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Items: 31


Clinically-approved CFTR modulators rescue Nrf2 dysfunction in cystic fibrosis airway epithelia.

Borcherding DC, Siefert ME, Lin S, Brewington J, Sadek H, Clancy JP, Plafker SM, Ziady AG.

J Clin Invest. 2019 May 30;129(8):3448-3463. doi: 10.1172/JCI96273.


Simvastatin inhibits protein isoprenylation in the brain.

Ostrowski SM, Johnson K, Siefert M, Shank S, Sironi L, Wolozin B, Landreth GE, Ziady AG.

Neuroscience. 2016 Aug 4;329:264-74. doi: 10.1016/j.neuroscience.2016.04.053. Epub 2016 May 12.


CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells.

Chirkova T, Lin S, Oomens AG, Gaston KA, Boyoglu-Barnum S, Meng J, Stobart CC, Cotton CU, Hartert TV, Moore ML, Ziady AG, Anderson LJ.

J Gen Virol. 2015 Sep;96(9):2543-56. doi: 10.1099/vir.0.000218. Epub 2015 Jun 25.


Capturing the Direct Binding of CFTR Correctors to CFTR by Using Click Chemistry.

Sinha C, Zhang W, Moon CS, Actis M, Yarlagadda S, Arora K, Woodroofe K, Clancy JP, Lin S, Ziady AG, Frizzell R, Fujii N, Naren AP.

Chembiochem. 2015 Sep 21;16(14):2017-22. doi: 10.1002/cbic.201500123. Epub 2015 Aug 11.


PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration.

Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Woodrooffe K, Lin S, Schuetz JD, Ziady AG, Naren AP.

Cell Signal. 2015 Jul;27(7):1345-55. doi: 10.1016/j.cellsig.2015.03.022. Epub 2015 Apr 2.


Redox balance in cystic fibrosis.

Ziady AG, Hansen J.

Int J Biochem Cell Biol. 2014 Jul;52:113-23. doi: 10.1016/j.biocel.2014.03.006. Epub 2014 Mar 20. Review.


Interaction with CREB binding protein modulates the activities of Nrf2 and NF-κB in cystic fibrosis airway epithelial cells.

Ziady AG, Sokolow A, Shank S, Corey D, Myers R, Plafker S, Kelley TJ.

Am J Physiol Lung Cell Mol Physiol. 2012 Jun 1;302(11):L1221-31. doi: 10.1152/ajplung.00156.2011. Epub 2012 Mar 30.


Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5.

Li Q, Ding X, Thomas JJ, Harding CV, Pecora ND, Ziady AG, Shank S, Boom WH, Lancioni CL, Rojas RE.

J Leukoc Biol. 2012 Feb;91(2):311-20. doi: 10.1189/jlb.0711364. Epub 2011 Dec 7.


Genetic variation and clinical heterogeneity in cystic fibrosis.

Drumm ML, Ziady AG, Davis PB.

Annu Rev Pathol. 2012;7:267-82. doi: 10.1146/annurev-pathol-011811-120900. Epub 2011 Oct 17. Review.


Methods for evaluating inflammation in cystic fibrosis.

Ziady AG, Davis PB.

Methods Mol Biol. 2011;742:51-76. doi: 10.1007/978-1-61779-120-8_4.


DNA nanoparticles: detection of long-term transgene activity in brain using bioluminescence imaging.

Yurek DM, Fletcher AM, McShane M, Kowalczyk TH, Padegimas L, Weatherspoon MR, Kaytor MD, Cooper MJ, Ziady AG.

Mol Imaging. 2011 Oct;10(5):327-39. doi: 10.2310/7290.2010.00053. Epub 2011 Apr 27.


Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.

Lancioni CL, Li Q, Thomas JJ, Ding X, Thiel B, Drage MG, Pecora ND, Ziady AG, Shank S, Harding CV, Boom WH, Rojas RE.

Infect Immun. 2011 Feb;79(2):663-73. doi: 10.1128/IAI.00806-10. Epub 2010 Nov 15.


Nucleolin-mediated cellular trafficking of DNA nanoparticle is lipid raft and microtubule dependent and can be modulated by glucocorticoid.

Chen X, Shank S, Davis PB, Ziady AG.

Mol Ther. 2011 Jan;19(1):93-102. doi: 10.1038/mt.2010.214. Epub 2010 Oct 19.


