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Items: 1 to 50 of 116

1.

Use of Adeno-associated viral vectors to improve delivery of a DNA vaccine against dengue virus.

Slon-Campos JL, Poggianella M, Zentilin L, Burrone OR.

J Gen Virol. 2019 Nov 8. doi: 10.1099/jgv.0.001351. [Epub ahead of print]

PMID:
31702541
2.

mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca2+ Dynamics In Vivo.

Greotti E, Fortunati I, Pendin D, Ferrante C, Galla L, Zentilin L, Giacca M, Kaludercic N, Di Sante M, Mariotti L, Lia A, Gómez-Gonzalo M, Sessolo M, Di Lisa F, Carmignoto G, Bozio R, Pozzan T.

iScience. 2019 Sep 27;19:161. doi: 10.1016/j.isci.2019.07.031. Epub 2019 Jul 30. No abstract available.

3.

Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.

Benigni A, Cassis P, Conti S, Perico L, Corna D, Cerullo D, Zentilin L, Zoja C, Perna A, Lionetti V, Giacca M, Trionfini P, Tomasoni S, Remuzzi G.

Antioxid Redox Signal. 2019 Dec;31(17):1255-1271. doi: 10.1089/ars.2018.7703. Epub 2019 Aug 2.

PMID:
31269804
4.

Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases.

De Caneva A, Porro F, Bortolussi G, Sola R, Lisjak M, Barzel A, Giacca M, Kay MA, Vlahoviček K, Zentilin L, Muro AF.

JCI Insight. 2019 Jun 18;5. pii: 128863. doi: 10.1172/jci.insight.128863.

5.

mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca2+ Dynamics In Vivo.

Greotti E, Fortunati I, Pendin D, Ferrante C, Galla L, Zentilin L, Giacca M, Kaludercic N, Di Sante M, Mariotti L, Lia A, Gómez-Gonzalo M, Sessolo M, Di Lisa F, Carmignoto G, Bozio R, Pozzan T.

iScience. 2019 Jun 28;16:340-355. doi: 10.1016/j.isci.2019.05.031. Epub 2019 May 27. Erratum in: iScience. 2019 Sep 27;19:161.

6.

Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.

Torrini C, Cubero RJ, Dirkx E, Braga L, Ali H, Prosdocimo G, Gutierrez MI, Collesi C, Licastro D, Zentilin L, Mano M, Zacchigna S, Vendruscolo M, Marsili M, Samal A, Giacca M.

Cell Rep. 2019 May 28;27(9):2759-2771.e5. doi: 10.1016/j.celrep.2019.05.005.

7.

MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs.

Gabisonia K, Prosdocimo G, Aquaro GD, Carlucci L, Zentilin L, Secco I, Ali H, Braga L, Gorgodze N, Bernini F, Burchielli S, Collesi C, Zandonà L, Sinagra G, Piacenti M, Zacchigna S, Bussani R, Recchia FA, Giacca M.

Nature. 2019 May;569(7756):418-422. doi: 10.1038/s41586-019-1191-6. Epub 2019 May 8.

8.

Intracoronary Gene Delivery of the Cytoprotective Factor Vascular Endothelial Growth Factor-B167 in Canine Patients with Dilated Cardiomyopathy: A Short-Term Feasibility Study.

Paradies P, Carlucci L, Woitek F, Staffieri F, Lacitignola L, Ceci L, Romano D, Sasanelli M, Zentilin L, Giacca M, Salvadori S, Crovace A, Recchia FA.

Vet Sci. 2019 Mar 6;6(1). pii: E23. doi: 10.3390/vetsci6010023.

9.

MicroRNA hsa-miR-29a-3p is a plasma biomarker for the differential diagnosis and monitoring of tuberculosis.

Ndzi EN, Nkenfou CN, Mekue LM, Zentilin L, Tamgue O, Pefura EWY, Kuiaté JR, Giacca M, Ndjolo A.

Tuberculosis (Edinb). 2019 Jan;114:69-76. doi: 10.1016/j.tube.2018.12.001. Epub 2018 Dec 6.

PMID:
30711160
10.

Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure.

Raso A, Dirkx E, Philippen LE, Fernandez-Celis A, De Majo F, Sampaio-Pinto V, Sansonetti M, Juni R, El Azzouzi H, Calore M, Bitsch N, Olieslagers S, Oerlemans MIFJ, Huibers MM, de Weger RA, Reckman YJ, Pinto YM, Zentilin L, Zacchigna S, Giacca M, da Costa Martins PA, López-Andrés N, De Windt LJ.

