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[Diagnostic value of antibody detection in invasive candidiasis].

Yang LM, Zhou QT, He B.

Zhonghua Jie He He Hu Xi Za Zhi. 2019 Nov 12;42(11):868-872. doi: 10.3760/cma.j.issn.1001-0939.2019.11.018. Chinese.


Physicochemical and Pharmacokinetic Evaluation of Spray-Dried Coformulation of Salvia miltiorrhiza Polyphenolic Acid and L-Leucine with Improved Bioavailability.

Lu P, Xing Y, Peng H, Liu Z, Zhou QT, Xue Z, Ma Z, Kebebe D, Zhang B, Liu H.

J Aerosol Med Pulm Drug Deliv. 2019 Oct 29. doi: 10.1089/jamp.2019.1538. [Epub ahead of print]


Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Pseudomonas aeruginosa.

Lin YW, Han ML, Zhao J, Zhu Y, Rao G, Forrest A, Song J, Kaye KS, Hertzog P, Purcell A, Creek D, Zhou QT, Velkov T, Li J.

Front Pharmacol. 2019 Oct 3;10:1146. doi: 10.3389/fphar.2019.01146. eCollection 2019.


Metabolomics study of the synergistic killing of polymyxin B in combination with amikacin against polymyxin-susceptible and -resistant Pseudomonas aeruginosa.

Hussein M, Han ML, Zhu Y, Zhou QT, Lin YW, Hancock REW, Hoyer D, Creek DJ, Li J, Velkov T.

Antimicrob Agents Chemother. 2019 Oct 14. pii: AAC.01587-19. doi: 10.1128/AAC.01587-19. [Epub ahead of print]


Evaluation of co-delivery of colistin and ciprofloxacin in liposomes using an in vitro human lung epithelial cell model.

Chai G, Park H, Yu S, Zhou F, Li J, Xu Q, Zhou QT.

Int J Pharm. 2019 Oct 5;569:118616. doi: 10.1016/j.ijpharm.2019.118616. Epub 2019 Aug 12.


Correlations between surface composition and aerosolization of jet-milled dry powder inhaler formulations with pharmaceutical lubricants.

Mangal S, Park H, Nour R, Shetty N, Cavallaro A, Zemlyanov D, Thalberg K, Puri V, Nicholas M, Narang AS, Zhou QT.

Int J Pharm. 2019 Sep 10;568:118504. doi: 10.1016/j.ijpharm.2019.118504. Epub 2019 Jul 9.


Effects of drying method and excipient on structure and stability of protein solids using solid-state hydrogen/deuterium exchange mass spectrometry (ssHDX-MS).

Wilson NE, Topp EM, Zhou QT.

Int J Pharm. 2019 Aug 15;567:118470. doi: 10.1016/j.ijpharm.2019.118470. Epub 2019 Jun 25.


Simultaneous Particle Size Reduction and Homogeneous Mixing to Produce Combinational Powder Formulations for Inhalation by the Single-Step Co-Jet Milling.

Ling J, Mangal S, Park H, Wang S, Cavallaro A, Zhou QT.

J Pharm Sci. 2019 Sep;108(9):3146-3151. doi: 10.1016/j.xphs.2019.05.011. Epub 2019 May 18.


Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution.

Lu P, Xing Y, Xue Z, Ma Z, Zhang B, Peng H, Zhou QT, Liu H, Liu Z, Li J.

Biomed Chromatogr. 2019 Aug;33(8):e4561. doi: 10.1002/bmc.4561. Epub 2019 May 10.


Pharmacokinetic-pharmacodynamic analysis of ciprofloxacin in elderly Chinese patients with lower respiratory tract infections caused by Gram-negative bacteria.

Gai XY, Bo SN, Shen N, Zhou QT, Yin AY, Lu W.

Chin Med J (Engl). 2019 Mar 20;132(6):638-646. doi: 10.1097/CM9.0000000000000136.


Effects of the antibiotic component on in-vitro bacterial killing, physico-chemical properties, aerosolization and dissolution of a ternary-combinational inhalation powder formulation of antibiotics for pan-drug resistant Gram-negative lung infections.

Mangal S, Huang J, Shetty N, Park H, Lin YW, Yu HH, Zemlyanov D, Velkov T, Li J, Zhou QT.

