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Items: 45


Spatial Organization of Single mRNPs at Different Stages of the Gene Expression Pathway.

Adivarahan S, Livingston N, Nicholson B, Rahman S, Wu B, Rissland OS, Zenklusen D.

Mol Cell. 2018 Nov 15;72(4):727-738.e5. doi: 10.1016/j.molcel.2018.10.010. Epub 2018 Nov 8.


Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.

Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G.

Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25.


Visualization of Arenavirus RNA Species in Individual Cells by Single-Molecule Fluorescence In Situ Hybridization Suggests a Model of Cyclical Infection and Clearance during Persistence.

King BR, Samacoits A, Eisenhauer PL, Ziegler CM, Bruce EA, Zenklusen D, Zimmer C, Mueller F, Botten J.

J Virol. 2018 May 29;92(12). pii: e02241-17. doi: 10.1128/JVI.02241-17. Print 2018 Jun 15.


Measuring mRNA Decay in Budding Yeast Using Single Molecule FISH.

Trcek T, Rahman S, Zenklusen D.

Methods Mol Biol. 2018;1720:35-54. doi: 10.1007/978-1-4939-7540-2_4.


Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.

Scott DD, Trahan C, Zindy PJ, Aguilar LC, Delubac MY, Van Nostrand EL, Adivarahan S, Wei KE, Yeo GW, Zenklusen D, Oeffinger M.

Nucleic Acids Res. 2017 Dec 1;45(21):12509-12528. doi: 10.1093/nar/gkx963.


Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly.

King BR, Kellner S, Eisenhauer PL, Bruce EA, Ziegler CM, Zenklusen D, Botten JW.

J Gen Virol. 2017 Sep 27. doi: 10.1099/jgv.0.000930. [Epub ahead of print]


Single-cell profiling reveals that eRNA accumulation at enhancer-promoter loops is not required to sustain transcription.

Rahman S, Zorca CE, Traboulsi T, Noutahi E, Krause MR, Mader S, Zenklusen D.

Nucleic Acids Res. 2017 Apr 7;45(6):3017-3030. doi: 10.1093/nar/gkw1220.


Structure and Function of the Nuclear Pore Complex Cytoplasmic mRNA Export Platform.

Fernandez-Martinez J, Kim SJ, Shi Y, Upla P, Pellarin R, Gagnon M, Chemmama IE, Wang J, Nudelman I, Zhang W, Williams R, Rice WJ, Stokes DL, Zenklusen D, Chait BT, Sali A, Rout MP.

Cell. 2016 Nov 17;167(5):1215-1228.e25. doi: 10.1016/j.cell.2016.10.028. Epub 2016 Nov 10.


Imaging single mRNAs to study dynamics of mRNA export in the yeast Saccharomyces cerevisiae.

Bensidoun P, Raymond P, Oeffinger M, Zenklusen D.

Methods. 2016 Apr 1;98:104-114. doi: 10.1016/j.ymeth.2016.01.006. Epub 2016 Jan 16.


The nuclear basket mediates perinuclear mRNA scanning in budding yeast.

Saroufim MA, Bensidoun P, Raymond P, Rahman S, Krause MR, Oeffinger M, Zenklusen D.

J Cell Biol. 2015 Dec 21;211(6):1131-40. doi: 10.1083/jcb.201503070.


In vivo single-particle imaging of nuclear mRNA export in budding yeast demonstrates an essential role for Mex67p.

Smith C, Lari A, Derrer CP, Ouwehand A, Rossouw A, Huisman M, Dange T, Hopman M, Joseph A, Zenklusen D, Weis K, Grunwald D, Montpetit B.

J Cell Biol. 2015 Dec 21;211(6):1121-30. doi: 10.1083/jcb.201503135.


Promoter-Autonomous Functioning in a Controlled Environment using Single Molecule FISH.

Hocine S, Vera M, Zenklusen D, Singer RH.

Sci Rep. 2015 May 28;5:9934. doi: 10.1038/srep09934.


Myosin VI regulates gene pairing and transcriptional pause release in T cells.

