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Items: 1 to 50 of 280

1.

Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status.

Basse AL, Dalbram E, Larsson L, Gerhart-Hines Z, Zierath JR, Treebak JT.

Front Physiol. 2018 Aug 28;9:1198. doi: 10.3389/fphys.2018.01198. eCollection 2018.

2.

Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans.

Cedernaes J, Schönke M, Westholm JO, Mi J, Chibalin A, Voisin S, Osler M, Vogel H, Hörnaeus K, Dickson SL, Lind SB, Bergquist J, Schiöth HB, Zierath JR, Benedict C.

Sci Adv. 2018 Aug 22;4(8):eaar8590. doi: 10.1126/sciadv.aar8590. eCollection 2018 Aug.

3.

AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle.

Lassiter DG, Sjögren RJO, Gabriel BM, Krook A, Zierath JR.

Mol Metab. 2018 Jul 25. pii: S2212-8778(18)30460-5. doi: 10.1016/j.molmet.2018.07.004. [Epub ahead of print]

4.

Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals.

Savikj M, Ruby MA, Kostovski E, Iversen PO, Zierath JR, Krook A, Widegren U.

Physiol Rep. 2018 Jun;6(12):e13739. doi: 10.14814/phy2.13739.

5.

Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells.

Pillon NJ, Frendo-Cumbo S, Jacobson MR, Liu Z, Milligan PL, Hoang Bui H, Zierath JR, Bilan PJ, Brozinick JT, Klip A.

J Lipid Res. 2018 Jul;59(7):1148-1163. doi: 10.1194/jlr.M080788. Epub 2018 May 23.

PMID:
29794037
6.

Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism.

Schönke M, Massart J, Zierath JR.

J Lipid Res. 2018 Jul;59(7):1276-1282. doi: 10.1194/jlr.D082370. Epub 2018 May 8.

PMID:
29739863
7.

Author Correction: Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans.

Laker RC, Garde C, Camera DM, Smiles WJ, Zierath JR, Hawley JA, Barrès R.

Sci Rep. 2018 Mar 19;8(1):5008. doi: 10.1038/s41598-018-23227-3.

8.

The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals.

Younis S, Schönke M, Massart J, Hjortebjerg R, Sundström E, Gustafson U, Björnholm M, Krook A, Frystyk J, Zierath JR, Andersson L.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2048-E2057. doi: 10.1073/pnas.1719278115. Epub 2018 Feb 12.

9.

Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury.

Lundell LS, Savikj M, Kostovski E, Iversen PO, Zierath JR, Krook A, Chibalin AV, Widegren U.

Acta Physiol (Oxf). 2018 Jul;223(3):e13051. doi: 10.1111/apha.13051. Epub 2018 Feb 28.

PMID:
29423932
10.

Proteomics Analysis of Skeletal Muscle from Leptin-Deficient ob/ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition.

Schönke M, Björnholm M, Chibalin AV, Zierath JR, Deshmukh AS.

Proteomics. 2018 Mar;18(5-6):e1700375. doi: 10.1002/pmic.201700375. Epub 2018 Feb 20.

PMID:
29350465
11.

Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet.

Nascimento EBM, Mannerås-Holm L, Chibalin AV, Björnholm M, Zierath JR.

J Lipid Res. 2018 Feb;59(2):273-282. doi: 10.1194/jlr.M079517. Epub 2017 Dec 12.

PMID:
29233919
12.

Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans.

Laker RC, Garde C, Camera DM, Smiles WJ, Zierath JR, Hawley JA, Barrès R.

Sci Rep. 2017 Nov 9;7(1):15134. doi: 10.1038/s41598-017-15420-7. Erratum in: Sci Rep. 2018 Mar 19;8(1):5008.

13.

DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism.

Benziane B, Borg ML, Tom RZ, Riedl I, Massart J, Björnholm M, Gilbert M, Chibalin AV, Zierath JR.

J Lipid Res. 2017 Dec;58(12):2324-2333. doi: 10.1194/jlr.M079723. Epub 2017 Oct 24.

PMID:
29066466
14.

FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle.

Lassiter DG, Nylén C, Sjögren RJO, Chibalin AV, Wallberg-Henriksson H, Näslund E, Krook A, Zierath JR.

Diabetologia. 2018 Feb;61(2):424-432. doi: 10.1007/s00125-017-4451-8. Epub 2017 Oct 11.

PMID:
29022062
15.

Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle.

Ruby MA, Riedl I, Massart J, Åhlin M, Zierath JR.

Am J Physiol Endocrinol Metab. 2017 Oct 1;313(4):E483-E491. doi: 10.1152/ajpendo.00147.2017. Epub 2017 Jul 18.

PMID:
28720584
16.

Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle.

Alm PS, de Castro Barbosa T, Barrès R, Krook A, Zierath JR.

Mol Metab. 2017 May 22;6(7):621-630. doi: 10.1016/j.molmet.2017.05.009. eCollection 2017 Jul.

17.

The Limits of Exercise Physiology: From Performance to Health.

Gabriel BM, Zierath JR.

Cell Metab. 2017 May 2;25(5):1000-1011. doi: 10.1016/j.cmet.2017.04.018. Review.

18.

Early vertebrate origin and diversification of small transmembrane regulators of cellular ion transport.

Pirkmajer S, Kirchner H, Lundell LS, Zelenin PV, Zierath JR, Makarova KS, Wolf YI, Chibalin AV.

J Physiol. 2017 Jul 15;595(14):4611-4630. doi: 10.1113/JP274254. Epub 2017 May 29.

19.

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle.

Massart J, Sjögren RJO, Lundell LS, Mudry JM, Franck N, O'Gorman DJ, Egan B, Zierath JR, Krook A.

Diabetes. 2017 Jul;66(7):1807-1818. doi: 10.2337/db17-0141. Epub 2017 Apr 12.

20.

Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice.

Mannerås-Holm L, Schönke M, Brozinick JT, Vetterli L, Bui HH, Sanders P, Nascimento EBM, Björnholm M, Chibalin AV, Zierath JR.

J Lipid Res. 2017 May;58(5):907-915. doi: 10.1194/jlr.M074443. Epub 2017 Feb 28.

21.

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.

Ruby MA, Massart J, Hunerdosse DM, Schönke M, Correia JC, Louie SM, Ruas JL, Näslund E, Nomura DK, Zierath JR.

Cell Rep. 2017 Jan 17;18(3):636-646. doi: 10.1016/j.celrep.2016.12.070.

22.

Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.

Mudry JM, Lassiter DG, Nylén C, García-Calzón S, Näslund E, Krook A, Zierath JR.

Diabetes. 2017 Mar;66(3):651-662. doi: 10.2337/db16-0882. Epub 2016 Dec 23.

23.

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Lotta LA, Scott RA, Sharp SJ, Burgess S, Luan J, Tillin T, Schmidt AF, Imamura F, Stewart ID, Perry JR, Marney L, Koulman A, Karoly ED, Forouhi NG, Sjögren RJ, Näslund E, Zierath JR, Krook A, Savage DB, Griffin JL, Chaturvedi N, Hingorani AD, Khaw KT, Barroso I, McCarthy MI, O'Rahilly S, Wareham NJ, Langenberg C.

PLoS Med. 2016 Nov 29;13(11):e1002179. doi: 10.1371/journal.pmed.1002179. eCollection 2016 Nov.

24.

Building Bridges through Scientific Conferences.

Zierath JR.

Cell. 2016 Nov 17;167(5):1155-1158. doi: 10.1016/j.cell.2016.11.006.

25.

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

Kjøbsted R, Munk-Hansen N, Birk JB, Foretz M, Viollet B, Björnholm M, Zierath JR, Treebak JT, Wojtaszewski JF.

Diabetes. 2017 Mar;66(3):598-612. doi: 10.2337/db16-0530. Epub 2016 Oct 26.

26.

SnapShot: Exercise Metabolism.

Egan B, Hawley JA, Zierath JR.

Cell Metab. 2016 Aug 9;24(2):342-342.e1. doi: 10.1016/j.cmet.2016.07.013.

