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Items: 1 to 50 of 56

1.

Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics.

Galemou Yoga E, Haapanen O, Wittig I, Siegmund K, Sharma V, Zickermann V.

Biochim Biophys Acta Bioenerg. 2019 Jul 1;1860(7):573-581. doi: 10.1016/j.bbabio.2019.06.006. Epub 2019 Jun 19.

2.

Noncovalent Functionalization of Carbon Substrates with Hydrogels Improves Structural Analysis of Vitrified Proteins by Electron Cryo-Microscopy.

Scherr J, Neuhaus A, Parey K, Klusch N, Murphy BJ, Zickermann V, Kühlbrandt W, Terfort A, Rhinow D.

ACS Nano. 2019 Jun 25;13(6):7185-7190. doi: 10.1021/acsnano.9b02651. Epub 2019 May 24.

PMID:
31117383
3.

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps.

Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, Zickermann V, Hunte C, Brandt U.

Nat Commun. 2018 Oct 29;9(1):4500. doi: 10.1038/s41467-018-06955-y.

4.

Cryo-EM structure of respiratory complex I at work.

Parey K, Brandt U, Xie H, Mills DJ, Siegmund K, Vonck J, Kühlbrandt W, Zickermann V.

Elife. 2018 Oct 2;7. pii: e39213. doi: 10.7554/eLife.39213.

5.

Acyl modification and binding of mitochondrial ACP to multiprotein complexes.

Angerer H, Schönborn S, Gorka J, Bahr U, Karas M, Wittig I, Heidler J, Hoffmann J, Morgner N, Zickermann V.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1913-1920. doi: 10.1016/j.bbamcr.2017.08.006. Epub 2017 Aug 9.

6.

Self-Perforated Hydrogel Nanomembranes Facilitate Structural Analysis of Proteins by Electron Cryo-Microscopy.

Scherr J, Parey K, Klusch N, Murphy BJ, Balser S, Neuhaus A, Zickermann V, Kühlbrandt W, Terfort A, Rhinow D.

ACS Nano. 2017 Jun 27;11(6):6467-6473. doi: 10.1021/acsnano.7b03099. Epub 2017 Jun 15.

PMID:
28598595
7.

Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I.

Krishnathas R, Bonke E, Dröse S, Zickermann V, Nasiri HR.

Medchemcomm. 2017 Feb 20;8(3):657-661. doi: 10.1039/c6md00655h. eCollection 2017 Mar 1.

8.

Accessory subunit NUYM (NDUFS4) is required for stability of the electron input module and activity of mitochondrial complex I.

Kahlhöfer F, Kmita K, Wittig I, Zwicker K, Zickermann V.

Biochim Biophys Acta Bioenerg. 2017 Feb;1858(2):175-181. doi: 10.1016/j.bbabio.2016.11.010. Epub 2016 Nov 19.

9.

Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism.

D'Imprima E, Mills DJ, Parey K, Brandt U, Kühlbrandt W, Zickermann V, Vonck J.

Biochim Biophys Acta. 2016 Dec;1857(12):1935-1942. doi: 10.1016/j.bbabio.2016.09.014. Epub 2016 Sep 30.

10.

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology.

Hahn A, Parey K, Bublitz M, Mills DJ, Zickermann V, Vonck J, Kühlbrandt W, Meier T.

Mol Cell. 2016 Aug 4;63(3):445-56. doi: 10.1016/j.molcel.2016.05.037. Epub 2016 Jun 30.

11.

Preface to complex I special issue.

Brandt UU, Zickermann V.

Biochim Biophys Acta. 2016 Jul;1857(7):861-2. doi: 10.1016/j.bbabio.2016.04.006. Epub 2016 Apr 21. No abstract available.

12.

Structure and function of mitochondrial complex I.

Wirth C, Brandt U, Hunte C, Zickermann V.

Biochim Biophys Acta. 2016 Jul;1857(7):902-14. doi: 10.1016/j.bbabio.2016.02.013. Epub 2016 Feb 24. Review.

