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32 results

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Page 1
ZFP281-BRCA2 prevents R-loop accumulation during DNA replication.
Wang Y, Ma B, Liu X, Gao G, Che Z, Fan M, Meng S, Zhao X, Sugimura R, Cao H, Zhou Z, Xie J, Lin C, Luo Z. Wang Y, et al. Nat Commun. 2022 Jun 17;13(1):3493. doi: 10.1038/s41467-022-31211-9. Nat Commun. 2022. PMID: 35715464 Free PMC article.
ZFP281 depletion reduces PCNA levels on chromatin and impairs DNA replication. Mechanistically, we demonstrate that ZFP281 can interact with BRCA2, and that BRCA2 is enriched at G/C-rich promoters and requires both ZFP281 and PRC2 for its proper recruitment t …
ZFP281 depletion reduces PCNA levels on chromatin and impairs DNA replication. Mechanistically, we demonstrate that ZFP281 can …
ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung.
Nobre AR, Dalla E, Yang J, Huang X, Wullkopf L, Risson E, Razghandi P, Anton ML, Zheng W, Seoane JA, Curtis C, Kenigsberg E, Wang J, Aguirre-Ghiso JA. Nobre AR, et al. Nat Cancer. 2022 Oct;3(10):1165-1180. doi: 10.1038/s43018-022-00424-8. Epub 2022 Sep 1. Nat Cancer. 2022. PMID: 36050483
Downregulation of ZFP281 leads to a loss of an invasive, M-like dormancy phenotype and a switch to lung metastatic outgrowth. We also show that FGF2 and TWIST1 induce ZFP281 expression to induce the M-like state, which is linked to CDH1 downregulation and upregulati …
Downregulation of ZFP281 leads to a loss of an invasive, M-like dormancy phenotype and a switch to lung metastatic outgrowth. We also …
Zfp281 and Zfp148 control CD4(+) T cell thymic development and T(H)2 functions.
Chopp LB, Zhu X, Gao Y, Nie J, Singh J, Kumar P, Young KZ, Patel S, Li C, Balmaceno-Criss M, Vacchio MS, Wang MM, Livak F, Merchant JL, Wang L, Kelly MC, Zhu J, Bosselut R. Chopp LB, et al. Sci Immunol. 2023 Nov 10;8(89):eadi9066. doi: 10.1126/sciimmunol.adi9066. Epub 2023 Nov 10. Sci Immunol. 2023. PMID: 37948511
We found that Zfp281 interacts with Gata3 and is recruited to Gata3 genomic binding sites at loci encoding Thpok and T(H)2 cytokines. Thus, Zfp148 and Zfp281 collaborate with Gata3 to promote CD4(+) T cell development and T(H)2 cell responses....
We found that Zfp281 interacts with Gata3 and is recruited to Gata3 genomic binding sites at loci encoding Thpok and T(H)2 cytokines. …
ZFP281 coordinates DNMT3 and TET1 for transcriptional and epigenetic control in pluripotent state transitions.
Huang X, Balmer S, Lyu C, Xiang Y, Malik V, Wang H, Zhang Y, Xie W, Hadjantonakis AK, Zhou H, Wang J. Huang X, et al. bioRxiv [Preprint]. 2023 Mar 25:2023.03.24.534143. doi: 10.1101/2023.03.24.534143. bioRxiv. 2023. PMID: 36993548 Free PMC article. Updated. Preprint.
However, the upstream regulators that coordinate these events are relatively underexplored. Here, using Zfp281 knockout mouse and degron knock-in cell models, we uncover the direct transcriptional activation of Dnmt3a/3b by ZFP281 in pluripotent stem cells. ...ZF …
However, the upstream regulators that coordinate these events are relatively underexplored. Here, using Zfp281 knockout mouse and deg …
ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation.
Luo Z, Liu X, Xie H, Wang Y, Lin C. Luo Z, et al. Mol Cell Biol. 2019 Nov 25;39(24):e00329-19. doi: 10.1128/MCB.00329-19. Print 2019 Dec 15. Mol Cell Biol. 2019. PMID: 31570506 Free PMC article.
At the genome scale, ZFP281 is broadly associated with MYC, and the depletion of ZFP281 significantly reduces the levels of MYC and RNA polymerase II at the ZFP281- and MYC-cobound genes. Specially, we found that recruitment is required for the regulation of …
At the genome scale, ZFP281 is broadly associated with MYC, and the depletion of ZFP281 significantly reduces the levels of MY …
ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation.
Nicolai S, Pieraccioli M, Smirnov A, Pitolli C, Anemona L, Mauriello A, Candi E, Annicchiarico-Petruzzelli M, Shi Y, Wang Y, Melino G, Raschellà G. Nicolai S, et al. Mol Oncol. 2020 Feb;14(2):294-308. doi: 10.1002/1878-0261.12605. Epub 2019 Dec 24. Mol Oncol. 2020. PMID: 31782884 Free PMC article.
Here, we demonstrate that the zinc finger transcription factor ZNF281/Zfp281 is down-regulated during epithelial, muscle, and granulocytic differentiation in vitro. ...Many of these miRs are involved in differentiation pathways of distinct cell lineages. Of interest, ZNF28 …
Here, we demonstrate that the zinc finger transcription factor ZNF281/Zfp281 is down-regulated during epithelial, muscle, and granulo …
Zfp281 Inhibits the Pluripotent-to-Totipotent State Transition in Mouse Embryonic Stem Cells.
Wen X, Lin Z, Wu H, Cao L, Fu X. Wen X, et al. Front Cell Dev Biol. 2022 May 20;10:879428. doi: 10.3389/fcell.2022.879428. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35669510 Free PMC article.
Zfp281 is a transcriptional factor involved in the cell-fate transition. ...Interestingly, we found that the inhibitory effect of Zfp281 on the 2C-like transition leads to an impaired 2C-like-transition ability in primed-state mESCs. ...
Zfp281 is a transcriptional factor involved in the cell-fate transition. ...Interestingly, we found that the inhibitory effect of …
Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development.
Ishiuchi T, Ohishi H, Sato T, Kamimura S, Yorino M, Abe S, Suzuki A, Wakayama T, Suyama M, Sasaki H. Ishiuchi T, et al. Cell Rep. 2019 May 7;27(6):1742-1754.e6. doi: 10.1016/j.celrep.2019.04.028. Cell Rep. 2019. PMID: 31067460 Free article.
Here, we conduct a forward genetic screen to identify regulators for extraembryonic development and identify Zfp281 as a key factor. Zfp281 overexpression in mouse embryonic stem cells facilitates the induction of trophoblast stem-like cells. Zfp281 is prefer …
Here, we conduct a forward genetic screen to identify regulators for extraembryonic development and identify Zfp281 as a key factor. …
ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.
Huang X, Balmer S, Lyu C, Xiang Y, Malik V, Wang H, Zhang Y, Cai B, Xie W, Hadjantonakis AK, Zhou H, Wang J. Huang X, et al. Dev Cell. 2024 Feb 26;59(4):465-481.e6. doi: 10.1016/j.devcel.2023.12.018. Epub 2024 Jan 17. Dev Cell. 2024. PMID: 38237590
However, the upstream regulators that coordinate these events are relatively underexplored. Here, using Zfp281 knockout mouse and degron knockin cell models, we identify the direct transcriptional activation of Dnmt3a/3b by ZFP281 in pluripotent stem cells. ...ZF …
However, the upstream regulators that coordinate these events are relatively underexplored. Here, using Zfp281 knockout mouse and deg …
32 results