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Items: 1 to 50 of 119

1.

Action of six pyrethrins purified from the botanical insecticide pyrethrum on cockroach sodium channels expressed in Xenopus oocytes.

Chen M, Du Y, Zhu G, Takamatsu G, Ihara M, Matsuda K, Zhorov BS, Dong K.

Pestic Biochem Physiol. 2018 Oct;151:82-89. doi: 10.1016/j.pestbp.2018.05.002. Epub 2018 May 3.

PMID:
30704718
2.

Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels.

Finol-Urdaneta RK, McArthur JR, Goldschen-Ohm MP, Gaudet R, Tikhonov DB, Zhorov BS, French RJ.

J Gen Physiol. 2019 Feb 4;151(2):186-199. doi: 10.1085/jgp.201812278. Epub 2018 Dec 26.

3.

Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies.

Tikhonov DB, Zhorov BS.

Front Pharmacol. 2018 Aug 7;9:880. doi: 10.3389/fphar.2018.00880. eCollection 2018. Review.

4.

Optical control of L-type Ca2+ channels using a diltiazem photoswitch.

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D.

Nat Chem Biol. 2018 Aug;14(8):764-767. doi: 10.1038/s41589-018-0090-8. Epub 2018 Jul 16.

PMID:
30013061
5.

Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels.

Du Y, Tikhonov DB, Nomura Y, Dong K, Zhorov BS.

Arch Biochem Biophys. 2018 Aug 15;652:59-70. doi: 10.1016/j.abb.2018.06.008. Epub 2018 Jun 21.

PMID:
29936083
6.

Molecular basis of selective resistance of the bumblebee BiNav1 sodium channel to tau-fluvalinate.

Wu S, Nomura Y, Du Y, Zhorov BS, Dong K.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12922-12927. doi: 10.1073/pnas.1711699114. Epub 2017 Nov 20.

7.

Conservation and variability of the pore-lining helices in P-loop channels.

Tikhonov DB, Zhorov BS.

Channels (Austin). 2017 Nov 2;11(6):660-672. doi: 10.1080/19336950.2017.1395536. Epub 2017 Dec 1.

8.

Structural Models of Ligand-Bound Sodium Channels.

Zhorov BS.

Handb Exp Pharmacol. 2018;246:251-269. doi: 10.1007/164_2017_44. Review.

PMID:
29079902
9.

Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid.

Maleeva G, Peiretti F, Zhorov BS, Bregestovski P.

Front Mol Neurosci. 2017 May 16;10:125. doi: 10.3389/fnmol.2017.00125. eCollection 2017.

10.

Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants.

Tikhonov DB, Zhorov BS.

J Gen Physiol. 2017 Apr 3;149(4):465-481. doi: 10.1085/jgp.201611668. Epub 2017 Mar 3.

11.

Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance.

Chen M, Du Y, Nomura Y, Zhu G, Zhorov BS, Dong K.

Insect Biochem Mol Biol. 2017 Mar;82:1-10. doi: 10.1016/j.ibmb.2017.01.007. Epub 2017 Jan 20.

12.

Molecular Mechanism of Action and Selectivity of Sodium Ch annel Blocker Insecticides.

Silver K, Dong K, Zhorov BS.

Curr Med Chem. 2017;24(27):2912-2924. doi: 10.2174/0929867323666161216143844. Review.

13.

Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti.

Du Y, Nomura Y, Zhorov BS, Dong K.

Insects. 2016 Oct 31;7(4). pii: E60. Review.

14.

Phenotypic Variability from Benign Infantile Epilepsy to Ohtahara Syndrome Associated with a Novel Mutation in SCN2A.

Syrbe S, Zhorov BS, Bertsche A, Bernhard MK, Hornemann F, Mütze U, Hoffmann J, Hörtnagel K, Kiess W, Hirsch FW, Lemke JR, Merkenschlager A.

Mol Syndromol. 2016 Sep;7(4):182-188. Epub 2016 Jul 19.

15.

Computational Structural Pharmacology and Toxicology of Voltage-Gated Sodium Channels.

Zhorov BS, Tikhonov DB.

Curr Top Membr. 2016;78:117-44. doi: 10.1016/bs.ctm.2015.12.001. Epub 2016 Mar 14.

PMID:
27586283
16.

Elucidation of pyrethroid and DDT receptor sites in the voltage-gated sodium channel.

Zhorov BS, Dong K.

Neurotoxicology. 2017 May;60:171-177. doi: 10.1016/j.neuro.2016.08.013. Epub 2016 Aug 25. Review.

17.

The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides.

Zhang Y, Du Y, Jiang D, Behnke C, Nomura Y, Zhorov BS, Dong K.

