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Items: 1 to 50 of 69

1.

Efflux pumps of Burkholderia thailandensis control the permeability barrier of the outer membrane.

Krishnamoorthy G, Weeks JW, Zhang Z, Chandler C, Xue H, Schweizer HP, Ernst RK, Zgurskaya HI.

Antimicrob Agents Chemother. 2019 Aug 5. pii: AAC.00956-19. doi: 10.1128/AAC.00956-19. [Epub ahead of print]

PMID:
31383661
2.

The MmpL3 interactome reveals a complex crosstalk between cell envelope biosynthesis and cell elongation and division in mycobacteria.

Belardinelli JM, Stevens CM, Li W, Tan YZ, Jones V, Mancia F, Zgurskaya HI, Jackson M.

Sci Rep. 2019 Jul 24;9(1):10728. doi: 10.1038/s41598-019-47159-8.

3.

Permeability barriers of Gram-negative pathogens.

Zgurskaya HI, Rybenkov VV.

Ann N Y Acad Sci. 2019 Jun 4. doi: 10.1111/nyas.14134. [Epub ahead of print] Review.

PMID:
31165502
4.

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors.

Li Y, Gardner JJ, Fortney KR, Leus IV, Bonifay V, Zgurskaya HI, Pletnev AA, Zhang S, Zhang ZY, Gribble GW, Spinola SM, Duerfeldt AS.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1836-1841. doi: 10.1016/j.bmcl.2019.05.003. Epub 2019 May 6.

PMID:
31104993
5.

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds.

Li W, Stevens CM, Pandya AN, Darzynkiewicz Z, Bhattarai P, Tong W, Gonzalez-Juarrero M, North EJ, Zgurskaya HI, Jackson M.

ACS Infect Dis. 2019 Jun 14;5(6):1001-1012. doi: 10.1021/acsinfecdis.9b00048. Epub 2019 Mar 28.

6.

Identification of Binding Sites for Efflux Pump Inhibitors of the AcrAB-TolC Component AcrA.

Darzynkiewicz ZM, Green AT, Abdali N, Hazel A, Fulton RL, Kimball J, Gryczynski Z, Gumbart JC, Parks JM, Smith JC, Zgurskaya HI.

Biophys J. 2019 Feb 19;116(4):648-658. doi: 10.1016/j.bpj.2019.01.010. Epub 2019 Jan 12.

PMID:
30691677
7.

Small Molecule Condensin Inhibitors.

Zhao H, Petrushenko ZM, Walker JK, Baudry J, Zgurskaya HI, Rybenkov VV.

ACS Infect Dis. 2018 Dec 14;4(12):1737-1745. doi: 10.1021/acsinfecdis.8b00222. Epub 2018 Oct 22.

PMID:
30346684
8.

Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa.

Cooper SJ, Krishnamoorthy G, Wolloscheck D, Walker JK, Rybenkov VV, Parks JM, Zgurskaya HI.

ACS Infect Dis. 2018 Aug 10;4(8):1223-1234. doi: 10.1021/acsinfecdis.8b00036. Epub 2018 May 25.

9.

Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii.

Leus IV, Weeks JW, Bonifay V, Smith L, Richardson S, Zgurskaya HI.

J Bacteriol. 2018 Jun 11;200(13). pii: e00049-18. doi: 10.1128/JB.00049-18. Print 2018 Jul 1.

10.

Trans-envelope multidrug efflux pumps of Gram-negative bacteria and their synergism with the outer membrane barrier.

Zgurskaya HI, Rybenkov VV, Krishnamoorthy G, Leus IV.

Res Microbiol. 2018 Sep - Oct;169(7-8):351-356. doi: 10.1016/j.resmic.2018.02.002. Epub 2018 Feb 16. Review.

PMID:
29454787
11.

Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface.

López CA, Travers T, Pos KM, Zgurskaya HI, Gnanakaran S.

Sci Rep. 2017 Nov 28;7(1):16521. doi: 10.1038/s41598-017-16497-w.

12.

Biochemical Reconstitution and Characterization of Multicomponent Drug Efflux Transporters.

Picard M, Tikhonova EB, Broutin I, Lu S, Verchère A, Zgurskaya HI.

Methods Mol Biol. 2018;1700:113-145. doi: 10.1007/978-1-4939-7454-2_8.

PMID:
29177829
13.

Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux Pump.

Yue Z, Chen W, Zgurskaya HI, Shen J.

J Chem Theory Comput. 2017 Dec 12;13(12):6405-6414. doi: 10.1021/acs.jctc.7b00874. Epub 2017 Nov 20.

14.

Kinetic Control of Quorum Sensing in Pseudomonas aeruginosa by Multidrug Efflux Pumps.

Wolloscheck D, Krishnamoorthy G, Nguyen J, Zgurskaya HI.

ACS Infect Dis. 2018 Feb 9;4(2):185-195. doi: 10.1021/acsinfecdis.7b00160. Epub 2017 Nov 10.

15.

Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria.

Krishnamoorthy G, Leus IV, Weeks JW, Wolloscheck D, Rybenkov VV, Zgurskaya HI.

