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Items: 1 to 50 of 964

1.

Hepatitis C therapy with direct antiviral agents in patients with advanced chronic kidney disease: real-world experience of the German Hepatitis C-Registry (Deutsches Hepatitis C-Register).

Wiegand J, Buggisch P, Mauss S, Boeker KHW, Klinker H, Müller T, Günther R, Serfert Y, Manns MP, Zeuzem S, Berg T, Hinrichsen H, C-Registry GH.

Eur J Gastroenterol Hepatol. 2019 Nov;31(11):1424-1431. doi: 10.1097/MEG.0000000000001426.

PMID:
31589184
2.

Three years of progress towards achieving hepatitis C elimination in the country of Georgia, April 2015 - March 2018.

Tsertsvadze T, Gamkrelidze A, Chkhartishvili N, Abutidze A, Sharvadze L, Kerashvili V, Butsashvili M, Metreveli D, Gvinjilia L, Shadaker S, Nasrullah M, Adamia E, Zeuzem S, Afdhal N, Arora S, Thornton K, Skaggs B, Kuchuloria T, Lagvilava M, Sergeenko D, Averhoff F.

Clin Infect Dis. 2019 Sep 29. pii: ciz956. doi: 10.1093/cid/ciz956. [Epub ahead of print]

PMID:
31563938
3.

Efficacy of Direct-acting Antivirals for Chronic Hepatitis C Virus Infection in People Who Inject Drugs or Receive Opioid Substitution Therapy: A Systematic Review and Meta-analysis.

Graf C, Mücke MM, Dultz G, Peiffer KH, Kubesch A, Ingiliz P, Zeuzem S, Herrmann E, Vermehren J.

Clin Infect Dis. 2019 Sep 12. pii: ciz696. doi: 10.1093/cid/ciz696. [Epub ahead of print]

PMID:
31513710
4.

Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes.

Chaturvedi N, Svarovskaia ES, Mo H, Osinusi AO, Brainard DM, Subramanian GM, McHutchison JG, Zeuzem S, Fellay J.

Elife. 2019 Sep 3;8. pii: e42542. doi: 10.7554/eLife.42542.

5.

Fast Interpretation of Thromboelastometry and Aggregometry in Patients Suffering from Chronic Liver Disease.

Stegewerth K, Weber CF, Moehlmann M, Adam EH, Zacharowski K, Zeuzem S, Weiler N.

Clin Lab. 2019 Aug 1;65(8). doi: 10.7754/Clin.Lab.2019.190505.

PMID:
31414765
6.

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS.

Queck A, Carnevale R, Uschner FE, Schierwagen R, Klein S, Jansen C, Meyer C, Praktiknjo M, Thomas D, Strassburg C, Zeuzem S, Violi F, Trebicka J.

Gut. 2019 Jul 3. pii: gutjnl-2019-319044. doi: 10.1136/gutjnl-2019-319044. [Epub ahead of print] No abstract available.

7.

Baseline risk factors determine lack of biochemical response after SVR in chronic hepatitis C patients treated with DAAs.

Tacke F, Boeker KHW, Klinker H, Heyne R, Buggisch P, Pathil A, Wiegand J, Cornberg M, Lange C, Berg T, Zeuzem S, Mauss S.

Liver Int. 2019 Jun 26. doi: 10.1111/liv.14186. [Epub ahead of print]

PMID:
31241820
8.

Quinolone- and multidrug-resistance predict failure of antibiotic prophylaxis of spontaneous bacterial peritonitis.

Mücke MM, Mayer A, Kessel J, Mücke VT, Bon D, Schwarzkopf K, Rüschenbaum S, Queck A, Göttig S, Vermehren A, Weiler N, Welker MW, Reinheimer C, Hogardt M, Vermehren J, Herrmann E, Kempf VAJ, Zeuzem S, Lange CM.

Clin Infect Dis. 2019 Jun 20. pii: ciz540. doi: 10.1093/cid/ciz540. [Epub ahead of print]

PMID:
31228250
9.