J Biol Chem. 2016 Sep 16;291(38):20113-24. doi: 10.1074/jbc.M116.742056. Epub 2016 Aug 3.

18.

Side chain flexibility and the pore dimensions in the GABAA receptor.

Rossokhin AV, Zhorov BS.

J Comput Aided Mol Des. 2016 Jul;30(7):559-67. doi: 10.1007/s10822-016-9929-9. Epub 2016 Jul 26.

PMID:
27460059
19.

Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids.

Chen M, Du Y, Nomura Y, Zhu G, Zhorov BS, Dong K.

Neurotoxicology. 2017 May;60:197-206. doi: 10.1016/j.neuro.2016.06.009. Epub 2016 Jun 18.

20.

[MOLECULAR EVOLUTION OF ION CHANNELS: AMINO ACID SEQUENCES AND 3D STRUCTURES].

Korkosh VS, Zhorov BS, Tikhonov DB.

Zh Evol Biokhim Fiziol. 2016 Jan-Feb;52(1):26-33. Russian.

PMID:
27220237
21.

Modeling interactions between blocking and permeant cations in the NavMs channel.

Korkosh VS, Zhorov BS, Tikhonov DB.

Eur J Pharmacol. 2016 Jun 5;780:188-93. doi: 10.1016/j.ejphar.2016.03.048. Epub 2016 Mar 26.

PMID:
27020546
22.

Analysis of inter-residue contacts reveals folding stabilizers in P-loops of potassium, sodium, and TRPV channels.

Korkosh VS, Zhorov BS, Tikhonov DB.

Eur Biophys J. 2016 May;45(4):321-9. doi: 10.1007/s00249-015-1098-6. Epub 2015 Dec 8.

PMID:
26646260
23.

Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels.

Du Y, Nomura Y, Zhorov BS, Dong K.

J Biol Chem. 2016 Feb 26;291(9):4638-48. doi: 10.1074/jbc.M115.678672. Epub 2015 Dec 4.

24.

Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics.

Jiang D, Du Y, Nomura Y, Wang X, Wu Y, Zhorov BS, Dong K.

Insect Biochem Mol Biol. 2015 Nov;66:88-95. doi: 10.1016/j.ibmb.2015.09.011. Epub 2015 Sep 25.

25.

Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels.

Stephens RF, Guan W, Zhorov BS, Spafford JD.

Front Physiol. 2015 May 19;6:153. doi: 10.3389/fphys.2015.00153. eCollection 2015. Review.

26.

Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel.

Du Y, Nomura Y, Zhorov BS, Dong K.

Mol Pharmacol. 2015 Aug;88(2):273-80. doi: 10.1124/mol.115.098707. Epub 2015 May 13.

27.

Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.

Rinkevich FD, Du Y, Tolinski J, Ueda A, Wu CF, Zhorov BS, Dong K.

Neurotoxicology. 2015 Mar;47:99-106. doi: 10.1016/j.neuro.2015.02.001. Epub 2015 Feb 14.

28.

A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance.

Wang L, Nomura Y, Du Y, Liu N, Zhorov BS, Dong K.

Mol Pharmacol. 2015;87(3):421-9. doi: 10.1124/mol.114.094730. Epub 2014 Dec 18.

29.

Interaction of the BKCa channel gating ring with dendrotoxins.

Takacs Z, Imredy JP, Bingham JP, Zhorov BS, Moczydlowski EG.

Channels (Austin). 2014;8(5):421-32. doi: 10.4161/19336950.2014.949186.

31.

State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels.

Tikhonov DB, Bruhova I, Garden DP, Zhorov BS.

Pflugers Arch. 2015 Feb;467(2):253-66. doi: 10.1007/s00424-014-1508-0. Epub 2014 Apr 15.

PMID:
24728659
32.

Molecular biology of insect sodium channels and pyrethroid resistance.

Dong K, Du Y, Rinkevich F, Nomura Y, Xu P, Wang L, Silver K, Zhorov BS.

Insect Biochem Mol Biol. 2014 Jul;50:1-17. doi: 10.1016/j.ibmb.2014.03.012. Epub 2014 Apr 3.

33.

Voltage-Gated Sodium Channels as Insecticide Targets.

Silver KS, Du Y, Nomura Y, Oliveira EE, Salgado VL, Zhorov BS, Dong K.

Adv In Insect Phys. 2014;46:389-433. doi: 10.1016/B978-0-12-417010-0.00005-7.

34.

Homology modeling of Kv1.5 channel block by cationic and electroneutral ligands.

Tikhonov DB, Zhorov BS.

Biochim Biophys Acta. 2014 Mar;1838(3):978-87. doi: 10.1016/j.bbamem.2013.11.019. Epub 2013 Dec 5.

