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Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.

Love HD, Ao M, Jorgensen S, Swearingen L, Ferrell NJ, Evans RC, Gewin L, Harris RC, Zent R, Roy S, Fissell WH.

Tissue Eng Part A. 2018 Nov 28. doi: 10.1089/ten.TEA.2018.0182. [Epub ahead of print]


LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Fässler R, Böttcher RT.

J Cell Sci. 2018 Nov 21;131(22). pii: jcs218214. doi: 10.1242/jcs.218214.


NIX-mediated mitophagy protects against proteinuria-induced tubular cell apoptosis and renal injury.

Xu D, Chen P, Wang B, Wang Y, Miao N, Yin F, Cheng Q, Zhou Z, Xie H, Zhou L, Liu J, Wang X, Zent R, Lu L, Zhang W.

Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F382-F395. doi: 10.1152/ajprenal.00360.2018. Epub 2018 Sep 12.


The laminin binding α3 and α6 integrins cooperate to promote epithelial cell adhesion and growth.

Yazlovitskaya EM, Viquez OM, Tu T, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Pozzi A, Zent R.

Matrix Biol. 2018 Sep 4. pii: S0945-053X(18)30262-2. doi: 10.1016/j.matbio.2018.08.010. [Epub ahead of print]


The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.

Sausville LN, Gangadhariah MH, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A.

Cancer Res. 2018 Sep 1;78(17):4865-4877. doi: 10.1158/0008-5472.CAN-17-3977. Epub 2018 Jul 16.


Lkb1 deficiency confers glutamine dependency in polycystic kidney disease.

Flowers EM, Sudderth J, Zacharias L, Mernaugh G, Zent R, DeBerardinis RJ, Carroll TJ.

Nat Commun. 2018 Feb 26;9(1):814. doi: 10.1038/s41467-018-03036-y.


Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains.

Brown KL, Banerjee S, Feigley A, Abe H, Blackwell TS, Pozzi A, Hudson BG, Zent R.

Sci Rep. 2018 Feb 13;8(1):2916. doi: 10.1038/s41598-018-21231-1.


Vinculin is required to maintain glomerular barrier integrity.

Lausecker F, Tian X, Inoue K, Wang Z, Pedigo CE, Hassan H, Liu C, Zimmer M, Jinno S, Huckle AL, Hamidi H, Ross RS, Zent R, Ballestrem C, Lennon R, Ishibe S.

Kidney Int. 2018 Mar;93(3):643-655. doi: 10.1016/j.kint.2017.09.021. Epub 2017 Dec 12.


Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients.

Deger SM, Hung AM, Gamboa JL, Siew ED, Ellis CD, Booker C, Sha F, Li H, Bian A, Stewart TG, Zent R, Mitch WE, Abumrad NN, Ikizler TA.

JCI Insight. 2017 Nov 16;2(22). pii: 95185. doi: 10.1172/jci.insight.95185. [Epub ahead of print]


Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of GPCRs.

Cleghorn WM, Bulus N, Kook S, Gurevich VV, Zent R, Gurevich EV.

Cell Signal. 2018 Jan;42:259-269. doi: 10.1016/j.cellsig.2017.11.003. Epub 2017 Nov 11.


Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.

Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R.

Development. 2017 Nov 15;144(22):4148-4158. doi: 10.1242/dev.149914. Epub 2017 Oct 9.


Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.

Böttcher RT, Veelders M, Rombaut P, Faix J, Theodosiou M, Stradal TE, Rottner K, Zent R, Herzog F, Fässler R.

J Cell Biol. 2017 Nov 6;216(11):3785-3798. doi: 10.1083/jcb.201701176. Epub 2017 Sep 14.


Pharmacologic Inhibition of β-Catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor.

Polosukhina D, Love HD, Moses HL, Lee E, Zent R, Clark PE.

