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Items: 1 to 50 of 946

1.

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Sandelius Å, Portelius E, Källén Å, Zetterberg H, Rot U, Olsson B, Toledo JB, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, Kostanjevecki V, Vandijck M, McBride J, Trojanowski JQ, Blennow K.

Alzheimers Dement. 2018 Oct 12. pii: S1552-5260(18)33515-5. doi: 10.1016/j.jalz.2018.08.006. [Epub ahead of print]

PMID:
30321501
2.

Vitamin D supplementation and neurofilament light chain in multiple sclerosis.

Holmøy T, Røsjø E, Zetterberg H, Blennow K, Lindstrøm JC, Steffensen LH, Kampman MT.

Acta Neurol Scand. 2018 Oct 13. doi: 10.1111/ane.13037. [Epub ahead of print]

PMID:
30317548
3.

Intrathecal treatment trial of rituximab in progressive MS: An open-label phase 1b study.

Bergman J, Burman J, Gilthorpe JD, Zetterberg H, Jiltsova E, Bergenheim T, Svenningsson A.

Neurology. 2018 Oct 10. pii: 10.1212/WNL.0000000000006500. doi: 10.1212/WNL.0000000000006500. [Epub ahead of print]

PMID:
30305449
4.

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic.

Hampel H, O'Bryant SE, Molinuevo JL, Zetterberg H, Masters CL, Lista S, Kiddle SJ, Batrla R, Blennow K.

Nat Rev Neurol. 2018 Oct 8. doi: 10.1038/s41582-018-0079-7. [Epub ahead of print] Review.

PMID:
30297701
5.

Mutated thyroid hormone transporter OATP1C1 associates with severe brain hypometabolism and juvenile neurodegeneration.

Stromme P, Groeneweg S, Lima de Souza EC, Zevenbergen C, Torgersbråten A, Holmgren A, Gurcan E, Meima M, Peeters R, Visser WE, Høneren Johansson L, Babovic A, Zetterberg H, Heuer H, Frengen E, Misceo D, Visser TJ.

Thyroid. 2018 Oct 8. doi: 10.1089/thy.2018.0595. [Epub ahead of print]

PMID:
30296914
6.

Interlaboratory validation of cerebrospinal fluid α-synuclein quantification in the diagnosis of sporadic Creutzfeldt-Jakob disease.

Kruse N, Heslegrave A, Gupta V, Foiani M, Villar-Piqué A, Schmitz M, Lehmann S, Teunissen C, Blennow K, Zetterberg H, Mollenhauer B, Zerr I, Llorens F.

Alzheimers Dement (Amst). 2018 Jul 7;10:461-470. doi: 10.1016/j.dadm.2018.06.005. eCollection 2018.

7.

CSF pro-orexin and amyloid-β38 expression in Alzheimer's disease and frontotemporal dementia.

Heywood WE, Hallqvist J, Heslegrave AJ, Zetterberg H, Fenoglio C, Scarpini E, Rohrer JD, Galimberti D, Mills K.

Neurobiol Aging. 2018 Aug 25;72:171-176. doi: 10.1016/j.neurobiolaging.2018.08.019. [Epub ahead of print]

8.

GM1 locates to mature amyloid structures implicating a prominent role for glycolipid-protein interactions in Alzheimer pathology.

Michno W, Wehrli PM, Zetterberg H, Blennow K, Hanrieder J.

Biochim Biophys Acta Proteins Proteom. 2018 Sep 28. pii: S1570-9639(18)30164-X. doi: 10.1016/j.bbapap.2018.09.010. [Epub ahead of print]

PMID:
30273679
9.

MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study.

Ten Kate M, Redolfi A, Peira E, Bos I, Vos SJ, Vandenberghe R, Gabel S, Schaeverbeke J, Scheltens P, Blin O, Richardson JC, Bordet R, Wallin A, Eckerstrom C, Molinuevo JL, Engelborghs S, Van Broeckhoven C, Martinez-Lage P, Popp J, Tsolaki M, Verhey FRJ, Baird AL, Legido-Quigley C, Bertram L, Dobricic V, Zetterberg H, Lovestone S, Streffer J, Bianchetti S, Novak GP, Revillard J, Gordon MF, Xie Z, Wottschel V, Frisoni G, Visser PJ, Barkhof F.

