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Heterogenous Renal Injury Biomarker Production Reveals Human Sepsis-Associated Acute Kidney Injury Subtypes.

Jou-Valencia D, Koeze J, Popa ER, Aslan A, Zwiers PJ, Molema G, Zijlstra JG, van Meurs M, Moser J.

Crit Care Explor. 2019 Oct 14;1(10):e0047. doi: 10.1097/CCE.0000000000000047. eCollection 2019 Oct.


Continuous versus intermittent infusion of cefotaxime in critically ill patients: a randomized controlled trial comparing plasma concentrations.

Aardema H, Bult W, van Hateren K, Dieperink W, Touw DJ, Alffenaar JC, Zijlstra JG.

J Antimicrob Chemother. 2020 Feb 1;75(2):441-448. doi: 10.1093/jac/dkz463.


Identifying Sepsis Phenotypes.

Moser J, van Meurs M, Zijlstra JG.

JAMA. 2019 Oct 8;322(14):1416. doi: 10.1001/jama.2019.12587. No abstract available.


Short- and long-term complications of surgical and percutaneous dilatation tracheotomies: a large single-centre retrospective cohort study.

de Kleijn BJ, Wedman J, Zijlstra JG, Dikkers FG, van der Laan BFAM.

Eur Arch Otorhinolaryngol. 2019 Jun;276(6):1823-1828. doi: 10.1007/s00405-019-05394-9. Epub 2019 Apr 2.


Commentary: Precision Immunotherapy for Sepsis.

Zijlstra JG, van Meurs M, Moser J.

Front Immunol. 2019 Jan 31;10:20. doi: 10.3389/fimmu.2019.00020. eCollection 2019. No abstract available.


Kidney histopathology in lethal human sepsis.

Aslan A, van den Heuvel MC, Stegeman CA, Popa ER, Leliveld AM, Molema G, Zijlstra JG, Moser J, van Meurs M.

Crit Care. 2018 Dec 27;22(1):359. doi: 10.1186/s13054-018-2287-3.


Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in A Vascular Bed and Organ-Specific Way.

Jongman RM, Zwiers PJ, van de Sluis B, van der Laan M, Moser J, Zijlstra JG, Dekker D, Huijkman N, Moorlag HE, Popa ER, Molema G, van Meurs M.

Shock. 2019 Jun;51(6):757-769. doi: 10.1097/SHK.0000000000001226.


Identifying improvement opportunities for patient- and family-centered care in the ICU: Using qualitative methods to understand family perspectives.

Ågård AS, Hofhuis JGM, Koopmans M, Gerritsen RT, Spronk PE, Engelberg RA, Randall Curtis J, Zijlstra JG, Jensen HI.

J Crit Care. 2019 Feb;49:33-37. doi: 10.1016/j.jcrc.2018.10.008. Epub 2018 Oct 12.


Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice.

Jou-Valencia D, Molema G, Popa E, Aslan A, van Dijk F, Mencke R, Hillebrands JL, Heeringa P, Hoenderop JG, Zijlstra JG, van Meurs M, Moser J.

Crit Care Med. 2018 Dec;46(12):e1196-e1203. doi: 10.1097/CCM.0000000000003427.


Times are A-Changin': self-poisoning and ICU admissions in the northern part of the Netherlands.

Dobbe A, Zijlstra JG, Ter Maaten JC, Ligtenberg J.

Acute Med. 2018;17(3):121-123.


Invalid methods lead to inappropriate conclusions.

Girbes ARJ, de Grooth HJ, Zijlstra JG, Hein L.

Int J Qual Health Care. 2019 Feb 1;31(1):72. doi: 10.1093/intqhc/mzy165. No abstract available.


Molecular Regulation of Acute Tie2 Suppression in Sepsis.

Thamm K, Schrimpf C, Retzlaff J, Idowu TO, van Meurs M, Zijlstra JG, Ghosh CC, Zeitvogel J, Werfel TA, Haller H, Parikh SM, David S.

Crit Care Med. 2018 Sep;46(9):e928-e936. doi: 10.1097/CCM.0000000000003269.


A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?

Stolmeijer R, Bouma HR, Zijlstra JG, Drost-de Klerck AM, Ter Maaten JC, Ligtenberg JJM.

Biomed Res Int. 2018 May 14;2018:7841295. doi: 10.1155/2018/7841295. eCollection 2018. Review.


Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia.