MBio. 2017 Oct 31;8(5). pii: e01172-17. doi: 10.1128/mBio.01172-17.

16.

Bifurcation kinetics of drug uptake by Gram-negative bacteria.

Westfall DA, Krishnamoorthy G, Wolloscheck D, Sarkar R, Zgurskaya HI, Rybenkov VV.

PLoS One. 2017 Sep 19;12(9):e0184671. doi: 10.1371/journal.pone.0184671. eCollection 2017.

17.

Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.

Haynes KM, Abdali N, Jhawar V, Zgurskaya HI, Parks JM, Green AT, Baudry J, Rybenkov VV, Smith JC, Walker JK.

J Med Chem. 2017 Jul 27;60(14):6205-6219. doi: 10.1021/acs.jmedchem.7b00453. Epub 2017 Jul 11.

18.

Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump.

Abdali N, Parks JM, Haynes KM, Chaney JL, Green AT, Wolloscheck D, Walker JK, Rybenkov VV, Baudry J, Smith JC, Zgurskaya HI.

ACS Infect Dis. 2017 Jan 13;3(1):89-98. doi: 10.1021/acsinfecdis.6b00167. Epub 2016 Nov 2.

19.

Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis.

Belardinelli JM, Yazidi A, Yang L, Fabre L, Li W, Jacques B, Angala SK, Rouiller I, Zgurskaya HI, Sygusch J, Jackson M.

ACS Infect Dis. 2016 Oct 14;2(10):702-713. doi: 10.1021/acsinfecdis.6b00095. Epub 2016 Sep 1.

20.

Breaking the Permeability Barrier of Escherichia coli by Controlled Hyperporination of the Outer Membrane.

Krishnamoorthy G, Wolloscheck D, Weeks JW, Croft C, Rybenkov VV, Zgurskaya HI.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7372-7381. Print 2016 Dec.

21.

Opening the Channel: the Two Functional Interfaces of Pseudomonas aeruginosa OpmH with the Triclosan Efflux Pump TriABC.

Ntreh AT, Weeks JW, Nickels LM, Zgurskaya HI.

J Bacteriol. 2016 Nov 4;198(23):3176-3185. Print 2016 Dec 1.

22.

Pseudomonas aeruginosa Condensins Support Opposite Differentiation States.

Zhao H, Clevenger AL, Ritchey JW, Zgurskaya HI, Rybenkov VV.

J Bacteriol. 2016 Oct 7;198(21):2936-2944. Print 2016 Nov 1.

23.

Novobiocin Susceptibility of MukBEF-Deficient Escherichia coli Is Combinatorial with Efflux and Resides in DNA Topoisomerases.

Petrushenko ZM, Zhao H, Zgurskaya HI, Rybenkov VV.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2949-53. doi: 10.1128/AAC.03102-15. Print 2016 May.

24.

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It.

Zgurskaya HI, Löpez CA, Gnanakaran S.

ACS Infect Dis. 2015;1(11):512-522.

25.

Non-equivalent roles of two periplasmic subunits in the function and assembly of triclosan pump TriABC from Pseudomonas aeruginosa.

Weeks JW, Nickels LM, Ntreh AT, Zgurskaya HI.

Mol Microbiol. 2015 Oct;98(2):343-56. doi: 10.1111/mmi.13124. Epub 2015 Aug 18.

26.

Mechanism of coupling drug transport reactions located in two different membranes.

Zgurskaya HI, Weeks JW, Ntreh AT, Nickels LM, Wolloscheck D.

Front Microbiol. 2015 Feb 24;6:100. doi: 10.3389/fmicb.2015.00100. eCollection 2015. Review.

27.

RND transporters protect Corynebacterium glutamicum from antibiotics by assembling the outer membrane.

Yang L, Lu S, Belardinelli J, Huc-Claustre E, Jones V, Jackson M, Zgurskaya HI.

Microbiologyopen. 2014 Aug;3(4):484-96. doi: 10.1002/mbo3.182. Epub 2014 Jun 18.

28.
29.

On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein.

Krishnamoorthy G, Tikhonova EB, Dhamdhere G, Zgurskaya HI.

Mol Microbiol. 2013 Mar;87(5):982-97. doi: 10.1111/mmi.12143. Epub 2013 Jan 21.

30.

Assessment of multidrug efflux assemblies by surface plasmon resonance.

Tikhonova EB, Zgurskaya HI.

Methods Mol Biol. 2013;966:133-55. doi: 10.1007/978-1-62703-245-2_9.

PMID:
23299733
31.

Role of ATP binding and hydrolysis in assembly of MacAB-TolC macrolide transporter.

Lu S, Zgurskaya HI.

Mol Microbiol. 2012 Dec;86(5):1132-43. doi: 10.1111/mmi.12046. Epub 2012 Oct 12.

32.

Parallel lipoplex folding pathways revealed using magnetic tweezers.

Sun Z, Tikhonova EB, Zgurskaya HI, Rybenkov VV.

Biomacromolecules. 2012 Oct 8;13(10):3395-400. doi: 10.1021/bm301155w. Epub 2012 Sep 28.

33.

