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Items: 1 to 50 of 85

1.

Combined Loss of Ghrelin Receptor and Cannabinoid CB1 Receptor in Mice Decreases Survival but Does Not Additively Reduce Body Weight or Eating.

Mani BK, Castorena CM, Vianna CR, Lee CE, Metzger NP, Vijayaraghavan P, Osborne-Lawrence S, Elmquist JK, Zigman JM.

Neuroscience. 2019 Sep 11. pii: S0306-4522(19)30650-5. doi: 10.1016/j.neuroscience.2019.09.005. [Epub ahead of print]

PMID:
31520709
2.

LEAP2 changes with body mass and food intake in humans and mice.

Mani BK, Puzziferri N, He Z, Rodriguez JA, Osborne-Lawrence S, Metzger NP, Chhina N, Gaylinn B, Thorner MO, Thomas EL, Bell JD, Williams KW, Goldstone AP, Zigman JM.

J Clin Invest. 2019 Sep 3;129(9):3909-3923. doi: 10.1172/JCI125332.

3.

Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer's disease.

Tian J, Guo L, Sui S, Driskill C, Phensy A, Wang Q, Gauba E, Zigman JM, Swerdlow RH, Kroener S, Du H.

Sci Transl Med. 2019 Aug 14;11(505). pii: eaav6278. doi: 10.1126/scitranslmed.aav6278.

4.

Ghrelin's Relationship to Blood Glucose.

Mani BK, Shankar K, Zigman JM.

Endocrinology. 2019 May 1;160(5):1247-1261. doi: 10.1210/en.2019-00074.

PMID:
30874792
5.

β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress.

Gupta D, Chuang JC, Mani BK, Shankar K, Rodriguez JA, Osborne-Lawrence S, Metzger NP, Zigman JM.

Neuropsychopharmacology. 2019 Jun;44(7):1319-1327. doi: 10.1038/s41386-019-0334-7. Epub 2019 Feb 8.

PMID:
30758330
6.

Ghrelin Receptor Agonist Rescues Excess Neonatal Mortality in a Prader-Willi Syndrome Mouse Model.

Rodriguez JA, Bruggeman EC, Mani BK, Osborne-Lawrence S, Lord CC, Roseman HF, Viroslav HL, Vijayaraghavan P, Metzger NP, Gupta D, Shankar K, Pietra C, Liu C, Zigman JM.

Endocrinology. 2018 Dec 1;159(12):4006-4022. doi: 10.1210/en.2018-00801.

PMID:
30380028
7.

Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract.

Cornejo MP, De Francesco PN, García Romero G, Portiansky EL, Zigman JM, Reynaldo M, Perello M.

Brain Struct Funct. 2018 Sep;223(7):3133-3147. doi: 10.1007/s00429-018-1682-5. Epub 2018 May 14.

PMID:
29761230
8.

Ghrelin mediates exercise endurance and the feeding response post-exercise.

Mani BK, Castorena CM, Osborne-Lawrence S, Vijayaraghavan P, Metzger NP, Elmquist JK, Zigman JM.

Mol Metab. 2018 Mar;9:114-130. doi: 10.1016/j.molmet.2018.01.006. Epub 2018 Jan 31.

9.

Hypothalamic loss of Snord116 and Prader-Willi syndrome hyperphagia: the buck stops here?

Rodriguez JA, Zigman JM.

J Clin Invest. 2018 Mar 1;128(3):900-902. doi: 10.1172/JCI99725. Epub 2018 Jan 29.

10.

Ghrelin as a Survival Hormone.

Mani BK, Zigman JM.

Trends Endocrinol Metab. 2017 Dec;28(12):843-854. doi: 10.1016/j.tem.2017.10.001. Epub 2017 Oct 30. Review.

11.

The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting.

Mani BK, Osborne-Lawrence S, Mequinion M, Lawrence S, Gautron L, Andrews ZB, Zigman JM.

Mol Metab. 2017 Jun 22;6(8):882-896. doi: 10.1016/j.molmet.2017.06.011. eCollection 2017 Aug.

12.

Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.