Zorca CE, Kim LK, Kim YJ, Krause MR, Zenklusen D, Spilianakis CG, Flavell RA.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1587-93. doi: 10.1073/pnas.1502461112. Epub 2015 Mar 13.


Single-molecule resolution fluorescent in situ hybridization (smFISH) in the yeast S. cerevisiae.

Rahman S, Zenklusen D.

Methods Mol Biol. 2013;1042:33-46. doi: 10.1007/978-1-62703-526-2_3.


Bimodal expression of PHO84 is modulated by early termination of antisense transcription.

Castelnuovo M, Rahman S, Guffanti E, Infantino V, Stutz F, Zenklusen D.

Nat Struct Mol Biol. 2013 Jul;20(7):851-8. doi: 10.1038/nsmb.2598. Epub 2013 Jun 16.


A nutrient-responsive pathway that determines M phase timing through control of B-cyclin mRNA stability.

Messier V, Zenklusen D, Michnick SW.

Cell. 2013 May 23;153(5):1080-93. doi: 10.1016/j.cell.2013.04.035.


Single-molecule analysis of gene expression using two-color RNA labeling in live yeast.

Hocine S, Raymond P, Zenklusen D, Chao JA, Singer RH.

Nat Methods. 2013 Feb;10(2):119-21. doi: 10.1038/nmeth.2305. Epub 2012 Dec 23.


To the pore and through the pore: a story of mRNA export kinetics.

Oeffinger M, Zenklusen D.

Biochim Biophys Acta. 2012 Jun;1819(6):494-506. doi: 10.1016/j.bbagrm.2012.02.011. Epub 2012 Feb 22. Review.


Single-mRNA counting using fluorescent in situ hybridization in budding yeast.

Trcek T, Chao JA, Larson DR, Park HY, Zenklusen D, Shenoy SM, Singer RH.

Nat Protoc. 2012 Feb 2;7(2):408-19. doi: 10.1038/nprot.2011.451.


Real-time observation of transcription initiation and elongation on an endogenous yeast gene.

Larson DR, Zenklusen D, Wu B, Chao JA, Singer RH.

Science. 2011 Apr 22;332(6028):475-8. doi: 10.1126/science.1202142.


Transcription of functionally related constitutive genes is not coordinated.

Gandhi SJ, Zenklusen D, Lionnet T, Singer RH.

Nat Struct Mol Biol. 2011 Jan;18(1):27-34. doi: 10.1038/nsmb.1934. Epub 2010 Dec 5.


A nucleoporin, Nup60p, affects the nuclear and cytoplasmic localization of ASH1 mRNA in S. cerevisiae.

Powrie EA, Zenklusen D, Singer RH.

RNA. 2011 Jan;17(1):134-44. doi: 10.1261/rna.1210411. Epub 2010 Oct 29.


Analyzing mRNA expression using single mRNA resolution fluorescent in situ hybridization.

Zenklusen D, Singer RH.

Methods Enzymol. 2010;470:641-59. doi: 10.1016/S0076-6879(10)70026-4. Epub 2010 Mar 1.


Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate.

Silverman SJ, Petti AA, Slavov N, Parsons L, Briehof R, Thiberge SY, Zenklusen D, Gandhi SJ, Larson DR, Singer RH, Botstein D.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6946-51. doi: 10.1073/pnas.1002422107. Epub 2010 Mar 24. Erratum in: Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12185.


Rrp17p is a eukaryotic exonuclease required for 5' end processing of Pre-60S ribosomal RNA.

Oeffinger M, Zenklusen D, Ferguson A, Wei KE, El Hage A, Tollervey D, Chait BT, Singer RH, Rout MP.

Mol Cell. 2009 Dec 11;36(5):768-81. doi: 10.1016/j.molcel.2009.11.011.


A single molecule view of gene expression.

Larson DR, Singer RH, Zenklusen D.

Trends Cell Biol. 2009 Nov;19(11):630-7. doi: 10.1016/j.tcb.2009.08.008. Epub 2009 Oct 8. Review.


