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Items: 1 to 50 of 1124

1.

Detection of early-stage Alzheimer's pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients.

DeMarshall C, Oh E, Kheirkhah R, Sieber F, Zetterberg H, Blennow K, Nagele RG.

PLoS One. 2019 Nov 15;14(11):e0225178. doi: 10.1371/journal.pone.0225178. eCollection 2019.

PMID:
31730624
2.

Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease.

Palmqvist S, Insel PS, Stomrud E, Janelidze S, Zetterberg H, Brix B, Eichenlaub U, Dage JL, Chai X, Blennow K, Mattsson N, Hansson O.

EMBO Mol Med. 2019 Nov 11:e11170. doi: 10.15252/emmm.201911170. [Epub ahead of print]

3.

Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition.

Osborn KE, Khan OA, Kresge HA, Bown CW, Liu D, Moore EE, Gifford KA, Acosta LMY, Bell SP, Hohman TJ, Blennow K, Zetterberg H, Jefferson AL.

Alzheimers Dement (Amst). 2019 Oct 22;11:700-709. doi: 10.1016/j.dadm.2019.08.008. eCollection 2019 Dec.

4.

Fluid biomarker-based molecular phenotyping of Alzheimer's disease patients in research and clinical settings.

Blennow K, Zetterberg H.

Prog Mol Biol Transl Sci. 2019;168:3-23. doi: 10.1016/bs.pmbts.2019.07.006. Epub 2019 Jul 24.

PMID:
31699324
5.

Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.

Arboleda-Velasquez JF, Lopera F, O'Hare M, Delgado-Tirado S, Marino C, Chmielewska N, Saez-Torres KL, Amarnani D, Schultz AP, Sperling RA, Leyton-Cifuentes D, Chen K, Baena A, Aguillon D, Rios-Romenets S, Giraldo M, Guzmán-Vélez E, Norton DJ, Pardilla-Delgado E, Artola A, Sanchez JS, Acosta-Uribe J, Lalli M, Kosik KS, Huentelman MJ, Zetterberg H, Blennow K, Reiman RA, Luo J, Chen Y, Thiyyagura P, Su Y, Jun GR, Naymik M, Gai X, Bootwalla M, Ji J, Shen L, Miller JB, Kim LA, Tariot PN, Johnson KA, Reiman EM, Quiroz YT.

Nat Med. 2019 Nov;25(11):1680-1683. doi: 10.1038/s41591-019-0611-3. Epub 2019 Nov 4.

PMID:
31686034
6.

Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals.

Benedet AL, Ashton NJ, Pascoal TA, Leuzy A, Mathotaarachchi S, Kang MS, Therriault J, Savard M, Chamoun M, Schöll M, Zimmer ER, Gauthier S, Labbe A, Zetterberg H, Blennow K, Neto PR.

Alzheimers Dement (Amst). 2019 Sep 27;11:679-689. doi: 10.1016/j.dadm.2019.08.002. eCollection 2019 Dec.

7.

Measuring longitudinal cognition: Individual tests versus composites.

Jonaitis EM, Koscik RL, Clark LR, Ma Y, Betthauser TJ, Berman SE, Allison SL, Mueller KD, Hermann BP, Van Hulle CA, Christian BT, Bendlin BB, Blennow K, Zetterberg H, Carlsson CM, Asthana S, Johnson SC.

Alzheimers Dement (Amst). 2019 Jan 11;11:74-84. doi: 10.1016/j.dadm.2018.11.006. eCollection 2019 Dec.

8.

Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration.

Höglund K, Schussler N, Kvartsberg H, Smailovic U, Brinkmalm G, Liman V, Becker B, Zetterberg H, Cedazo-Minguez A, Janelidze S, Lefevre IA, Eyquem S, Hansson O, Blennow K.

Neurobiol Dis. 2019 Oct 25;134:104645. doi: 10.1016/j.nbd.2019.104645. [Epub ahead of print]

9.

Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias.

Antonell A, Tort-Merino A, Ríos J, Balasa M, Borrego-Écija S, Auge JM, Muñoz-García C, Bosch B, Falgàs N, Rami L, Ramos-Campoy O, Blennow K, Zetterberg H, Molinuevo JL, Lladó A, Sánchez-Valle R.