Li R, Kowalski PS, Morselt HWM, Schepel I, Jongman RM, Aslan A, Ruiters MHJ, Zijlstra JG, Molema G, van Meurs M, Kamps JAAM.

PLoS One. 2018 May 15;13(5):e0196976. doi: 10.1371/journal.pone.0196976. eCollection 2018.


Early Heterogenic Response of Renal Microvasculature to Hemorrhagic Shock/Resuscitation and the Influence of NF-κB Pathway Blockade.

Yan R, van Meurs M, Popa ER, Li R, Zwiers PJ, Zijlstra JG, Moser J, Molema G.

Shock. 2019 Feb;51(2):200-212. doi: 10.1097/SHK.0000000000001126.


Quality of dying and death in the ICU. The euroQ2 project.

Gerritsen RT, Jensen HI, Koopmans M, Curtis JR, Downey L, Hofhuis JGM, Engelberg RA, Spronk PE, Zijlstra JG.

J Crit Care. 2018 Apr;44:376-382. doi: 10.1016/j.jcrc.2017.12.015. Epub 2017 Dec 26.


Pharmacokinetic Properties of Micafungin in Critically Ill Patients Diagnosed with Invasive Candidiasis.

Boonstra JM, van der Elst KC, Veringa A, Jongedijk EM, Brüggemann RJ, Koster RA, Kampinga GA, Kosterink JG, van der Werf TS, Zijlstra JG, Touw DJ, Alffenaar JWC.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01398-17. doi: 10.1128/AAC.01398-17. Print 2017 Dec.


Satisfaction with quality of ICU care for patients and families: the euroQ2 project.

Jensen HI, Gerritsen RT, Koopmans M, Downey L, Engelberg RA, Curtis JR, Spronk PE, Zijlstra JG, Ørding H.

Crit Care. 2017 Sep 7;21(1):239. doi: 10.1186/s13054-017-1826-7.


Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB.

Yan R, van Meurs M, Popa ER, Jongman RM, Zwiers PJ, Niemarkt AE, Kuiper T, Kamps JA, Heeringa P, Zijlstra JG, Molema G, Moser J.

J Innate Immun. 2017;9(6):546-560. doi: 10.1159/000477211. Epub 2017 Jun 29.


There Are More Things in Heaven and Earth, Horatio, Than Are Dreamt of in Our Philosophy.

Moser J, van Meurs M, Zijlstra JG.

Crit Care Med. 2017 Jul;45(7):e740. doi: 10.1097/CCM.0000000000002426. No abstract available.


Target attainment with continuous dosing of piperacillin/tazobactam in critical illness: a prospective observational study.

Aardema H, Nannan Panday P, Wessels M, van Hateren K, Dieperink W, Kosterink JGW, Alffenaar JW, Zijlstra JG.

Int J Antimicrob Agents. 2017 Jul;50(1):68-73. doi: 10.1016/j.ijantimicag.2017.02.020. Epub 2017 May 10.


Naming and Blaming, SIRS-UO.

van Meurs M, Ligtenberg JJM, Zijlstra JG.

Chest. 2017 Mar;151(3):723-724. doi: 10.1016/j.chest.2016.10.062. No abstract available.


Incidence, timing and outcome of AKI in critically ill patients varies with the definition used and the addition of urine output criteria.

Koeze J, Keus F, Dieperink W, van der Horst IC, Zijlstra JG, van Meurs M.

BMC Nephrol. 2017 Feb 20;18(1):70. doi: 10.1186/s12882-017-0487-8. Review.


Organ-Specific Differences in Endothelial Permeability-Regulating Molecular Responses in Mouse and Human Sepsis.

Aslan A, van Meurs M, Moser J, Popa ER, Jongman RM, Zwiers PJ, Molema G, Zijlstra JG.

Shock. 2017 Jul;48(1):69-77. doi: 10.1097/SHK.0000000000000841.


Bioavailability of voriconazole in hospitalised patients.

Veringa A, Geling S, Span LF, Vermeulen KM, Zijlstra JG, van der Werf TS, Kosterink JG, Alffenaar JC.

Int J Antimicrob Agents. 2017 Feb;49(2):243-246. doi: 10.1016/j.ijantimicag.2016.10.010. Epub 2016 Nov 23.