Bioluminescent imaging of reporter gene expression in the lungs of wildtype and model mice following the administration of PEG-stabilized DNA nanoparticles.

Ziady AG, Kotlarchyk M, Bryant L, McShane M, Lee Z.

Microsc Res Tech. 2010 Sep;73(9):918-28. doi: 10.1002/jemt.20855.


The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease.

Nichols DP, Ziady AG, Shank SL, Eastman JF, Davis PB.

Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L828-36. doi: 10.1152/ajplung.00171.2009. Epub 2009 Aug 21.


Real-time imaging of gene delivery and expression with DNA nanoparticle technologies.

Sun W, Ziady AG.

Methods Mol Biol. 2009;544:525-46. doi: 10.1007/978-1-59745-483-4_33.


Protein sequencing with tandem mass spectrometry.

Ziady AG, Kinter M.

Methods Mol Biol. 2009;544:325-41. doi: 10.1007/978-1-59745-483-4_21.


Long-term transgene expression in the central nervous system using DNA nanoparticles.

Yurek DM, Fletcher AM, Smith GM, Seroogy KB, Ziady AG, Molter J, Kowalczyk TH, Padegimas L, Cooper MJ.

Mol Ther. 2009 Apr;17(4):641-50. doi: 10.1038/mt.2009.2. Epub 2009 Feb 17.


Dysfunction of Nrf-2 in CF epithelia leads to excess intracellular H2O2 and inflammatory cytokine production.

Chen J, Kinter M, Shank S, Cotton C, Kelley TJ, Ziady AG.

PLoS One. 2008;3(10):e3367. doi: 10.1371/journal.pone.0003367. Epub 2008 Oct 10.


Current prospects for gene therapy of cystic fibrosis.

Ziady AG, Davis PB.

Curr Opin Pharmacol. 2006 Oct;6(5):515-21. Epub 2006 Aug 4. Review.


Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum.

Yike I, Distler AM, Ziady AG, Dearborn DG.

Environ Health Perspect. 2006 Aug;114(8):1221-6.


Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution.

Konstan MW, Davis PB, Wagener JS, Hilliard KA, Stern RC, Milgram LJ, Kowalczyk TH, Hyatt SL, Fink TL, Gedeon CR, Oette SM, Payne JM, Muhammad O, Ziady AG, Moen RC, Cooper MJ.

Hum Gene Ther. 2004 Dec;15(12):1255-69.


Defining strategies to extend duration of gene expression from targeted compacted DNA vectors.

Ziady AG, Kim J, Colla J, Davis PB.

Gene Ther. 2004 Sep;11(18):1378-90.


Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung.

Ziady AG, Gedeon CR, Muhammad O, Stillwell V, Oette SM, Fink TL, Quan W, Kowalczyk TH, Hyatt SL, Payne J, Peischl A, Seng JE, Moen RC, Cooper MJ, Davis PB.

Mol Ther. 2003 Dec;8(6):948-56.


Transfection of airway epithelium by stable PEGylated poly-L-lysine DNA nanoparticles in vivo.

Ziady AG, Gedeon CR, Miller T, Quan W, Payne JM, Hyatt SL, Fink TL, Muhammad O, Oette S, Kowalczyk T, Pasumarthy MK, Moen RC, Cooper MJ, Davis PB.

Mol Ther. 2003 Dec;8(6):936-47.


Non-viral gene transfer therapy for cystic fibrosis.

Ziady AG, Davis PB, Konstan MW.

Expert Opin Biol Ther. 2003 Jun;3(3):449-58. Review.


Receptor-directed molecular conjugates for gene transfer.

Ziady AG, Davis PB.

Methods Mol Med. 2002;69:25-48. Review. No abstract available.


Ligand substitution of receptor targeted DNA complexes affects gene transfer into hepatoma cells.

Ziady AG, Ferkol T, Gerken T, Dawson DV, Perlmutter DH, Davis PB.

Gene Ther. 1998 Dec;5(12):1685-97. Erratum in: Gene Ther 1999 Jul;6(7):1346.


Gene transfer into hepatoma cell lines via the serpin enzyme complex receptor.

Ziady AG, Perales JC, Ferkol T, Gerken T, Beegen H, Perlmutter DH, Davis PB.

Am J Physiol. 1997 Aug;273(2 Pt 1):G545-52.

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