35.

Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel.

Du Y, Nomura Y, Satar G, Hu Z, Nauen R, He SY, Zhorov BS, Dong K.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11785-90. doi: 10.1073/pnas.1305118110. Epub 2013 Jul 2.

36.

Interaction of local anesthetics with the K (+) channel pore domain: KcsA as a model for drug-dependent tetramer stability.

Gray NW, Zhorov BS, Moczydlowski EG.

Channels (Austin). 2013 May-Jun;7(3):182-93. doi: 10.4161/chan.24455. Epub 2013 Apr 1.

37.

Ligand action on sodium, potassium, and calcium channels: role of permeant ions.

Zhorov BS, Tikhonov DB.

Trends Pharmacol Sci. 2013 Mar;34(3):154-61. doi: 10.1016/j.tips.2013.01.002. Epub 2013 Feb 1.

PMID:
23375737
38.

1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 2): action in other targets and antitargets.

Carosati E, Ioan P, Micucci M, Broccatelli F, Cruciani G, Zhorov BS, Chiarini A, Budriesi R.

Curr Med Chem. 2012;19(25):4306-23. Review.

PMID:
22709009
39.

Architecture and pore block of eukaryotic voltage-gated sodium channels in view of NavAb bacterial sodium channel structure.

Tikhonov DB, Zhorov BS.

Mol Pharmacol. 2012 Jul;82(1):97-104. doi: 10.1124/mol.112.078212. Epub 2012 Apr 13.

PMID:
22505150
40.

1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 1): action in ion channels and GPCRs.

Ioan P, Carosati E, Micucci M, Cruciani G, Broccatelli F, Zhorov BS, Chiarini A, Budriesi R.

Curr Med Chem. 2011;18(32):4901-22. Review.

PMID:
22050742
41.

Interactions of drugs and toxins with permeant ions in potassium, sodium, and calcium channels.

Zhorov BS.

Ross Fiziol Zh Im I M Sechenova. 2011 Jul;97(7):661-77. Review.

PMID:
21961291
42.

Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels.

Du Y, Garden D, Khambay B, Zhorov BS, Dong K.

Mol Pharmacol. 2011 Sep;80(3):426-33. doi: 10.1124/mol.111.072504. Epub 2011 Jun 16.

43.

Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.

Du Y, Garden DP, Wang L, Zhorov BS, Dong K.

J Biol Chem. 2011 Apr 15;286(15):13151-60. doi: 10.1074/jbc.M110.208496. Epub 2011 Feb 8.

44.

Why does the inner-helix mutation A413C double the stoichiometry of Kv1.3 channel block by emopamil but not by verapamil?

Rossokhin A, Dreker T, Grissmer S, Zhorov BS.

Mol Pharmacol. 2011 Apr;79(4):681-91. doi: 10.1124/mol.110.068031. Epub 2011 Jan 10.

PMID:
21220411
45.

Possible roles of exceptionally conserved residues around the selectivity filters of sodium and calcium channels.

Tikhonov DB, Zhorov BS.

J Biol Chem. 2011 Jan 28;286(4):2998-3006. doi: 10.1074/jbc.M110.175406. Epub 2010 Nov 16.

46.

Overlapping binding sites of structurally different antiarrhythmics flecainide and propafenone in the subunit interface of potassium channel Kv2.1.

Madeja M, Steffen W, Mesic I, Garic B, Zhorov BS.

J Biol Chem. 2010 Oct 29;285(44):33898-905. doi: 10.1074/jbc.M110.159897. Epub 2010 Aug 13.

47.

Potassium channel block by a tripartite complex of two cationophilic ligands and a potassium ion.

Zimin PI, Garic B, Bodendiek SB, Mahieux C, Wulff H, Zhorov BS.

Mol Pharmacol. 2010 Oct;78(4):588-99. doi: 10.1124/mol.110.064014. Epub 2010 Jul 2.

48.

A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM data.

Bruhova I, Zhorov BS.

J Gen Physiol. 2010 Mar;135(3):261-74. doi: 10.1085/jgp.200910288.

49.

Docking flexible ligands in proteins with a solvent exposure- and distance-dependent dielectric function.

Garden DP, Zhorov BS.

J Comput Aided Mol Des. 2010 Feb;24(2):91-105. doi: 10.1007/s10822-009-9317-9. Epub 2010 Jan 30.

PMID:
20119653
50.

Structural modeling of calcium binding in the selectivity filter of the L-type calcium channel.

Cheng RC, Tikhonov DB, Zhorov BS.

Eur Biophys J. 2010 Apr;39(5):839-53. doi: 10.1007/s00249-009-0574-2. Epub 2010 Jan 7.

PMID:
20054687

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