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Items: 34


Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy.

Brazill JM, Cruz B, Zhu Y, Zhai RG.

Dis Model Mech. 2018 Jun 12;11(6). pii: dmm032938. doi: 10.1242/dmm.032938.


Publisher Correction: Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome.

Li C, Brazill JM, Liu S, Bello C, Zhu Y, Morimoto M, Cascio L, Pauly R, Diaz-Perez Z, Malicdan MCV, Wang H, Boccuto L, Schwartz CE, Gahl WA, Boerkoel CF, Zhai RG.

Nat Commun. 2018 Jan 18;9(1):337. doi: 10.1038/s41467-017-02462-8.


Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome.

Li C, Brazill JM, Liu S, Bello C, Zhu Y, Morimoto M, Cascio L, Pauly R, Diaz-Perez Z, Malicdan MCV, Wang H, Boccuto L, Schwartz CE, Gahl WA, Boerkoel CF, Zhai RG.

Nat Commun. 2017 Nov 2;8(1):1257. doi: 10.1038/s41467-017-01289-7. Erratum in: Nat Commun. 2018 Jan 18;9(1):337.


Defining Disease, Diagnosis, and Translational Medicine within a Homeostatic Perturbation Paradigm: The National Institutes of Health Undiagnosed Diseases Program Experience.

Gall T, Valkanas E, Bello C, Markello T, Adams C, Bone WP, Brandt AJ, Brazill JM, Carmichael L, Davids M, Davis J, Diaz-Perez Z, Draper D, Elson J, Flynn ED, Godfrey R, Groden C, Hsieh CK, Fischer R, Golas GA, Guzman J, Huang Y, Kane MS, Lee E, Li C, Links AE, Maduro V, Malicdan MCV, Malik FS, Nehrebecky M, Park J, Pemberton P, Schaffer K, Simeonov D, Sincan M, Smedley D, Valivullah Z, Wahl C, Washington N, Wolfe LA, Xu K, Zhu Y, Gahl WA, Tifft CJ, Toro C, Adams DR, He M, Robinson PN, Haendel MA, Zhai RG, Boerkoel CF.

Front Med (Lausanne). 2017 May 26;4:62. doi: 10.3389/fmed.2017.00062. eCollection 2017.


NMNAT: It's an NAD+ synthase… It's a chaperone… It's a neuroprotector.

Brazill JM, Li C, Zhu Y, Zhai RG.

Curr Opin Genet Dev. 2017 Jun;44:156-162. doi: 10.1016/j.gde.2017.03.014. Epub 2017 Apr 23. Review.


Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging.

Ruetenik AL, Ocampo A, Ruan K, Zhu Y, Li C, Zhai RG, Barrientos A.

Microb Cell. 2016 Jul 26;3(8):338-351. doi: 10.15698/mic2016.08.518.


Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress.

Ruan K, Zhu Y, Li C, Brazill JM, Zhai RG.

Nat Commun. 2015 Nov 30;6:10057. doi: 10.1038/ncomms10057.


NMNATs, evolutionarily conserved neuronal maintenance factors.

Ali YO, Li-Kroeger D, Bellen HJ, Zhai RG, Lu HC.

Trends Neurosci. 2013 Nov;36(11):632-40. doi: 10.1016/j.tins.2013.07.002. Epub 2013 Aug 20. Review.


Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria.

Kitay BM, McCormack R, Wang Y, Tsoulfas P, Zhai RG.

Hum Mol Genet. 2013 Apr 15;22(8):1601-14. doi: 10.1093/hmg/ddt009. Epub 2013 Jan 11.


The role of autophagy in Nmnat-mediated protection against hypoxia-induced dendrite degeneration.

Wen Y, Zhai RG, Kim MD.

Mol Cell Neurosci. 2013 Jan;52:140-51. doi: 10.1016/j.mcn.2012.11.008. Epub 2012 Nov 15.


Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot.

Zang S, Ali YO, Ruan K, Zhai RG.

EMBO Rep. 2013 Jan;14(1):87-94. doi: 10.1038/embor.2012.181. Epub 2012 Nov 16.


β-N-methylamino-L-alanine induces neurological deficits and shortened life span in Drosophila.

Zhou X, Escala W, Papapetropoulos S, Zhai RG.

Toxins (Basel). 2010 Nov;2(11):2663-79. doi: 10.3390/toxins2112663. Epub 2010 Nov 3.


Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini.

Ouyang H, Ali YO, Ravichandran M, Dong A, Qiu W, MacKenzie F, Dhe-Paganon S, Arrowsmith CH, Zhai RG.

J Biol Chem. 2012 Jan 20;287(4):2317-27. doi: 10.1074/jbc.M111.273730. Epub 2011 Nov 8.


CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy.

Ljungberg MC, Ali YO, Zhu J, Wu CS, Oka K, Zhai RG, Lu HC.

Hum Mol Genet. 2012 Jan 15;21(2):251-67. doi: 10.1093/hmg/ddr492. Epub 2011 Oct 25.


NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy.

Ali YO, Ruan K, Zhai RG.

Hum Mol Genet. 2012 Jan 15;21(2):237-50. doi: 10.1093/hmg/ddr449. Epub 2011 Sep 30.


Nmnat exerts neuroprotective effects in dendrites and axons.

Wen Y, Parrish JZ, He R, Zhai RG, Kim MD.

Mol Cell Neurosci. 2011 Sep;48(1):1-8. doi: 10.1016/j.mcn.2011.05.002. Epub 2011 May 9.


Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1alpha pathway.

Ali YO, McCormack R, Darr A, Zhai RG.

J Biol Chem. 2011 May 27;286(21):19089-99. doi: 10.1074/jbc.M111.219295. Epub 2011 Apr 8.


Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration.

Ali YO, Escala W, Ruan K, Zhai RG.

J Vis Exp. 2011 Mar 11;(49). pii: 2504. doi: 10.3791/2504.


Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration.

Ali YO, Kitay BM, Zhai RG.

Molecules. 2010 Oct 8;15(10):6859-87. doi: 10.3390/molecules15106859. Review.


BMAA neurotoxicity in Drosophila.

Zhou X, Escala W, Papapetropoulos S, Bradley WG, Zhai RG.

Amyotroph Lateral Scler. 2009;10 Suppl 2:61-6. doi: 10.3109/17482960903273445.


Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme.

Zhai RG, Rizzi M, Garavaglia S.

Cell Mol Life Sci. 2009 Sep;66(17):2805-18. doi: 10.1007/s00018-009-0047-x. Epub 2009 May 16. Review.


NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

Zhai RG, Zhang F, Hiesinger PR, Cao Y, Haueter CM, Bellen HJ.

Nature. 2008 Apr 17;452(7189):887-91. doi: 10.1038/nature06721. Epub 2008 Mar 16.


Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity.

Zhai RG, Cao Y, Hiesinger PR, Zhou Y, Mehta SQ, Schulze KL, Verstreken P, Bellen HJ.

PLoS Biol. 2006 Nov;4(12):e416.


Activity-independent prespecification of synaptic partners in the visual map of Drosophila.

Hiesinger PR, Zhai RG, Zhou Y, Koh TW, Mehta SQ, Schulze KL, Cao Y, Verstreken P, Clandinin TR, Fischbach KF, Meinertzhagen IA, Bellen HJ.

Curr Biol. 2006 Sep 19;16(18):1835-43.


The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.

Hiesinger PR, Fayyazuddin A, Mehta SQ, Rosenmund T, Schulze KL, Zhai RG, Verstreken P, Cao Y, Zhou Y, Kunz J, Bellen HJ.

Cell. 2005 May 20;121(4):607-620. doi: 10.1016/j.cell.2005.03.012.


Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components.

Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ.

Neuron. 2005 Apr 21;46(2):219-32.


Hauling t-SNAREs on the microtubule highway.

Zhai RG, Bellen HJ.

Nat Cell Biol. 2004 Oct;6(10):918-9. No abstract available.


The architecture of the active zone in the presynaptic nerve terminal.

Zhai RG, Bellen HJ.

Physiology (Bethesda). 2004 Oct;19:262-70. Review.


Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating.

Verstreken P, Koh TW, Schulze KL, Zhai RG, Hiesinger PR, Zhou Y, Mehta SQ, Cao Y, Roos J, Bellen HJ.

Neuron. 2003 Nov 13;40(4):733-48.


Mapping Drosophila mutations with molecularly defined P element insertions.

Zhai RG, Hiesinger PR, Koh TW, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJ.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10860-5. Epub 2003 Sep 5.


Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesicles.

Shapira M, Zhai RG, Dresbach T, Bresler T, Torres VI, Gundelfinger ED, Ziv NE, Garner CC.

Neuron. 2003 Apr 24;38(2):237-52.


Molecular mechanisms of CNS synaptogenesis.

Garner CC, Zhai RG, Gundelfinger ED, Ziv NE.

Trends Neurosci. 2002 May;25(5):243-51. Review.


Assembling the presynaptic active zone: a characterization of an active one precursor vesicle.

Zhai RG, Vardinon-Friedman H, Cases-Langhoff C, Becker B, Gundelfinger ED, Ziv NE, Garner CC.

Neuron. 2001 Jan;29(1):131-43.

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