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Items: 1 to 50 of 187


Evidence of β-blockers drug repurposing for the treatment of triple negative breast cancer: A systematic review.

Spini A, Roberto G, Gini R, Bartolini C, Bazzani L, Donnini S, Crispino S, Ziche M.

Neoplasma. 2019 Nov;66(6):963-970. doi: 10.4149/neo_2019_190110N34. Epub 2019 Oct 8.


mPGES-1 as a new target to overcome acquired resistance to gefitinib in non-small cell lung cancer cell lines.

Terzuoli E, Costanza F, Ciccone V, Ziche M, Morbidelli L, Donnini S.

Prostaglandins Other Lipid Mediat. 2019 Aug;143:106344. doi: 10.1016/j.prostaglandins.2019.106344. Epub 2019 Jun 15.


Targeting endothelial-to-mesenchymal transition: the protective role of hydroxytyrosol sulfate metabolite.

Terzuoli E, Nannelli G, Giachetti A, Morbidelli L, Ziche M, Donnini S.

Eur J Nutr. 2019 Feb 6. doi: 10.1007/s00394-019-01920-x. [Epub ahead of print]


Correction to: Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells.

Ciccone V, Terzuoli E, Donnini S, Giachetti A, Morbidelli L, Ziche M.

J Exp Clin Cancer Res. 2019 Feb 1;38(1):45. doi: 10.1186/s13046-019-1045-y.


Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells.

Ciccone V, Terzuoli E, Donnini S, Giachetti A, Morbidelli L, Ziche M.

J Exp Clin Cancer Res. 2018 Dec 12;37(1):311. doi: 10.1186/s13046-018-0975-0. Erratum in: J Exp Clin Cancer Res. 2019 Feb 1;38(1):45.


ALDH2 Activity Reduces Mitochondrial Oxygen Reserve Capacity in Endothelial Cells and Induces Senescence Properties.

Nannelli G, Terzuoli E, Giorgio V, Donnini S, Lupetti P, Giachetti A, Bernardi P, Ziche M.

Oxid Med Cell Longev. 2018 Nov 14;2018:9765027. doi: 10.1155/2018/9765027. eCollection 2018.


Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1.

Terzuoli E, Corti F, Nannelli G, Giachetti A, Donnini S, Ziche M.

Int J Mol Sci. 2018 Sep 6;19(9). pii: E2638. doi: 10.3390/ijms19092638.


PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells.

Bazzani L, Donnini S, Giachetti A, Christofori G, Ziche M.

Oncotarget. 2018 Feb 15;9(19):14939-14958. doi: 10.18632/oncotarget.24499. eCollection 2018 Mar 13.


Involvement of Bradykinin B2 Receptor in Pathological Vascularization in Oxygen-Induced Retinopathy in Mice and Rabbit Cornea.

Terzuoli E, Morbidelli L, Nannelli G, Giachetti A, Donnini S, Ziche M.

Int J Mol Sci. 2018 Jan 23;19(2). pii: E330. doi: 10.3390/ijms19020330.


Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells.

Terzuoli E, Nannelli G, Frosini M, Giachetti A, Ziche M, Donnini S.

Oncotarget. 2017 Aug 24;8(47):83207-83224. doi: 10.18632/oncotarget.20544. eCollection 2017 Oct 10.


PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells.

Bazzani L, Donnini S, Finetti F, Christofori G, Ziche M.

Oncotarget. 2017 May 9;8(19):31270-31287. doi: 10.18632/oncotarget.16116.


Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells.

Terzuoli E, Finetti F, Costanza F, Giachetti A, Ziche M, Donnini S.

Nitric Oxide. 2017 Jun 1;66:17-29. doi: 10.1016/j.niox.2017.02.010. Epub 2017 Mar 1.


Formulation of liposomes functionalized with Lotus lectin and effective in targeting highly proliferative cells.

Della Giovampaola C, Capone A, Ermini L, Lupetti P, Vannuccini E, Finetti F, Donnini S, Ziche M, Magnani A, Leone G, Rossi C, Rosati F, Bonechi C.

Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):860-870. doi: 10.1016/j.bbagen.2017.01.015. Epub 2017 Jan 15.


Monitoring Endothelial and Tissue Responses to Cobalt Ferrite Nanoparticles and Hybrid Hydrogels.

Finetti F, Terzuoli E, Donnini S, Uva M, Ziche M, Morbidelli L.

PLoS One. 2016 Dec 30;11(12):e0168727. doi: 10.1371/journal.pone.0168727. eCollection 2016.


VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis.

Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, Bleck C, Mercer J, Christoforidis S.

J Cell Sci. 2016 Nov 1;129(21):4091-4104. Epub 2016 Sep 21.


H2S dependent and independent anti-inflammatory activity of zofenoprilat in cells of the vascular wall.

Monti M, Terzuoli E, Ziche M, Morbidelli L.

Pharmacol Res. 2016 Nov;113(Pt A):426-437. doi: 10.1016/j.phrs.2016.09.017. Epub 2016 Sep 17.


Miniaturizing VEGF: Peptides mimicking the discontinuous VEGF receptor-binding site modulate the angiogenic response.

De Rosa L, Finetti F, Diana D, Di Stasi R, Auriemma S, Romanelli A, Fattorusso R, Ziche M, Morbidelli L, D'Andrea LD.

Sci Rep. 2016 Aug 8;6:31295. doi: 10.1038/srep31295.


Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer.

Terzuoli E, Donnini S, Finetti F, Nesi G, Villari D, Hanaka H, Radmark O, Giachetti A, Ziche M.

Oncotarget. 2016 Jul 12;7(28):44350-44364. doi: 10.18632/oncotarget.10051.


Studying Vascular Angiogenesis and Senescence in Zebrafish Embryos.

Ristori E, Donnini S, Ziche M.

Methods Mol Biol. 2016;1430:387-400. doi: 10.1007/978-1-4939-3628-1_27.


The Rabbit Corneal Pocket Assay.

Morbidelli L, Ziche M.

Methods Mol Biol. 2016;1430:299-310. doi: 10.1007/978-1-4939-3628-1_20.


Nitric Oxide and PGE-2 Cross-Talk in EGFR-Driven Epithelial Tumor Cells.

Donnini S, Bazzani L, Ziche M, Terzuoli E.

Crit Rev Oncog. 2016;21(5-6):325-331. doi: 10.1615/CritRevOncog.2017021204.


Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation.

Terzuoli E, Giachetti A, Ziche M, Donnini S.

Mol Nutr Food Res. 2016 Mar;60(3):519-29. doi: 10.1002/mnfr.201500498. Epub 2015 Dec 17.


mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.

Finetti F, Terzuoli E, Giachetti A, Santi R, Villari D, Hanaka H, Radmark O, Ziche M, Donnini S.

Endocr Relat Cancer. 2015 Aug;22(4):665-78. doi: 10.1530/ERC-15-0277. Epub 2015 Jun 25.


Prostaglandin E2 transactivates the colony-stimulating factor-1 receptor and synergizes with colony-stimulating factor-1 in the induction of macrophage migration via the mitogen-activated protein kinase ERK1/2.

Digiacomo G, Ziche M, Dello Sbarba P, Donnini S, Rovida E.

FASEB J. 2015 Jun;29(6):2545-54. doi: 10.1096/fj.14-258939. Epub 2015 Mar 10.


Characterization of zofenoprilat as an inducer of functional angiogenesis through increased H2 S availability.

Terzuoli E, Monti M, Vellecco V, Bucci M, Cirino G, Ziche M, Morbidelli L.

Br J Pharmacol. 2015 Jun;172(12):2961-73. doi: 10.1111/bph.13101. Epub 2015 Mar 27.


The corneal pocket assay.

Ziche M, Morbidelli L.

Methods Mol Biol. 2015;1214:15-28. doi: 10.1007/978-1-4939-1462-3_2.


Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation.

Terzuoli E, Meini S, Cucchi P, Catalani C, Cialdai C, Maggi CA, Giachetti A, Ziche M, Donnini S.

PLoS One. 2014 Jan 2;9(1):e84358. doi: 10.1371/journal.pone.0084358. eCollection 2014.


The sulphydryl containing ACE inhibitor Zofenoprilat protects coronary endothelium from Doxorubicin-induced apoptosis.

Monti M, Terzuoli E, Ziche M, Morbidelli L.

Pharmacol Res. 2013 Oct;76:171-81. doi: 10.1016/j.phrs.2013.08.003. Epub 2013 Aug 18.


PKCε activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting.

Monti M, Donnini S, Morbidelli L, Giachetti A, Mochly-Rosen D, Mignatti P, Ziche M.

J Mol Cell Cardiol. 2013 Oct;63:107-17. doi: 10.1016/j.yjmcc.2013.07.006. Epub 2013 Jul 20.


The syndecan-4/protein kinase Cα pathway mediates prostaglandin E2-induced extracellular regulated kinase (ERK) activation in endothelial cells and angiogenesis in vivo.

Corti F, Finetti F, Ziche M, Simons M.

J Biol Chem. 2013 May 3;288(18):12712-21. doi: 10.1074/jbc.M113.452383. Epub 2013 Mar 22.


Hydrogen peroxide mediates endothelium-dependent dilation of coronary arterioles in obese rats on a low-carbohydrate diet.

Focardi M, Picchi A, Donnini S, Cameli M, Ziche M, Marzilli M, Mondillo S.

Microcirculation. 2013 Oct;20(7):599-608. doi: 10.1111/micc.12058.


Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis.

Solito R, Corti F, Chen CH, Mochly-Rosen D, Giachetti A, Ziche M, Donnini S.

J Cell Sci. 2013 May 1;126(Pt 9):1952-61. doi: 10.1242/jcs.117184. Epub 2013 Feb 27.


Assessing vascular senescence in zebrafish.

Donnini S, Giachetti A, Ziche M.

Methods Mol Biol. 2013;965:517-31. doi: 10.1007/978-1-62703-239-1_34.


Pharmacological inhibition of microsomal prostaglandin E synthase-1 suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesis.

Finetti F, Terzuoli E, Bocci E, Coletta I, Polenzani L, Mangano G, Alisi MA, Cazzolla N, Giachetti A, Ziche M, Donnini S.

PLoS One. 2012;7(7):e40576. doi: 10.1371/journal.pone.0040576. Epub 2012 Jul 18.


The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth.

Bellou S, Karali E, Bagli E, Al-Maharik N, Morbidelli L, Ziche M, Adlercreutz H, Murphy C, Fotsis T.

Mol Cancer. 2012 May 14;11:35. doi: 10.1186/1476-4598-11-35.


Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis.

Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD.

Biochem Pharmacol. 2012 Aug 1;84(3):303-11. doi: 10.1016/j.bcp.2012.04.011. Epub 2012 Apr 21.


EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity.

Donnini S, Finetti F, Terzuoli E, Giachetti A, Iñiguez MA, Hanaka H, Fresno M, Rådmark O, Ziche M.

Oncogene. 2012 Jul 19;31(29):3457-66. doi: 10.1038/onc.2011.503. Epub 2011 Nov 14.


A novel protein from the serum of Python sebae, structurally homologous with type-γ phospholipase A(2) inhibitor, displays antitumour activity.

Donnini S, Finetti F, Francese S, Boscaro F, Dani FR, Maset F, Frasson R, Palmieri M, Pazzagli M, De Filippis V, Garaci E, Ziche M.

Biochem J. 2011 Dec 1;440(2):251-62. doi: 10.1042/BJ20100739.


Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesis.

Pisanti S, Picardi P, Prota L, Proto MC, Laezza C, McGuire PG, Morbidelli L, Gazzerro P, Ziche M, Das A, Bifulco M.