Capnography monitoring of non-anesthesiologist provided sedation during percutaneous endoscopic gastrostomy placement: A prospective, controlled, randomized trial.

Peveling-Oberhag J, Michael F, Tal A, Welsch C, Vermehren J, Farnik H, Grammatikos G, Lange C, Walter D, Blumenstein I, Filmann N, Herrmann E, Albert J, Zeuzem S, Bojunga J, Friedrich-Rust M.

J Gastroenterol Hepatol. 2019 Jun 20. doi: 10.1111/jgh.14760. [Epub ahead of print]

PMID:
31222832
10.

Establishing an indwelling peritoneal catheter as a standard procedure for hospitalized patients with ascites: Retrospective data on feasibility, effectiveness and safety.

Stratmann K, Fitting D, Zeuzem S, Bojunga J, Trebicka J, Friedrich-Rust M, Dultz G.

United European Gastroenterol J. 2019 Jun;7(5):673-681. doi: 10.1177/2050640619842442. Epub 2019 Apr 3.

11.

Serum sphingolipids predict de novo hepatocellular carcinoma in hepatitis C cirrhotic patients with sustained virologic response.

Mücke VT, Thomas D, Mücke MM, Waidmann O, Zeuzem S, Sarrazin C, Pfeilschifter J, Vermehren J, Finkelmeier F, Grammatikos G.

Liver Int. 2019 Jun 17. doi: 10.1111/liv.14178. [Epub ahead of print]

PMID:
31207039
12.

miRNA-26b downregulation in peripheral blood mononuclear cells of patients with hepatitis C associated lymphomas is restored by successful interferon-free antiviral therapy.

Peveling-Oberhag J, Bankov K, Dultz G, Ballo O, Lohmeyer J, Brunnberg U, Marcu V, Walter D, Zeuzem S, Hansmann ML, Welzel TM, Vermehren J.

Antivir Ther. 2019 Jun 10. doi: 10.3851/IMP3322. [Epub ahead of print]

PMID:
31180334
13.

Poor Prognosis of Advanced Cholangiocarcinoma: Real-World Data from a Tertiary Referral Center.

Koch C, Franzke C, Bechstein WO, Schnitzbauer AA, Filmann N, Vogl T, Gruber-Rouh T, Zeuzem S, Waidmann O, Trojan J.

Digestion. 2019 May 24:1-8. doi: 10.1159/000500894. [Epub ahead of print]

PMID:
31129660
14.

Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants.

Doncheva NT, Domingues FS, McGivern DR, Shimakami T, Zeuzem S, Lengauer T, Lange CM, Albrecht M, Welsch C.

J Mol Biol. 2019 May 31;431(12):2354-2368. doi: 10.1016/j.jmb.2019.04.034. Epub 2019 Apr 30.

PMID:
31051172
15.

Performance of Three Common Hepatitis C Virus (HCV) Genotyping Assays for Identification of HCV Genotype 2/1 Chimeras.

Peiffer KH, Kuhnhenn L, Stelzl E, Dietz J, Susser S, Tal AO, Finkelmeier F, Zuckerman E, Cornberg M, Barak M, Piazzolla V, Mangia A, Zeuzem S, Kessler HH, Vermehren J, Sarrazin C.

J Clin Microbiol. 2019 Jun 25;57(7). pii: e00060-19. doi: 10.1128/JCM.00060-19. Print 2019 Jul.

PMID:
31043467
16.

Efficacy and safety of direct-acting antivirals for hepatitis C in the elderly: A systematic review and meta-analysis.

Mücke MM, Herrmann E, Mücke VT, Graf C, Zeuzem S, Vermehren J.

Liver Int. 2019 Sep;39(9):1652-1660. doi: 10.1111/liv.14126. Epub 2019 May 15.

PMID:
31033122
17.

Optimisation of the use of APRI and FIB-4 to rule out cirrhosis in patients with chronic hepatitis B: results from the SONIC-B study.

Sonneveld MJ, Brouwer WP, Chan HL, Piratvisuth T, Jia JD, Zeuzem S, Liaw YF, Hansen BE, Choi H, Wat C, Pavlovic V, Gaggar A, Xie Q, Buti M, de Knegt RJ, Janssen HLA.