YknWXYZ is an unusual four-component transporter with a role in protection against sporulation-delaying-protein-induced killing of Bacillus subtilis.

Yamada Y, Tikhonova EB, Zgurskaya HI.

J Bacteriol. 2012 Aug;194(16):4386-94. doi: 10.1128/JB.00223-12. Epub 2012 Jun 15.

34.

Tackling antibiotic resistance.

Bush K, Courvalin P, Dantas G, Davies J, Eisenstein B, Huovinen P, Jacoby GA, Kishony R, Kreiswirth BN, Kutter E, Lerner SA, Levy S, Lewis K, Lomovskaya O, Miller JH, Mobashery S, Piddock LJ, Projan S, Thomas CM, Tomasz A, Tulkens PM, Walsh TR, Watson JD, Witkowski J, Witte W, Wright G, Yeh P, Zgurskaya HI.

Nat Rev Microbiol. 2011 Nov 2;9(12):894-6. doi: 10.1038/nrmicro2693. Review.

35.

Mechanism and Function of the Outer Membrane Channel TolC in Multidrug Resistance and Physiology of Enterobacteria.

Zgurskaya HI, Krishnamoorthy G, Ntreh A, Lu S.

Front Microbiol. 2011 Sep 16;2:189. doi: 10.3389/fmicb.2011.00189. eCollection 2011.

36.

The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by MacB transporter.

Modali SD, Zgurskaya HI.

Mol Microbiol. 2011 Aug;81(4):937-51. doi: 10.1111/j.1365-2958.2011.07744.x. Epub 2011 Jul 4.

37.

Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC.

Tikhonova EB, Yamada Y, Zgurskaya HI.

Chem Biol. 2011 Apr 22;18(4):454-63. doi: 10.1016/j.chembiol.2011.02.011.

38.

Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.

Dhamdhere G, Krishnamoorthy G, Zgurskaya HI.

Antimicrob Agents Chemother. 2010 Dec;54(12):5366-8. doi: 10.1128/AAC.00719-10. Epub 2010 Sep 27.

39.

Metabolic shutdown in Escherichia coli cells lacking the outer membrane channel TolC.

Dhamdhere G, Zgurskaya HI.

Mol Microbiol. 2010 Aug;77(3):743-54. doi: 10.1111/j.1365-2958.2010.07245.x. Epub 2010 Jun 1.

40.

Kinetic control of TolC recruitment by multidrug efflux complexes.

Tikhonova EB, Dastidar V, Rybenkov VV, Zgurskaya HI.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16416-21. doi: 10.1073/pnas.0906601106. Epub 2009 Sep 2.

41.

Multicomponent drug efflux complexes: architecture and mechanism of assembly.

Zgurskaya HI.

Future Microbiol. 2009 Sep;4(7):919-32. doi: 10.2217/fmb.09.62. Review.

42.

Epistatic effects of the protease/chaperone HflB on some damaged forms of the Escherichia coli ammonium channel AmtB.

Inwood WB, Hall JA, Kim KS, Demirkhanyan L, Wemmer D, Zgurskaya H, Kustu S.

Genetics. 2009 Dec;183(4):1327-40. doi: 10.1534/genetics.109.103747. Epub 2009 Jul 13.

43.

The C-terminal domain of AcrA is essential for the assembly and function of the multidrug efflux pump AcrAB-TolC.

Ge Q, Yamada Y, Zgurskaya H.

J Bacteriol. 2009 Jul;191(13):4365-71. doi: 10.1128/JB.00204-09. Epub 2009 May 1.

44.

Mechanisms of drug efflux and strategies to combat them. Preface.

Zgurskaya HI.

Biochim Biophys Acta. 2009 May;1794(5):723-4. doi: 10.1016/j.bbapap.2009.03.017. No abstract available.

PMID:
19380106
45.

Covalently linked AcrB giant offers a new powerful tool for mechanistic analysis of multidrug efflux in bacteria.

Zgurskaya HI.

J Bacteriol. 2009 Mar;191(6):1727-8. doi: 10.1128/JB.01718-08. Epub 2009 Jan 9. No abstract available.

46.

Structural and functional diversity of bacterial membrane fusion proteins.

Zgurskaya HI, Yamada Y, Tikhonova EB, Ge Q, Krishnamoorthy G.

Biochim Biophys Acta. 2009 May;1794(5):794-807. doi: 10.1016/j.bbapap.2008.10.010. Epub 2008 Nov 6. Review.

PMID:
19041958
47.
48.

Drug-induced conformational changes in multidrug efflux transporter AcrB from Haemophilus influenzae.

Dastidar V, Mao W, Lomovskaya O, Zgurskaya HI.

J Bacteriol. 2007 Aug;189(15):5550-8. Epub 2007 May 25.

49.

Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.

Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI.

Mol Microbiol. 2007 Feb;63(3):895-910. Epub 2007 Jan 4.

50.

Waltzing transporters and 'the dance macabre' between humans and bacteria.

Lomovskaya O, Zgurskaya HI, Totrov M, Watkins WJ.

Nat Rev Drug Discov. 2007 Jan;6(1):56-65. Epub 2006 Dec 8. Review.

PMID:
17159924

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