Blood. 2011 May 19;117(20):5541-50. doi: 10.1182/blood-2010-09-307355. Epub 2011 Apr 1.


Non-peptide NK1 receptor ligands based on the 4-phenylpyridine moiety.

Giuliani G, Cappelli A, Matarrese M, Masiello V, Turolla EA, Monterisi C, Fazio F, Anzini M, Pericot Mohr G, Riitano D, Finetti F, Morbidelli L, Ziche M, Giorgi G, Vomero S.

Bioorg Med Chem. 2011 Apr 1;19(7):2242-51. doi: 10.1016/j.bmc.2011.02.031. Epub 2011 Feb 24.


The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo.

Yeh JC, Cindrova-Davies T, Belleri M, Morbidelli L, Miller N, Cho CW, Chan K, Wang YT, Luo GA, Ziche M, Presta M, Charnock-Jones DS, Fan TP.

Angiogenesis. 2011 May;14(2):187-97. doi: 10.1007/s10456-011-9202-8. Epub 2011 Feb 15.


Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion.

Terzuoli E, Puppo M, Rapisarda A, Uranchimeg B, Cao L, Burger AM, Ziche M, Melillo G.

Cancer Res. 2010 Sep 1;70(17):6837-48. doi: 10.1158/0008-5472.CAN-10-1075. Epub 2010 Aug 24.


Inhibition of hypoxia inducible factor-1alpha by dihydroxyphenylethanol, a product from olive oil, blocks microsomal prostaglandin-E synthase-1/vascular endothelial growth factor expression and reduces tumor angiogenesis.

Terzuoli E, Donnini S, Giachetti A, Iñiguez MA, Fresno M, Melillo G, Ziche M.

Clin Cancer Res. 2010 Aug 15;16(16):4207-16. doi: 10.1158/1078-0432.CCR-10-0156. Epub 2010 Aug 3.


RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation.

Palumberi D, Aldi S, Ermini L, Ziche M, Finetti F, Donnini S, Rosati F.

J Cell Biochem. 2010 Sep 1;111(1):229-38. doi: 10.1002/jcb.22692.


Vimentin expression influences flow dependent VASP phosphorylation and regulates cell migration and proliferation.

Lund N, Henrion D, Tiede P, Ziche M, Schunkert H, Ito WD.

Biochem Biophys Res Commun. 2010 May 7;395(3):401-6. doi: 10.1016/j.bbrc.2010.04.033. Epub 2010 Apr 9.


Abeta peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis.

Donnini S, Solito R, Cetti E, Corti F, Giachetti A, Carra S, Beltrame M, Cotelli F, Ziche M.

FASEB J. 2010 Jul;24(7):2385-95. doi: 10.1096/fj.09-146456. Epub 2010 Mar 5.


Molecular regulation of tumour angiogenesis by nitric oxide.

Ziche M, Morbidelli L.

Eur Cytokine Netw. 2009 Dec;20(4):164-70. doi: 10.1684/ecn.2009.0169. Review.


The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.

Morbidelli L, Pyriochou A, Filippi S, Vasileiadis I, Roussos C, Zhou Z, Loutrari H, Waltenberger J, Stössel A, Giannis A, Ziche M, Papapetropoulos A.

Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R824-32. doi: 10.1152/ajpregu.00222.2009. Epub 2009 Dec 23.


Sulfhydryl angiotensin-converting enzyme inhibitor promotes endothelial cell survival through nitric-oxide synthase, fibroblast growth factor-2, and telomerase cross-talk.

Donnini S, Terzuoli E, Ziche M, Morbidelli L.

J Pharmacol Exp Ther. 2010 Mar;332(3):776-84. doi: 10.1124/jpet.109.159178. Epub 2009 Dec 3.


deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification.

Monti M, Donnini S, Giachetti A, Mochly-Rosen D, Ziche M.

J Mol Cell Cardiol. 2010 Apr;48(4):746-56. doi: 10.1016/j.yjmcc.2009.11.002. Epub 2009 Nov 11.

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