Int J Pharm. 2019 Apr 20;561:102-113. doi: 10.1016/j.ijpharm.2019.02.018. Epub 2019 Feb 21.


Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae.

Lin YW, Abdul Rahim N, Zhao J, Han ML, Yu HH, Wickremasinghe H, Chen K, Wang J, Paterson DL, Zhu Y, Rao GG, Zhou QT, Forrest A, Velkov T, Li J.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02176-18. doi: 10.1128/AAC.02176-18. Print 2019 Apr.


[Clinical analysis of candidemia in immunocompetent patients].

Ding YL, Shen N, Zhou QT, He B, Zheng JJ, Zhao XM.

Beijing Da Xue Xue Bao Yi Xue Ban. 2018 Dec 18;50(6):1063-1069. Chinese.


Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa.

Hussein M, Han ML, Zhu Y, Schneider-Futschik EK, Hu X, Zhou QT, Lin YW, Anderson D, Creek DJ, Hoyer D, Li J, Velkov T.

Comput Struct Biotechnol J. 2018 Nov 10;16:587-599. doi: 10.1016/j.csbj.2018.11.001. eCollection 2018.


Formulation and Manufacturing of Solid Dosage Forms.

Zhou QT, Li T.

Pharm Res. 2018 Nov 27;36(1):16. doi: 10.1007/s11095-018-2547-6. No abstract available.


Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation.

Mangal S, Xu R, Park H, Zemlyanov D, Shetty N, Lin YW, Morton D, Chan HK, Li J, Zhou QT.

Pharm Res. 2018 Nov 7;36(1):6. doi: 10.1007/s11095-018-2527-x.


Intracellular localization of polymyxins in human alveolar epithelial cells.

Ahmed MU, Velkov T, Zhou QT, Fulcher AJ, Callaghan J, Zhou F, Chan K, Azad MAK, Li J.

J Antimicrob Chemother. 2019 Jan 1;74(1):48-57. doi: 10.1093/jac/dky409.


Dry powder inhaler formulations of poorly water-soluble itraconazole: A balance between in-vitro dissolution and in-vivo distribution is necessary.

Huang Z, Lin L, McGoverin C, Liu H, Wang L, Zhou QT, Lu M, Wu C.

Int J Pharm. 2018 Nov 15;551(1-2):103-110. doi: 10.1016/j.ijpharm.2018.09.018. Epub 2018 Sep 11.


[Sepsis: how to evaluate tissue hypoperfusion in clinical practice].

Zhou QT.

Zhonghua Jie He He Hu Xi Za Zhi. 2018 Sep 12;41(9):680-682. doi: 10.3760/cma.j.issn.1001-0939.2018.09.005. Chinese. No abstract available.


Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Klebsiella pneumoniae Clinical Isolates.

Jasim R, Han ML, Zhu Y, Hu X, Hussein MH, Lin YW, Zhou QT, Dong CYD, Li J, Velkov T.

Int J Mol Sci. 2018 Aug 10;19(8). pii: E2356. doi: 10.3390/ijms19082356.


Co-Delivery of Ciprofloxacin and Colistin in Liposomal Formulations with Enhanced In Vitro Antimicrobial Activities against Multidrug Resistant Pseudomonas aeruginosa.

Wang S, Yu S, Lin Y, Zou P, Chai G, Yu HH, Wickremasinghe H, Shetty N, Ling J, Li J, Zhou QT.

Pharm Res. 2018 Aug 9;35(10):187. doi: 10.1007/s11095-018-2464-8.


Improved Physical Stability and Aerosolization of Inhalable Amorphous Ciprofloxacin Powder Formulations by Incorporating Synergistic Colistin.

Shetty N, Ahn P, Park H, Bhujbal S, Zemlyanov D, Cavallaro A, Mangal S, Li J, Zhou QT.

Mol Pharm. 2018 Sep 4;15(9):4004-4020. doi: 10.1021/acs.molpharmaceut.8b00445. Epub 2018 Aug 3.


Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation.

Mangal S, Park H, Zeng L, Yu HH, Lin YW, Velkov T, Denman JA, Zemlyanov D, Li J, Zhou QT.

Int J Pharm. 2018 Sep 5;548(1):443-453. doi: 10.1016/j.ijpharm.2018.07.010. Epub 2018 Jul 3.