13.

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.

Kmita K, Wirth C, Warnau J, Guerrero-Castillo S, Hunte C, Hummer G, Kaila VR, Zwicker K, Brandt U, Zickermann V.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5685-90. doi: 10.1073/pnas.1424353112. Epub 2015 Apr 20.

14.

Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I.

Zickermann V, Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C, Brandt U.

Science. 2015 Jan 2;347(6217):44-9. doi: 10.1126/science.1259859.

15.

The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity.

Angerer H, Radermacher M, Mańkowska M, Steger M, Zwicker K, Heide H, Wittig I, Brandt U, Zickermann V.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5207-12. doi: 10.1073/pnas.1322438111. Epub 2014 Mar 24.

16.

Accessory subunits of mitochondrial complex I.

Kmita K, Zickermann V.

Biochem Soc Trans. 2013 Oct;41(5):1272-9. doi: 10.1042/BST20130091. Review.

PMID:
24059519
17.

3D Reconstruction of a Subcomplex of NADH-ubiquinone-oxidoreductase (Complex I) from Yarrowia lipolytica.

Radermacher M, Ruiz T, Fowler DJ, Yu L, Dröse S, Krack S, Kerscher S, Zickermann V, Brandt U.

Microsc Microanal. 2011 Jul;17(S2):90-91. No abstract available.

18.

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.

Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Cámara Y, Milenkovic D, Zickermann V, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Brandt U, Stewart JB, Gustafsson CM, Larsson NG.

EMBO J. 2012 Jan 18;31(2):443-56. doi: 10.1038/emboj.2011.392. Epub 2011 Nov 1.

19.

Functional dissection of the proton pumping modules of mitochondrial complex I.

Dröse S, Krack S, Sokolova L, Zwicker K, Barth HD, Morgner N, Heide H, Steger M, Nübel E, Zickermann V, Kerscher S, Brutschy B, Radermacher M, Brandt U.

PLoS Biol. 2011 Aug;9(8):e1001128. doi: 10.1371/journal.pbio.1001128. Epub 2011 Aug 23.

20.

Macromolecular organization of ATP synthase and complex I in whole mitochondria.

Davies KM, Strauss M, Daum B, Kief JH, Osiewacz HD, Rycovska A, Zickermann V, Kühlbrandt W.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14121-6. doi: 10.1073/pnas.1103621108. Epub 2011 Aug 11.

21.

A scaffold of accessory subunits links the peripheral arm and the distal proton-pumping module of mitochondrial complex I.

Angerer H, Zwicker K, Wumaier Z, Sokolova L, Heide H, Steger M, Kaiser S, Nübel E, Brutschy B, Radermacher M, Brandt U, Zickermann V.

Biochem J. 2011 Jul 15;437(2):279-88. doi: 10.1042/BJ20110359.

22.

A high-definition native polyacrylamide gel electrophoresis system for the analysis of membrane complexes.

Ladig R, Sommer MS, Hahn A, Leisegang MS, Papasotiriou DG, Ibrahim M, Elkehal R, Karas M, Zickermann V, Gutensohn M, Brandt U, Klösgen RB, Schleiff E.

Plant J. 2011 Jul;67(1):181-94. doi: 10.1111/j.1365-313X.2011.04577.x. Epub 2011 Apr 28.

23.

Functional modules and structural basis of conformational coupling in mitochondrial complex I.

Hunte C, Zickermann V, Brandt U.

Science. 2010 Jul 23;329(5990):448-51. doi: 10.1126/science.1191046. Epub 2010 Jul 1.

24.

Quinone binding and reduction by respiratory complex I.

Tocilescu MA, Zickermann V, Zwicker K, Brandt U.

Biochim Biophys Acta. 2010 Dec;1797(12):1883-90. doi: 10.1016/j.bbabio.2010.05.009. Epub 2010 May 20. Review.

25.

Small single transmembrane domain (STMD) proteins organize the hydrophobic subunits of large membrane protein complexes.