Lancet Gastroenterol Hepatol. 2019 Jul;4(7):538-544. doi: 10.1016/S2468-1253(19)30087-1. Epub 2019 Apr 9.

PMID:
30975477
18.

Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.

Knop V, Neuberger SC, Marienfeld S, Bojunga J, Herrmann E, Poynard T, Zeuzem S, Blumenstein I, Friedrich-Rust M.

Nutrition. 2019 Jul - Aug;63-64:134-140. doi: 10.1016/j.nut.2019.02.001. Epub 2019 Feb 13.

PMID:
30959382
19.

Not Achieving Sustained Viral Eradication of Hepatitis C Virus After Treatment Leads to Worsening of Patient-Reported Outcomes.

Younossi ZM, Stepanova M, Jacobson I, Muir AJ, Pol S, Zeuzem S, Younes Z, Herring R, Lawitz E, Younossi I, Racila A.

Clin Infect Dis. 2019 Apr 5. pii: ciz243. doi: 10.1093/cid/ciz243. [Epub ahead of print]

PMID:
30949674
20.

Identification of 19 Novel Hepatitis C Virus Subtypes-Further Expanding HCV Classification.

Hedskog C, Parhy B, Chang S, Zeuzem S, Moreno C, Shafran SD, Borgia SM, Asselah T, Alric L, Abergel A, Chen JJ, Collier J, Kapoor D, Hyland RH, Simmonds P, Mo H, Svarovskaia ES.

Open Forum Infect Dis. 2019 Feb 22;6(3):ofz076. doi: 10.1093/ofid/ofz076. eCollection 2019 Mar.

21.

Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis.

Trebicka J, Amoros A, Pitarch C, Titos E, Alcaraz-Quiles J, Schierwagen R, Deulofeu C, Fernandez-Gomez J, Piano S, Caraceni P, Oettl K, Sola E, Laleman W, McNaughtan J, Mookerjee RP, Coenraad MJ, Welzel T, Steib C, Garcia R, Gustot T, Rodriguez Gandia MA, Bañares R, Albillos A, Zeuzem S, Vargas V, Saliba F, Nevens F, Alessandria C, de Gottardi A, Zoller H, Ginès P, Sauerbruch T, Gerbes A, Stauber RE, Bernardi M, Angeli P, Pavesi M, Moreau R, Clària J, Jalan R, Arroyo V.

Front Immunol. 2019 Mar 19;10:476. doi: 10.3389/fimmu.2019.00476. eCollection 2019.

22.

IL-22 and IL-22-Binding Protein Are Associated With Development of and Mortality From Acute-on-Chronic Liver Failure.

Schwarzkopf K, Rüschenbaum S, Barat S, Cai C, Mücke MM, Fitting D, Weigert A, Brüne B, Zeuzem S, Welsch C, Lange CM.

Hepatol Commun. 2019 Jan 17;3(3):392-405. doi: 10.1002/hep4.1303. eCollection 2019 Mar.

23.

Downregulation of SPTAN1 is related to MLH1 deficiency and metastasis in colorectal cancer.

Ackermann A, Schrecker C, Bon D, Friedrichs N, Bankov K, Wild P, Plotz G, Zeuzem S, Herrmann E, Hansmann ML, Brieger A.

PLoS One. 2019 Mar 11;14(3):e0213411. doi: 10.1371/journal.pone.0213411. eCollection 2019.

24.

Peginterferon alfa-2a plus tenofovir disoproxil fumarate for hepatitis D (HIDIT-II): a randomised, placebo controlled, phase 2 trial.

Wedemeyer H, Yurdaydin C, Hardtke S, Caruntu FA, Curescu MG, Yalcin K, Akarca US, Gürel S, Zeuzem S, Erhardt A, Lüth S, Papatheodoridis GV, Keskin O, Port K, Radu M, Celen MK, Idilman R, Weber K, Stift J, Wittkop U, Heidrich B, Mederacke I, von der Leyen H, Dienes HP, Cornberg M, Koch A, Manns MP; HIDIT-II study team.