Alzheimers Res Ther. 2018 Sep 27;10(1):100. doi: 10.1186/s13195-018-0428-1.

10.

Effects of methylprednisolone on blood-brain barrier and cerebral inflammation in cardiac surgery-a randomized trial.

Danielson M, Reinsfelt B, Westerlind A, Zetterberg H, Blennow K, Ricksten SE.

J Neuroinflammation. 2018 Sep 27;15(1):283. doi: 10.1186/s12974-018-1318-y.

11.

Parkinson's disease: evolution of cognitive impairment and CSF Aβ1-42 profiles in a prospective longitudinal study.

Lerche S, Wurster I, Röben B, Machetanz G, Zimmermann M, Bernhard F, Stransky E, Deuschle C, Schulte C, Hansson O, Zetterberg H, Gasser T, Berg D, Maetzler W, Brockmann K.

J Neurol Neurosurg Psychiatry. 2018 Sep 25. pii: jnnp-2018-318956. doi: 10.1136/jnnp-2018-318956. [Epub ahead of print]

PMID:
30254084
12.

Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia.

Oh ES, Blennow K, Bigelow GE, Inouye SK, Marcantonio ER, Neufeld KJ, Rosenberg PB, Troncoso JC, Wang NY, Zetterberg H, Sieber FE, Lyketsos CG.

PLoS One. 2018 Sep 25;13(9):e0204695. doi: 10.1371/journal.pone.0204695. eCollection 2018.

13.

The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer's disease.

Kvartsberg H, Lashley T, Murray CE, Brinkmalm G, Cullen NC, Höglund K, Zetterberg H, Blennow K, Portelius E.

Acta Neuropathol. 2018 Sep 22. doi: 10.1007/s00401-018-1910-3. [Epub ahead of print]

PMID:
30244311
14.

Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases.

Brinkmalm A, Portelius E, Brinkmalm G, Pannee J, Dahlén R, Gobom J, Blennow K, Zetterberg H.

J Neurochem. 2018 Sep 20. doi: 10.1111/jnc.14594. [Epub ahead of print] Review.

PMID:
30238462
15.

Heading in soccer increases serum neurofilament light protein and SCAT3 symptom metrics.

Wallace C, Smirl JD, Zetterberg H, Blennow K, Bryk K, Burma J, Dierijck J, Wright AD, van Donkelaar P.

BMJ Open Sport Exerc Med. 2018 Aug 27;4(1):e000433. doi: 10.1136/bmjsem-2018-000433. eCollection 2018.

16.

Integration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis.

Herman S, Khoonsari PE, Tolf A, Steinmetz J, Zetterberg H, Åkerfeldt T, Jakobsson PJ, Larsson A, Spjuth O, Burman J, Kultima K.

Theranostics. 2018 Aug 7;8(16):4477-4490. doi: 10.7150/thno.26249. eCollection 2018.

17.

Stability of blood-based biomarkers of Alzheimer's disease over multiple freeze-thaw cycles.

Keshavan A, Heslegrave A, Zetterberg H, Schott JM.

Alzheimers Dement (Amst). 2018 Jul 2;10:448-451. doi: 10.1016/j.dadm.2018.06.001. eCollection 2018.

18.

Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease.

Byrne LM, Rodrigues FB, Johnson EB, Wijeratne PA, De Vita E, Alexander DC, Palermo G, Czech C, Schobel S, Scahill RI, Heslegrave A, Zetterberg H, Wild EJ.

Sci Transl Med. 2018 Sep 12;10(458). pii: eaat7108. doi: 10.1126/scitranslmed.aat7108.

PMID:
30209243
19.

Aβ42/Aβ40 and Aβ42/Aβ38 Ratios Are Associated with Measures of Gait Variability and Activities of Daily Living in Mild Alzheimer's Disease: A Pilot Study.

Koychev I, Galna B, Zetterberg H, Lawson J, Zamboni G, Ridha BH, Rowe JB, Thomas A, Howard R, Malhotra P, Ritchie C, Lovestone S, Rochester L.

J Alzheimers Dis. 2018;65(4):1377-1383. doi: 10.3233/JAD-180622.

