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Items: 1 to 50 of 54

1.

Fingerprints of CD8+ T cells on human pre-plasma and memory B cells.

Strittmatter-Keller U, Walter C, Rauld C, Egli N, Regairaz C, Rabe S, Zenke G, Carballido J, Schweighoffer T.

PLoS One. 2018 Dec 12;13(12):e0208187. doi: 10.1371/journal.pone.0208187. eCollection 2018.

2.

Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-α/β.

van Eis MJ, Evenou J, Schuler W, Zenke G, Vangrevelinghe E, Wagner J, von Matt P.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):781-786. doi: 10.1016/j.bmcl.2017.01.038. Epub 2017 Jan 16.

PMID:
28131714
3.

Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2.

Arenas-Ramirez N, Zou C, Popp S, Zingg D, Brannetti B, Wirth E, Calzascia T, Kovarik J, Sommer L, Zenke G, Woytschak J, Regnier CH, Katopodis A, Boyman O.

Sci Transl Med. 2016 Nov 30;8(367):367ra166.

PMID:
27903862
4.

Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.

Bornancin F, Renner F, Touil R, Sic H, Kolb Y, Touil-Allaoui I, Rush JS, Smith PA, Bigaud M, Junker-Walker U, Burkhart C, Dawson J, Niwa S, Katopodis A, Nuesslein-Hildesheim B, Weckbecker G, Zenke G, Kinzel B, Traggiai E, Brenner D, Brüstle A, St Paul M, Zamurovic N, McCoy KD, Rolink A, Régnier CH, Mak TW, Ohashi PS, Patel DD, Calzascia T.

J Immunol. 2015 Apr 15;194(8):3723-34. doi: 10.4049/jimmunol.1402254. Epub 2015 Mar 11.

5.

Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a.

Arduin E, Arora S, Bamert PR, Kuiper T, Popp S, Geisse S, Grau R, Calzascia T, Zenke G, Kovarik J.

Mol Immunol. 2015 Feb;63(2):456-63. doi: 10.1016/j.molimm.2014.09.017. Epub 2014 Oct 18.

PMID:
25451975
6.

Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.

Wagner J, von Matt P, Faller B, Cooke NG, Albert R, Sedrani R, Wiegand H, Jean C, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S.

J Med Chem. 2011 Sep 8;54(17):6028-39. doi: 10.1021/jm200469u. Epub 2011 Aug 8.

PMID:
21797275
7.

A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection.

Mallaun M, Zenke G, Palmer E.

J Recept Signal Transduct Res. 2010 Dec;30(6):430-43. doi: 10.3109/10799893.2010.518151. Epub 2010 Oct 14.

8.

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.

Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A, Cowan-Jacob SW, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S.

J Med Chem. 2009 Oct 22;52(20):6193-6. doi: 10.1021/jm901108b.

PMID:
19827831
9.

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

Evenou JP, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, Welzenbach KA, Weitz-Schmidt G, Guntermann C, Towbin H, Cottens S, Kaminski S, Letschka T, Lutz-Nicoladoni C, Gruber T, Hermann-Kleiter N, Thuille N, Baier G.

J Pharmacol Exp Ther. 2009 Sep;330(3):792-801. doi: 10.1124/jpet.109.153205. Epub 2009 Jun 2.

PMID:
19491325
10.

The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation.

Koziczak-Holbro M, Littlewood-Evans A, Pöllinger B, Kovarik J, Dawson J, Zenke G, Burkhart C, Müller M, Gram H.

Arthritis Rheum. 2009 Jun;60(6):1661-71. doi: 10.1002/art.24552.

11.

Anti-LFA-1 monotherapy prevents neointimal formation in a murine model of transplant intimal hyperplasia.

Soleimani B, Wieczorek G, Katopodis A, Zenke G, George AJ, Hornick PI, Weitz-Schmidt G.

J Heart Lung Transplant. 2007 Jul;26(7):724-31.

PMID:
17613404
12.

Strongly reduced alloreactivity and long-term survival times of cardiac allografts in Vav1- and Vav1/Vav2-knockout mice.

Weckbecker G, Bruns C, Fischer KD, Heusser C, Li J, Metzler B, Morris RE, Nuesslein-Hildesheim B, Raulf F, Wieczorek G, Zenke G.

Transpl Int. 2007 Apr;20(4):353-64.

13.

Pimecrolimus: absorption, distribution, metabolism, and excretion in healthy volunteers after a single oral dose and supplementary investigations in vitro.

Zollinger M, Waldmeier F, Hartmann S, Zenke G, Zimmerlin AG, Glaenzel U, Baldeck JP, Schweitzer A, Berthier S, Moenius T, Grassberger MA.

