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Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.

Mosaei H, Molodtsov V, Kepplinger B, Harbottle J, Moon CW, Jeeves RE, Ceccaroni L, Shin Y, Morton-Laing S, Marrs ECL, Wills C, Clegg W, Yuzenkova Y, Perry JD, Bacon J, Errington J, Allenby NEE, Hall MJ, Murakami KS, Zenkin N.

Mol Cell. 2018 Oct 18;72(2):263-274.e5. doi: 10.1016/j.molcel.2018.08.028. Epub 2018 Sep 20.


Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.

Talavera A, Hendrix J, Versées W, Jurėnas D, Van Nerom K, Vandenberk N, Singh RK, Konijnenberg A, De Gieter S, Castro-Roa D, Barth A, De Greve H, Sobott F, Hofkens J, Zenkin N, Loris R, Garcia-Pino A.

Sci Adv. 2018 Mar 14;4(3):eaap9714. doi: 10.1126/sciadv.aap9714. eCollection 2018 Mar.


Transcription fidelity and its roles in the cell.

Gamba P, Zenkin N.

Curr Opin Microbiol. 2018 Apr;42:13-18. doi: 10.1016/j.mib.2017.08.004. Epub 2017 Sep 29. Review.


Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase.

Forrest D, James K, Yuzenkova Y, Zenkin N.

Nat Commun. 2017 Jun 6;8:15774. doi: 10.1038/ncomms15774.


Deep sequencing approaches for the analysis of prokaryotic transcriptional boundaries and dynamics.

James K, Cockell SJ, Zenkin N.

Methods. 2017 May 1;120:76-84. doi: 10.1016/j.ymeth.2017.04.016. Epub 2017 Apr 21. Review.


Structural Reassignment and Absolute Stereochemistry of Madurastatin C1 (MBJ-0034) and the Related Aziridine Siderophores: Madurastatins A1, B1, and MBJ-0035.

Tyler AR, Mosaei H, Morton S, Waddell PG, Wills C, McFarlane W, Gray J, Goodfellow M, Errington J, Allenby N, Zenkin N, Hall MJ.

J Nat Prod. 2017 May 26;80(5):1558-1562. doi: 10.1021/acs.jnatprod.7b00082. Epub 2017 Apr 11.


Misincorporation by RNA polymerase is a major source of transcription pausing in vivo.

James K, Gamba P, Cockell SJ, Zenkin N.

Nucleic Acids Res. 2017 Feb 17;45(3):1105-1113. doi: 10.1093/nar/gkw969.


A link between transcription fidelity and pausing in vivo.

Gamba P, James K, Zenkin N.

Transcription. 2017 Mar 15;8(2):99-105. doi: 10.1080/21541264.2016.1274812. Epub 2017 Jan 10.


Ribonucleoprotein particles of bacterial small non-coding RNA IsrA (IS61 or McaS) and its interaction with RNA polymerase core may link transcription to mRNA fate.

van Nues RW, Castro-Roa D, Yuzenkova Y, Zenkin N.

Nucleic Acids Res. 2016 Apr 7;44(6):2577-92. doi: 10.1093/nar/gkv1302. Epub 2015 Nov 24.


New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel.

Zenkin N, Yuzenkova Y.

Biomolecules. 2015 Jun 25;5(3):1195-209. doi: 10.3390/biom5031195. Review.


Methodology for the analysis of transcription and translation in transcription-coupled-to-translation systems in vitro.

Castro-Roa D, Zenkin N.

Methods. 2015 Sep 15;86:51-9. doi: 10.1016/j.ymeth.2015.05.029. Epub 2015 Jun 14. Review.


Bacteriophage Xp10 anti-termination factor p7 induces forward translocation by host RNA polymerase.

Zenkin N, Severinov K, Yuzenkova Y.

Nucleic Acids Res. 2015 Jul 27;43(13):6299-308. doi: 10.1093/nar/gkv586. Epub 2015 Jun 1.


Methods for the assembly and analysis of in vitro transcription-coupled-to-translation systems.

Castro-Roa D, Zenkin N.

Methods Mol Biol. 2015;1276:81-99. doi: 10.1007/978-1-4939-2392-2_5.


Bacterial global regulators DksA/ppGpp increase fidelity of transcription.

Roghanian M, Zenkin N, Yuzenkova Y.

Nucleic Acids Res. 2015 Feb 18;43(3):1529-36. doi: 10.1093/nar/gkv003. Epub 2015 Jan 20.


Control of transcription elongation by GreA determines rate of gene expression in Streptococcus pneumoniae.