Oncol Res. 2017 Nov 2;25(9):1653-1664. doi: 10.3727/096504017X14992942781895. Epub 2017 Jul 10.


Clustering of integrin α5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells.

Starchenko A, Graves-Deal R, Yang YP, Li C, Zent R, Singh B, Coffey RJ.

Mol Biol Cell. 2017 May 15;28(10):1288-1300. doi: 10.1091/mbc.E16-12-0852. Epub 2017 Mar 29.


Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors.

Polosukhina D, Love HD, Correa H, Su Z, Dahlman KB, Pao W, Moses HL, Arteaga CL, Lovvorn HN 3rd, Zent R, Clark PE.

Mol Oncol. 2017 Apr;11(4):405-421. doi: 10.1002/1878-0261.12044. Epub 2017 Mar 15.


Integrin alpha6 maintains the structural integrity of the kidney collecting system.

Viquez OM, Yazlovitskaya EM, Tu T, Mernaugh G, Secades P, McKee KK, Georges-Labouesse E, De Arcangelis A, Quaranta V, Yurchenco P, Gewin LC, Sonnenberg A, Pozzi A, Zent R.

Matrix Biol. 2017 Jan;57-58:244-257. doi: 10.1016/j.matbio.2016.12.003. Epub 2016 Dec 30.


Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.

Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R.

Elife. 2016 Dec 8;5. pii: e18633. doi: 10.7554/eLife.18633.


Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis.

Borza CM, Su Y, Tran TL, Yu L, Steyns N, Temple KJ, Skwark MJ, Meiler J, Lindsley CW, Hicks BR, Leitinger B, Zent R, Pozzi A.

Matrix Biol. 2017 Jan;57-58:258-271. doi: 10.1016/j.matbio.2016.11.009. Epub 2016 Dec 1.


Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance.

Williams AS, Trefts E, Lantier L, Grueter CA, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH.

Diabetes. 2017 Feb;66(2):325-334. doi: 10.2337/db16-0484. Epub 2016 Nov 29.


Progression of chronic kidney disease: too much cellular talk causes damage.

Gewin L, Zent R, Pozzi A.

Kidney Int. 2017 Mar;91(3):552-560. doi: 10.1016/j.kint.2016.08.025. Epub 2016 Oct 20. Review.


Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics.

Haake SM, Li J, Bai Y, Kinose F, Fang B, Welsh EA, Zent R, Dhillon J, Pow-Sang JM, Chen YA, Koomen JM, Rathmell WK, Fishman M, Haura EB.

Clin Cancer Res. 2016 Nov 15;22(22):5605-5616. doi: 10.1158/1078-0432.CCR-15-1673. Epub 2016 May 24.


Extracellular chloride signals collagen IV network assembly during basement membrane formation.

Cummings CF, Pedchenko V, Brown KL, Colon S, Rafi M, Jones-Paris C, Pokydeshava E, Liu M, Pastor-Pareja JC, Stothers C, Ero-Tolliver IA, McCall AS, Vanacore R, Bhave G, Santoro S, Blackwell TS, Zent R, Pozzi A, Hudson BG.

J Cell Biol. 2016 May 23;213(4):479-94. doi: 10.1083/jcb.201510065.


Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice.

Kang L, Mokshagundam S, Reuter B, Lark DS, Sneddon CC, Hennayake C, Williams AS, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH.

Diabetes. 2016 Jun;65(6):1590-600. doi: 10.2337/db15-1434. Epub 2016 Apr 5.


Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.

Theodosiou M, Widmaier M, Böttcher RT, Rognoni E, Veelders M, Bharadwaj M, Lambacher A, Austen K, Müller DJ, Zent R, Fässler R.

Elife. 2016 Jan 27;5:e10130. doi: 10.7554/eLife.10130.


Deleting the TGF-β receptor in proximal tubules impairs HGF signaling.

Nlandu Khodo S, Neelisetty S, Woodbury L, Green E, Harris RC, Zent R, Gewin L.

Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F499-510. doi: 10.1152/ajprenal.00446.2015. Epub 2016 Jan 6.


Vinculin controls talin engagement with the actomyosin machinery.

Atherton P, Stutchbury B, Wang DY, Jethwa D, Tsang R, Meiler-Rodriguez E, Wang P, Bate N, Zent R, Barsukov IL, Goult BT, Critchley DR, Ballestrem C.

Nat Commun. 2015 Dec 4;6:10038. doi: 10.1038/ncomms10038.


Cell Receptor-Basement Membrane Interactions in Health and Disease: A Kidney-Centric View.

Borza CM, Chen X, Zent R, Pozzi A.

Curr Top Membr. 2015;76:231-53. doi: 10.1016/bs.ctm.2015.07.003. Review.


Extracellular rigidity sensing by talin isoform-specific mechanical linkages.

Austen K, Ringer P, Mehlich A, Chrostek-Grashoff A, Kluger C, Klingner C, Sabass B, Zent R, Rief M, Grashoff C.

Nat Cell Biol. 2015 Dec;17(12):1597-606. doi: 10.1038/ncb3268. Epub 2015 Nov 2.


Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.

Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R.

J Cell Sci. 2015 Dec 1;128(23):4293-305. doi: 10.1242/jcs.164509. Epub 2015 Oct 21.


A Murine Model of K-RAS and β-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor.

Yi Y, Polosukhina D, Love HD, Hembd A, Pickup M, Moses HL, Lovvorn HN 3rd, Zent R, Clark PE.

J Urol. 2015 Dec;194(6):1762-70. doi: 10.1016/j.juro.2015.04.090. Epub 2015 Apr 29.


Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt.

Yazlovitskaya EM, Tseng HY, Viquez O, Tu T, Mernaugh G, McKee KK, Riggins K, Quaranta V, Pathak A, Carter BD, Yurchenco P, Sonnenberg A, Böttcher RT, Pozzi A, Zent R.

Mol Biol Cell. 2015 May 15;26(10):1857-74. doi: 10.1091/mbc.E14-07-1203. Epub 2015 Mar 25.


Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells.

Neelisetty S, Alford C, Reynolds K, Woodbury L, Nlandu-Khodo S, Yang H, Fogo AB, Hao CM, Harris RC, Zent R, Gewin L.

Kidney Int. 2015 Sep;88(3):503-14. doi: 10.1038/ki.2015.51. Epub 2015 Mar 11.


Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells.

Keller B, Mühlenkamp M, Deuschle E, Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jiménez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E.

Cell Microbiol. 2015 Aug;17(8):1179-204. doi: 10.1111/cmi.12429. Epub 2015 Mar 20.


The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites.

Karaköse E, Geiger T, Flynn K, Lorenz-Baath K, Zent R, Mann M, Fässler R.

J Cell Sci. 2015 Mar 1;128(5):1023-33. doi: 10.1242/jcs.162545. Epub 2015 Jan 20.


p47(phox) contributes to albuminuria and kidney fibrosis in mice.

Wang H, Chen X, Su Y, Paueksakon P, Hu W, Zhang MZ, Harris RC, Blackwell TS, Zent R, Pozzi A.

Kidney Int. 2015 May;87(5):948-62. doi: 10.1038/ki.2014.386. Epub 2015 Jan 7.


Arrestins regulate cell spreading and motility via focal adhesion dynamics.

Cleghorn WM, Branch KM, Kook S, Arnette C, Bulus N, Zent R, Kaverina I, Gurevich EV, Weaver AM, Gurevich VV.

Mol Biol Cell. 2015 Feb 15;26(4):622-35. doi: 10.1091/mbc.E14-02-0740. Epub 2014 Dec 24.


Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization.

Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R.

Development. 2014 Dec;141(24):4751-62. doi: 10.1242/dev.117200. Epub 2014 Nov 13.


Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.

Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A.

J Am Soc Nephrol. 2015 Mar;26(3):597-610. doi: 10.1681/ASN.2013090980. Epub 2014 Jul 28.


Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.

Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Fässler R, Zent R, Pozzi A.

J Clin Invest. 2014 Aug;124(8):3295-310. doi: 10.1172/JCI71668. Epub 2014 Jul 1.


Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells.

Miller CG, Pozzi A, Zent R, Schwarzbauer JE.

Mol Biol Cell. 2014 Aug 15;25(16):2342-50. doi: 10.1091/mbc.E14-03-0800. Epub 2014 Jun 18.


The kidney research predicament.

Bryan L, Ibrahim T, Zent R, Fischer MJ.

J Am Soc Nephrol. 2014 May;25(5):898-903. doi: 10.1681/ASN.2013121313. Epub 2014 Mar 20.


Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.

Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S.

J Clin Invest. 2014 Mar;124(3):1098-113. doi: 10.1172/JCI69778. Epub 2014 Feb 17. Erratum in: J Clin Invest. 2015 Feb;125(2):882.


The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells.

Elias BC, Mathew S, Srichai MB, Palamuttam R, Bulus N, Mernaugh G, Singh AB, Sanders CR, Harris RC, Pozzi A, Zent R.

J Biol Chem. 2014 Mar 21;289(12):8532-44. doi: 10.1074/jbc.M113.526509. Epub 2014 Feb 7.


Glomerular cell cross-talk influences composition and assembly of extracellular matrix.

Byron A, Randles MJ, Humphries JD, Mironov A, Hamidi H, Harris S, Mathieson PW, Saleem MA, Satchell SC, Zent R, Humphries MJ, Lennon R.

J Am Soc Nephrol. 2014 May;25(5):953-66. doi: 10.1681/ASN.2013070795. Epub 2014 Jan 16.


Global analysis reveals the complexity of the human glomerular extracellular matrix.

Lennon R, Byron A, Humphries JD, Randles MJ, Carisey A, Murphy S, Knight D, Brenchley PE, Zent R, Humphries MJ.

J Am Soc Nephrol. 2014 May;25(5):939-51. doi: 10.1681/ASN.2013030233. Epub 2014 Jan 16.


PPARα activation can help prevent and treat non-small cell lung cancer.

Skrypnyk N, Chen X, Hu W, Su Y, Mont S, Yang S, Gangadhariah M, Wei S, Falck JR, Jat JL, Zent R, Capdevila JH, Pozzi A.

Cancer Res. 2014 Jan 15;74(2):621-31. doi: 10.1158/0008-5472.CAN-13-1928. Epub 2013 Dec 3.


Cdc42 promotes host defenses against fatal infection.

Lee K, Boyd KL, Parekh DV, Kehl-Fie TE, Baldwin HS, Brakebusch C, Skaar EP, Boothby M, Zent R.

Infect Immun. 2013 Aug;81(8):2714-23. doi: 10.1128/IAI.01114-12. Epub 2013 May 20.


Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice.

Moik D, Böttcher A, Makhina T, Grashoff C, Bulus N, Zent R, Fässler R.

J Biol Chem. 2013 Jun 28;288(26):18863-71. doi: 10.1074/jbc.M113.470476. Epub 2013 May 8.


Integrins in kidney disease.

Pozzi A, Zent R.

J Am Soc Nephrol. 2013 Jun;24(7):1034-9. doi: 10.1681/ASN.2013010012. Epub 2013 May 2. Review.


Deleting the TGF-β receptor attenuates acute proximal tubule injury.

Gewin L, Vadivelu S, Neelisetty S, Srichai MB, Paueksakon P, Pozzi A, Harris RC, Zent R.

J Am Soc Nephrol. 2012 Dec;23(12):2001-11. doi: 10.1681/ASN.2012020139. Epub 2012 Nov 15.

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