Influence of excipients on physical and aerosolization stability of spray dried high-dose powder formulations for inhalation.

Shetty N, Park H, Zemlyanov D, Mangal S, Bhujbal S, Zhou QT.

Int J Pharm. 2018 Jun 10;544(1):222-234. doi: 10.1016/j.ijpharm.2018.04.034. Epub 2018 Apr 18.


A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens.

Lin YW, Chen K, Wang J, Velkov T, Zhou QT, Li J.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02527-17. doi: 10.1128/AAC.02527-17. Print 2018 May.


Correction to: Effects of Moisture-Induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations.

Shetty N, Zeng L, Mangal S, Nie H, Rowles MR, Guo R, Han Y, Park JH, Zhou QT.

Pharm Res. 2018 Feb 8;35(3):54. doi: 10.1007/s11095-018-2354-0.


Physico-Chemical Properties, Aerosolization and Dissolution of Co-Spray Dried Azithromycin Particles with L-Leucine for Inhalation.

Mangal S, Nie H, Xu R, Guo R, Cavallaro A, Zemlyanov D, Zhou QT.

Pharm Res. 2018 Jan 8;35(2):28. doi: 10.1007/s11095-017-2334-9.


The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models.

Lu X, Chan T, Zhu L, Bao X, Velkov T, Zhou QT, Li J, Chan HK, Zhou F.

Eur J Pharm Sci. 2018 Mar 30;115:132-143. doi: 10.1016/j.ejps.2018.01.002. Epub 2018 Jan 5.


Effects of Drying Process on an IgG1 Monoclonal Antibody Using Solid-State Hydrogen Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS).

Moussa EM, Wilson NE, Zhou QT, Singh SK, Nema S, Topp EM.

Pharm Res. 2018 Jan 3;35(1):12. doi: 10.1007/s11095-017-2318-9.


Effects of Moisture-Induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations.

Shetty N, Zeng L, Mangal S, Nie H, Rowles MR, Guo R, Han Y, Park JH, Zhou QT.

Pharm Res. 2018 Jan 2;35(1):7. doi: 10.1007/s11095-017-2281-5. Erratum in: Pharm Res. 2018 Feb 8;35(3):54.


Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model.

Lin YW, Zhou QT, Han ML, Onufrak NJ, Chen K, Wang J, Forrest A, Chan HK, Li J.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01965-17. doi: 10.1128/AAC.01965-17. Print 2018 Mar.


Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-Resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model.

Lin YW, Zhou QT, Han ML, Chen K, Onufrak NJ, Wang J, Turnidge JD, Howden BP, Forrest A, Chan HK, Li J.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01790-17. doi: 10.1128/AAC.01790-17. Print 2018 Feb.


Pulmonary Pharmacokinetics of Colistin following Administration of Dry Powder Aerosols in Rats.

Lin YW, Zhou QT, Hu Y, Onufrak NJ, Sun S, Wang J, Forrest A, Chan HK, Li J.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e00973-17. doi: 10.1128/AAC.00973-17. Print 2017 Nov.


Investigation of L-leucine in reducing the moisture-induced deterioration of spray-dried salbutamol sulfate power for inhalation.

Li L, Leung SSY, Gengenbach T, Yu J, Gao GF, Tang P, Zhou QT, Chan HK.

Int J Pharm. 2017 Sep 15;530(1-2):30-39. doi: 10.1016/j.ijpharm.2017.07.033. Epub 2017 Jul 11.


Effects of Coating Materials and Processing Conditions on Flow Enhancement of Cohesive Acetaminophen Powders by High-Shear Processing With Pharmaceutical Lubricants.

Wei G, Mangal S, Denman J, Gengenbach T, Lee Bonar K, Khan RI, Qu L, Li T, Zhou QT.

J Pharm Sci. 2017 Oct;106(10):3022-3032. doi: 10.1016/j.xphs.2017.05.020. Epub 2017 May 24.


Pulmonary delivery of nanoparticle chemotherapy for the treatment of lung cancers: challenges and opportunities.

Mangal S, Gao W, Li T, Zhou QT.

Acta Pharmacol Sin. 2017 Jun;38(6):782-797. doi: 10.1038/aps.2017.34. Epub 2017 May 1. Review.


Potential Toxicity of Polymyxins in Human Lung Epithelial Cells.

