Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 148

1.

Rat CYP2D2, not 2D1, is functionally conserved with human CYP2D6 in endogenous morphine formation.

Grobe N, Kutchan TM, Zenk MH.

FEBS Lett. 2012 Jun 21;586(13):1749-53. doi: 10.1016/j.febslet.2012.05.021. Epub 2012 May 26.

2.

Distinct pharmacological properties of morphine metabolites at G(i)-protein and β-arrestin signaling pathways activated by the human μ-opioid receptor.

Frölich N, Dees C, Paetz C, Ren X, Lohse MJ, Nikolaev VO, Zenk MH.

Biochem Pharmacol. 2011 May 15;81(10):1248-54. doi: 10.1016/j.bcp.2011.03.001. Epub 2011 Mar 17.

PMID:
21396918
3.

An (R)-specific N-methyltransferase involved in human morphine biosynthesis.

Grobe N, Ren X, Kutchan TM, Zenk MH.

Arch Biochem Biophys. 2011 Feb 1;506(1):42-7. doi: 10.1016/j.abb.2010.11.010. Epub 2010 Nov 17.

4.

The biosynthesis of papaverine proceeds via (S)-reticuline.

Han X, Lamshöft M, Grobe N, Ren X, Fist AJ, Kutchan TM, Spiteller M, Zenk MH.

Phytochemistry. 2010 Aug;71(11-12):1305-12. doi: 10.1016/j.phytochem.2010.04.022. Epub 2010 May 20.

5.

Urinary excretion of morphine and biosynthetic precursors in mice.

Grobe N, Lamshöft M, Orth RG, Dräger B, Kutchan TM, Zenk MH, Spiteller M.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8147-52. doi: 10.1073/pnas.1003423107. Epub 2010 Apr 26.

6.

Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis.

Grobe N, Zhang B, Fisinger U, Kutchan TM, Zenk MH, Guengerich FP.

J Biol Chem. 2009 Sep 4;284(36):24425-31. doi: 10.1074/jbc.M109.011320. Epub 2009 Jun 26.

7.

Functional and structural characterization of a cation-dependent O-methyltransferase from the cyanobacterium Synechocystis sp. strain PCC 6803.

Kopycki JG, Stubbs MT, Brandt W, Hagemann M, Porzel A, Schmidt J, Schliemann W, Zenk MH, Vogt T.

J Biol Chem. 2008 Jul 25;283(30):20888-96. doi: 10.1074/jbc.M801943200. Epub 2008 May 23.

8.

Evolution and current status of the phytochemistry of nitrogenous compounds.

Zenk MH, Juenger M.

Phytochemistry. 2007 Nov-Dec;68(22-24):2757-72. Epub 2007 Aug 24. Review.

PMID:
17719615
9.

Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors.

Nikolaev VO, Boettcher C, Dees C, Bünemann M, Lohse MJ, Zenk MH.

J Biol Chem. 2007 Sep 14;282(37):27126-32. Epub 2007 Jul 6.

10.

Poppy alkaloid profiling by electrospray tandem mass spectrometry and electrospray FT-ICR mass spectrometry after [ring-13C6]-tyramine feeding.

Schmidt J, Boettcher C, Kuhnt C, Kutchan TM, Zenk MH.

Phytochemistry. 2007 Jan;68(2):189-202. Epub 2006 Nov 20.

PMID:
17113612
11.

Comment on "Human white blood cells synthesize morphine: CYP2D6 modulation".

Boettcher C, Fischer W, Zenk MH.

J Immunol. 2006 May 15;176(10):5703-4; author reply 5704. No abstract available.

12.

Membrane-bound geranylgeranyl diphosphate phosphatases: purification and characterization from Croton stellatopilosus leaves.

Nualkaew N, De-Eknamkul W, Kutchan TM, Zenk MH.

Phytochemistry. 2006 Aug;67(15):1613-20. Epub 2006 Jan 30.

PMID:
16445953
13.

Strong induction of phytochelatin synthesis by zinc in marine green alga, Dunaliella tertiolecta.

Hirata K, Tsujimoto Y, Namba T, Ohta T, Hirayanagi N, Miyasaka H, Zenk MH, Miyamoto K.

J Biosci Bioeng. 2001;92(1):24-9.

PMID:
16233052
14.

Analysis of benzylisoquinoline-type alkaloids by electrospray tandem mass spectrometry and atmospheric pressure photoionization.