Lancet Infect Dis. 2019 Mar;19(3):275-286. doi: 10.1016/S1473-3099(18)30663-7.

PMID:
30833068
25.

Human colon organoids reveal distinct physiologic and oncogenic Wnt responses.

Michels BE, Mosa MH, Grebbin BM, Yepes D, Darvishi T, Hausmann J, Urlaub H, Zeuzem S, Kvasnicka HM, Oellerich T, Farin HF.

J Exp Med. 2019 Mar 4;216(3):704-720. doi: 10.1084/jem.20180823. Epub 2019 Feb 21.

26.

Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation.

Schwarzkopf KM, Queck A, Thomas D, Angioni C, Cai C, Freygang Y, Rüschenbaum S, Geisslinger G, Zeuzem S, Welsch C, Lange CM.

PLoS One. 2019 Jan 31;14(1):e0211537. doi: 10.1371/journal.pone.0211537. eCollection 2019.

27.

JNJ-4178 (AL-335, Odalasvir, and Simeprevir) for 6 or 8 Weeks in Hepatitis C Virus-Infected Patients Without Cirrhosis: OMEGA-1.

Zeuzem S, Bourgeois S, Greenbloom S, Buti M, Aghemo A, Lampertico P, Janczewska E, Lim SG, Moreno C, Buggisch P, Tam E, Corbett C, Willems W, Vijgen L, Fevery B, Ouwerkerk-Mahadevan S, Ackaert O, Beumont M, Kalmeijer R, Sinha R, Biermer M; OMEGA-1 study team.

Hepatology. 2019 Jun;69(6):2349-2363. doi: 10.1002/hep.30527. Epub 2019 Mar 14.

PMID:
30693573
28.

Feasibility and reproducibility of liver and pancreatic stiffness in patients with alcohol-related liver disease.

Conti CB, Weiler N, Casazza G, Schrecker C, Schneider M, Mücke MM, Queck A, Herrmann E, Conte D, Colombo M, Zeuzem S, Fraquelli M, Friedrich-Rust M.

Dig Liver Dis. 2019 Jul;51(7):1023-1029. doi: 10.1016/j.dld.2018.12.017. Epub 2019 Jan 3.

PMID:
30658941
29.

Analysis of MUTYH alternative transcript expression, promoter function, and the effect of human genetic variants.

Köger N, Brieger A, Hinrichsen IM, Zeuzem S, Plotz G.

Hum Mutat. 2019 Apr;40(4):472-482. doi: 10.1002/humu.23709. Epub 2019 Jan 24.

PMID:
30653782
30.

Absence of HBV Reactivation in Patients With Resolved HBV Infection Following DAA Therapy for Hepatitis C: A 1-Year Follow-up Study.

Mücke MM, Mücke VT, Peiffer KH, Sarrazin C, Zeuzem S, Berger A, Vermehren J.

Open Forum Infect Dis. 2018 Dec 15;6(1):ofy340. doi: 10.1093/ofid/ofy340. eCollection 2019 Jan.

31.

[4 years of direct-acting antivirals (DAAs) in the German Hepatitis C-Registry (DHC-R)].

Hüppe D, Serfert Y, Buggisch P, Mauss S, Böker KHW, Müller T, Klinker H, Günther R, Berg T, Cornberg M, Niederau C, Sarrazin C, Simon KG, Zeuzem S, Manns MP, Wedemeyer H.

Z Gastroenterol. 2019 Jan;57(1):27-36. doi: 10.1055/a-0821-7188. Epub 2019 Jan 14. German.

PMID:
30641600
32.

Use of prothrombin complex concentrates in patients with decompensated liver cirrhosis is associated with thromboembolic events.

Tischendorf M, Fuchs A, Zeuzem S, Lange CM.

J Hepatol. 2019 Apr;70(4):800-801. doi: 10.1016/j.jhep.2018.11.019. Epub 2019 Jan 7. No abstract available.

PMID:
30630599
33.