Alzheimers Dement. 2019 Oct 24. pii: S1552-5260(19)35369-5. doi: 10.1016/j.jalz.2019.09.001. [Epub ahead of print]

PMID:
31668967
10.

Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin.

Mielke MM, Syrjanen JA, Blennow K, Zetterberg H, Skoog I, Vemuri P, Machulda MM, Graff-Radford J, Knopman DS, Jack CR Jr, Petersen RC, Kern S.

Alzheimers Dement. 2019 Oct 23. pii: S1552-5260(19)35132-5. doi: 10.1016/j.jalz.2019.07.009. [Epub ahead of print]

PMID:
31668594
11.

Serum Neurofilament Light, Glial Fibrillary Acidic Protein and Tau Are Possible Serum Biomarkers for Activity of Brain Metastases and Gliomas.

Hepner A, Porter J, Hare F, Nasir SS, Zetterberg H, Blennow K, Martin MG.

World J Oncol. 2019 Oct;10(4-5):169-175. doi: 10.14740/wjon1228. Epub 2019 Sep 20.

12.

Plasma neurofilament light in progressive multiple sclerosis.

Zetterberg H.

Acta Neurol Scand. 2019 Oct 16. doi: 10.1111/ane.13184. [Epub ahead of print]

PMID:
31618445
13.

Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer's disease.

Michno W, Wehrli P, Meier SR, Sehlin D, Syvänen S, Zetterberg H, Blennow K, Hanrieder J.

J Neurochem. 2019 Oct 12. doi: 10.1111/jnc.14888. [Epub ahead of print]

PMID:
31605538
14.

Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid.

Frankel R, Törnquist M, Meisl G, Hansson O, Andreasson U, Zetterberg H, Blennow K, Frohm B, Cedervall T, Knowles TPJ, Leiding T, Linse S.

Commun Biol. 2019 Oct 8;2:365. doi: 10.1038/s42003-019-0612-2. eCollection 2019.

15.

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease.

Chatterjee P, Zetterberg H, Goozee K, Lim CK, Jacobs KR, Ashton NJ, Hye A, Pedrini S, Sohrabi HR, Shah T, Asih PR, Dave P, Shen K, Taddei K, Lovejoy DB, Guillemin GJ, Blennow K, Martins RN.

J Neuroinflammation. 2019 Oct 10;16(1):186. doi: 10.1186/s12974-019-1567-4.

16.

Cerebrospinal Fluid Changes in the Renin-Angiotensin System in Alzheimer's Disease.

Kehoe PG, Al Mulhim N, Zetterberg H, Blennow K, Miners JS.

J Alzheimers Dis. 2019 Oct 3. doi: 10.3233/JAD-190721. [Epub ahead of print]

PMID:
31594235
17.

Biomarker-guided clustering of Alzheimer's disease clinical syndromes.

Toschi N, Lista S, Baldacci F, Cavedo E, Zetterberg H, Blennow K, Kilimann I, Teipel SJ, Melo Dos Santos A, Epelbaum S, Lamari F, Genthon R, Habert MO, Dubois B, Floris R, Garaci F, Vergallo A, Hampel H; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI).

Neurobiol Aging. 2019 Nov;83:42-53. doi: 10.1016/j.neurobiolaging.2019.08.032. Epub 2019 Sep 10.

18.

Plasma neurofilament light chain concentration is increased and correlates with the severity of neuropathy in hereditary transthyretin amyloidosis.

Kapoor M, Foiani M, Heslegrave A, Zetterberg H, Lunn MP, Malaspina A, Gillmore JD, Rossor AM, Reilly MM.

J Peripher Nerv Syst. 2019 Oct 3. doi: 10.1111/jns.12350. [Epub ahead of print]

PMID:
31583784
19.

Plasma pNfH levels differentiate SBMA from ALS.

Lombardi V, Bombaci A, Zampedri L, Lu CH, Malik B, Zetterberg H, Heslegrave AJ, Rinaldi C, Greensmith L, Hanna MG, Malaspina A, Fratta P.