Schmidt J, Raith K, Boettcher C, Zenk MH.

Eur J Mass Spectrom (Chichester). 2005;11(3):325-33.

PMID:
16107747
15.

How human neuroblastoma cells make morphine.

Boettcher C, Fellermeier M, Boettcher C, Dräger B, Zenk MH.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8495-500. Epub 2005 Jun 3.

16.

Biosynthesis of benzofuran derivatives in root cultures of Tagetes patula via phenylalanine and 1-deoxy-D-xylulose 5-phosphate.

Margl L, Ettenhuber C, Gyurján I, Zenk MH, Bacher A, Eisenreich W.

Phytochemistry. 2005 Apr;66(8):887-99.

PMID:
15845407
17.
18.

Analgesia: morphine-pathway block in top1 poppies.

Millgate AG, Pogson BJ, Wilson IW, Kutchan TM, Zenk MH, Gerlach WL, Fist AJ, Larkin PJ.

Nature. 2004 Sep 23;431(7007):413-4.

PMID:
15386001
19.

Endogenous formation of morphine in human cells.

Poeaknapo C, Schmidt J, Brandsch M, Dräger B, Zenk MH.

Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14091-6. Epub 2004 Sep 21.

20.

Evaluation of the mass spectrometric fragmentation of codeine and morphine after 13C-isotope biosynthetic labeling.

Poeaknapo C, Fisinger U, Zenk MH, Schmidt J.

Phytochemistry. 2004 May;65(10):1413-20.

PMID:
15231415
21.

1,2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway.

Hirata K, Poeaknapo C, Schmidt J, Zenk MH.

Phytochemistry. 2004 Apr;65(8):1039-46.

PMID:
15110683
22.

Functional analysis of the final steps of the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway to isoprenoids in plants using virus-induced gene silencing.

Page JE, Hause G, Raschke M, Gao W, Schmidt J, Zenk MH, Kutchan TM.

Plant Physiol. 2004 Apr;134(4):1401-13. Epub 2004 Apr 2.

24.

Electrospray tandem mass spectrometric investigations of morphinans.

Raith K, Neubert R, Poeaknapo C, Boettcher C, Zenk MH, Schmidt J.

J Am Soc Mass Spectrom. 2003 Nov;14(11):1262-9.

25.

Early steps of deoxyxylulose phosphate pathway in chromoplasts of higher plants.

Fellermeier M, Sagner S, Spiteller P, Spiteller M, Zenk MH.

Phytochemistry. 2003 Sep;64(1):199-207.

PMID:
12946418
26.

Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata.

Wang CZ, Maier UH, Keil M, Zenk MH, Bacher A, Rohdich F, Eisenreich W.

Eur J Biochem. 2003 Jul;270(14):2950-8.

27.

Metabolomic analysis of the consequences of cadmium exposure in Silene cucubalus cell cultures via 1H NMR spectroscopy and chemometrics.

Bailey NJ, Oven M, Holmes E, Nicholson JK, Zenk MH.

Phytochemistry. 2003 Mar;62(6):851-8.

PMID:
12590112
28.

Immunocytological localization of two enzymes involved in berberine biosynthesis.

Bock A, Wanner G, Zenk MH.

Planta. 2002 Nov;216(1):57-63. Epub 2002 Nov 12.

PMID:
12430014
30.

(E)-4-Hydroxy-3-methylbut-2-enyl diphosphate: an intermediate in the formation of terpenoids in plant chromoplasts.

Gao W, Loeser R, Raschke M, Dessoy MA, Fulhorst M, Alpermann H, Wessjohann LA, Zenk MH.

Angew Chem Int Ed Engl. 2002 Jul 15;41(14):2604-7. No abstract available.

PMID:
12203549
31.

Enhancement of tolerance to heavy metals and oxidative stress in Dunaliella tertiolecta by Zn-induced phytochelatin synthesis.

Tsuji N, Hirayanagi N, Okada M, Miyasaka H, Hirata K, Zenk MH, Miyamoto K.

Biochem Biophys Res Commun. 2002 Apr 26;293(1):653-9.

PMID:
12054653
32.

Increase of free cysteine and citric acid in plant cells exposed to cobalt ions.

Oven M, Grill E, Golan-Goldhirsh A, Kutchan TM, Zenk MH.