27.

The role of diet and exercise in the transgenerational epigenetic landscape of T2DM.

Barrès R, Zierath JR.

Nat Rev Endocrinol. 2016 Aug;12(8):441-51. doi: 10.1038/nrendo.2016.87. Epub 2016 Jun 17. Review.

PMID:
27312865
28.

Exercise Promotes Healthy Aging of Skeletal Muscle.

Cartee GD, Hepple RT, Bamman MM, Zierath JR.

Cell Metab. 2016 Jun 14;23(6):1034-1047. doi: 10.1016/j.cmet.2016.05.007. Review.

29.

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients.

Kirchner H, Sinha I, Gao H, Ruby MA, Schönke M, Lindvall JM, Barrès R, Krook A, Näslund E, Dahlman-Wright K, Zierath JR.

Mol Metab. 2016 Jan 2;5(3):171-183. doi: 10.1016/j.molmet.2015.12.004. eCollection 2016 Mar.

30.

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring.

de Castro Barbosa T, Ingerslev LR, Alm PS, Versteyhe S, Massart J, Rasmussen M, Donkin I, Sjögren R, Mudry JM, Vetterli L, Gupta S, Krook A, Zierath JR, Barrès R.

Mol Metab. 2015 Dec 25;5(3):184-197. doi: 10.1016/j.molmet.2015.12.002. eCollection 2016 Mar.

31.

Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes.

Mudry JM, Alm PS, Erhardt S, Goiny M, Fritz T, Caidahl K, Zierath JR, Krook A, Wallberg-Henriksson H.

Diabetes Metab Res Rev. 2016 Oct;32(7):754-761. doi: 10.1002/dmrr.2798. Epub 2016 May 1.

PMID:
26946084
32.

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.

Correia JC, Massart J, de Boer JF, Porsmyr-Palmertz M, Martínez-Redondo V, Agudelo LZ, Sinha I, Meierhofer D, Ribeiro V, Björnholm M, Sauer S, Dahlman-Wright K, Zierath JR, Groen AK, Ruas JL.

Mol Metab. 2015 Sep 26;4(12):891-902. doi: 10.1016/j.molmet.2015.09.005. eCollection 2015 Dec.

33.

AMPKγ3 is dispensable for skeletal muscle hypertrophy induced by functional overload.

Riedl I, Osler ME, Björnholm M, Egan B, Nader GA, Chibalin AV, Zierath JR.

Am J Physiol Endocrinol Metab. 2016 Mar 15;310(6):E461-72. doi: 10.1152/ajpendo.00387.2015. Epub 2016 Jan 12.

34.

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans.

Donkin I, Versteyhe S, Ingerslev LR, Qian K, Mechta M, Nordkap L, Mortensen B, Appel EV, Jørgensen N, Kristiansen VB, Hansen T, Workman CT, Zierath JR, Barrès R.

Cell Metab. 2016 Feb 9;23(2):369-78. doi: 10.1016/j.cmet.2015.11.004. Epub 2015 Dec 6.

35.

MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression.

Boon H, Sjögren RJ, Massart J, Egan B, Kostovski E, Iversen PO, Hjeltnes N, Chibalin AV, Widegren U, Zierath JR.

Physiol Rep. 2015 Nov;3(11). pii: e12622. doi: 10.14814/phy2.12622. Epub 2015 Nov 24.

36.

Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics.

Jiang LQ, de Castro Barbosa T, Massart J, Deshmukh AS, Löfgren L, Duque-Guimaraes DE, Ozilgen A, Osler ME, Chibalin AV, Zierath JR.

Am J Physiol Endocrinol Metab. 2016 Jan 1;310(1):E51-60. doi: 10.1152/ajpendo.00209.2015. Epub 2015 Nov 3.

37.

Erratum to: Turning the page.

Zierath JR.

Diabetologia. 2015 Dec;58(12):2899. doi: 10.1007/s00125-015-3782-6. No abstract available.

PMID:
26471902
38.

Turning the page.

Zierath JR.