PMID:
30198873
20.

Inflammatory markers of CHMP2B-mediated frontotemporal dementia.

Roos P, von Essen MR, Nielsen TT, Johannsen P, Stokholm J, Bie AS, Waldemar G, Simonsen AH, Heslegrave A, Zetterberg H; FReJA consortium, Sellebjerg F, Nielsen JE.

J Neuroimmunol. 2018 Nov 15;324:136-142. doi: 10.1016/j.jneuroim.2018.08.009. Epub 2018 Aug 17.

PMID:
30193769
21.

Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species.

Oliveira F, Leuzy A, Castelhano J, Chiotis K, Hasselbalch SG, Rinne J, Mendonça A, Otto M, Lleó A, Santana I, Johansson J, Anderl-Straub S, Arnim C, Beer A, Blesa R, Fortea J, Sanna-Kaisa H, Portelius E, Pannee J, Zetterberg H, Blennow K, Moreira AP, Abrunhosa A, Nordberg A, Castelo-Branco M.

Neuroimage Clin. 2018 Aug 19;20:603-610. doi: 10.1016/j.nicl.2018.08.023. eCollection 2018.

22.

Cerebrospinal fluid concentrations of inflammatory markers in Parkinson's disease and atypical parkinsonian disorders.

Hall S, Janelidze S, Surova Y, Widner H, Zetterberg H, Hansson O.

Sci Rep. 2018 Sep 5;8(1):13276. doi: 10.1038/s41598-018-31517-z.

23.

Barrier properties and transcriptome expression in human iPSC-derived models of the blood-brain barrier.

Delsing L, Dönnes P, Sánchez J, Clausen M, Voulgaris D, Falk A, Herland A, Brolén G, Zetterberg H, Hicks R, Synnergren J.

Stem Cells. 2018 Sep 1. doi: 10.1002/stem.2908. [Epub ahead of print]

PMID:
30171748
24.

Neurofilaments as biomarkers in neurological disorders.

Khalil M, Teunissen CE, Otto M, Piehl F, Sormani MP, Gattringer T, Barro C, Kappos L, Comabella M, Fazekas F, Petzold A, Blennow K, Zetterberg H, Kuhle J.

Nat Rev Neurol. 2018 Oct;14(10):577-589. doi: 10.1038/s41582-018-0058-z. Review.

PMID:
30171200
25.

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase.

Becker B, Nazir FH, Brinkmalm G, Camporesi E, Kvartsberg H, Portelius E, Boström M, Kalm M, Höglund K, Olsson M, Zetterberg H, Blennow K.

Mol Neurodegener. 2018 Aug 29;13(1):47. doi: 10.1186/s13024-018-0279-z.

26.

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.

Garcia-Reitboeck P, Phillips A, Piers TM, Villegas-Llerena C, Butler M, Mallach A, Rodrigues C, Arber CE, Heslegrave A, Zetterberg H, Neumann H, Neame S, Houlden H, Hardy J, Pocock JM.

Cell Rep. 2018 Aug 28;24(9):2300-2311. doi: 10.1016/j.celrep.2018.07.094.

27.

Midlife Stress in Relation to Late-Life Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: A 25-Year Follow-Up Study.

Johansson L, Kern S, Zetterberg H, Blennow K, Börjesson-Hansson A, Rosengren L, Guo X, Skoog I.

Dement Geriatr Cogn Disord. 2018;46(1-2):90-99. doi: 10.1159/000490885. Epub 2018 Aug 24.

PMID:
30145588
28.

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.

Mollenhauer B, DuBois BF, Drake D, Duong J, Blennow K, El-Agnaf O, Shaw LM, Masucci J, Taylor P, Umek RM, Dunty IM, Smith CL, Stoops E, Vanderstichele H, Schmid AW, Moniatte M, Zhang J, Kruse N, Lashuel HA, Teunissen C, Schubert T, Dave KD, Hutten SJ, Zetterberg H.

J Neurochem. 2018 Aug 20. doi: 10.1111/jnc.14569. [Epub ahead of print]

PMID:
30125936
29.

Biomarkers for Antidepressant Efficacy of Electroconvulsive Therapy: An Exploratory Cerebrospinal Fluid Study.