Use of Antiplatelet Agents Is Inversely Associated With Liver Fibrosis in Patients With Cardiovascular Disease.

Schwarzkopf K, Bojunga J, Rüschenbaum S, Martinez Y, Mücke MM, Seeger F, Schoelzel F, Zeuzem S, Friedrich-Rust M, Lange CM.

Hepatol Commun. 2018 Oct 5;2(12):1601-1609. doi: 10.1002/hep4.1254. eCollection 2018 Dec.

34.

Glycogen Synthase Kinase 3β Enhances Hepatitis C Virus Replication by Supporting miR-122.

Saleh M, Rüschenbaum S, Welsch C, Zeuzem S, Moradpour D, Gouttenoire J, Lange CM.

Front Microbiol. 2018 Nov 27;9:2949. doi: 10.3389/fmicb.2018.02949. eCollection 2018.

35.

[Treatment of Hepatitis C: State of the Art 2018].

Zeuzem S.

Dtsch Med Wochenschr. 2018 Dec;143(24):1784-1788. doi: 10.1055/a-0591-5916. Epub 2018 Dec 3. German.

PMID:
30508860
36.

Prolonged retention of prophylactic pancreatic stents is not associated with increased complications.

Dultz G, Gerber L, Zeuzem S, Bojunga J, Friedrich-Rust M.

Pancreatology. 2019 Jan;19(1):39-43. doi: 10.1016/j.pan.2018.11.011. Epub 2018 Nov 22.

PMID:
30502123
37.

Noninvasive screening identifies patients at risk for spontaneous bacterial peritonitis caused by multidrug-resistant organisms.

Ferstl PG, Müller M, Filmann N, Hogardt M, Kempf VA, Wichelhaus TA, Lange CM, Vermehren J, Zeuzem S, Reinheimer C, Waidmann O.

Infect Drug Resist. 2018 Nov 2;11:2047-2061. doi: 10.2147/IDR.S172587. eCollection 2018.

38.

Serum sphingolipid levels associate with upcoming virologic events and HBV genotype D in a cohort of patients with HBeAg-negative HBV infection.

Mücke VT, Jakobi K, Knop V, Thomas D, Mücke MM, Peiffer KH, Zeuzem S, Sarrazin C, Pfeilschifter J, Grammatikos G.

PLoS One. 2018 Nov 15;13(11):e0207293. doi: 10.1371/journal.pone.0207293. eCollection 2018.

39.

Vitamin D deficiency is associated with hepatic decompensation and inflammation in patients with liver cirrhosis: A prospective cohort study.

Kubesch A, Quenstedt L, Saleh M, Rüschenbaum S, Schwarzkopf K, Martinez Y, Welsch C, Zeuzem S, Welzel TM, Lange CM.

PLoS One. 2018 Nov 8;13(11):e0207162. doi: 10.1371/journal.pone.0207162. eCollection 2018.

40.

Liver Transplantation in Acute-on-Chronic Liver Failure: Considerations for a Systematic Approach to Decision Making.

Heise M, Weiler N, Iken S, Welker MW, Zeuzem S, Bechstein WO, Schnitzbauer AA.

Visc Med. 2018 Aug;34(4):291-294. doi: 10.1159/000492137. Epub 2018 Aug 10. Review.

41.

Acute-on-Chronic Liver Failure.

Bechstein WO, Zeuzem S.

Visc Med. 2018 Aug;34(4):243-244. doi: 10.1159/000492588. Epub 2018 Aug 17. No abstract available.

42.

Individual invitation letters lead to significant increase in attendance for screening colonoscopies: Results of a pilot study in Northern Hesse, Germany.

Stratmann K, Bock H, Filmann N, Fister P, Weber C, Tacke W, Simonis B, Höftmann M, Schröder O, Hausmann J, Zeuzem S, Blumenstein I.

United European Gastroenterol J. 2018 Aug;6(7):1082-1088. doi: 10.1177/2050640618769713. Epub 2018 Apr 16.

43.

Cholangiocarcinoma in Germany: Epidemiologic trends and impact of misclassification.