Diabetologia. 2015 Dec;58(12):2685-7. doi: 10.1007/s00125-015-3764-8. No abstract available. Erratum in: Diabetologia. 2015 Dec;58(12):2899.

PMID:
26407714
39.

Skeletal muscle AMP-activated protein kinase γ1(H151R) overexpression enhances whole body energy homeostasis and insulin sensitivity.

Schönke M, Myers MG Jr, Zierath JR, Björnholm M.

Am J Physiol Endocrinol Metab. 2015 Oct 1;309(7):E679-90. doi: 10.1152/ajpendo.00195.2015. Epub 2015 Aug 25.

40.

Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men.

Cedernaes J, Osler ME, Voisin S, Broman JE, Vogel H, Dickson SL, Zierath JR, Schiöth HB, Benedict C.

J Clin Endocrinol Metab. 2015 Sep;100(9):E1255-61. doi: 10.1210/JC.2015-2284. Epub 2015 Jul 13.

PMID:
26168277
41.

Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us?

Zierath JR, Wallberg-Henriksson H.

Cell Metab. 2015 Jul 7;22(1):25-30. doi: 10.1016/j.cmet.2015.06.015. Review.

42.

Effects of sleeping with reduced carbohydrate availability on acute training responses.

Lane SC, Camera DM, Lassiter DG, Areta JL, Bird SR, Yeo WK, Jeacocke NA, Krook A, Zierath JR, Burke LM, Hawley JA.

J Appl Physiol (1985). 2015 Sep 15;119(6):643-55. doi: 10.1152/japplphysiol.00857.2014. Epub 2015 Jun 25.

43.

Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance.

Ring M, Eriksson MJ, Fritz T, Nyberg G, Östenson CG, Krook A, Zierath JR, Caidahl K.

Diab Vasc Dis Res. 2015 Sep;12(5):315-24. doi: 10.1177/1479164115588548. Epub 2015 Jun 19.

44.

Diabetologia at 50: celebrating half a century of progress in diabetes research and care.

Zierath JR.

Diabetologia. 2015 Aug;58(8):1685-7. doi: 10.1007/s00125-015-3640-6. No abstract available.

PMID:
26013681
45.

mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.

Mannerås-Holm L, Kirchner H, Björnholm M, Chibalin AV, Zierath JR.

Physiol Rep. 2015 Apr;3(4). pii: e12372. doi: 10.14814/phy2.12372.

46.

Changes in gene expression in responders and nonresponders to a low-intensity walking intervention.

Osler ME, Fritz T, Caidahl K, Krook A, Zierath JR, Wallberg-Henriksson H.

Diabetes Care. 2015 Jun;38(6):1154-60. doi: 10.2337/dc14-2606. Epub 2015 Mar 20.

PMID:
25795414
47.

Association of the ACTN3 R577X polymorphism with glucose tolerance and gene expression of sarcomeric proteins in human skeletal muscle.

Riedl I, Osler ME, Benziane B, Chibalin AV, Zierath JR.

Physiol Rep. 2015 Mar;3(3). pii: e12314. doi: 10.14814/phy2.12314.

48.

Metabolism. Exercise remodels subcutaneous fat tissue and improves metabolism.

Wallberg-Henriksson H, Zierath JR.

Nat Rev Endocrinol. 2015 Apr;11(4):198-200. doi: 10.1038/nrendo.2015.24. Epub 2015 Feb 24. No abstract available.

PMID:
25707778
49.

Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes.

Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li Y, Rodriguez V, Drong A, Hussain M, Lindgren C, McCarthy M, Näslund E, Zierath JR, Wong GW, Feinberg AP.

Cell Metab. 2015 Jan 6;21(1):138-49. doi: 10.1016/j.cmet.2014.12.014.

50.

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.

Kjøbsted R, Treebak JT, Fentz J, Lantier L, Viollet B, Birk JB, Schjerling P, Björnholm M, Zierath JR, Wojtaszewski JF.

Diabetes. 2015 Jun;64(6):2042-55. doi: 10.2337/db14-1402. Epub 2014 Dec 31.

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