Kranaster L, Hoyer C, Aksay SS, Bumb JM, Müller N, Zill P, Schwarz MJ, Moll N, Lutz B, Bindila L, Zerr I, Schmitz M, Blennow K, Zetterberg H, Haffner D, Leifheit-Nestler M, Ozbalci C, Janke C, Thiel M, Sartorius A.

Neuropsychobiology. 2018 Aug 17:1-10. doi: 10.1159/000491401. [Epub ahead of print]

PMID:
30121652
30.

Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup.

Woollacott IOC, Nicholas JM, Heslegrave A, Heller C, Foiani MS, Dick KM, Russell LL, Paterson RW, Keshavan A, Fox NC, Warren JD, Schott JM, Zetterberg H, Rohrer JD.

Alzheimers Res Ther. 2018 Aug 16;10(1):79. doi: 10.1186/s13195-018-0405-8.

31.

Effects of APOE ε4 on neuroimaging, cerebrospinal fluid biomarkers, and cognition in prodromal Alzheimer's disease.

Mattsson N, Eriksson O, Lindberg O, Schöll M, Lampinen B, Nilsson M, Insel PS, Lautner R, Strandberg O, van Westen D, Zetterberg H, Blennow K, Palmqvist S, Stomrud E, Hansson O.

Neurobiol Aging. 2018 Nov;71:81-90. doi: 10.1016/j.neurobiolaging.2018.07.003. Epub 2018 Jul 11.

PMID:
30107289
32.

Neurofilament light chain in blood is negatively associated with neuropsychological performance in HIV-infected adults and declines with initiation of antiretroviral therapy.

Anderson AM, Easley KA, Kasher N, Franklin D, Heaton RK, Zetterberg H, Blennow K, Gisslen M, Letendre SL.

J Neurovirol. 2018 Aug 13. doi: 10.1007/s13365-018-0664-y. [Epub ahead of print]

PMID:
30105502
33.

Cerebrospinal fluid GAP-43 in early multiple sclerosis.

Rot U, Sandelius Å, Emeršič A, Zetterberg H, Blennow K.

Mult Scler J Exp Transl Clin. 2018 Aug 7;4(3):2055217318792931. doi: 10.1177/2055217318792931. eCollection 2018 Jul-Sep.

34.

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.

Taylor CG, Meisl G, Horrocks MH, Zetterberg H, Knowles TPJ, Klenerman D.

Anal Chem. 2018 Sep 4;90(17):10385-10393. doi: 10.1021/acs.analchem.8b02226. Epub 2018 Aug 13.

35.

Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer's disease.

Lewczuk P, Ermann N, Andreasson U, Schultheis C, Podhorna J, Spitzer P, Maler JM, Kornhuber J, Blennow K, Zetterberg H.

Alzheimers Res Ther. 2018 Jul 28;10(1):71. doi: 10.1186/s13195-018-0404-9.

36.

Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers.

Vergallo A, Bun RS, Toschi N, Baldacci F, Zetterberg H, Blennow K, Cavedo E, Lamari F, Habert MO, Dubois B, Floris R, Garaci F, Lista S, Hampel H; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI).

Alzheimers Dement. 2018 Jul 26. pii: S1552-5260(18)33241-2. doi: 10.1016/j.jalz.2018.06.3053. [Epub ahead of print]

PMID:
30055132
37.

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease.

Janelidze S, Mattsson N, Stomrud E, Lindberg O, Palmqvist S, Zetterberg H, Blennow K, Hansson O.

Neurology. 2018 Aug 28;91(9):e867-e877. doi: 10.1212/WNL.0000000000006082. Epub 2018 Jul 27.

38.

Biomarkers for Alzheimer's disease: current status and prospects for the future.

Blennow K, Zetterberg H.

J Intern Med. 2018 Jul 26. doi: 10.1111/joim.12816. [Epub ahead of print] Review.

PMID:
30051512
39.

Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.

Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA.

Alzheimers Dement. 2018 Sep;14(9):1159-1170. doi: 10.1016/j.jalz.2018.05.004. Epub 2018 Jul 23.

PMID:
30049650
40.

Levels of ADAM10 are reduced in Alzheimer's disease CSF.