Drug Metab Dispos. 2006 May;34(5):765-74. Epub 2006 Feb 7.

PMID:
16467136
14.

Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6 A resolution.

Kallen J, Sedrani R, Zenke G, Wagner J.

J Biol Chem. 2005 Jun 10;280(23):21965-71. Epub 2005 Mar 16.

15.

A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.

Hersperger R, Buchheit KH, Cammisuli S, Enz A, Lohse O, Ponelle M, Schuler W, Schweitzer A, Walker C, Zehender H, Zenke G, Zimmerlin AG, Zollinger M, Mazzoni L, Fozard JR.

J Med Chem. 2004 Sep 23;47(20):4950-7.

PMID:
15369399
16.

Sanglifehrin-cyclophilin interaction: degradation work, synthetic macrocyclic analogues, X-ray crystal structure, and binding data.

Sedrani R, Kallen J, Martin Cabrejas LM, Papageorgiou CD, Senia F, Rohrbach S, Wagner D, Thai B, Jutzi Eme AM, France J, Oberer L, Rihs G, Zenke G, Wagner J.

J Am Chem Soc. 2003 Apr 2;125(13):3849-59.

PMID:
12656618
17.
18.

Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action.

Zenke G, Strittmatter U, Fuchs S, Quesniaux VF, Brinkmann V, Schuler W, Zurini M, Enz A, Billich A, Sanglier JJ, Fehr T.

J Immunol. 2001 Jun 15;166(12):7165-71.

19.

Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.

Cruz MC, Del Poeta M, Wang P, Wenger R, Zenke G, Quesniaux VF, Movva NR, Perfect JR, Cardenas ME, Heitman J.

Antimicrob Agents Chemother. 2000 Jan;44(1):143-9.

20.

Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. I. Taxonomy, fermentation, isolation and biological activity.

Sanglier JJ, Quesniaux V, Fehr T, Hofmann H, Mahnke M, Memmert K, Schuler W, Zenke G, Gschwind L, Maurer C, Schilling W.

J Antibiot (Tokyo). 1999 May;52(5):466-73.

21.

A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology.

Grassberger M, Baumruker T, Enz A, Hiestand P, Hultsch T, Kalthoff F, Schuler W, Schulz M, Werner FJ, Winiski A, Wolff B, Zenke G.

Br J Dermatol. 1999 Aug;141(2):264-73.

PMID:
10468798
22.

Macrolide Analogues of the Novel Immunosuppressant Sanglifehrin: New Application of the Ring-Closing Metathesis Reaction.

Martin Cabrejas LM, Rohrbach S, Wagner D, Kallen J, Zenke G, Wagner J.

Angew Chem Int Ed Engl. 1999 Aug;38(16):2443-2446.

PMID:
10458816
23.

Preparation and immunosuppressive activity of 32-(O)-acylated and 32-(O)-thioacylated analogues of ascomycin.

Hersperger R, Schuler W, Zenke G.

Bioorg Med Chem Lett. 1999 Jan 18;9(2):227-32.

PMID:
10021934
24.

Contribution of donor-specific antibodies to acute allograft rejection: evidence from B cell-deficient mice.

Brändle D, Joergensen J, Zenke G, Bürki K, Hof RP.

Transplantation. 1998 Jun 15;65(11):1489-93.

PMID:
9645808
25.

Cymbimicin A and B, two novel cyclophilin-binding structures isolated from actinomycetes.

Fehr T, Quesniaux VF, Sanglier JJ, Oberer L, Gschwind L, Ponelle M, Schilling W, Wehrli S, Enz A, Zenke G, Schuler W.

J Antibiot (Tokyo). 1997 Nov;50(11):893-9.

26.

SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo.

Schuler W, Sedrani R, Cottens S, Häberlin B, Schulz M, Schuurman HJ, Zenke G, Zerwes HG, Schreier MH.

Transplantation. 1997 Jul 15;64(1):36-42.

PMID:
9233698
27.

SDZ RAD, a new rapamycin derivative: synergism with cyclosporine.

Schuurman HJ, Cottens S, Fuchs S, Joergensen J, Meerloo T, Sedrani R, Tanner M, Zenke G, Schuler W.

Transplantation. 1997 Jul 15;64(1):32-5.

PMID:
9233697
28.

Anti-lymphoproliferative activity of brown adipose tissue of hibernating ground squirrels is mainly caused by AMP.

Atanassov CL, Naegeli HU, Zenke G, Schneider C, Kramarova LI, Bronnikov GE, Van Regenmortel MH.

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Sep;112(1):93-100.