Mani BK, Uchida A, Lee Y, Osborne-Lawrence S, Charron MJ, Unger RH, Berglund ED, Zigman JM.

Diabetes. 2017 Jul;66(7):1847-1857. doi: 10.2337/db16-1303. Epub 2017 May 9.

13.

Circulating Ghrelin Acts on GABA Neurons of the Area Postrema and Mediates Gastric Emptying in Male Mice.

Cabral A, Cornejo MP, Fernandez G, De Francesco PN, Garcia-Romero G, Uriarte M, Zigman JM, Portiansky E, Reynaldo M, Perello M.

Endocrinology. 2017 May 1;158(5):1436-1449. doi: 10.1210/en.2016-1815.

PMID:
28204197
14.

The effect of glutamate on ghrelin release in mice.

Chacrabati R, Gong Z, Ikenoya C, Kondo D, Zigman JM, Sakai T, Sakata I.

Cell Biol Int. 2017 Mar;41(3):320-327. doi: 10.1002/cbin.10728. Epub 2017 Jan 23.

PMID:
28067437
15.

β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals.

Mani BK, Osborne-Lawrence S, Vijayaraghavan P, Hepler C, Zigman JM.

J Clin Invest. 2016 Sep 1;126(9):3467-78. doi: 10.1172/JCI86270. Epub 2016 Aug 22.

16.

Correction to 'Obesity Impairs the Action of the Neuroendocrine Ghrelin System': [Trends in Endocrinology and Metabolism, 27 (2016) 54-63].

Zigman JM, Bouret SG, Andrews ZB.

Trends Endocrinol Metab. 2016 May;27(5):348. doi: 10.1016/j.tem.2016.02.007. Epub 2016 Mar 9. No abstract available.

PMID:
27106266
17.

Brain imaging demonstrates a reduced neural impact of eating in obesity.

Puzziferri N, Zigman JM, Thomas BP, Mihalakos P, Gallagher R, Lutter M, Carmody T, Lu H, Tamminga CA.

Obesity (Silver Spring). 2016 Apr;24(4):829-36. doi: 10.1002/oby.21424. Epub 2016 Feb 19.

18.

Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus.

Cabral A, Portiansky E, Sánchez-Jaramillo E, Zigman JM, Perello M.

Psychoneuroendocrinology. 2016 May;67:27-39. doi: 10.1016/j.psyneuen.2016.01.027. Epub 2016 Feb 1.

19.

Obesity Impairs the Action of the Neuroendocrine Ghrelin System.

Zigman JM, Bouret SG, Andrews ZB.

Trends Endocrinol Metab. 2016 Jan;27(1):54-63. doi: 10.1016/j.tem.2015.09.010. Epub 2015 Nov 2. Review. Erratum in: Trends Endocrinol Metab. 2016 May;27(5):348.

20.

A Strong Stomach for Somatostatin.

Mani BK, Zigman JM.

Endocrinology. 2015 Nov;156(11):3876-9. doi: 10.1210/en.2015-1756. No abstract available.

21.

Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice.

Wellman MK, Patterson ZR, MacKay H, Darling JE, Mani BK, Zigman JM, Hougland JL, Abizaid A.

Front Endocrinol (Lausanne). 2015 Sep 25;6:144. doi: 10.3389/fendo.2015.00144. eCollection 2015.

22.

Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells.

Engelstoft MS, Lund ML, Grunddal KV, Egerod KL, Osborne-Lawrence S, Poulsen SS, Zigman JM, Schwartz TW.

Mol Endocrinol. 2015 Nov;29(11):1658-71. doi: 10.1210/me.2015-1106. Epub 2015 Sep 9.

23.

Ghrelin.

Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.

Mol Metab. 2015 Mar 21;4(6):437-60. doi: 10.1016/j.molmet.2015.03.005. eCollection 2015 Jun. Review.

24.

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model.

De Francesco PN, Valdivia S, Cabral A, Reynaldo M, Raingo J, Sakata I, Osborne-Lawrence S, Zigman JM, Perelló M.

Neuroscience. 2015 Mar 19;289:153-65. doi: 10.1016/j.neuroscience.2015.01.006. Epub 2015 Jan 13.

25.

Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass.

