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Building bridges to move recombination complexes.

Dubois E, De Muyt A, Soyer JL, Budin K, Legras M, Piolot T, Debuchy R, Kleckner N, Zickler D, Espagne E.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12400-12409. doi: 10.1073/pnas.1901237116. Epub 2019 May 30.


Per-Nucleus Crossover Covariation and Implications for Evolution.

Wang S, Veller C, Sun F, Ruiz-Herrera A, Shang Y, Liu H, Zickler D, Chen Z, Kleckner N, Zhang L.

Cell. 2019 Apr 4;177(2):326-338.e16. doi: 10.1016/j.cell.2019.02.021. Epub 2019 Mar 14.


Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro.

Hegner B, Schaub T, Janke D, Zickler D, Lange C, Girndt M, Jankowski J, Schindler R, Dragun D.

Sci Rep. 2018 Aug 14;8(1):12087. doi: 10.1038/s41598-018-30626-z.


SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling.

Voelkl J, Luong TT, Tuffaha R, Musculus K, Auer T, Lian X, Daniel C, Zickler D, Boehme B, Sacherer M, Metzler B, Kuhl D, Gollasch M, Amann K, Müller DN, Pieske B, Lang F, Alesutan I.

J Clin Invest. 2018 Jul 2;128(7):3024-3040. doi: 10.1172/JCI96477. Epub 2018 Jun 11.


Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-κB.

Voelkl J, Tuffaha R, Luong TTD, Zickler D, Masyout J, Feger M, Verheyen N, Blaschke F, Kuro-O M, Tomaschitz A, Pilz S, Pasch A, Eckardt KU, Scherberich JE, Lang F, Pieske B, Alesutan I.

J Am Soc Nephrol. 2018 Jun;29(6):1636-1648. doi: 10.1681/ASN.2017050492. Epub 2018 Apr 13.


Expanded Haemodialysis Therapy of Chronic Haemodialysis Patients Prevents Calcification and Apoptosis of Vascular Smooth Muscle Cells in vitro.

Willy K, Girndt M, Voelkl J, Fiedler R, Martus P, Storr M, Schindler R, Zickler D.

Blood Purif. 2018;45(1-3):131-138. doi: 10.1159/000484925. Epub 2017 Dec 22.


Tumour necrosis factor-alpha in uraemic serum promotes osteoblastic transition and calcification of vascular smooth muscle cells via extracellular signal-regulated kinases and activator protein 1/c-FOS-mediated induction of interleukin 6 expression.

Zickler D, Luecht C, Willy K, Chen L, Witowski J, Girndt M, Fiedler R, Storr M, Kamhieh-Milz J, Schoon J, Geissler S, Ringdén O, Schindler R, Moll G, Dragun D, Catar R.

Nephrol Dial Transplant. 2018 Apr 1;33(4):574-585. doi: 10.1093/ndt/gfx316.


Asy2/Mer2: an evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction.

Tessé S, Bourbon HM, Debuchy R, Budin K, Dubois E, Liangran Z, Antoine R, Piolot T, Kleckner N, Zickler D, Espagne E.

Genes Dev. 2017 Sep 15;31(18):1880-1893. doi: 10.1101/gad.304543.117. Epub 2017 Oct 11.


Modulation of leucocytic angiotensin-converting enzymes expression in patients maintained on high-permeable haemodialysis.

Trojanowicz B, Ulrich C, Fiedler R, Martus P, Storr M, Boehler T, Werner K, Hulko M, Zickler D, Willy K, Schindler R, Girndt M.

Nephrol Dial Transplant. 2018 Jan 1;33(1):34-43. doi: 10.1093/ndt/gfx206.


In Vitro Dialysis of Cytokine-Rich Plasma With High and Medium Cut-Off Membranes Reduces Its Procalcific Activity.

Willy K, Hulko M, Storr M, Speidel R, Gauss J, Schindler R, Zickler D.

Artif Organs. 2017 Sep;41(9):803-809. doi: 10.1111/aor.12884. Epub 2017 May 19.


Inefficient Crossover Maturation Underlies Elevated Aneuploidy in Human Female Meiosis.

