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Items: 1 to 50 of 175

1.

Differential response of flat and polypoid colitis-associated colorectal neoplasias to chemopreventive agents and heterocyclic amines.

Chang WC, Zenser TV, Cooper HS, Clapper ML.

Cancer Lett. 2013 Jun 28;334(1):62-8. doi: 10.1016/j.canlet.2013.02.013. Epub 2013 Feb 13. Review.

2.
3.

Identification of new 2-amino-3-methylimidazo[4,5-f]quinoline urinary metabolites from beta-naphthoflavone-treated mice.

Lakshmi VM, Hsu FF, Zenser TV.

Drug Metab Dispos. 2009 Aug;37(8):1690-7. doi: 10.1124/dmd.109.027342. Epub 2009 May 18.

4.

Activation of aminoimidazole carcinogens by nitrosation: mutagenicity and nucleotide adducts.

Zenser TV, Lakshmi VM, Schut HA, Zhou HJ, Josephy P.

Mutat Res. 2009 Mar 17;673(2):109-15.

5.

N-Demethylation is a major route of 2-amino-3-methylimidazo[4,5-f]quinoline metabolism in mouse.

Lakshmi VM, Hsu FF, Zenser TV.

Drug Metab Dispos. 2008 Jun;36(6):1143-52. doi: 10.1124/dmd.107.019166. Epub 2008 Mar 20.

6.

Metabolism of a heterocyclic amine colon carcinogen in young and old rats.

Armbrecht HJ, Lakshmi VM, Wickstra J, Hsu FF, Zenser TV.

Drug Metab Dispos. 2007 Apr;35(4):633-9. Epub 2007 Jan 24.

7.
8.

Stability and reactivity of 2-nitrosoamino-3,8-dimethylimidazo[4,5-f]quinoxaline.

Lakshmi VM, Hsu FF, Schut HA, Zenser TV.

Chem Res Toxicol. 2006 Feb;19(2):325-33.

9.

2-Nitrosoamino-3-methylimidazo[4,5-f]quinoline activated by the inflammatory response forms nucleotide adducts.

Lakshmi VM, Schut HA, Zenser TV.

Food Chem Toxicol. 2005 Nov;43(11):1607-17.

PMID:
15964673
10.
11.
12.

Myeloperoxidase potentiates nitric oxide-mediated nitrosation.

Lakshmi VM, Nauseef WM, Zenser TV.

J Biol Chem. 2005 Jan 21;280(3):1746-53. Epub 2004 Nov 5.

13.

2-Nitrosoamino-3-methylimidazo[4,5-f]quinoline stability and reactivity.

Lakshmi VM, Hsu FF, Zenser TV.

Chem Res Toxicol. 2004 May;17(5):709-16.

PMID:
15144229
14.

Transformation and activation of benzidine by oxidants of the inflammatory response.

Lakshmi VM, Hsu FF, Zenser TV.

Chem Res Toxicol. 2003 Mar;16(3):367-74.

PMID:
12641437
15.

Metabolism of N-acetylbenzidine and initiation of bladder cancer.

Zenser TV, Lakshmi VM, Hsu FF, Davis BB.

Mutat Res. 2002 Sep 30;506-507:29-40. Review.

PMID:
12351142
16.

Nitrosation and nitration of 2-amino-3-methylimidazo[4,5-f]quinoline by reactive nitrogen oxygen species.

Lakshmi VM, Hsu FF, Zenser TV.

Chem Res Toxicol. 2002 Aug;15(8):1059-68.

PMID:
12184790
17.

Methemoglobin oxidation of N-acetylbenzidine to form a sulfinamide.

Zenser TV, Lakshmi VM, Hsu FF, Davis BB.

Drug Metab Dispos. 2001 Apr;29(4 Pt 1):401-6.

18.

Reactive nitrogen oxygen species metabolize N-acetylbenzidine.

Lakshmi VM, Hsu FF, Davis BB, Zenser TV.

Chem Res Toxicol. 2001 Mar;14(3):312-8.

PMID:
11258981
19.

Nitrating reactive nitric oxygen species transform acetaminophen to 3-nitroacetaminophen.

Lakshmi VM, Hsu FF, Davis BB, Zenser TV.

Chem Res Toxicol. 2000 Sep;13(9):891-9.

PMID:
10995262
20.