Walter D, Ferstl P, Waidmann O, Trojan J, Hartmann S, Schnitzbauer AA, Zeuzem S, Kraywinkel K.

Liver Int. 2019 Feb;39(2):316-323. doi: 10.1111/liv.13954. Epub 2018 Oct 8.

PMID:
30176117
44.

DNA mismatch repair activity of MutLα is regulated by CK2-dependent phosphorylation of MLH1 (S477).

Weßbecher IM, Hinrichsen I, Funke S, Oellerich T, Plotz G, Zeuzem S, Grus FH, Biondi RM, Brieger A.

Mol Carcinog. 2018 Dec;57(12):1723-1734. doi: 10.1002/mc.22892. Epub 2018 Sep 5.

PMID:
30136313
45.

Anti-EGF Receptor-Based Conversion Chemotherapy in RAS Wild-Type Colorectal Cancer Patients: Impact on Survival and Resection Rates.

Koch C, Schmidt N, Winkelmann R, Eichler K, Pession U, Bechstein WO, Zeuzem S, Waidmann O, Trojan J.

Digestion. 2018;98(4):263-269. doi: 10.1159/000490888. Epub 2018 Aug 21.

PMID:
30130797
46.

No impact of resistance-associated substitutions on the efficacy of sofosbuvir, velpatasvir, and voxilaprevir for 12 weeks in HCV DAA-experienced patients.

Sarrazin C, Cooper CL, Manns MP, Reddy KR, Kowdley KV, Roberts SK, Dvory-Sobol H, Svarovskia E, Martin R, Camus G, Doehle BP, Stamm LM, Hyland RH, Brainard DM, Mo H, Gordon SC, Bourliere M, Zeuzem S, Flamm SL.

J Hepatol. 2018 Dec;69(6):1221-1230. doi: 10.1016/j.jhep.2018.07.023. Epub 2018 Aug 9.

PMID:
30098373
47.

Impact of direct-acting antiviral therapy on the need for liver transplantation related to hepatitis C in Germany.

Herzer K, Gerken G, Kroy D, Tacke F, Plewe J, Eurich D, Spengler U, Strassburg CP, Welker MW, Pischke S, Sterneck M, Mehrabi A, Weiss KH, Herber A, Berg T, Zimmermann T, Galle PR, Heinzow H, Schmidt H, Markova A, Serfert Y, Manns MP, Zeuzem S, Wedemeyer H.

J Hepatol. 2018 Oct;69(4):982-984. doi: 10.1016/j.jhep.2018.07.001. Epub 2018 Aug 6. No abstract available.

PMID:
30089577
48.

Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry.

Dultz G, Müller T, Petersen J, Mauss S, Zimmermann T, Muche M, Simon KG, Berg T, Zeuzem S, Hüppe D, Böker K, Wedemeyer H, Welzel TM; Leberstiftungs-GmbH Deutschland.

Drugs Aging. 2018 Sep;35(9):843-857. doi: 10.1007/s40266-018-0572-0.

PMID:
30084012
49.

The portal vein as a distinct immunological compartment - A comprehensive immune phenotyping study.

Queck A, Rueschenbaum S, Kubesch A, Cai C, Zeuzem S, Weigert A, Brüne B, Nour-Eldin NA, Gruber-Rouh T, Vogl T, Lange CM.

Hum Immunol. 2018 Oct;79(10):716-723. doi: 10.1016/j.humimm.2018.07.233. Epub 2018 Jul 30.

PMID:
30071249
50.

Risk factors for early and late procedure-related adverse events in percutaneous endoscopic gastrostomy: A single center, retrospective study.

Peveling-Oberhag J, Osman I, Walter D, Filmann N, Stratmann K, Hausmann J, Knop V, Waidmann O, Vermehren J, Herrmann E, Zeuzem S, Friedrich-Rust M, Blumenstein I, Albert JG.

J Gastroenterol Hepatol. 2019 Feb;34(2):404-409. doi: 10.1111/jgh.14407. Epub 2018 Aug 23. No abstract available.

PMID:
30070394

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