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Items: 38


Synthetic Liposomal Mimics of Biological Viruses for the Study of Immune Responses to Infection and Vaccination.

Wholey WY, Mueller JL, Tan C, Brooks JF, Zikherman J, Cheng W.

Bioconjug Chem. 2020 Mar 18;31(3):685-697. doi: 10.1021/acs.bioconjchem.9b00825. Epub 2020 Jan 23.


Self-reactivity on a spectrum: A sliding scale of peripheral B cell tolerance.

Tan C, Noviski M, Huizar J, Zikherman J.

Immunol Rev. 2019 Nov;292(1):37-60. doi: 10.1111/imr.12818. Epub 2019 Oct 20. Review.


Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.

Rosenthal DG, Parwani P, Murray TO, Petek BJ, Benn BS, De Marco T, Gerstenfeld EP, Janmohamed M, Klein L, Lee BK, Moss JD, Scheinman MM, Hsia HH, Selby V, Koth LL, Pampaloni MH, Zikherman J, Vedantham V.

J Am Heart Assoc. 2019 Sep 17;8(18):e010952. doi: 10.1161/JAHA.118.010952. Epub 2019 Sep 6.


Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.

Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18517-18527. doi: 10.1073/pnas.1904271116. Epub 2019 Aug 27.


Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens.

Noviski M, Tan C, Huizar J, Vykunta V, Mueller JL, Zikherman J.

J Immunol. 2019 Jul 15;203(2):418-428. doi: 10.4049/jimmunol.1900175. Epub 2019 Jun 5.


GC B cells 'AKT' to blunt BCR signaling.

Zikherman J.

Nat Immunol. 2019 Jun;20(6):671-674. doi: 10.1038/s41590-019-0384-3. No abstract available.


Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.

Tan C, Mueller JL, Noviski M, Huizar J, Lau D, Dubinin A, Molofsky A, Wilson PC, Zikherman J.

J Immunol. 2019 May 15;202(10):2907-2923. doi: 10.4049/jimmunol.1801565. Epub 2019 Apr 8.


Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance.

Noviski M, Zikherman J.

Curr Opin Immunol. 2018 Dec;55:67-74. doi: 10.1016/j.coi.2018.09.015. Epub 2018 Oct 5. Review.


IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.

Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J.

Elife. 2018 Mar 9;7. pii: e35074. doi: 10.7554/eLife.35074.


Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells.

Huizar J, Tan C, Noviski M, Mueller JL, Zikherman J.

Immunohorizons. 2017 Nov 1;1(9):188-197. doi: 10.4049/immunohorizons.1700048.


B cell autoimmunity at the extremes.

Zikherman J, Lowell CA.

Nat Immunol. 2017 Sep 19;18(10):1065-1066. doi: 10.1038/ni.3840. No abstract available.


Tonic Signals: Why Do Lymphocytes Bother?

Myers DR, Zikherman J, Roose JP.

Trends Immunol. 2017 Nov;38(11):844-857. doi: 10.1016/ Epub 2017 Jul 25. Review.


Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.

Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP.

Cell Rep. 2017 May 23;19(8):1558-1571. doi: 10.1016/j.celrep.2017.04.076.


IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.

Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J.

J Immunol. 2017 Mar 15;198(6):2445-2456. doi: 10.4049/jimmunol.1601453. Epub 2017 Feb 3.


An extracatalytic function of CD45 in B cells is mediated by CD22.

Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6515-24. doi: 10.1073/pnas.1519925112. Epub 2015 Nov 11.


Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production.

Mills RE, Lam VC, Tan A, Cresalia N, Oksenberg N, Zikherman J, Anderson M, Weiss A, Hermiston ML.

J Immunol. 2015 Apr 15;194(8):3675-86. doi: 10.4049/jimmunol.1500026. Epub 2015 Mar 13.


Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.

Mueller J, Matloubian M, Zikherman J.

J Immunol. 2015 Apr 1;194(7):2993-7. doi: 10.4049/jimmunol.1403086. Epub 2015 Feb 27.


The role of T cell receptor signaling thresholds in guiding T cell fate decisions.

Zikherman J, Au-Yeung B.

Curr Opin Immunol. 2015 Apr;33:43-8. doi: 10.1016/j.coi.2015.01.012. Epub 2015 Feb 6. Review.


A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.

Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88. doi: 10.1073/pnas.1413726111. Epub 2014 Aug 18.


Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.

Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A.

Nat Immunol. 2014 Jul;15(7):687-94. doi: 10.1038/ni.2918. Epub 2014 Jun 8. Erratum in: Nat Immunol. 2015 Feb;16(2):214.


Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.

Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP.

Mol Cell Biol. 2014 Apr;34(8):1474-85. doi: 10.1128/MCB.01699-13. Epub 2014 Feb 10.


Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45.

Tan YX, Zikherman J, Weiss A.

Cold Spring Harb Symp Quant Biol. 2013;78:131-139. doi: 10.1101/sqb.2013.78.020347. Epub 2013 Oct 7.


The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

Zikherman J, Parameswaran R, Hermiston M, Weiss A.

J Immunol. 2013 Mar 15;190(6):2527-35. doi: 10.4049/jimmunol.1202928. Epub 2013 Feb 8.


Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.

Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A.

Sci Signal. 2013 Jan 1;6(256):ra1. doi: 10.1126/scisignal.2003220.


Endogenous antigen tunes the responsiveness of naive B cells but not T cells.

Zikherman J, Parameswaran R, Weiss A.

Nature. 2012 Sep 6;489(7414):160-4. doi: 10.1038/nature11311.


Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.

Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):E3-12. doi: 10.1073/pnas.1117374108. Epub 2011 Nov 30.


Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.

Zikherman J, Weiss A.

J Clin Invest. 2011 Dec;121(12):4618-21. doi: 10.1172/JCI60001. Epub 2011 Nov 14.


CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.

Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A.

Immunity. 2010 Mar 26;32(3):342-54. doi: 10.1016/j.immuni.2010.03.006.


Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.

Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J.

Sci Signal. 2009 Apr 14;2(66):pt2. doi: 10.1126/scisignal.266pt2.


PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A.

J Immunol. 2009 Apr 1;182(7):4093-106. doi: 10.4049/jimmunol.0803317.


CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells.

Hermiston ML, Zikherman J, Zhu JW.

Immunol Rev. 2009 Mar;228(1):288-311. doi: 10.1111/j.1600-065X.2008.00752.x. Review. Erratum in: Immunol Rev. 2009 May;229(1):387.


Antigen receptor signaling in the rheumatic diseases.

Zikherman J, Weiss A.

Arthritis Res Ther. 2009;11(1):202. doi: 10.1186/ar2528. Epub 2009 Jan 30. Review.


Digital signaling and hysteresis characterize ras activation in lymphoid cells.

Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP.

Cell. 2009 Jan 23;136(2):337-51. doi: 10.1016/j.cell.2008.11.051.


Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.

Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):546-51. doi: 10.1073/pnas.0811647106. Epub 2009 Jan 7.


Alternative splicing of CD45: the tip of the iceberg.

Zikherman J, Weiss A.

Immunity. 2008 Dec 19;29(6):839-41. doi: 10.1016/j.immuni.2008.12.005.


Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.

Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):528-33. doi: 10.1073/pnas.0805981105. Epub 2008 Dec 19.


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