Low Caspofungin Exposure in Patients in Intensive Care Units.

van der Elst KC, Veringa A, Zijlstra JG, Beishuizen A, Klont R, Brummelhuis-Visser P, Uges DR, Touw DJ, Kosterink JG, van der Werf TS, Alffenaar JC.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01582-16. doi: 10.1128/AAC.01582-16. Print 2017 Feb.


Interhospital critical care transports: have a safe trip!

Ligtenberg JJ, Kruger HL, Zijlstra JG.

Intensive Care Med. 2016 Nov;42(11):1836. Epub 2016 Sep 12. No abstract available.


How central obesity influences intra-abdominal pressure: a prospective, observational study in cardiothoracic surgical patients.

Smit M, Werner MJM, Lansink-Hartgring AO, Dieperink W, Zijlstra JG, van Meurs M.

Ann Intensive Care. 2016 Dec;6(1):99. doi: 10.1186/s13613-016-0195-8. Epub 2016 Oct 10.


Comparing Quality of Dying and Death Perceived by Family Members and Nurses for Patients Dying in US and Dutch ICUs.

Gerritsen RT, Koopmans M, Hofhuis JG, Curtis JR, Jensen HI, Zijlstra JG, Engelberg RA, Spronk PE.

Chest. 2017 Feb;151(2):298-307. doi: 10.1016/j.chest.2016.09.003. Epub 2016 Sep 19.


Voriconazole metabolism is influenced by severe inflammation: a prospective study.

Veringa A, Ter Avest M, Span LF, van den Heuvel ER, Touw DJ, Zijlstra JG, Kosterink JG, van der Werf TS, Alffenaar JC.

J Antimicrob Chemother. 2017 Jan;72(1):261-267. Epub 2016 Sep 6.


The Course of Skin and Serum Biomarkers of Advanced Glycation Endproducts and Its Association with Oxidative Stress, Inflammation, Disease Severity, and Mortality during ICU Admission in Critically Ill Patients: Results from a Prospective Pilot Study.

Meertens JH, Nienhuis HL, Lefrandt JD, Schalkwijk CG, Nyyssönen K, Ligtenberg JJ, Smit AJ, Zijlstra JG, Mulder DJ.

PLoS One. 2016 Aug 16;11(8):e0160893. doi: 10.1371/journal.pone.0160893. eCollection 2016.


Intra-Abdominal Pressure, Acute Kidney Injury, and Obesity in Critical Illness.

Smit M, van Meurs M, Zijlstra JG.

Crit Care Med. 2016 Aug;44(8):e766-7. doi: 10.1097/CCM.0000000000001779. No abstract available.


Erratum to: 'Emerging pan-resistance in Trichosporon species: a case report'.

Dos Santos CO, Zijlstra JG, Porte RJ, Kampinga GA, van Diepeningen AD, Sinha B, Bathoorn E.

BMC Infect Dis. 2016 Jun 11;16(1):279. No abstract available.


Automatic detection of oesophageal intubation based on ventilation pressure waveforms shows high sensitivity and specificity in patients with pulmonary disease.

Kalmar AF, Absalom A, Rombouts P, Roets J, Dewaele F, Verdonck P, Stemerdink A, Zijlstra JG, Monsieurs KG.

Resuscitation. 2016 Aug;105:36-40. doi: 10.1016/j.resuscitation.2016.05.010. Epub 2016 May 19.


Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin.

Moser J, Heeringa P, Jongman RM, Zwiers PJ, Niemarkt AE, Yan R, de Graaf IA, Li R, Ravasz Regan E, Kümpers P, Aird WC, van Nieuw Amerongen GP, Zijlstra JG, Molema G, van Meurs M.

J Immunol. 2016 Jun 1;196(11):4681-91. doi: 10.4049/jimmunol.1501819. Epub 2016 Apr 29.


Emerging pan-resistance in Trichosporon species: a case report.

Oliveira dos Santos C, Zijlstra JG, Porte RJ, Kampinga GA, van Diepeningen AD, Sinha B, Bathoorn E.

BMC Infect Dis. 2016 Apr 14;16:148. doi: 10.1186/s12879-016-1477-3. Erratum in: BMC Infect Dis. 2016;16(1):279.


Voriconazole Therapeutic Drug Monitoring Practices in Intensive Care.

van Wanrooy MJ, Rodgers MG, Span LF, Zijlstra JG, Uges DR, Kosterink JG, van der Werf TS, Alffenaar JW.