Uchida A, Zechner JF, Mani BK, Park WM, Aguirre V, Zigman JM.

Mol Metab. 2014 Aug 1;3(7):717-30. doi: 10.1016/j.molmet.2014.07.009. eCollection 2014 Oct.

26.

Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse.

Mani BK, Walker AK, Lopez Soto EJ, Raingo J, Lee CE, Perelló M, Andrews ZB, Zigman JM.

J Comp Neurol. 2014 Nov 1;522(16):3644-66. doi: 10.1002/cne.23627. Epub 2014 Jun 10.

27.

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.

Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM.

Mol Psychiatry. 2015 Apr;20(4):500-8. doi: 10.1038/mp.2014.34. Epub 2014 Apr 22.

28.

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin.

Wang Q, Liu C, Uchida A, Chuang JC, Walker A, Liu T, Osborne-Lawrence S, Mason BL, Mosher C, Berglund ED, Elmquist JK, Zigman JM.

Mol Metab. 2013 Oct 17;3(1):64-72. doi: 10.1016/j.molmet.2013.10.001. eCollection 2014 Feb.

29.

Estradiol modulates Kiss1 neuronal response to ghrelin.

Frazao R, Dungan Lemko HM, da Silva RP, Ratra DV, Lee CE, Williams KW, Zigman JM, Elias CF.

Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E606-14. doi: 10.1152/ajpendo.00211.2013. Epub 2014 Jan 28.

30.

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.

Engelstoft MS, Park WM, Sakata I, Kristensen LV, Husted AS, Osborne-Lawrence S, Piper PK, Walker AK, Pedersen MH, Nøhr MK, Pan J, Sinz CJ, Carrington PE, Akiyama TE, Jones RM, Tang C, Ahmed K, Offermanns S, Egerod KL, Zigman JM, Schwartz TW.

Mol Metab. 2013 Sep 4;2(4):376-92. doi: 10.1016/j.molmet.2013.08.006. eCollection 2013.

31.

G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro.

Gong Z, Yoshimura M, Aizawa S, Kurotani R, Zigman JM, Sakai T, Sakata I.

Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E28-35. doi: 10.1152/ajpendo.00306.2013. Epub 2013 Nov 12.

32.

Role of calcium and EPAC in norepinephrine-induced ghrelin secretion.

Mani BK, Chuang JC, Kjalarsdottir L, Sakata I, Walker AK, Kuperman A, Osborne-Lawrence S, Repa JJ, Zigman JM.

Endocrinology. 2014 Jan;155(1):98-107. doi: 10.1210/en.2013-1691. Epub 2013 Dec 20.

33.

The central nervous system sites mediating the orexigenic actions of ghrelin.

Mason BL, Wang Q, Zigman JM.

Annu Rev Physiol. 2014;76:519-33. doi: 10.1146/annurev-physiol-021113-170310. Epub 2013 Oct 2. Review.

34.

Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models.

Uchida A, Zigman JM, Perelló M.

Front Neurosci. 2013 Jul 16;7:121. doi: 10.3389/fnins.2013.00121. eCollection 2013.

35.

Expression of Serum Retinol Binding Protein and Transthyretin within Mouse Gastric Ghrelin Cells.

Walker AK, Gong Z, Park WM, Zigman JM, Sakata I.

PLoS One. 2013 Jun 19;8(6):e64882. doi: 10.1371/journal.pone.0064882. Print 2013.

36.

An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice.

Smith JT, Reichenbach A, Lemus M, Mani BK, Zigman JM, Andrews ZB.

Peptides. 2013 Sep;47:45-53. doi: 10.1016/j.peptides.2013.06.012. Epub 2013 Jul 4.

37.

A solitary hyperfunctioning thyroid nodule harboring thyroid carcinoma: review of the literature.

Mirfakhraee S, Mathews D, Peng L, Woodruff S, Zigman JM.

Thyroid Res. 2013 May 4;6(1):7. doi: 10.1186/1756-6614-6-7.

38.

Characterization of gastric and neuronal histaminergic populations using a transgenic mouse model.

Walker AK, Park WM, Chuang JC, Perello M, Sakata I, Osborne-Lawrence S, Zigman JM.