Wang S, Hassold T, Hunt P, White MA, Zickler D, Kleckner N, Zhang L.

Cell. 2017 Mar 9;168(6):977-989.e17. doi: 10.1016/j.cell.2017.02.002. Epub 2017 Mar 2.


Medium Cut-Off (MCO) Membranes Reduce Inflammation in Chronic Dialysis Patients-A Randomized Controlled Clinical Trial.

Zickler D, Schindler R, Willy K, Martus P, Pawlak M, Storr M, Hulko M, Boehler T, Glomb MA, Liehr K, Henning C, Templin M, Trojanowicz B, Ulrich C, Werner K, Fiedler R, Girndt M.

PLoS One. 2017 Jan 13;12(1):e0169024. doi: 10.1371/journal.pone.0169024. eCollection 2017.


Impact of serum and dialysates obtained from chronic hemodialysis patients maintained on high cut-off membranes on inflammation profile in human THP-1 monocytes.

Trojanowicz B, Ulrich C, Fiedler R, Storr M, Boehler T, Martus P, Pawlak M, Glomb MA, Henning C, Templin M, Werner K, Zickler D, Willy K, Schindler R, Girndt M.

Hemodial Int. 2017 Jul;21(3):348-358. doi: 10.1111/hdi.12494. Epub 2016 Sep 26.


High cut-off dialysis in chronic haemodialysis patients reduces serum procalcific activity.

Zickler D, Willy K, Girndt M, Fiedler R, Martus P, Storr M, Schindler R.

Nephrol Dial Transplant. 2016 Oct;31(10):1706-12. doi: 10.1093/ndt/gfw293. Epub 2016 Jul 20.


A few of our favorite things: Pairing, the bouquet, crossover interference and evolution of meiosis.

Zickler D, Kleckner N.

Semin Cell Dev Biol. 2016 Jun;54:135-48. doi: 10.1016/j.semcdb.2016.02.024. Epub 2016 Feb 27. Review.


Peroxisome dynamics during development of the fungus Podospora anserina.

Takano-Rojas H, Zickler D, Peraza-Reyes L.

Mycologia. 2016 May-Jun;108(3):590-602. doi: 10.3852/15-112. Epub 2016 Feb 23.


Sordaria, a model system to uncover links between meiotic pairing and recombination.

Zickler D, Espagne E.

Semin Cell Dev Biol. 2016 Jun;54:149-57. doi: 10.1016/j.semcdb.2016.02.012. Epub 2016 Feb 10. Review.


The challenge of evolving stable polyploidy: could an increase in "crossover interference distance" play a central role?

Bomblies K, Jones G, Franklin C, Zickler D, Kleckner N.

Chromosoma. 2016 Jun;125(2):287-300. doi: 10.1007/s00412-015-0571-4. Epub 2016 Jan 12. Review.


High cut-off dialysis in chronic haemodialysis patients.

Girndt M, Fiedler R, Martus P, Pawlak M, Storr M, Bohler T, Glomb MA, Liehr K, Henning C, Templin M, Trojanowicz B, Ulrich C, Werner K, Zickler D, Schindler R.

Eur J Clin Invest. 2015 Dec;45(12):1333-40. doi: 10.1111/eci.12559.


Chromosomes Progress to Metaphase in Multiple Discrete Steps via Global Compaction/Expansion Cycles.

Liang Z, Zickler D, Prentiss M, Chang FS, Witz G, Maeshima K, Kleckner N.

Cell. 2015 May 21;161(5):1124-1137. doi: 10.1016/j.cell.2015.04.030.


Recombination, Pairing, and Synapsis of Homologs during Meiosis.

Zickler D, Kleckner N.

Cold Spring Harb Perspect Biol. 2015 May 18;7(6). pii: a016626. doi: 10.1101/cshperspect.a016626. Review.


Meiotic crossover patterns: obligatory crossover, interference and homeostasis in a single process.

Wang S, Zickler D, Kleckner N, Zhang L.

Cell Cycle. 2015;14(3):305-14. doi: 10.4161/15384101.2014.991185. Review.


Interference-mediated synaptonemal complex formation with embedded crossover designation.

