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Items: 29


Mucosal-Pull Induction of Lung-Resident Memory CD8 T Cells in Parenteral TB Vaccine-Primed Hosts Requires Cognate Antigens and CD4 T Cells.

Haddadi S, Vaseghi-Shanjani M, Yao Y, Afkhami S, D'Agostino MR, Zganiacz A, Jeyanathan M, Xing Z.

Front Immunol. 2019 Sep 6;10:2075. doi: 10.3389/fimmu.2019.02075. eCollection 2019.


Single-Dose Mucosal Immunotherapy With Chimpanzee Adenovirus-Based Vaccine Accelerates Tuberculosis Disease Control and Limits Its Rebound After Antibiotic Cessation.

Afkhami S, Lai R, D'agostino MR, Vaseghi-Shanjani M, Zganiacz A, Yao Y, Jeyanathan M, Xing Z.

J Infect Dis. 2019 Sep 13;220(8):1355-1366. doi: 10.1093/infdis/jiz306.


CD11b+ Dendritic Cell-Mediated Anti-Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103+ Dendritic Cells via IL-10.

Lai R, Jeyanathan M, Afkhami S, Zganiacz A, Hammill JA, Yao Y, Kaushic C, Xing Z.

J Immunol. 2018 Mar 1;200(5):1746-1760. doi: 10.4049/jimmunol.1701109. Epub 2018 Jan 26.


Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine.

Yao Y, Lai R, Afkhami S, Haddadi S, Zganiacz A, Vahedi F, Ashkar AA, Kaushic C, Jeyanathan M, Xing Z.

J Infect Dis. 2017 Jul 1;216(1):135-145. doi: 10.1093/infdis/jix252.


Role of B Cells in Mucosal Vaccine-Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis.

Khera AK, Afkhami S, Lai R, Jeyanathan M, Zganiacz A, Mandur T, Hammill J, Damjanovic D, Xing Z.

J Immunol. 2015 Sep 15;195(6):2900-7. doi: 10.4049/jimmunol.1500981. Epub 2015 Aug 12.


Age at Mycobacterium bovis BCG Priming Has Limited Impact on Anti-Tuberculosis Immunity Boosted by Respiratory Mucosal AdHu5Ag85A Immunization in a Murine Model.

Damjanovic D, Khera A, Afkhami S, Lai R, Zganiacz A, Jeyanathan M, Xing Z.

PLoS One. 2015 Jun 22;10(6):e0131175. doi: 10.1371/journal.pone.0131175. eCollection 2015.


Novel chimpanzee adenovirus-vectored respiratory mucosal tuberculosis vaccine: overcoming local anti-human adenovirus immunity for potent TB protection.

Jeyanathan M, Thanthrige-Don N, Afkhami S, Lai R, Damjanovic D, Zganiacz A, Feng X, Yao XD, Rosenthal KL, Medina MF, Gauldie J, Ertl HC, Xing Z.

Mucosal Immunol. 2015 Nov;8(6):1373-87. doi: 10.1038/mi.2015.29. Epub 2015 Apr 15.


Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells.

Jeyanathan M, McCormick S, Lai R, Afkhami S, Shaler CR, Horvath CN, Damjanovic D, Zganiacz A, Barra N, Ashkar A, Jordana M, Aoki N, Xing Z.

Mucosal Immunol. 2014 May;7(3):670-83. doi: 10.1038/mi.2013.86. Epub 2013 Oct 30.


A human type 5 adenovirus-based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity.

Smaill F, Jeyanathan M, Smieja M, Medina MF, Thanthrige-Don N, Zganiacz A, Yin C, Heriazon A, Damjanovic D, Puri L, Hamid J, Xie F, Foley R, Bramson J, Gauldie J, Xing Z.

Sci Transl Med. 2013 Oct 2;5(205):205ra134. doi: 10.1126/scitranslmed.3006843.


Continuous and discontinuous cigarette smoke exposure differentially affects protective Th1 immunity against pulmonary tuberculosis.

Shaler CR, Horvath CN, McCormick S, Jeyanathan M, Khera A, Zganiacz A, Kasinska J, Stampfli MR, Xing Z.

PLoS One. 2013;8(3):e59185. doi: 10.1371/journal.pone.0059185. Epub 2013 Mar 19.


Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity.

Jeyanathan M, Damjanovic D, Shaler CR, Lai R, Wortzman M, Yin C, Zganiacz A, Lichty BD, Xing Z.

Mucosal Immunol. 2013 May;6(3):612-25. doi: 10.1038/mi.2012.103. Epub 2012 Nov 7.


Mechanisms of delayed anti-tuberculosis protection in the lung of parenteral BCG-vaccinated hosts: a critical role of airway luminal T cells.

Horvath CN, Shaler CR, Jeyanathan M, Zganiacz A, Xing Z.

Mucosal Immunol. 2012 Jul;5(4):420-31. doi: 10.1038/mi.2012.19. Epub 2012 Mar 28.


Negative regulation of lung inflammation and immunopathology by TNF-α during acute influenza infection.

Damjanovic D, Divangahi M, Kugathasan K, Small CL, Zganiacz A, Brown EG, Hogaboam CM, Gauldie J, Xing Z.

Am J Pathol. 2011 Dec;179(6):2963-76. doi: 10.1016/j.ajpath.2011.09.003. Epub 2011 Oct 14.


Respiratory mucosal immunization with adenovirus gene transfer vector induces helper CD4 T cell-independent protective immunity.

Mu J, Jeyanathan M, Shaler CR, Horvath C, Damjanovic D, Zganiacz A, Kugathasan K, McCormick S, Xing Z.

J Gene Med. 2010 Aug;12(8):693-704. doi: 10.1002/jgm.1487.


Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection.

Ngai P, McCormick S, Small C, Zhang X, Zganiacz A, Aoki N, Xing Z.

Infect Immun. 2007 May;75(5):2244-52. Epub 2007 Feb 16.


Mucosal luminal manipulation of T cell geography switches on protective efficacy by otherwise ineffective parenteral genetic immunization.

Santosuosso M, McCormick S, Roediger E, Zhang X, Zganiacz A, Lichty BD, Xing Z.

J Immunol. 2007 Feb 15;178(4):2387-95.


Intramuscular immunization with a monogenic plasmid DNA tuberculosis vaccine: Enhanced immunogenicity by electroporation and co-expression of GM-CSF transgene.

Zhang X, Divangahi M, Ngai P, Santosuosso M, Millar J, Zganiacz A, Wang J, Bramson J, Xing Z.

Vaccine. 2007 Jan 26;25(7):1342-52. Epub 2006 Oct 10.


Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis.

Wang J, Thorson L, Stokes RW, Santosuosso M, Huygen K, Zganiacz A, Hitt M, Xing Z.

J Immunol. 2004 Nov 15;173(10):6357-65.


Activation of CD8 T cells by mycobacterial vaccination protects against pulmonary tuberculosis in the absence of CD4 T cells.

Wang J, Santosuosso M, Ngai P, Zganiacz A, Xing Z.

J Immunol. 2004 Oct 1;173(7):4590-7.


TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection.

Zganiacz A, Santosuosso M, Wang J, Yang T, Chen L, Anzulovic M, Alexander S, Gicquel B, Wan Y, Bramson J, Inman M, Xing Z.

J Clin Invest. 2004 Feb;113(3):401-13.


Enhanced immunogenicity of BCG vaccine by using a viral-based GM-CSF transgene adjuvant formulation.

Wang J, Zganiacz A, Xing Z.

Vaccine. 2002 Jul 26;20(23-24):2887-98.


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