Zickermann V, Angerer H, Ding MG, Nübel E, Brandt U.

FEBS Lett. 2010 Jun 18;584(12):2516-25. doi: 10.1016/j.febslet.2010.04.021. Epub 2010 Apr 14. Review.

26.

Native immunoblotting of blue native gels to identify conformation-specific antibodies.

Zickermann V, Wumaier Z, Wrzesniewska B, Hunte C, Schägger H.

Proteomics. 2010 Jan;10(1):159-63. doi: 10.1002/pmic.200900468.

PMID:
19882660
27.

The structure of eukaryotic and prokaryotic complex I.

Clason T, Ruiz T, Schägger H, Peng G, Zickermann V, Brandt U, Michel H, Radermacher M.

J Struct Biol. 2010 Jan;169(1):81-8. doi: 10.1016/j.jsb.2009.08.017. Epub 2009 Sep 2.

28.

Architecture of complex I and its implications for electron transfer and proton pumping.

Zickermann V, Kerscher S, Zwicker K, Tocilescu MA, Radermacher M, Brandt U.

Biochim Biophys Acta. 2009 Jun;1787(6):574-83. doi: 10.1016/j.bbabio.2009.01.012. Epub 2009 Feb 7. Review.

29.

Challenges in elucidating structure and mechanism of proton pumping NADH:ubiquinone oxidoreductase (complex I).

Zickermann V, Dröse S, Tocilescu MA, Zwicker K, Kerscher S, Brandt U.

J Bioenerg Biomembr. 2008 Oct;40(5):475-83. doi: 10.1007/s10863-008-9171-9. Epub 2008 Nov 4. Review.

PMID:
18982432
30.

Subunit mass fingerprinting of mitochondrial complex I.

Morgner N, Zickermann V, Kerscher S, Wittig I, Abdrakhmanova A, Barth HD, Brutschy B, Brandt U.

Biochim Biophys Acta. 2008 Oct;1777(10):1384-91. doi: 10.1016/j.bbabio.2008.08.001. Epub 2008 Aug 15.

31.

Direct localization of the 51 and 24 kDa subunits of mitochondrial complex I by three-dimensional difference imaging.

Clason T, Zickermann V, Ruiz T, Brandt U, Radermacher M.

J Struct Biol. 2007 Sep;159(3):433-42. Epub 2007 May 17. Erratum in: J Struct Biol. 2008 Apr;162(1):193-5.

32.

The three families of respiratory NADH dehydrogenases.

Kerscher S, Dröse S, Zickermann V, Brandt U.

Results Probl Cell Differ. 2008;45:185-222. Review.

PMID:
17514372
33.

Characterization of a subcomplex of mitochondrial NADH:ubiquinone oxidoreductase (complex I) lacking the flavoprotein part of the N-module.

Zickermann V, Zwicker K, Tocilescu MA, Kerscher S, Brandt U.

Biochim Biophys Acta. 2007 May;1767(5):393-400. Epub 2007 Mar 15.

34.

Tight binding of NADPH to the 39-kDa subunit of complex I is not required for catalytic activity but stabilizes the multiprotein complex.

Abdrakhmanova A, Zwicker K, Kerscher S, Zickermann V, Brandt U.

Biochim Biophys Acta. 2006 Dec;1757(12):1676-82. Epub 2006 Sep 19.

35.

ATR-FTIR redox difference spectroscopy of Yarrowia lipolytica and bovine complex I.

Marshall D, Fisher N, Grigic L, Zickermann V, Brandt U, Shannon RJ, Hirst J, Lawrence R, Rich PR.

Biochemistry. 2006 May 2;45(17):5458-67.

PMID:
16634627
36.

The three-dimensional structure of complex I from Yarrowia lipolytica: a highly dynamic enzyme.

Radermacher M, Ruiz T, Clason T, Benjamin S, Brandt U, Zickermann V.