Mol Ther. 2019 Mar 6;27(3):584-599. doi: 10.1016/j.ymthe.2018.11.011. Epub 2018 Nov 17.

11.

VSV-G-Enveloped Vesicles for Traceless Delivery of CRISPR-Cas9.

Montagna C, Petris G, Casini A, Maule G, Franceschini GM, Zanella I, Conti L, Arnoldi F, Burrone OR, Zentilin L, Zacchigna S, Giacca M, Cereseto A.

Mol Ther Nucleic Acids. 2018 Sep 7;12:453-462. doi: 10.1016/j.omtn.2018.05.010. Epub 2018 Jul 11.

12.

Notch pathway activation enhances cardiosphere in vitro expansion.

Secco I, Barile L, Torrini C, Zentilin L, Vassalli G, Giacca M, Collesi C.

J Cell Mol Med. 2018 Nov;22(11):5583-5595. doi: 10.1111/jcmm.13832. Epub 2018 Aug 23.

13.

AAV9-mediated Rbm24 overexpression induces fibrosis in the mouse heart.

van den Hoogenhof MMG, van der Made I, de Groot NE, Damanafshan A, van Amersfoorth SCM, Zentilin L, Giacca M, Pinto YM, Creemers EE.

Sci Rep. 2018 Aug 3;8(1):11696. doi: 10.1038/s41598-018-29552-x.

14.

Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction.

Zacchigna S, Martinelli V, Moimas S, Colliva A, Anzini M, Nordio A, Costa A, Rehman M, Vodret S, Pierro C, Colussi G, Zentilin L, Gutierrez MI, Dirkx E, Long C, Sinagra G, Klatzmann D, Giacca M.

Nat Commun. 2018 Jun 26;9(1):2432. doi: 10.1038/s41467-018-04908-z.

15.

A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent.

Gioelli N, Maione F, Camillo C, Ghitti M, Valdembri D, Morello N, Darche M, Zentilin L, Cagnoni G, Qiu Y, Giacca M, Giustetto M, Paques M, Cascone I, Musco G, Tamagnone L, Giraudo E, Serini G.

Sci Transl Med. 2018 May 23;10(442). pii: eaah4807. doi: 10.1126/scitranslmed.aah4807. Erratum in: Sci Transl Med. 2018 Jul 25;10(451):.

16.

Tis21-gene therapy inhibits medulloblastoma growth in a murine allograft model.

Presutti D, Ceccarelli M, Micheli L, Papoff G, Santini S, Samperna S, Lalli C, Zentilin L, Ruberti G, Tirone F.

PLoS One. 2018 Mar 14;13(3):e0194206. doi: 10.1371/journal.pone.0194206. eCollection 2018.

17.

Reversible Notch1 acetylation tunes proliferative signalling in cardiomyocytes.

Collesi C, Felician G, Secco I, Gutierrez MI, Martelletti E, Ali H, Zentilin L, Myers MP, Giacca M.

Cardiovasc Res. 2018 Jan 1;114(1):103-122. doi: 10.1093/cvr/cvx228.

PMID:
29186476
18.

Postnatal Cardiac Gene Editing Using CRISPR/Cas9 With AAV9-Mediated Delivery of Short Guide RNAs Results in Mosaic Gene Disruption.

Johansen AK, Molenaar B, Versteeg D, Leitoguinho AR, Demkes C, Spanjaard B, de Ruiter H, Akbari Moqadam F, Kooijman L, Zentilin L, Giacca M, van Rooij E.

Circ Res. 2017 Oct 27;121(10):1168-1181. doi: 10.1161/CIRCRESAHA.116.310370. Epub 2017 Aug 29.

PMID:
28851809
19.

Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler-Najjar Syndrome Type I.

Bočkor L, Bortolussi G, Iaconcig A, Chiaruttini G, Tiribelli C, Giacca M, Benvenuti F, Zentilin L, Muro AF.

Gene Ther. 2017 Oct;24(10):649-660. doi: 10.1038/gt.2017.75. Epub 2017 Aug 14.

PMID:
28805798
20.

In Vivo Functional Selection Identifies Cardiotrophin-1 as a Cardiac Engraftment Factor for Mesenchymal Stromal Cells.