Ther Drug Monit. 2016 Jun;38(3):313-8. doi: 10.1097/FTD.0000000000000284.


Abdominal Compartment Syndrome and Intra-abdominal Ischemia in Patients with Severe Acute Pancreatitis.

Smit M, Buddingh KT, Bosma B, Nieuwenhuijs VB, Hofker HS, Zijlstra JG.

World J Surg. 2016 Jun;40(6):1454-61. doi: 10.1007/s00268-015-3388-7.


Does night shift, stress or both make us dumber?

Zijlstra JG.

Intensive Care Med. 2016 Mar;42(3):483. doi: 10.1007/s00134-015-4152-z. Epub 2015 Nov 26. No abstract available.


Comment on letter to the editor "In response to: Families' experiences of ICU quality of care: Development and validation of a European questionnaire (euroQ2)".

Jensen HI, Gerritsen RT, Koopmans M, Zijlstra JG, Curtis JR, Ørding H.

J Crit Care. 2015 Dec;30(6):1410-1. doi: 10.1016/j.jcrc.2015.07.034. Epub 2015 Aug 4. No abstract available.


Angiopoietin/Tie2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass.

Jongman RM, van Klarenbosch J, Molema G, Zijlstra JG, de Vries AJ, van Meurs M.

PLoS One. 2015 Aug 26;10(8):e0136205. doi: 10.1371/journal.pone.0136205. eCollection 2015.


Histone Deacetylase Inhibition and IκB Kinase/Nuclear Factor-κB Blockade Ameliorate Microvascular Proinflammatory Responses Associated With Hemorrhagic Shock/Resuscitation in Mice.

Li R, Aslan A, Yan R, Jongman RM, Moser J, Zwiers PJ, Moorlag HE, Zijlstra JG, Molema G, van Meurs M.

Crit Care Med. 2015 Dec;43(12):e567-80. doi: 10.1097/CCM.0000000000001203.


Families' experiences of intensive care unit quality of care: Development and validation of a European questionnaire (euroQ2).

Jensen HI, Gerritsen RT, Koopmans M, Zijlstra JG, Curtis JR, Ørding H.

J Crit Care. 2015 Oct;30(5):884-90. doi: 10.1016/j.jcrc.2015.06.004. Epub 2015 Jun 16.


Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis.

Volbeda M, Wetterslev J, Gluud C, Zijlstra JG, van der Horst IC, Keus F.

Intensive Care Med. 2015 Jul;41(7):1220-34. doi: 10.1007/s00134-015-3899-6. Epub 2015 Jun 23. Review.


Interplay of co-inherited diseases can turn benign syndromes in a deadly combination: haemoglobinopathy and bilirubin transport disorder.

Stolmeijer TM, van der Berg AP, Koeze J, Gouw AS, Croles FN, Sieders E, Zijlstra JG.

Neth J Med. 2015 Jun;73(5):247-52.


Burden of highly resistant microorganisms in a Dutch intensive care unit.

Aardema H, Arends JP, de Smet AM, Zijlstra JG.

Neth J Med. 2015 May;73(4):169-74.


Transferring the critically ill patient: are we there yet?

Droogh JM, Smit M, Absalom AR, Ligtenberg JJ, Zijlstra JG.

Crit Care. 2015 Feb 20;19:62. doi: 10.1186/s13054-015-0749-4. Review.


[Intensive care patients who want to die at home: how can we fulfil this last wish?].

Hoogveld LM, Bergmans DC, de Vries S, van Proemeren H, van den Beuken-van Everdingen MH, Zijlstra JG, van Mook WN.

Ned Tijdschr Geneeskd. 2015;159:A8711. Dutch.


Real-time information on preventable death provided by email from frontline intensivists: results in high response rates with useful information.

Dijkema LM, Keus F, Dieperink W, van der Horst IC, Zijlstra JG.

BMJ Qual Saf. 2015 Apr;24(4):288. doi: 10.1136/bmjqs-2014-003899. Epub 2015 Jan 7. No abstract available.


Effects of levosimendan for low cardiac output syndrome in critically ill patients: systematic review with meta-analysis and trial sequential analysis.

Koster G, Wetterslev J, Gluud C, Zijlstra JG, Scheeren TW, van der Horst IC, Keus F.

Intensive Care Med. 2015 Feb;41(2):203-21. doi: 10.1007/s00134-014-3604-1. Epub 2014 Dec 18. Review.


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