Phytochemistry. 2002 Jul;60(5):467-74.

PMID:
12052512
33.

Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants.

Fellermeier M, Raschke M, Sagner S, Wungsintaweekul J, Schuhr CA, Hecht S, Kis K, Radykewicz T, Adam P, Rohdich F, Eisenreich W, Bacher A, Arigoni D, Zenk MH.

Eur J Biochem. 2001 Dec;268(23):6302-10.

34.

Seven imidazole alkaloids from Lepidium sativum.

Maier UH, Gundlach H, Zenk MH.

Phytochemistry. 1998 Nov 20;49(6):1791-1795.

PMID:
11711103
35.

Molecular characterization of the homo-phytochelatin synthase of soybean Glycine max: relation to phytochelatin synthase.

Oven M, Page JE, Zenk MH, Kutchan TM.

J Biol Chem. 2002 Feb 15;277(7):4747-54. Epub 2001 Nov 12.

36.

Biosynthesis of thiophenes in Tagetes patula.

Margl L, Eisenreich W, Adam P, Bacher A, Zenk MH.

Phytochemistry. 2001 Nov;58(6):875-81.

PMID:
11684184
37.

Homo-phytochelatins are synthesized in response to cadmium in azuki beans.

Oven M, Raith K, Neubert RH, Kutchan TM, Zenk MH.

Plant Physiol. 2001 Jul;126(3):1275-80.

38.

Tracer studies with 13C-labeled carbohydrates in cultured plant cells. Retrobiosynthetic analysis of chelidonic acid biosynthesis.

Shen Z-W, Fisinger U, Poulev A, Eisenreich W, Werner I, Pleiner E, Bacher A, Zenk MH.

Phytochemistry. 2001 May;57(1):33-42.

PMID:
11336258
39.

Identification of phytochelatin-related peptides in maize seedlings exposed to cadmium and obtained enzymatically in vitro.

Chassaigne H, Vacchina V, Kutchan TM, Zenk MH.

Phytochemistry. 2001 Apr;56(7):657-68.

PMID:
11314950
40.

Biosynthesis of cannabinoids. Incorporation experiments with (13)C-labeled glucoses.

Fellermeier M, Eisenreich W, Bacher A, Zenk MH.

Eur J Biochem. 2001 Mar;268(6):1596-604.

41.

Phosphorylation of 1-deoxy-D-xylulose by D-xylulokinase of Escherichia coli.

Wungsintaweekul J, Herz S, Hecht S, Eisenreich W, Feicht R, Rohdich F, Bacher A, Zenk MH.

Eur J Biochem. 2001 Jan;268(2):310-6.

42.
43.

Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato.

Rohdich F, Wungsintaweekul J, Luttgen H, Fischer M, Eisenreich W, Schuhr CA, Fellermeier M, Schramek N, Zenk MH, Bacher A.

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8251-6.

44.

Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana.

Rohdich F, Wungsintaweekul J, Eisenreich W, Richter G, Schuhr CA, Hecht S, Zenk MH, Bacher A.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6451-6.

45.

An efficient preparation of 2-C-methyl-D-erythritol 4-phosphoric acid and its derivatives

Kis K, Wungsintaweekul J, Eisenreich W, Zenk MH, Bacher A.

J Org Chem. 2000 Jan 28;65(2):587-92. No abstract available.

PMID:
10813977
47.

Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate.

Herz S, Wungsintaweekul J, Schuhr CA, Hecht S, Luttgen H, Sagner S, Fellermeier M, Eisenreich W, Zenk MH, Bacher A, Rohdich F.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2486-90.

48.

Indoxyl-UDPG-glucosyltransferase from Baphicacanthus cusia.

Marcinek H, Weyler W, Deus-Neumann B, Zenk MH.

Phytochemistry. 2000 Jan;53(2):201-7.

PMID:
10680172
49.

Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

Lüttgen H, Rohdich F, Herz S, Wungsintaweekul J, Hecht S, Schuhr CA, Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W.

Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1062-7.

50.

Biosynthesis of terpenoids: 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Escherichia coli is a class B dehydrogenase.

Radykewicz T, Rohdich F, Wungsintaweekul J, Herz S, Kis K, Eisenreich W, Bacher A, Zenk MH, Arigoni D.

FEBS Lett. 2000 Jan 14;465(2-3):157-60.

Supplemental Content

Support Center