J Neurol Neurosurg Psychiatry. 2019 Oct 1. pii: jnnp-2019-320624. doi: 10.1136/jnnp-2019-320624. [Epub ahead of print] No abstract available.

PMID:
31575607
20.

Switching from a regimen containing abacavir/lamivudine or emtricitabine/tenofovir disoproxil fumarate to emtricitabine/tenofovir alafenamide fumarate does not affect central nervous system HIV-1 infection.

Yilmaz A, Mellgren Å, Fuchs D, Nilsson S, Blennow K, Zetterberg H, Gisslén M.

Infect Dis (Lond). 2019 Nov - Dec;51(11-12):838-846. doi: 10.1080/23744235.2019.1670352. Epub 2019 Sep 26.

PMID:
31556765
21.

A case series on the value of tau and neurofilament protein levels to predict and detect delirium in cardiac surgery patients.

Saller T, Petzold A, Zetterberg H, Kuhle J, Chappell D, von Dossow V, Klawitter F, Schurholz T, Hagl C, Reuter DA, Zwissler B, Ehler J.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019 Sep;163(3):241-246. doi: 10.5507/bp.2019.043. Epub 2019 Sep 16.

22.

Chemometric Strategies for Sensitive Annotation and Validation of Anatomical Regions of Interest in Complex Imaging Mass Spectrometry Data.

Wehrli PM, Michno W, Blennow K, Zetterberg H, Hanrieder J.

J Am Soc Mass Spectrom. 2019 Nov;30(11):2278-2288. doi: 10.1007/s13361-019-02327-y. Epub 2019 Sep 16.

PMID:
31529404
23.

Acute symptomatic seizures and epilepsy after mechanical thrombectomy.

Eriksson H, Löwhagen Hendén P, Rentzos A, Pujol-Calderón F, Karlsson JE, Höglund K, Blennow K, Zetterberg H, Rosengren L, Zelano J.

Epilepsy Behav. 2019 Sep 13:106520. doi: 10.1016/j.yebeh.2019.106520. [Epub ahead of print]

PMID:
31526644
24.

CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology.

Miners JS, Kehoe PG, Love S, Zetterberg H, Blennow K.

Alzheimers Res Ther. 2019 Sep 14;11(1):81. doi: 10.1186/s13195-019-0534-8.

25.

Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer's and Parkinson's disease.

Sjödin S, Brinkmalm G, Öhrfelt A, Parnetti L, Paciotti S, Hansson O, Hardy J, Blennow K, Zetterberg H, Brinkmalm A.

Alzheimers Res Ther. 2019 Sep 14;11(1):82. doi: 10.1186/s13195-019-0533-9.

26.

Dementia and CSF-biomarkers for Alzheimer's disease predict mortality after acute hip fracture.

Dutkiewicz R, Zetterberg H, Andreasson U, Blennow K, Nellgård B.

Acta Anaesthesiol Scand. 2019 Sep 11. doi: 10.1111/aas.13472. [Epub ahead of print]

PMID:
31508810
27.

Sex differences in the genetic predictors of Alzheimer's pathology.

Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M; Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative, Bennett DA, Schneider JA, Jefferson AL, Hohman TJ.

Brain. 2019 Sep 1;142(9):2581-2589. doi: 10.1093/brain/awz206.

PMID:
31497858
28.

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.

Shi L, Westwood S, Baird AL, Winchester L, Dobricic V, Kilpert F, Hong S, Franke A, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Buckley NJ, Kate MT, Scheltens P, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleó A, Alcolea D, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Teunissen CE, Freund-Levi Y, Frölich L, Legido-Quigley C, Barkhof F, Blennow K, Zetterberg H, Baker S, Morgan BP, Streffer J, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJ.

Alzheimers Dement. 2019 Sep 5. pii: S1552-5260(19)35118-0. doi: 10.1016/j.jalz.2019.06.4951. [Epub ahead of print]

29.

Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients.

Leavey N, Hammond SP, Shepstone L, Cross J, Zetterberg H, Cunningham C, MacLullich A, Leiv Otto Watne, Minihane AM, Ballard C, Knapskog AB, Hall R, Howard G, Hammond M, Fox C.

BMC Neurol. 2019 Sep 7;19(1):223. doi: 10.1186/s12883-019-1447-7.