PLoS One. 2013;8(3):e60276. doi: 10.1371/journal.pone.0060276. Epub 2013 Mar 29.

39.

Leptin signaling in Kiss1 neurons arises after pubertal development.

Cravo RM, Frazao R, Perello M, Osborne-Lawrence S, Williams KW, Zigman JM, Vianna C, Elias CF.

PLoS One. 2013;8(3):e58698. doi: 10.1371/journal.pone.0058698. Epub 2013 Mar 7.

40.

Shift in Kiss1 cell activity requires estrogen receptor α.

Frazão R, Cravo RM, Donato J Jr, Ratra DV, Clegg DJ, Elmquist JK, Zigman JM, Williams KW, Elias CF.

J Neurosci. 2013 Feb 13;33(7):2807-20. doi: 10.1523/JNEUROSCI.1610-12.2013.

41.

Differential effects of chronic social stress and fluoxetine on meal patterns in mice.

Kumar J, Chuang JC, Na ES, Kuperman A, Gillman AG, Mukherjee S, Zigman JM, McClung CA, Lutter M.

Appetite. 2013 May;64:81-8. doi: 10.1016/j.appet.2012.12.023. Epub 2013 Jan 11.

42.

A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.

Egerod KL, Engelstoft MS, Grunddal KV, Nøhr MK, Secher A, Sakata I, Pedersen J, Windeløv JA, Füchtbauer EM, Olsen J, Sundler F, Christensen JP, Wierup N, Olsen JV, Holst JJ, Zigman JM, Poulsen SS, Schwartz TW.

Endocrinology. 2012 Dec;153(12):5782-95. doi: 10.1210/en.2012-1595. Epub 2012 Oct 12.

PMID:
23064014
43.

Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling.

Walker AK, Ibia IE, Zigman JM.

Physiol Behav. 2012 Dec 25;108:34-43. doi: 10.1016/j.physbeh.2012.10.003. Epub 2012 Oct 9.

44.

GOAT induced ghrelin acylation regulates hedonic feeding.

Davis JF, Perello M, Choi DL, Magrisso IJ, Kirchner H, Pfluger PT, Tschoep M, Zigman JM, Benoit SC.

Horm Behav. 2012 Nov;62(5):598-604. doi: 10.1016/j.yhbeh.2012.08.009. Epub 2012 Sep 8.

45.

Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose.

Scott MM, Perello M, Chuang JC, Sakata I, Gautron L, Lee CE, Lauzon D, Elmquist JK, Zigman JM.

PLoS One. 2012;7(8):e44089. doi: 10.1371/journal.pone.0044089. Epub 2012 Aug 31.

46.

Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness.

Yanovsky Y, Zigman JM, Kernder A, Bein A, Sakata I, Osborne-Lawrence S, Haas HL, Sergeeva OA.

Front Syst Neurosci. 2012 Apr 13;6:23. doi: 10.3389/fnsys.2012.00023. eCollection 2012.

47.

The role of ghrelin in reward-based eating.

Perelló M, Zigman JM.

Biol Psychiatry. 2012 Sep 1;72(5):347-53. doi: 10.1016/j.biopsych.2012.02.016. Epub 2012 Mar 28. Review.

48.

Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells.

Sakata I, Park WM, Walker AK, Piper PK, Chuang JC, Osborne-Lawrence S, Zigman JM.

Am J Physiol Endocrinol Metab. 2012 May 1;302(10):E1300-10. doi: 10.1152/ajpendo.00041.2012. Epub 2012 Mar 13.

49.

Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents.

Cabral A, Suescun O, Zigman JM, Perello M.

PLoS One. 2012;7(2):e31462. doi: 10.1371/journal.pone.0031462. Epub 2012 Feb 20.

50.

Ghrelin directly stimulates glucagon secretion from pancreatic alpha-cells.

Chuang JC, Sakata I, Kohno D, Perello M, Osborne-Lawrence S, Repa JJ, Zigman JM.

Mol Endocrinol. 2011 Sep;25(9):1600-11. doi: 10.1210/me.2011-1001. Epub 2011 Jun 30.

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