Imaging transcription in living cells.

Darzacq X, Yao J, Larson DR, Causse SZ, Bosanac L, de Turris V, Ruda VM, Lionnet T, Zenklusen D, Guglielmi B, Tjian R, Singer RH.

Annu Rev Biophys. 2009;38:173-96. doi: 10.1146/annurev.biophys.050708.133728. Review.


Single-RNA counting reveals alternative modes of gene expression in yeast.

Zenklusen D, Larson DR, Singer RH.

Nat Struct Mol Biol. 2008 Dec;15(12):1263-71. doi: 10.1038/nsmb.1514. Epub 2008 Nov 16.


YRA1 autoregulation requires nuclear export and cytoplasmic Edc3p-mediated degradation of its pre-mRNA.

Dong S, Li C, Zenklusen D, Singer RH, Jacobson A, He F.

Mol Cell. 2007 Feb 23;25(4):559-73.


Imaging real-time gene expression in living systems with single-transcript resolution: construct design and imaging system setup.

Wells AL, Condeelis JS, Singer RH, Zenklusen D.

CSH Protoc. 2007 Nov 1;2007:pdb.top28. doi: 10.1101/pdb.top28.


Imaging Real-Time Gene Expression in Living Systems with Single-Transcript Resolution: Single mRNA Particle Tracking with ImageJ-Based Analysis.

Wells AL, Condeelis JS, Singer RH, Zenklusen D.

CSH Protoc. 2007 Nov 1;2007:pdb.prot4872. doi: 10.1101/pdb.prot4872.


Imaging real-time gene expression in living systems with single-transcript resolution: image analysis of single mRNA transcripts.

Wells AL, Condeelis JS, Singer RH, Zenklusen D.

CSH Protoc. 2007 Nov 1;2007:pdb.prot4871. doi: 10.1101/pdb.prot4871.


Imaging real-time gene expression in living yeast.

Zenklusen D, Wells AL, Condeelis JS, Singer RH.

CSH Protoc. 2007 Nov 1;2007:pdb.prot4870. doi: 10.1101/pdb.prot4870.


Imaging real-time gene expression in Mammalian cells with single-transcript resolution.

Wells AL, Condeelis JS, Singer RH, Zenklusen D.

CSH Protoc. 2007 Nov 1;2007:pdb.prot4869. doi: 10.1101/pdb.prot4869.


Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.

Hüttelmaier S, Zenklusen D, Lederer M, Dictenberg J, Lorenz M, Meng X, Bassell GJ, Condeelis J, Singer RH.

Nature. 2005 Nov 24;438(7067):512-5.


Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export.

Vinciguerra P, Iglesias N, Camblong J, Zenklusen D, Stutz F.

EMBO J. 2005 Feb 23;24(4):813-23. Epub 2005 Feb 3.


She2p is a novel RNA binding protein with a basic helical hairpin motif.

Niessing D, Hüttelmaier S, Zenklusen D, Singer RH, Burley SK.

Cell. 2004 Nov 12;119(4):491-502.


RNA asymmetric distribution and daughter/mother differentiation in yeast.

Darzacq X, Powrie E, Gu W, Singer RH, Zenklusen D.

Curr Opin Microbiol. 2003 Dec;6(6):614-20. Review.


Coupling of termination, 3' processing, and mRNA export.

Hammell CM, Gross S, Zenklusen D, Heath CV, Stutz F, Moore C, Cole CN.

Mol Cell Biol. 2002 Sep;22(18):6441-57.


Nuclear export of mRNA.

Zenklusen D, Stutz F.

FEBS Lett. 2001 Jun 8;498(2-3):150-6. Review.


The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p.

Zenklusen D, Vinciguerra P, Strahm Y, Stutz F.

Mol Cell Biol. 2001 Jul;21(13):4219-32.


Positive and negative mutant selection in the human histone hairpin-binding protein using the yeast three-hybrid system.

Martin F, Michel F, Zenklusen D, Müller B, Schümperli D.

Nucleic Acids Res. 2000 Apr 1;28(7):1594-603.


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