Bortolotti F, Ruozi G, Falcione A, Doimo S, Dal Ferro M, Lesizza P, Zentilin L, Banks L, Zacchigna S, Giacca M.

Circulation. 2017 Oct 17;136(16):1509-1524. doi: 10.1161/CIRCULATIONAHA.117.029003. Epub 2017 Jul 28.

PMID:
28754835
21.

Promoterless gene targeting without nucleases rescues lethality of a Crigler-Najjar syndrome mouse model.

Porro F, Bortolussi G, Barzel A, De Caneva A, Iaconcig A, Vodret S, Zentilin L, Kay MA, Muro AF.

EMBO Mol Med. 2017 Oct;9(10):1346-1355. doi: 10.15252/emmm.201707601.

22.

Unacylated Ghrelin Enhances Satellite Cell Function and Relieves the Dystrophic Phenotype in Duchenne Muscular Dystrophy mdx Model.

Reano S, Angelino E, Ferrara M, Malacarne V, Sustova H, Sabry O, Agosti E, Clerici S, Ruozi G, Zentilin L, Prodam F, Geuna S, Giacca M, Graziani A, Filigheddu N.

Stem Cells. 2017 Jul;35(7):1733-1746. doi: 10.1002/stem.2632. Epub 2017 May 7.

23.

AAV9-mediated engineering of autotransplanted kidney of non-human primates.

Tomasoni S, Trionfini P, Azzollini N, Zentilin L, Giacca M, Aiello S, Longaretti L, Cozzi E, Baldan N, Remuzzi G, Benigni A.

Gene Ther. 2017 May;24(5):308-313. doi: 10.1038/gt.2017.21. Epub 2017 Mar 27.

PMID:
28346435
24.

Neuronal hemoglobin affects dopaminergic cells' response to stress.

Codrich M, Bertuzzi M, Russo R, Francescatto M, Espinoza S, Zentilin L, Giacca M, Cesselli D, Beltrami AP, Ascenzi P, Zucchelli S, Persichetti F, Leanza G, Gustincich S.

Cell Death Dis. 2017 Jan 5;8(1):e2538. doi: 10.1038/cddis.2016.458.

25.

MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Ménétrier-like gastropathy.

Piccolo P, Attanasio S, Secco I, Sangermano R, Strisciuglio C, Limongelli G, Miele E, Mutarelli M, Banfi S, Nigro V, Pons T, Valencia A, Zentilin L, Campione S, Nardone G, Lynnes TC, Celestino-Soper PB, Spoonamore KG, D'Armiento FP, Giacca M, Staiano A, Vatta M, Collesi C, Brunetti-Pierri N.

Hum Mol Genet. 2017 Jan 1;26(1):33-43. doi: 10.1093/hmg/ddw365.

26.

Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction.

Fattah C, Nather K, McCarroll CS, Hortigon-Vinagre MP, Zamora V, Flores-Munoz M, McArthur L, Zentilin L, Giacca M, Touyz RM, Smith GL, Loughrey CM, Nicklin SA.

J Am Coll Cardiol. 2016 Dec 20;68(24):2652-2666. doi: 10.1016/j.jacc.2016.09.946.

27.

VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans.

Kazemi M, Carrer A, Moimas S, Zandonà L, Bussani R, Casagranda B, Palmisano S, Prelazzi P, Giacca M, Zentilin L, De Manzini N, Giacca M, Zacchigna S.

Cancer Gene Ther. 2016 May;23(5):125-32. doi: 10.1038/cgt.2016.12. Epub 2016 Apr 1.

PMID:
27033458
28.

AAV vector encoding human VEGF165-transduced pectineus muscular flaps increase the formation of new tissue through induction of angiogenesis in an in vivo chamber for tissue engineering: A technique to enhance tissue and vessels in microsurgically engineered tissue.

Moimas S, Manasseri B, Cuccia G, Stagno d'Alcontres F, Geuna S, Pattarini L, Zentilin L, Giacca M, Colonna MR.

J Tissue Eng. 2015 Dec 7;6:2041731415611717. doi: 10.1177/2041731415611717. eCollection 2015 Jan-Dec.

29.

A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9.

Carroll KJ, Makarewich CA, McAnally J, Anderson DM, Zentilin L, Liu N, Giacca M, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):338-43. doi: 10.1073/pnas.1523918113. Epub 2015 Dec 30.