30.

In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury.

Gorgoraptis N, Li LM, Whittington A, Zimmerman KA, Maclean LM, McLeod C, Ross E, Heslegrave A, Zetterberg H, Passchier J, Matthews PM, Gunn RN, McMillan TM, Sharp DJ.

Sci Transl Med. 2019 Sep 4;11(508). pii: eaaw1993. doi: 10.1126/scitranslmed.aaw1993.

31.

Growth factors and neurotrophins in patients with stress-related exhaustion disorder.

Sjörs Dahlman A, Blennow K, Zetterberg H, Glise K, Jonsdottir IH.

Psychoneuroendocrinology. 2019 Nov;109:104415. doi: 10.1016/j.psyneuen.2019.104415. Epub 2019 Aug 20.

32.

Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood-brain barrier model.

Delsing L, Kallur T, Zetterberg H, Hicks R, Synnergren J.

Fluids Barriers CNS. 2019 Aug 29;16(1):27. doi: 10.1186/s12987-019-0147-4.

33.

Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease.

Chatterjee P, Elmi M, Goozee K, Shah T, Sohrabi HR, Dias CB, Pedrini S, Shen K, Asih PR, Dave P, Taddei K, Vanderstichele H, Zetterberg H, Blennow K, Martins RN.

J Alzheimers Dis. 2019;71(3):775-783. doi: 10.3233/JAD-190533.

PMID:
31424403
34.

Leptin deficiency reverses high metabolic state and weight loss without affecting central pathology in the R6/2 mouse model of Huntington's disease.

Sjögren M, Soylu-Kucharz R, Dandunna U, Stan TL, Cavalera M, Sandelius Å, Zetterberg H, Björkqvist M.

Neurobiol Dis. 2019 Dec;132:104560. doi: 10.1016/j.nbd.2019.104560. Epub 2019 Aug 13.

PMID:
31419548
35.

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.

Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C, Brett TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C.

Sci Transl Med. 2019 Aug 14;11(505). pii: eaau2291. doi: 10.1126/scitranslmed.aau2291.

PMID:
31413141
36.

Gene replacement therapy after neuropathy onset provides therapeutic benefit in a model of CMT1X.

Kagiava A, Richter J, Tryfonos C, Karaiskos C, Heslegrave AJ, Sargiannidou I, Rossor AM, Zetterberg H, Reilly MM, Christodoulou C, Kleopa KA.

Hum Mol Genet. 2019 Aug 14. pii: ddz199. doi: 10.1093/hmg/ddz199. [Epub ahead of print]

PMID:
31411673
37.

Cerebrospinal fluid neurofilament light chain predicts disease activity after the first demyelinating event suggestive of multiple sclerosis.

Gaetani L, Eusebi P, Mancini A, Gentili L, Borrelli A, Parnetti L, Calabresi P, Sarchielli P, Blennow K, Zetterberg H, Di Filippo M.

Mult Scler Relat Disord. 2019 Oct;35:228-232. doi: 10.1016/j.msard.2019.07.025. Epub 2019 Jul 27.

PMID:
31404762
38.

Adverse Vascular Risk Relates to Cerebrospinal Fluid Biomarker Evidence of Axonal Injury in the Presence of Alzheimer's Disease Pathology.

Osborn KE, Alverio JM, Dumitrescu L, Pechman KR; Alzheimer’s Disease Neuroimaging Initiative, Gifford KA, Hohman TJ, Blennow K, Zetterberg H, Jefferson AL.

J Alzheimers Dis. 2019;71(1):281-290. doi: 10.3233/JAD-190077.

PMID:
31381510
39.

Circulating neurofilament light in ischemic stroke: temporal profile and outcome prediction.

Pedersen A, Stanne TM, Nilsson S, Klasson S, Rosengren L, Holmegaard L, Jood K, Blennow K, Zetterberg H, Jern C.

J Neurol. 2019 Nov;266(11):2796-2806. doi: 10.1007/s00415-019-09477-9. Epub 2019 Aug 2.

40.

Plasma neurofilament light chain concentration is increased in anorexia nervosa.