J Struct Biol. 2006 Jun;154(3):269-79. Epub 2006 Mar 24.

37.

Cluster N1 of complex I from Yarrowia lipolytica studied by pulsed EPR spectroscopy.

Maly T, Grgic L, Zwicker K, Zickermann V, Brandt U, Prisner T.

J Biol Inorg Chem. 2006 Apr;11(3):343-50. Epub 2006 Feb 26.

PMID:
16502321
38.

Structure-function relationships in mitochondrial complex I of the strictly aerobic yeast Yarrowia lipolytica.

Brandt U, Abdrakhmanova A, Zickermann V, Galkin A, Dröse S, Zwicker K, Kerscher S.

Biochem Soc Trans. 2005 Aug;33(Pt 4):840-4.

PMID:
16042611
39.

Histidine 129 in the 75-kDa subunit of mitochondrial complex I from Yarrowia lipolytica is not a ligand for [Fe4S4] cluster N5 but is required for catalytic activity.

Waletko A, Zwicker K, Abdrakhmanova A, Zickermann V, Brandt U, Kerscher S.

J Biol Chem. 2005 Feb 18;280(7):5622-5. Epub 2004 Nov 30.

40.

Subunit composition of mitochondrial complex I from the yeast Yarrowia lipolytica.

Abdrakhmanova A, Zickermann V, Bostina M, Radermacher M, Schägger H, Kerscher S, Brandt U.

Biochim Biophys Acta. 2004 Jul 23;1658(1-2):148-56.

41.

Proton pumping by NADH:ubiquinone oxidoreductase. A redox driven conformational change mechanism?

Brandt U, Kerscher S, Dröse S, Zwicker K, Zickermann V.

FEBS Lett. 2003 Jun 12;545(1):9-17. Review.

42.

Functional implications from an unexpected position of the 49-kDa subunit of NADH:ubiquinone oxidoreductase.

Zickermann V, Bostina M, Hunte C, Ruiz T, Radermacher M, Brandt U.

J Biol Chem. 2003 Aug 1;278(31):29072-8. Epub 2003 May 16.

43.

Isolation, characterization and electron microscopic single particle analysis of the NADH:ubiquinone oxidoreductase (complex I) from the hyperthermophilic eubacterium Aquifex aeolicus.

Peng G, Fritzsch G, Zickermann V, Schägger H, Mentele R, Lottspeich F, Bostina M, Radermacher M, Huber R, Stetter KO, Michel H.

Biochemistry. 2003 Mar 18;42(10):3032-9.

PMID:
12627969
44.

Yarrowia lipolytica, a yeast genetic system to study mitochondrial complex I.

Kerscher S, Dröse S, Zwicker K, Zickermann V, Brandt U.

Biochim Biophys Acta. 2002 Sep 10;1555(1-3):83-91. Review.

45.

Exploring the catalytic core of complex I by Yarrowia lipolytica yeast genetics.

Kerscher S, Kashani-Poor N, Zwicker K, Zickermann V, Brandt U.

J Bioenerg Biomembr. 2001 Jun;33(3):187-96. Review.

PMID:
11695828
46.
47.
48.

Binding of detergents and inhibitors to bovine complex I - a novel purification procedure for bovine complex I retaining full inhibitor sensitivity.

Okun JG, Zickermann V, Zwicker K, Schägger H, Brandt U.

Biochim Biophys Acta. 2000 Jul 20;1459(1):77-87.

49.

The NADH oxidation domain of complex I: do bacterial and mitochondrial enzymes catalyze ferricyanide reduction similarly?

Zickermann V, Kurki S, Kervinen M, Hassinen I, Finel M.

Biochim Biophys Acta. 2000 Jul 20;1459(1):61-8.

50.

Properties of the common inhibitor-binding domain in mitochondrial NADH-dehydrogenase (complex I).

Okun JG, Zickermann V, Brandt U.

Biochem Soc Trans. 1999 Aug;27(4):596-601. Review. No abstract available.

PMID:
10917649

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