Yuzenkova Y, Gamba P, Herber M, Attaiech L, Shafeeq S, Kuipers OP, Klumpp S, Zenkin N, Veening JW.

Nucleic Acids Res. 2014;42(17):10987-99. doi: 10.1093/nar/gku790. Epub 2014 Sep 4.


Transcription. Response to Comment on "Mechanism of eukaryotic RNA polymerase III transcription termination".

Nielsen S, Zenkin N.

Science. 2014 Aug 1;345(6196):524. doi: 10.1126/science.1254246. Epub 2014 Jul 31.


Multiple personalities of the RNA polymerase active centre.

Zenkin N.

Microbiology. 2014 Jul;160(Pt 7):1316-20. doi: 10.1099/mic.0.079020-0. Epub 2014 Apr 24.


Optimized delivery of fluorescently labeled proteins in live bacteria using electroporation.

Sustarsic M, Plochowietz A, Aigrain L, Yuzenkova Y, Zenkin N, Kapanidis A.

Histochem Cell Biol. 2014 Jul;142(1):113-24. doi: 10.1007/s00418-014-1213-2. Epub 2014 Apr 3.


Ancient RNA stems that terminate transcription.

Zenkin N.

RNA Biol. 2014;11(4):295-7. doi: 10.4161/rna.28342. Epub 2014 Mar 5. Review.


The many faces of Fic: structural and functional aspects of Fic enzymes.

Garcia-Pino A, Zenkin N, Loris R.

Trends Biochem Sci. 2014 Mar;39(3):121-9. doi: 10.1016/j.tibs.2014.01.001. Epub 2014 Feb 5. Review.


Antibiotic streptolydigin requires noncatalytic Mg2+ for binding to RNA polymerase.

Zorov S, Yuzenkova Y, Nikiforov V, Severinov K, Zenkin N.

Antimicrob Agents Chemother. 2014;58(3):1420-4. doi: 10.1128/AAC.02248-13. Epub 2013 Dec 16.


Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II.

Nielsen S, Zenkin N.

Transcription. 2013 Sep-Dec;4(5):209-12. No abstract available.


RNA secondary structure-dependent termination of transcription.

Zenkin N.

Cell Cycle. 2014;13(1):3-4. doi: 10.4161/cc.27018. Epub 2013 Nov 14. No abstract available.


Protein biosynthesis in mitochondria.

Kuzmenko AV, Levitskii SA, Vinogradova EN, Atkinson GC, Hauryliuk V, Zenkin N, Kamenski PA.

Biochemistry (Mosc). 2013 Aug;78(8):855-66. doi: 10.1134/S0006297913080014. Review.


The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu.

Castro-Roa D, Garcia-Pino A, De Gieter S, van Nuland NAJ, Loris R, Zenkin N.

Nat Chem Biol. 2013 Dec;9(12):811-7. doi: 10.1038/nchembio.1364. Epub 2013 Oct 20.


Molecular mechanism of bacterial persistence by HipA.

Germain E, Castro-Roa D, Zenkin N, Gerdes K.

Mol Cell. 2013 Oct 24;52(2):248-54. doi: 10.1016/j.molcel.2013.08.045. Epub 2013 Oct 3.


Mitochondrial translation initiation machinery: conservation and diversification.

Kuzmenko A, Atkinson GC, Levitskii S, Zenkin N, Tenson T, Hauryliuk V, Kamenski P.

Biochimie. 2014 May;100:132-40. doi: 10.1016/j.biochi.2013.07.024. Epub 2013 Aug 14. Review.


Tagetitoxin inhibits transcription by stabilizing pre-translocated state of the elongation complex.

Yuzenkova Y, Roghanian M, Bochkareva A, Zenkin N.

Nucleic Acids Res. 2013 Nov;41(20):9257-65. doi: 10.1093/nar/gkt708. Epub 2013 Aug 9.


Mechanism of eukaryotic RNA polymerase III transcription termination.

Nielsen S, Yuzenkova Y, Zenkin N.

Science. 2013 Jun 28;340(6140):1577-80. doi: 10.1126/science.1237934.


The σ70 region 1.2 regulates promoter escape by unwinding DNA downstream of the transcription start site.

Bochkareva A, Zenkin N.

Nucleic Acids Res. 2013 Apr;41(8):4565-72. doi: 10.1093/nar/gkt116. Epub 2013 Feb 20.


Multiple active centers of multi-subunit RNA polymerases.

Yuzenkova Y, Roghanian M, Zenkin N.

Transcription. 2012 May-Jun;3(3):115-8. doi: 10.4161/trns.19887.