Nilsson IAK, Millischer V, Karrenbauer VD, Juréus A, Salehi AM, Norring C, von Hausswolff-Juhlin Y, Schalling M, Blennow K, Bulik CM, Zetterberg H, Landén M.

Transl Psychiatry. 2019 Aug 1;9(1):180. doi: 10.1038/s41398-019-0518-2.

41.

Screening with a high-precision blood-based assay for Alzheimer disease.

Bendlin BB, Zetterberg H.

Neurology. 2019 Oct 22;93(17):737-738. doi: 10.1212/WNL.0000000000008080. Epub 2019 Aug 1. No abstract available.

PMID:
31371570
42.

A tear fluid proteome of Parkinson's disease.

Zetterberg H, Compta Y.

Parkinsonism Relat Disord. 2019 Jun;63:1-2. doi: 10.1016/j.parkreldis.2019.07.028. Epub 2019 Jul 23. No abstract available.

PMID:
31353307
43.

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.

De S, Whiten DR, Ruggeri FS, Hughes C, Rodrigues M, Sideris DI, Taylor CG, Aprile FA, Muyldermans S, Knowles TPJ, Vendruscolo M, Bryant C, Blennow K, Skoog I, Kern S, Zetterberg H, Klenerman D.

Acta Neuropathol Commun. 2019 Jul 26;7(1):120. doi: 10.1186/s40478-019-0777-4.

44.

Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease.

Fossati S, Ramos Cejudo J, Debure L, Pirraglia E, Sone JY, Li Y, Chen J, Butler T, Zetterberg H, Blennow K, de Leon MJ.

Alzheimers Dement (Amst). 2019 Jun 28;11:483-492. doi: 10.1016/j.dadm.2019.05.001. eCollection 2019 Dec.

45.

Human cerebrospinal fluid promotes spontaneous gamma oscillations in the hippocampus in vitro.

Bjorefeldt A, Roshan F, Forsberg M, Zetterberg H, Hanse E, Fisahn A.

Hippocampus. 2019 Jul 17. doi: 10.1002/hipo.23135. [Epub ahead of print]

PMID:
31313871
46.

Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.

Johansson V, Erhardt S, Engberg G, Kegel M, Bhat M, Schwieler L, Blennow K, Zetterberg H, Cannon TD, Wetterberg L, Hultman CM, Landén M.

Eur Arch Psychiatry Clin Neurosci. 2019 Jul 13. doi: 10.1007/s00406-019-01042-9. [Epub ahead of print]

PMID:
31302732
47.

Characterization of Cerebrospinal Fluid BACE1 Species.

Lopez-Font I, Boix CP, Zetterberg H, Blennow K, Sáez-Valero J.

Mol Neurobiol. 2019 Dec;56(12):8603-8616. doi: 10.1007/s12035-019-01677-8. Epub 2019 Jul 9.

PMID:
31290061
48.

Interleukin 9 alterations linked to alzheimer disease in african americans.

Wharton W, Kollhoff AL, Gangishetti U, Verble DD, Upadhya S, Zetterberg H, Kumar V, Watts KD, Kippels AJ, Gearing M, Howell JC, Parker MW, Hu WT.

Ann Neurol. 2019 Sep;86(3):407-418. doi: 10.1002/ana.25543. Epub 2019 Jul 22.

49.

Comparison of different MRI-based morphometric estimates for defining neurodegeneration across the Alzheimer's disease continuum.

Allison SL, Koscik RL, Cary RP, Jonaitis EM, Rowley HA, Chin NA, Zetterberg H, Blennow K, Carlsson CM, Asthana S, Bendlin BB, Johnson SC.

Neuroimage Clin. 2019;23:101895. doi: 10.1016/j.nicl.2019.101895. Epub 2019 Jun 10.

50.

Correlations between serum and CSF pNfH levels in ALS, FTD and controls: a comparison of three analytical approaches.

Wilke C, Pujol-Calderón F, Barro C, Stransky E, Blennow K, Michalak Z, Deuschle C, Jeromin A, Zetterberg H, Schüle R, Höglund K, Kuhle J, Synofzik M.

Clin Chem Lab Med. 2019 Sep 25;57(10):1556-1564. doi: 10.1515/cclm-2019-0015.

PMID:
31251725

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