Sogorb-Esteve A, García-Ayllón MS, Gobom J, Alom J, Zetterberg H, Blennow K, Sáez-Valero J.

J Neuroinflammation. 2018 Jul 25;15(1):213. doi: 10.1186/s12974-018-1255-9.

41.

Molecular Imaging Mass Spectrometry for Probing Neuronal Protein Dynamics in Neurodegenerative Disease Pathology.

Michno W, Wehrli PM, Blennow K, Zetterberg H, Hanrieder J.

J Neurochem. 2018 Jul 24. doi: 10.1111/jnc.14559. [Epub ahead of print] Review.

PMID:
30040875
42.

Neurofilament relates to white matter microstructure in older adults.

Moore EE, Hohman TJ, Badami FS, Pechman KR, Osborn KE, Acosta LMY, Bell SP, Babicz MA, Gifford KA, Anderson AW, Goldstein LE, Blennow K, Zetterberg H, Jefferson AL.

Neurobiol Aging. 2018 Oct;70:233-241. doi: 10.1016/j.neurobiolaging.2018.06.023. Epub 2018 Jun 28.

PMID:
30036759
43.

The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease.

Murray CE, Gami-Patel P, Gkanatsiou E, Brinkmalm G, Portelius E, Wirths O, Heywood W, Blennow K, Ghiso J, Holton JL, Mills K, Zetterberg H, Revesz T, Lashley T.

Acta Neuropathol Commun. 2018 Jul 20;6(1):62. doi: 10.1186/s40478-018-0563-8.

44.

Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis.

Håkansson I, Tisell A, Cassel P, Blennow K, Zetterberg H, Lundberg P, Dahle C, Vrethem M, Ernerudh J.

J Neuroinflammation. 2018 Jul 18;15(1):209. doi: 10.1186/s12974-018-1249-7.

45.

Socioeconomic status, gender and dementia: The influence of work environment exposures and their interactions with APOE ɛ4.

Hasselgren C, Dellve L, Ekbrand H, Zettergren A, Zetterberg H, Blennow K, Skoog I, Halleröd B.

SSM Popul Health. 2018 Jun 22;5:171-179. doi: 10.1016/j.ssmph.2018.06.009. eCollection 2018 Aug.

46.

No association of salivary total tau concentration with Alzheimer's disease.

Ashton NJ, Ide M, Schöll M, Blennow K, Lovestone S, Hye A, Zetterberg H.

Neurobiol Aging. 2018 Oct;70:125-127. doi: 10.1016/j.neurobiolaging.2018.06.014. Epub 2018 Jun 20.

PMID:
30007161
47.

Persistent central nervous system immune activation following more than 10 years of effective HIV antiretroviral treatment.

Ulfhammer G, Edén A, Mellgren Å, Fuchs D, Zetterberg H, Hagberg L, Nilsson S, Yilmaz A, Gisslén M.

AIDS. 2018 Sep 24;32(15):2171-2178. doi: 10.1097/QAD.0000000000001950.

PMID:
30005007
48.

Cerebrospinal fluid neurofilament light is associated with survival in mitochondrial disease patients.

Sofou K, Shahim P, Tulinius M, Blennow K, Zetterberg H, Mattsson N, Darin N.

Mitochondrion. 2018 Jul 9. pii: S1567-7249(18)30022-9. doi: 10.1016/j.mito.2018.07.002. [Epub ahead of print]

PMID:
30004022
49.

Lumbar drains can affect CSF biomarker levels.

Craven CL, Chapman MD, D'Antona L, Thompson SD, Lakdawala N, Zetterberg H, Watkins LD, Toma AK.

J Clin Pathol. 2018 Jul 11. pii: jclinpath-2018-205296. doi: 10.1136/jclinpath-2018-205296. [Epub ahead of print] No abstract available.

PMID:
29997233
50.

Low fasting serum insulin and dementia in nondiabetic women followed for 34 years.

Mehlig K, Lapidus L, Thelle DS, Waern M, Zetterberg H, Björkelund C, Skoog I, Lissner L.

Neurology. 2018 Jul 31;91(5):e427-e435. doi: 10.1212/WNL.0000000000005911. Epub 2018 Jul 11.

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