Hypothesis: emergence of translation as a result of RNA helicase evolution.

Zenkin N.

J Mol Evol. 2012 Jun;74(5-6):249-56. doi: 10.1007/s00239-012-9503-6. Epub 2012 Apr 28.


In vitro experimental system for analysis of transcription-translation coupling.

Castro-Roa D, Zenkin N.

Nucleic Acids Res. 2012 Mar;40(6):e45. doi: 10.1093/nar/gkr1262. Epub 2011 Dec 30.


Factor-independent transcription pausing caused by recognition of the RNA-DNA hybrid sequence.

Bochkareva A, Yuzenkova Y, Tadigotla VR, Zenkin N.

EMBO J. 2012 Feb 1;31(3):630-9. doi: 10.1038/emboj.2011.432. Epub 2011 Nov 29.


A new basal promoter element recognized by RNA polymerase core enzyme.

Yuzenkova Y, Tadigotla VR, Severinov K, Zenkin N.

EMBO J. 2011 Jul 26;30(18):3766-75. doi: 10.1038/emboj.2011.252.


Controlled interplay between trigger loop and Gre factor in the RNA polymerase active centre.

Roghanian M, Yuzenkova Y, Zenkin N.

Nucleic Acids Res. 2011 May;39(10):4352-9. doi: 10.1093/nar/gkq1359. Epub 2011 Jan 25.


Central role of the RNA polymerase trigger loop in intrinsic RNA hydrolysis.

Yuzenkova Y, Zenkin N.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10878-83. doi: 10.1073/pnas.0914424107. Epub 2010 Jun 1.


Stepwise mechanism for transcription fidelity.

Yuzenkova Y, Bochkareva A, Tadigotla VR, Roghanian M, Zorov S, Severinov K, Zenkin N.

BMC Biol. 2010 May 7;8:54. doi: 10.1186/1741-7007-8-54.


RNA polymerase -the third class of primases.

Zenkin N, Severinov K.

Cell Mol Life Sci. 2008 Aug;65(15):2280-8. doi: 10.1007/s00018-008-8020-7. Review.


Mapping of RNA polymerase residues that interact with bacteriophage Xp10 transcription antitermination factor p7.

Yuzenkova Y, Zenkin N, Severinov K.

J Mol Biol. 2008 Jan 4;375(1):29-35. Epub 2007 Oct 25.


Region 1.2 of the RNA polymerase sigma subunit controls recognition of the -10 promoter element.

Zenkin N, Kulbachinskiy A, Yuzenkova Y, Mustaev A, Bass I, Severinov K, Brodolin K.

EMBO J. 2007 Feb 21;26(4):955-64. Epub 2007 Feb 1.


Transcript-assisted transcriptional proofreading.

Zenkin N, Yuzenkova Y, Severinov K.

Science. 2006 Jul 28;313(5786):518-20.


The mechanism of DNA replication primer synthesis by RNA polymerase.

Zenkin N, Naryshkina T, Kuznedelov K, Severinov K.

Nature. 2006 Feb 2;439(7076):617-20.


Structural basis of transcription inhibition by antibiotic streptolydigin.

Temiakov D, Zenkin N, Vassylyeva MN, Perederina A, Tahirov TH, Kashkina E, Savkina M, Zorov S, Nikiforov V, Igarashi N, Matsugaki N, Wakatsuki S, Severinov K, Vassylyev DG.

Mol Cell. 2005 Sep 2;19(5):655-66.


Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase.

Campbell EA, Pavlova O, Zenkin N, Leon F, Irschik H, Jansen R, Severinov K, Darst SA.

EMBO J. 2005 Feb 23;24(4):674-82. Epub 2005 Feb 3.


A new Bacillus cereus DNA-binding protein, HlyIIR, negatively regulates expression of B. cereus haemolysin II.

Budarina ZI, Nikitin DV, Zenkin N, Zakharova M, Semenova E, Shlyapnikov MG, Rodikova EA, Masyukova S, Ogarkov O, Baida GE, Solonin AS, Severinov K.

Microbiology. 2004 Nov;150(Pt 11):3691-701.


Regulated communication between the upstream face of RNA polymerase and the beta' subunit jaw domain.

Wigneshweraraj SR, Burrows PC, Nechaev S, Zenkin N, Severinov K, Buck M.

EMBO J. 2004 Oct 27;23(21):4264-74. Epub 2004 Oct 7.


Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25.

Adelman K, Yuzenkova J, La Porta A, Zenkin N, Lee J, Lis JT, Borukhov S, Wang MD, Severinov K.

Mol Cell. 2004 Jun 18;14(6):753-62.

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