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Biochem Soc Trans. 2017 Jun 15;45(3):693-701. doi: 10.1042/BST20160169.

Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes.

Author information

1
Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A.
2
Department of Microbiology, Immunology & Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A.
3
Beirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A.
4
Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A.
5
Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A. db8g@virginia.edu.

Abstract

Protein phosphatase-6 (PP6) is a member of the PPP family of Ser/Thr phosphatases involved in intracellular signaling. PP6 is conserved among all eukaryotes, and genetics in model organisms indicates it has non-redundant functions relative to other PPP phosphatases. PP6 functions in association with conserved SAPS subunits and, in vertebrate species, forms heterotrimers with Ankrd subunits. Multiple studies have demonstrated how PP6 exerts negative control at different steps of nuclear factor kappaB signaling. Expression of PP6 catalytic subunit and the PPP6R1 subunit is especially high in hematopoietic cells and lymphoid tissues. Recent efforts at conditionally knocking out genes for PP6c or PP6R1 (SAPS1) have revealed distinctive effects on development of and signaling in lymphocytes.

KEYWORDS:

T-cells; knockout mice; nuclear factor kappaB; phosphorylation/dephosphorylation

PMID:
28620030
PMCID:
PMC5473023
DOI:
10.1042/BST20160169
[Indexed for MEDLINE]
Free PMC Article

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