Zhang L, Espagne E, de Muyt A, Zickler D, Kleckner NE.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5059-68. doi: 10.1073/pnas.1416411111. Epub 2014 Nov 7.


Absence of SUN-domain protein Slp1 blocks karyogamy and switches meiotic recombination and synapsis from homologs to sister chromatids.

Vasnier C, de Muyt A, Zhang L, Tessé S, Kleckner NE, Zickler D, Espagne E.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4015-23. doi: 10.1073/pnas.1415758111. Epub 2014 Sep 10.


E3 ligase Hei10: a multifaceted structure-based signaling molecule with roles within and beyond meiosis.

De Muyt A, Zhang L, Piolot T, Kleckner N, Espagne E, Zickler D.

Genes Dev. 2014 May 15;28(10):1111-23. doi: 10.1101/gad.240408.114.


Elimination of middle-sized uremic solutes with high-flux and high-cut-off membranes: a randomized in vivo study.

Kneis C, Beck W, Boenisch O, Klefisch F, Deppisch R, Zickler D, Schindler R.

Blood Purif. 2013;36(3-4):287-94. doi: 10.1159/000356224. Epub 2013 Dec 20.


Molecular biology. Chromosome capture brings it all together.

Kleckner N, Zickler D, Witz G.

Science. 2013 Nov 22;342(6161):940-1. doi: 10.1126/science.1247514. No abstract available.


The chiasmatype theory. A new interpretation of the maturation divisions. 1909.

Janssens FA, Koszul R, Zickler D.

Genetics. 2012 Jun;191(2):319-46. doi: 10.1534/genetics.112.139725. No abstract available.


The centenary of Janssens's chiasmatype theory.

Koszul R, Meselson M, Van Doninck K, Vandenhaute J, Zickler D.

Genetics. 2012 Jun;191(2):309-17. doi: 10.1534/genetics.112.139733. Erratum in: Genetics. 2012 Oct;192(2):757.


Wood utilization is dependent on catalase activities in the filamentous fungus Podospora anserina.

Bourdais A, Bidard F, Zickler D, Berteaux-Lecellier V, Silar P, Espagne E.

PLoS One. 2012;7(4):e29820. doi: 10.1371/journal.pone.0029820. Epub 2012 Apr 27.


Immunoglobulin free light chain levels and recovery from myeloma kidney on treatment with chemotherapy and high cut-off haemodialysis.

Hutchison CA, Heyne N, Airia P, Schindler R, Zickler D, Cook M, Cockwell P, Grima D.

Nephrol Dial Transplant. 2012 Oct;27(10):3823-8. doi: 10.1093/ndt/gfr773. Epub 2012 Jan 23.


The importomer peroxins are differentially required for peroxisome assembly and meiotic development in Podospora anserina: insights into a new peroxisome import pathway.

Peraza-Reyes L, Arnaise S, Zickler D, Coppin E, Debuchy R, Berteaux-Lecellier V.

Mol Microbiol. 2011 Oct;82(2):365-77. doi: 10.1111/j.1365-2958.2011.07816.x. Epub 2011 Sep 12.


Sme4 coiled-coil protein mediates synaptonemal complex assembly, recombinosome relocalization, and spindle pole body morphogenesis.

Espagne E, Vasnier C, Storlazzi A, Kleckner NE, Silar P, Zickler D, Malagnac F.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10614-9. doi: 10.1073/pnas.1107272108. Epub 2011 Jun 10.


De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis.

Nowrousian M, Stajich JE, Chu M, Engh I, Espagne E, Halliday K, Kamerewerd J, Kempken F, Knab B, Kuo HC, Osiewacz HD, Pöggeler S, Read ND, Seiler S, Smith KM, Zickler D, Kück U, Freitag M.

PLoS Genet. 2010 Apr 8;6(4):e1000891. doi: 10.1371/journal.pgen.1000891.


Recombination proteins mediate meiotic spatial chromosome organization and pairing.

Storlazzi A, Gargano S, Ruprich-Robert G, Falque M, David M, Kleckner N, Zickler D.

Cell. 2010 Apr 2;141(1):94-106. doi: 10.1016/j.cell.2010.02.041.


Observing meiosis in filamentous fungi: Sordaria and Neurospora.

