashkov AE, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2013 Jun 1;304(11):H1428-38. doi: 10.1152/ajpheart.00969.2012. Epub 2013 Apr 19.


Ca²+/calmodulin-dependent protein kinase II (CaMKII) activity and sinoatrial nodal pacemaker cell energetics.

Yaniv Y, Spurgeon HA, Ziman BD, Lakatta EG.

PLoS One. 2013;8(2):e57079. doi: 10.1371/journal.pone.0057079. Epub 2013 Feb 25.


RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells.

Yang D, Lyashkov AE, Li Y, Ziman BD, Lakatta EG.

J Mol Cell Cardiol. 2012 Nov;53(5):687-94. doi: 10.1016/j.yjmcc.2012.08.007. Epub 2012 Aug 19.


The "funny" current (I(f)) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells.

Yaniv Y, Maltsev VA, Ziman BD, Spurgeon HA, Lakatta EG.

Molecules. 2012 Jul 9;17(7):8241-54. doi: 10.3390/molecules17078241.


Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.

Yaniv Y, Spurgeon HA, Lyashkov AE, Yang D, Ziman BD, Maltsev VA, Lakatta EG.

PLoS One. 2012;7(5):e37582. doi: 10.1371/journal.pone.0037582. Epub 2012 May 29.


Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm.

Yaniv Y, Maltsev VA, Escobar AL, Spurgeon HA, Ziman BD, Stern MD, Lakatta EG.

J Mol Cell Cardiol. 2011 Dec;51(6):902-5. doi: 10.1016/j.yjmcc.2011.08.029. Epub 2011 Sep 14.


Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore.

Juhaszova M, Zorov DB, Kim SH, Pepe S, Fu Q, Fishbein KW, Ziman BD, Wang S, Ytrehus K, Antos CL, Olson EN, Sollott SJ.

J Clin Invest. 2004 Jun;113(11):1535-49.


Opposing effects of alpha 1-adrenergic receptor subtypes on Ca2+ and pH homeostasis in rat cardiac myocytes.

Gambassi G, Spurgeon HA, Ziman BD, Lakatta EG, Capogrossi MC.

Am J Physiol. 1998 Apr;274(4 Pt 2):H1152-62.


Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine.

Korzick DH, Xiao RP, Ziman BD, Koch WJ, Lefkowitz RJ, Lakatta EG.

Am J Physiol. 1997 Jan;272(1 Pt 2):H590-6.


Actomyosin interaction modulates resting length of unstimulated cardiac ventricular cells.

Sollott SJ, Ziman BD, Warshaw DM, Spurgeon HA, Lakatta EG.

Am J Physiol. 1996 Sep;271(3 Pt 2):H896-905.


L- and T-type calcium currents differ in finch and rat ventricular cardiomyocytes.

Bogdanov KY, Ziman BD, Spurgeon HA, Lakatta EG.

J Mol Cell Cardiol. 1995 Dec;27(12):2581-93.


Novel technique to load indo-1 free acid into single adult cardiac myocytes to assess cytosolic Ca2+.

Sollott SJ, Ziman BD, Lakatta EG.

Am J Physiol. 1992 Jun;262(6 Pt 2):H1941-9.


Cytosolic calcium and myofilaments in single rat cardiac myocytes achieve a dynamic equilibrium during twitch relaxation.

Spurgeon HA, duBell WH, Stern MD, Sollott SJ, Ziman BD, Silverman HS, Capogrossi MC, Talo A, Lakatta EG.

J Physiol. 1992 Feb;447:83-102.


Effect of U-50,488H on the contractile response of cardiomyopathic hamster ventricular myocytes.

Kasper E, Ventura C, Ziman BD, Lakatta EG, Weisman H, Capogrossi MC.

Life Sci. 1992;50(26):2029-35.


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