Ahmed MU, Velkov T, Lin YW, Yun B, Nowell CJ, Zhou F, Zhou QT, Chan K, Azad MAK, Li J.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02690-16. doi: 10.1128/AAC.02690-16. Print 2017 Jun.


Stability of pharmaceutical salts in solid oral dosage forms.

Nie H, Byrn SR, Zhou QT.

Drug Dev Ind Pharm. 2017 Aug;43(8):1215-1228. doi: 10.1080/03639045.2017.1304960. Epub 2017 Apr 18.


Meropenem Dosing Based on a Population Pharmacokinetic-Pharmacodynamic Model in Elderly Patients with Infection of the Lower Respiratory Tract.

Zhou QT, He B, Shen N, Liang Y, Sun LN.

Drugs Aging. 2017 Feb;34(2):115-121. doi: 10.1007/s40266-016-0431-9.


Pharmacokinetics/Pharmacodynamics of Pulmonary Delivery of Colistin against Pseudomonas aeruginosa in a Mouse Lung Infection Model.

Lin YW, Zhou QT, Cheah SE, Zhao J, Chen K, Wang J, Chan HK, Li J.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02025-16. doi: 10.1128/AAC.02025-16. Print 2017 Mar.


Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression.

Qu L, Stewart PJ, Hapgood KP, Lakio S, Morton DAV, Zhou QT.

J Pharm Sci. 2017 Jan;106(1):159-167. doi: 10.1016/j.xphs.2016.07.017. Epub 2016 Sep 21.


How Much Surface Coating of Hydrophobic Azithromycin Is Sufficient to Prevent Moisture-Induced Decrease in Aerosolisation of Hygroscopic Amorphous Colistin Powder?

Zhou QT, Loh ZH, Yu J, Sun SP, Gengenbach T, Denman JA, Li J, Chan HK.

AAPS J. 2016 Sep;18(5):1213-1224. doi: 10.1208/s12248-016-9934-x. Epub 2016 Jun 2.


Understanding the Different Effects of Inhaler Design on the Aerosol Performance of Drug-Only and Carrier-Based DPI Formulations. Part 1: Grid Structure.

Leung CMS, Tong Z, Zhou QT, Chan JGY, Tang P, Sun S, Yang R, Chan HK.

AAPS J. 2016 Sep;18(5):1159-1167. doi: 10.1208/s12248-016-9922-1. Epub 2016 May 9.


Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization.

Jong T, Li J, Morton DA, Zhou QT, Larson I.

J Pharm Sci. 2016 Mar;105(3):1156-63. doi: 10.1016/S0022-3549(15)00189-6. Epub 2016 Jan 30.


[The effect of renal clearance on serum trough concentration of vancomycin in elderly patients with severe pneumonia].

Zhou QT, He B, Shen N, Sun LN.

Zhonghua Jie He He Hu Xi Za Zhi. 2016 Feb;39(2):105-9. doi: 10.3760/cma.j.issn.1001-0939.2016.02.006. Chinese.


Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases.

Jin L, Zhou QT, Chan HK, Larson IC, Pennington MW, Morales RAV, Boyd BJ, Norton RS, Nicolazzo JA.

J Pharm Sci. 2016 Feb;105(2):650-656. doi: 10.1016/j.xphs.2015.10.025. Epub 2016 Jan 12.


Effects of Surface Composition on the Aerosolisation and Dissolution of Inhaled Antibiotic Combination Powders Consisting of Colistin and Rifampicin.

Wang W, Zhou QT, Sun SP, Denman JA, Gengenbach TR, Barraud N, Rice SA, Li J, Yang M, Chan HK.

AAPS J. 2016 Mar;18(2):372-84. doi: 10.1208/s12248-015-9848-z. Epub 2015 Nov 24.


Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins.

Lu X, Chan T, Xu C, Zhu L, Zhou QT, Roberts KD, Chan HK, Li J, Zhou F.

J Antimicrob Chemother. 2016 Feb;71(2):403-12. doi: 10.1093/jac/dkv340. Epub 2015 Oct 22.


Editorial: Advances in Particle Engineering and Powder Technology for Pharmaceutical Solid Dosage Forms.

Zhou QT, Morton DA.

Curr Pharm Des. 2015;21(40):5749-50. No abstract available.


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