30.

Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction.

Mano M, Ippodrino R, Zentilin L, Zacchigna S, Giacca M.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11276-81. doi: 10.1073/pnas.1503607112. Epub 2015 Aug 24.

31.

Recombinant AAV-mediated in vivo long-term expression and antitumour activity of an anti-ganglioside GM3(Neu5Gc) antibody.

Piperno GM, López-Requena A, Predonzani A, Dorvignit D, Labrada M, Zentilin L, Burrone OR, Cesco-Gaspere M.

Gene Ther. 2015 Dec;22(12):960-7. doi: 10.1038/gt.2015.71. Epub 2015 Jul 16.

PMID:
26181624
32.

Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy.

Woitek F, Zentilin L, Hoffman NE, Powers JC, Ottiger I, Parikh S, Kulczycki AM, Hurst M, Ring N, Wang T, Shaikh F, Gross P, Singh H, Kolpakov MA, Linke A, Houser SR, Rizzo V, Sabri A, Madesh M, Giacca M, Recchia FA.

J Am Coll Cardiol. 2015 Jul 14;66(2):139-53. doi: 10.1016/j.jacc.2015.04.071.

33.

AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia.

Ruozi G, Bortolotti F, Falcione A, Dal Ferro M, Ukovich L, Macedo A, Zentilin L, Filigheddu N, Gortan Cappellari G, Baldini G, Zweyer M, Barazzoni R, Graziani A, Zacchigna S, Giacca M.

Nat Commun. 2015 Jun 11;6:7388. doi: 10.1038/ncomms8388.

34.

Conditional Cripto overexpression in satellite cells promotes myogenic commitment and enhances early regeneration.

Prezioso C, Iaconis S, Andolfi G, Zentilin L, Iavarone F, Guardiola O, Minchiotti G.

Front Cell Dev Biol. 2015 May 21;3:31. doi: 10.3389/fcell.2015.00031. eCollection 2015.

35.

Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation.

Gambarotta G, Pascal D, Ronchi G, Morano M, Jager SB, Moimas S, Zentilin L, Giacca M, Perroteau I, Tos P, Geuna S, Raimondo S.

Gene Ther. 2015 Nov;22(11):901-7. doi: 10.1038/gt.2015.46. Epub 2015 May 4.

PMID:
25938193
36.

Targeting of surface alpha-enolase inhibits the invasiveness of pancreatic cancer cells.

Principe M, Ceruti P, Shih NY, Chattaragada MS, Rolla S, Conti L, Bestagno M, Zentilin L, Yang SH, Migliorini P, Cappello P, Burrone O, Novelli F.

Oncotarget. 2015 May 10;6(13):11098-113.

37.

The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo.

Mammucari C, Gherardi G, Zamparo I, Raffaello A, Boncompagni S, Chemello F, Cagnin S, Braga A, Zanin S, Pallafacchina G, Zentilin L, Sandri M, De Stefani D, Protasi F, Lanfranchi G, Rizzuto R.

Cell Rep. 2015 Mar 3;10(8):1269-79. doi: 10.1016/j.celrep.2015.01.056. Epub 2015 Feb 26.

38.

Proliferation of Multiple Cell Types in the Skeletal Muscle Tissue Elicited by Acute p21 Suppression.

Biferi MG, Nicoletti C, Falcone G, Puggioni EMR, Passaro N, Mazzola A, Pajalunga D, Zaccagnini G, Rizzuto E, Auricchio A, Zentilin L, De Luca G, Giacca M, Martelli F, Musio A, Musarò A, Crescenzi M.

Mol Ther. 2015 May;23(5):885-895. doi: 10.1038/mt.2015.27. Epub 2015 Feb 11.

39.

Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material.

Ayuso E, Blouin V, Lock M, McGorray S, Leon X, Alvira MR, Auricchio A, Bucher S, Chtarto A, Clark KR, Darmon C, Doria M, Fountain W, Gao G, Gao K, Giacca M, Kleinschmidt J, Leuchs B, Melas C, Mizukami H, Müller M, Noordman Y, Bockstael O, Ozawa K, Pythoud C, Sumaroka M, Surosky R, Tenenbaum L, van der Linden I, Weins B, Wright JF, Zhang X, Zentilin L, Bosch F, Snyder RO, Moullier P.

Hum Gene Ther. 2014 Nov;25(11):977-87. doi: 10.1089/hum.2014.057.