PMID:
8564792
29.

Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphatase.

Su Q, Weber L, Le Hir M, Zenke G, Ryffel B.

Ren Physiol Biochem. 1995 May-Jun;18(3):128-39.

PMID:
7542793
31.

Molecular mechanisms of immunosuppression by cyclosporins.

Zenke G, Baumann G, Wenger R, Hiestand P, Quesniaux V, Andersen E, Schreier MH.

Ann N Y Acad Sci. 1993 Jun 23;685:330-5. Review.

PMID:
7689806
32.

Phage display as a rapid gene expression system: production of bioactive cytokine-phage and generation of neutralizing monoclonal antibodies.

Gram H, Strittmatter U, Lorenz M, Glück D, Zenke G.

J Immunol Methods. 1993 May 26;161(2):169-76.

PMID:
8505547
33.

Autocrine or paracrine transforming growth factor-beta modulates the phenotype of chick embryo sternal chondrocytes in serum-free agarose culture.

Tschan T, Böhme K, Conscience-Egli M, Zenke G, Winterhalter KH, Bruckner P.

J Biol Chem. 1993 Mar 5;268(7):5156-61.

34.

Inhibition of T-cell signaling pathways by immunophilin drug complexes: are side effects inherent to immunosuppressive properties?

Schreier MH, Baumann G, Zenke G.

Transplant Proc. 1993 Feb;25(1 Pt 1):502-7. Review. No abstract available.

PMID:
7679818
35.
36.

The continuing search for new immunomodulators.

Schreier MH, Zenke G, Borel JF, Baumann G.

Transplant Proc. 1992 Aug;24(4 Suppl 2):19-21. No abstract available.

PMID:
1496684
37.

High-level expression of a human immunoglobulin gamma 1 transgene depends on switch region sequences.

Gram H, Zenke G, Geisse S, Kleuser B, Bürki K.

Eur J Immunol. 1992 May;22(5):1185-91.

PMID:
1577061
38.

Molecular mechanisms of immunosuppression.

Baumann G, Zenke G, Wenger R, Hiestand P, Quesniaux V, Andersen E, Schreier MH.

J Autoimmun. 1992 Apr;5 Suppl A:67-72. Review.

PMID:
1380246
39.
40.

Anti-cyclosporine monoclonal antibodies and their anti-idiotopic counterpart: structure and biological activity.

Zenke G, Zeder G, Strittmatter U, Andersen E, Kocher HP, Quesniaux VF, Schreier MH, Van Regenmortel MH.

Mol Immunol. 1992 Mar;29(3):343-51.

PMID:
1557045
41.

Purification and characterization of natural human interleukin-3.

Zenke G, Lokker NA, Strittmatter U, Fagg B, Geisse S, Huber-Wegmann G, Kocher HP.

Lymphokine Cytokine Res. 1991 Aug;10(4):329-35.

PMID:
1932378
42.

Structure-activity relationship study of human interleukin-3: role of the C-terminal region for biological activity.

Lokker NA, Zenke G, Strittmatter U, Fagg B, Movva NR.

EMBO J. 1991 Aug;10(8):2125-31.

43.
44.

Mapping the epitopes of neutralizing anti-human IL-3 monoclonal antibodies. Implications for structure-activity relationship.

Lokker NA, Strittmatter U, Steiner C, Fagg B, Graff P, Kocher HP, Zenke G.

J Immunol. 1991 Feb 1;146(3):893-8.

PMID:
1703185
45.

A cocktail of three monoclonal antibodies significantly increases the sensitivity of an enzyme immunoassay for human granulocyte-macrophage colony-stimulating factor.

Zenke G, Strittmatter U, Tees R, Andersen E, Fagg B, Kocher HP, Schreier MH.

J Immunoassay. 1991;12(2):185-206.

PMID:
1710626
46.

Interleukin-3 is a differentiation factor for human basophils.

Valent P, Schmidt G, Besemer J, Mayer P, Zenke G, Liehl E, Hinterberger W, Lechner K, Maurer D, Bettelheim P.

Blood. 1989 May 15;73(7):1763-9.

48.

Isotype restriction of idiotopes associated with human anti-streptococcal A carbohydrate antibodies.

Emmrich F, Zenke G, Eichmann K.

Eur J Immunol. 1986 May;16(5):542-6.

PMID:
2422045
49.
50.

Two human IgM myeloma proteins with unusual specificities for streptococcal carbohydrate-associated epitopes.

Emmrich F, Bundle D, van der Zee J, Out T, Zenke G, Eichmann K.

Scand J Immunol. 1985 Feb;21(2):119-26.

PMID:
2579417

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