Zickler D.

Methods Mol Biol. 2009;558:91-114. doi: 10.1007/978-1-60761-103-5_7. Review.


Peroxisomal ABC transporters and beta-oxidation during the life cycle of the filamentous fungus Podospora anserina.

Boisnard S, Espagne E, Zickler D, Bourdais A, Riquet AL, Berteaux-Lecellier V.

Fungal Genet Biol. 2009 Jan;46(1):55-66. doi: 10.1016/j.fgb.2008.10.006. Epub 2008 Oct 22.


The peroxisome RING-finger complex is required for meiocyte formation in the fungus Podospora anserina.

Peraza-Reyes L, Zickler D, Berteaux-Lecellier V.

Traffic. 2008 Nov;9(11):1998-2009. doi: 10.1111/j.1600-0854.2008.00812.x. Epub 2008 Aug 9.


Coupling meiotic chromosome axis integrity to recombination.

Storlazzi A, Tesse S, Ruprich-Robert G, Gargano S, Pöggeler S, Kleckner N, Zickler D.

Genes Dev. 2008 Mar 15;22(6):796-809. doi: 10.1101/gad.459308.


Mutations in mating-type genes greatly decrease repeat-induced point mutation process in the fungus Podospora anserina.

Arnaise S, Zickler D, Bourdais A, Dequard-Chablat M, Debuchy R.

Fungal Genet Biol. 2008 Mar;45(3):207-20. Epub 2007 Oct 30.


The peroxisomal import proteins PEX2, PEX5 and PEX7 are differently involved in Podospora anserina sexual cycle.

Bonnet C, Espagne E, Zickler D, Boisnard S, Bourdais A, Berteaux-Lecellier V.

Mol Microbiol. 2006 Oct;62(1):157-69.


From early homologue recognition to synaptonemal complex formation.

Zickler D.

Chromosoma. 2006 Jun;115(3):158-74. Epub 2006 Mar 29. Review.


SAD-2 is required for meiotic silencing by unpaired DNA and perinuclear localization of SAD-1 RNA-directed RNA polymerase.

Shiu PK, Zickler D, Raju NB, Ruprich-Robert G, Metzenberg RL.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2243-8. Epub 2006 Feb 6.


A mechanical basis for chromosome function.

Kleckner N, Zickler D, Jones GH, Dekker J, Padmore R, Henle J, Hutchinson J.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12592-7. Epub 2004 Aug 6.


GermOnline, a cross-species community knowledgebase on germ cell differentiation.

Wiederkehr C, Basavaraj R, Sarrauste de Menthière C, Hermida L, Koch R, Schlecht U, Amon A, Brachat S, Breitenbach M, Briza P, Caburet S, Cherry M, Davis R, Deutschbauer A, Dickinson HG, Dumitrescu T, Fellous M, Goldman A, Grootegoed JA, Hawley R, Ishii R, Jégou B, Kaufman RJ, Klein F, Lamb N, Maro B, Nasmyth K, Nicolas A, Orr-Weaver T, Philippsen P, Pineau C, Rabitsch KP, Reinke V, Roest H, Saunders W, Schröder M, Schedl T, Siep M, Villeneuve A, Wolgemuth DJ, Yamamoto M, Zickler D, Esposito RE, Primig M.

Nucleic Acids Res. 2004 Jan 1;32(Database issue):D560-7.


GermOnline, a new cross-species community annotation database on germ-line development and gametogenesis.

Primig M, Wiederkehr C, Basavaraj R, Sarrauste de Menthière C, Hermida L, Koch R, Schlecht U, Dickinson HG, Fellous M, Grootegoed JA, Hawley RS, Jégou B, Maro B, Nicolas A, Orr-Weaver T, Schedl T, Villeneuve A, Wolgemuth DJ, Yamamoto M, Zickler D, Lamb N, Esposito RE.

Nat Genet. 2003 Dec;35(4):291-2. No abstract available.


Coordinate variation in meiotic pachytene SC length and total crossover/chiasma frequency under conditions of constant DNA length.

Kleckner N, Storlazzi A, Zickler D.

Trends Genet. 2003 Nov;19(11):623-8. No abstract available.


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