40.

Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour.

Brai E, Marathe S, Zentilin L, Giacca M, Nimpf J, Kretz R, Scotti A, Alberi L.

Eur J Neurosci. 2014 Nov;40(10):3436-49. doi: 10.1111/ejn.12719. Epub 2014 Sep 19.

PMID:
25234246
41.

Epigenetic modification at Notch responsive promoters blunts efficacy of inducing notch pathway reactivation after myocardial infarction.

Felician G, Collesi C, Lusic M, Martinelli V, Ferro MD, Zentilin L, Zacchigna S, Giacca M.

Circ Res. 2014 Sep 12;115(7):636-49. doi: 10.1161/CIRCRESAHA.115.304517. Epub 2014 Aug 11.

PMID:
25114098
42.

Adeno-associated virus vectors as therapeutic and investigational tools in the cardiovascular system.

Zacchigna S, Zentilin L, Giacca M.

Circ Res. 2014 May 23;114(11):1827-46. doi: 10.1161/CIRCRESAHA.114.302331. Review.

PMID:
24855205
43.

The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver.

Panattoni M, Maiorino L, Lukacs A, Zentilin L, Mazza D, Sanvito F, Sitia G, Guidotti LG, Pardi R.

Hepatology. 2014 Jun;59(6):2331-43. doi: 10.1002/hep.27028. Epub 2014 Apr 30.

PMID:
24452456
44.

Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia.

Jazwa A, Tomczyk M, Taha HM, Hytonen E, Stoszko M, Zentilin L, Giacca M, Yla-Herttuala S, Emanueli C, Jozkowicz A, Dulak J.

Vasc Cell. 2013 Jul 1;5:13. doi: 10.1186/2045-824X-5-13. eCollection 2013.

45.

Carbon nanotubes instruct physiological growth and functionally mature syncytia: nongenetic engineering of cardiac myocytes.

Martinelli V, Cellot G, Toma FM, Long CS, Caldwell JH, Zentilin L, Giacca M, Turco A, Prato M, Ballerini L, Mestroni L.

ACS Nano. 2013 Jul 23;7(7):5746-56. doi: 10.1021/nn4002193. Epub 2013 Jun 11.

PMID:
23734857
46.

Effect of vascular endothelial growth factor gene therapy on post-traumatic peripheral nerve regeneration and denervation-related muscle atrophy.

Moimas S, Novati F, Ronchi G, Zacchigna S, Fregnan F, Zentilin L, Papa G, Giacca M, Geuna S, Perroteau I, Arnež ZM, Raimondo S.

Gene Ther. 2013 Oct;20(10):1014-21. doi: 10.1038/gt.2013.26. Epub 2013 May 30.

47.

MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors.

Ganesan J, Ramanujam D, Sassi Y, Ahles A, Jentzsch C, Werfel S, Leierseder S, Loyer X, Giacca M, Zentilin L, Thum T, Laggerbauer B, Engelhardt S.

Circulation. 2013 May 28;127(21):2097-106. doi: 10.1161/CIRCULATIONAHA.112.000882. Epub 2013 Apr 26.

PMID:
23625957
48.

Functional screening identifies miRNAs inducing cardiac regeneration.

Eulalio A, Mano M, Dal Ferro M, Zentilin L, Sinagra G, Zacchigna S, Giacca M.

Nature. 2012 Dec 20;492(7429):376-81. doi: 10.1038/nature11739. Epub 2012 Dec 5.

PMID:
23222520
49.

Neuropilin-1 identifies a subset of bone marrow Gr1- monocytes that can induce tumor vessel normalization and inhibit tumor growth.

Carrer A, Moimas S, Zacchigna S, Pattarini L, Zentilin L, Ruozi G, Mano M, Sinigaglia M, Maione F, Serini G, Giraudo E, Bussolino F, Giacca M.

Cancer Res. 2012 Dec 15;72(24):6371-81. doi: 10.1158/0008-5472.CAN-12-0762. Epub 2012 Dec 7.

50.

Inhibition of choroidal and corneal pathologic neovascularization by Plgf1-de gene transfer.

Tarallo V, Bogdanovich S, Hirano Y, Tudisco L, Zentilin L, Giacca M, Ambati J, De Falco S.

Invest Ophthalmol Vis Sci. 2012 Dec 5;53(13):7989-96. doi: 10.1167/iovs.12-10658.

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