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Items: 23


An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

Wang L, Leite de Oliveira R, Huijberts S, Bosdriesz E, Pencheva N, Brunen D, Bosma A, Song JY, Zevenhoven J, Los-de Vries GT, Horlings H, Nuijen B, Beijnen JH, Schellens JHM, Bernards R.

Cell. 2018 May 31;173(6):1413-1425.e14. doi: 10.1016/j.cell.2018.04.012. Epub 2018 May 10.


The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model.

Melis MHM, Nevedomskaya E, van Burgsteden J, Cioni B, van Zeeburg HJT, Song JY, Zevenhoven J, Hawinkels LJAC, de Visser KE, Bergman AM.

Oncotarget. 2017 Sep 28;8(55):93867-93877. doi: 10.18632/oncotarget.21305. eCollection 2017 Nov 7.


Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients.

Semenova EA, Kwon MC, Monkhorst K, Song JY, Bhaskaran R, Krijgsman O, Kuilman T, Peters D, Buikhuisen WA, Smit EF, Pritchard C, Cozijnsen M, van der Vliet J, Zevenhoven J, Lambooij JP, Proost N, van Montfort E, Velds A, Huijbers IJ, Berns A.

Cell Rep. 2016 Jul 19;16(3):631-43. doi: 10.1016/j.celrep.2016.06.020. Epub 2016 Jun 30.


Paracrine signaling between tumor subclones of mouse SCLC: a critical role of ETS transcription factor Pea3 in facilitating metastasis.

Kwon MC, Proost N, Song JY, Sutherland KD, Zevenhoven J, Berns A.

Genes Dev. 2015 Aug 1;29(15):1587-92. doi: 10.1101/gad.262998.115. Epub 2015 Jul 27.


Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.

Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X.

J Biol Chem. 2014 Sep 12;289(37):25783-96. doi: 10.1074/jbc.M114.577353. Epub 2014 Jul 29.


Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma.

Sutherland KD, Song JY, Kwon MC, Proost N, Zevenhoven J, Berns A.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4952-7. doi: 10.1073/pnas.1319963111. Epub 2014 Feb 28.


Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.

Desmet CJ, Gallenne T, Prieur A, Reyal F, Visser NL, Wittner BS, Smit MA, Geiger TR, Laoukili J, Iskit S, Rodenko B, Zwart W, Evers B, Horlings H, Ajouaou A, Zevenhoven J, van Vliet M, Ramaswamy S, Wessels LF, Peeper DS.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5139-44. doi: 10.1073/pnas.1222085110. Epub 2013 Mar 12.


GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.

Westerman BA, Blom M, Tanger E, van der Valk M, Song JY, van Santen M, Gadiot J, Cornelissen-Steijger P, Zevenhoven J, Prosser HM, Uren A, Aronica E, van Lohuizen M.

PLoS One. 2012;7(5):e35943. doi: 10.1371/journal.pone.0035943. Epub 2012 May 4.


Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

Nacerddine K, Beaudry JB, Ginjala V, Westerman B, Mattiroli F, Song JY, van der Poel H, Ponz OB, Pritchard C, Cornelissen-Steijger P, Zevenhoven J, Tanger E, Sixma TK, Ganesan S, van Lohuizen M.

J Clin Invest. 2012 May;122(5):1920-32. doi: 10.1172/JCI57477. Epub 2012 Apr 16.


Reverse genetics of SARS-related coronavirus using vaccinia virus-based recombination.

van den Worm SH, Eriksson KK, Zevenhoven JC, Weber F, Züst R, Kuri T, Dijkman R, Chang G, Siddell SG, Snijder EJ, Thiel V, Davidson AD.

PLoS One. 2012;7(3):e32857. doi: 10.1371/journal.pone.0032857. Epub 2012 Mar 7.


Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours.

Krimpenfort P, Song JY, Proost N, Zevenhoven J, Jonkers J, Berns A.

Nature. 2012 Feb 22;482(7386):538-41. doi: 10.1038/nature10790.


The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.

van der Velden YU, Wang L, Zevenhoven J, van Rooijen E, van Lohuizen M, Giles RH, Clevers H, Haramis AP.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4358-63. doi: 10.1073/pnas.1010210108. Epub 2011 Mar 1.


Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies.

de Vries NA, Bruggeman SW, Hulsman D, de Vries HI, Zevenhoven J, Buckle T, Hamans BC, Leenders WP, Beijnen JH, van Lohuizen M, Berns AJ, van Tellingen O.

Clin Cancer Res. 2010 Jul 1;16(13):3431-41. doi: 10.1158/1078-0432.CCR-09-3414. Epub 2010 May 14.


Pim1 regulates androgen-dependent survival signaling in prostate cancer cells.

van der Poel HG, Zevenhoven J, Bergman AM.

Urol Int. 2010;84(2):212-20. doi: 10.1159/000277601. Epub 2010 Mar 4.


High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.

Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, Zander SA, Derksen PW, de Bruin M, Zevenhoven J, Lau A, Boulter R, Cranston A, O'Connor MJ, Martin NM, Borst P, Jonkers J.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17079-84. doi: 10.1073/pnas.0806092105. Epub 2008 Oct 29.


A conditional mouse model for malignant mesothelioma.

Jongsma J, van Montfort E, Vooijs M, Zevenhoven J, Krimpenfort P, van der Valk M, van de Vijver M, Berns A.

Cancer Cell. 2008 Mar;13(3):261-71. doi: 10.1016/j.ccr.2008.01.030.


Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.

Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J, van Tellingen O, van Lohuizen M.

Cancer Cell. 2007 Oct;12(4):328-41.


p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a.

Krimpenfort P, Ijpenberg A, Song JY, van der Valk M, Nawijn M, Zevenhoven J, Berns A.

Nature. 2007 Aug 23;448(7156):943-6.


Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.

Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers J.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6. Epub 2007 Jul 11.


Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff RD, Berns A, Jonkers J.

Cancer Cell. 2006 Nov;10(5):437-49.


Frat is dispensable for canonical Wnt signaling in mammals.

van Amerongen R, Nawijn M, Franca-Koh J, Zevenhoven J, van der Gulden H, Jonkers J, Berns A.

Genes Dev. 2005 Feb 15;19(4):425-30. Epub 2005 Jan 28.


Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB.

Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E, Peeper DS.

Nature. 2004 Aug 26;430(7003):1034-9.


Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model.

Meuwissen R, Linn SC, Linnoila RI, Zevenhoven J, Mooi WJ, Berns A.

Cancer Cell. 2003 Sep;4(3):181-9.

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