N-Acetylbenzidine-DNA adduct formation by phorbol 12-myristate-stimulated human polymorphonuclear neutrophils.

Lakshmi VM, Hsu FF, Davis BB, Zenser TV.

Chem Res Toxicol. 2000 Aug;13(8):785-92.

PMID:
10956067
21.

Hypochlorous acid-mediated activation of N-acetylbenzidine to form N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine.

Lakshmi VM, Hsu FF, McGarry AE, Davis BB, Zenser TV.

Toxicol Sci. 2000 Feb;53(2):202-12.

PMID:
10696768
22.

Sulfinamide formation following peroxidatic metabolism of N-acetylbenzidine.

Lakshmi VM, Hsu FF, Davis BB, Zenser TV.

Chem Res Toxicol. 2000 Feb;13(2):96-102.

PMID:
10688533
23.

Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides.

Ciotti M, Lakshmi VM, Basu N, Davis BB, Owens IS, Zenser TV.

Carcinogenesis. 1999 Oct;20(10):1963-9.

PMID:
10506112
25.

Peroxygenase metabolism of N-acetylbenzidine by prostaglandin H synthase. Formation of an N-hydroxylamine.

Zenser TV, Lakshmi VM, Hsu FF, Davis BB.

J Biol Chem. 1999 May 21;274(21):14850-6.

26.

N-glucuronidation of benzidine and its metabolites. Role in bladder cancer.

Zenser TV, Lakshmi VM, Davis BB.

Drug Metab Dispos. 1998 Sep;26(9):856-9. Review.

27.

N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine formation by peroxidative metabolism.

Lakshmi VM, Zenser TV, Davis BB.

Carcinogenesis. 1998 May;19(5):911-7.

PMID:
9635882
28.

Acidic urine pH is associated with elevated levels of free urinary benzidine and N-acetylbenzidine and urothelial cell DNA adducts in exposed workers.

Rothman N, Talaska G, Hayes RB, Bhatnagar VK, Bell DA, Lakshmi VM, Kashyap SK, Dosemeci M, Kashyap R, Hsu FF, Jaeger M, Hirvonen A, Parikh DJ, Davis BB, Zenser TV.

Cancer Epidemiol Biomarkers Prev. 1997 Dec;6(12):1039-42.

29.

Urinary mutagenicity as a biomarker in workers exposed to benzidine: correlation with urinary metabolites and urothelial DNA adducts.

DeMarini DM, Brooks LR, Bhatnagar VK, Hayes RB, Eischen BT, Shelton ML, Zenser TV, Talaska G, Kashyap SK, Dosemeci M, Kashyap R, Parikh DJ, Lakshmi V, Hsu F, Davis BB, Jaeger M, Rothman N.

Carcinogenesis. 1997 May;18(5):981-8.

PMID:
9163684
30.

Rat liver cytochrome P450 metabolism of N-acetylbenzidine and N,N'-diacetylbenzidine.

Lakshmi VM, Zenser TV, Davis BB.

Drug Metab Dispos. 1997 Apr;25(4):481-8.

31.

The glutathione S-transferase M1 (GSTM1) null genotype and benzidine-associated bladder cancer, urine mutagenicity, and exfoliated urothelial cell DNA adducts.

Rothman N, Hayes RB, Zenser TV, DeMarini DM, Bi W, Hirvonen A, Talaska G, Bhatnagar VK, Caporaso NE, Brooks LR, Lakshmi VM, Feng P, Kashyap SK, You X, Eischen BT, Kashyap R, Shelton ML, Hsu FF, Jaeger M, Parikh DJ, Davis BB, Yin S, Bell DA.

Cancer Epidemiol Biomarkers Prev. 1996 Dec;5(12):979-83.

32.

NADPH-dependent oxidation of benzidine by rat liver.

Lakshmi VM, Zenser NT, Hsu FF, Mattammal MB, Zenser TV, Davis BB.

Carcinogenesis. 1996 Sep;17(9):1941-7.

PMID:
8824518
33.

Human N-acetylation of benzidine: role of NAT1 and NAT2.

Zenser TV, Lakshmi VM, Rustan TD, Doll MA, Deitz AC, Davis BB, Hein DW.

Cancer Res. 1996 Sep 1;56(17):3941-7.

34.

Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver.

Babu SR, Lakshmi VM, Huang GP, Zenser TV, Davis BB.

