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Items: 9

1.

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper.

Prasad B, Achour B, Artursson P, Hop CECA, Lai Y, Smith PC, Barber J, Wisniewski JR, Spellman D, Uchida Y, Zientek MA, Unadkat JD, Rostami-Hodjegan A.

Clin Pharmacol Ther. 2019 Sep;106(3):525-543. doi: 10.1002/cpt.1537. Epub 2019 Jul 26.

PMID:
31175671
2.

Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms.

Leung L, Yang X, Strelevitz TJ, Montgomery J, Brown MF, Zientek MA, Banfield C, Gilbert AM, Thorarensen A, Dowty ME.

Drug Metab Dispos. 2017 Jan;45(1):1-7. Epub 2016 Oct 26.

PMID:
27784718
3.

In Vitro Kinetic Characterization of Axitinib Metabolism.

Zientek MA, Goosen TC, Tseng E, Lin J, Bauman JN, Walker GS, Kang P, Jiang Y, Freiwald S, Neul D, Smith BJ.

Drug Metab Dispos. 2016 Jan;44(1):102-14. doi: 10.1124/dmd.115.065615. Epub 2015 Oct 28.

PMID:
26512042
4.

Reaction phenotyping: advances in the experimental strategies used to characterize the contribution of drug-metabolizing enzymes.

Zientek MA, Youdim K.

Drug Metab Dispos. 2015 Jan;43(1):163-81. doi: 10.1124/dmd.114.058750. Epub 2014 Oct 8. Review.

PMID:
25297949
5.

Relative contributions of cytochrome CYP3A4 versus CYP3A5 for CYP3A-cleared drugs assessed in vitro using a CYP3A4-selective inactivator (CYP3cide).

Tseng E, Walsky RL, Luzietti RA Jr, Harris JJ, Kosa RE, Goosen TC, Zientek MA, Obach RS.

Drug Metab Dispos. 2014 Jul;42(7):1163-73. doi: 10.1124/dmd.114.057000. Epub 2014 Apr 15.

PMID:
24737844
6.

Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.

Hutzler JM, Obach RS, Dalvie D, Zientek MA.

Expert Opin Drug Metab Toxicol. 2013 Feb;9(2):153-68. doi: 10.1517/17425255.2013.738668. Epub 2012 Dec 12. Review.

PMID:
23231678
7.

Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.

Walsky RL, Obach RS, Hyland R, Kang P, Zhou S, West M, Geoghegan KF, Helal CJ, Walker GS, Goosen TC, Zientek MA.

Drug Metab Dispos. 2012 Sep;40(9):1686-97. doi: 10.1124/dmd.112.045302. Epub 2012 May 29.

PMID:
22645092
8.

Quantifying and predicting the promiscuity and isoform specificity of small-molecule cytochrome P450 inhibitors.

Nath A, Zientek MA, Burke BJ, Jiang Y, Atkins WM.

Drug Metab Dispos. 2010 Dec;38(12):2195-203. doi: 10.1124/dmd.110.034645. Epub 2010 Sep 14.

9.

Characterization of endothelin converting enzyme from intact cells of a permanent human endothelial cell line, EA.hy926.

Ahn K, Pan SM, Zientek MA, Guy PM, Sisneros AM.

Biochem Mol Biol Int. 1996 Jun;39(3):573-80.

PMID:
8828809

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