Biochem Pharmacol. 1996 Jun 28;51(12):1679-85.

PMID:
8687483
35.

The impact of interindividual variation in NAT2 activity on benzidine urinary metabolites and urothelial DNA adducts in exposed workers.

Rothman N, Bhatnagar VK, Hayes RB, Zenser TV, Kashyap SK, Butler MA, Bell DA, Lakshmi V, Jaeger M, Kashyap R, Hirvonen A, Schulte PA, Dosemeci M, Hsu F, Parikh DJ, Davis BB, Talaska G.

Proc Natl Acad Sci U S A. 1996 May 14;93(10):5084-9.

36.

Glucuronidation of N-hydroxy metabolites of N-acetylbenzidine.

Babu SR, Lakshmi VM, Hsu FF, Zenser TV, Davis BB.

Carcinogenesis. 1995 Dec;16(12):3069-74.

PMID:
8603487
37.

N-acetylbenzidine and N,N'-diacetylbenzidine formation by rat and human liver slices exposed to benzidine.

Lakshmi VM, Bell DA, Watson MA, Zenser TV, Davis BB.

Carcinogenesis. 1995 Jul;16(7):1565-71.

PMID:
7614690
38.

The role of acetylation in benzidine metabolism and DNA adduct formation in dog and rat liver.

Lakshmi VM, Zenser TV, Goldman HD, Spencer GG, Gupta RC, Hsu FF, Davis BB.

Chem Res Toxicol. 1995 Jul-Aug;8(5):711-20.

PMID:
7548754
39.

Glucuronidation of N-acetylbenzidine by human liver.

Babu SR, Lakshmi VM, Zenser TV, Davis BB.

Drug Metab Dispos. 1994 Nov-Dec;22(6):922-7.

PMID:
7895611
40.

Human liver glucuronidation of benzidine.

Babu SR, Lakshmi VM, Owens IS, Zenser TV, Davis BB.

Carcinogenesis. 1994 Sep;15(9):2003-7.

PMID:
7923596
41.

Mechanism of 3-(glutathion-S-yl)-benzidine formation.

Lakshmi VM, Zenser TV, Davis BB.

Toxicol Appl Pharmacol. 1994 Apr;125(2):256-63.

PMID:
8171433
42.

N-acetylbenzidine-N'-glucuronidation by human, dog and rat liver.

Babu SR, Lakshmi VM, Hsu FF, Kane RE, Zenser TV, Davis BB.

Carcinogenesis. 1993 Dec;14(12):2605-11.

PMID:
8269633
43.

Phenylbutazone peroxidatic metabolism and conjugation.

Lakshmi VM, Zenser TV, Mattammal MB, Davis BB.

J Pharmacol Exp Ther. 1993 Jul;266(1):81-8.

PMID:
8331577
44.

Benzidine glucuronidation in dog liver.

Babu SR, Wongsurawat VJ, Zenser TV, Davis BB.

Carcinogenesis. 1993 May;14(5):893-7.

PMID:
8389254
45.

Evaluation of renal concentrating and diluting ability.

Davis BB, Zenser TV.

Clin Lab Med. 1993 Mar;13(1):131-4. Review.

PMID:
8462256
47.

Liver NADPH-dependent oxidation of the 5-nitrofurans, FANFT and ANFT, by guinea pig and rat.

Dawley RM, Lakshmi VM, Babu SR, Zenser TV, Davis BB.

Xenobiotica. 1993 Feb;23(2):193-203.

PMID:
8498082
48.

Mechanism of formation of the thioether conjugate of the bladder carcinogen 2-amino-4-(5-nitro-2-furyl)-thiazole (ANFT).

Lakshmi VM, Zenser TV, Sohani S, Davis BB.

Carcinogenesis. 1992 Nov;13(11):2087-93.

PMID:
1423880
49.

Role of N-glucuronidation in benzidine-induced bladder cancer in dog.

Babu SR, Lakshmi VM, Hsu FF, Zenser TV, Davis BB.

Carcinogenesis. 1992 Jul;13(7):1235-40.

PMID:
1638692
50.

Altered regulation of arachidonic acid metabolism by SV40 immortalized human urothelial cells.

Thomas DJ, Jacob AK, Reznikoff CA, Zenser TV, Davis BB.

Carcinogenesis. 1992 Mar;13(3):447-51.

PMID:
1312397

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