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Items: 38


IL-22: There Is a Gap in Our Knowledge.

Zenewicz LA.

Immunohorizons. 2018 Jul 5;2(6):198-207. doi: 10.4049/immunohorizons.1800006. Review.


Glucocorticoids Inhibit Group 3 Innate Lymphocyte IL-22 Production.

Seshadri S, Pope RL, Zenewicz LA.

J Immunol. 2018 Aug 15;201(4):1267-1274. doi: 10.4049/jimmunol.1800484. Epub 2018 Jul 6.


IL-22 deficiency increases CD4 T cell responses to mucosal immunization.

Budda SA, Zenewicz LA.

Vaccine. 2018 Jun 14;36(25):3694-3700. doi: 10.1016/j.vaccine.2018.05.011. Epub 2018 May 5.


Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling.

Seshadri S, Allan DSJ, Carlyle JR, Zenewicz LA.

PLoS Pathog. 2017 Oct 23;13(10):e1006690. doi: 10.1371/journal.ppat.1006690. eCollection 2017 Oct.


Oxygen Levels and Immunological Studies.

Zenewicz LA.

Front Immunol. 2017 Mar 21;8:324. doi: 10.3389/fimmu.2017.00324. eCollection 2017. No abstract available.


Hypoxic modulation of hepatocyte responses to the cytokine interleukin-22.

Budda SA, Bhattarai K, Alexander JL, Zenewicz LA.

Immunol Cell Biol. 2017 Apr;95(4):380-387. doi: 10.1038/icb.2016.107. Epub 2016 Oct 31.


Transcription Factor HIF-1α Controls Expression of the Cytokine IL-22 in CD4 T Cells.

Budda SA, Girton A, Henderson JG, Zenewicz LA.

J Immunol. 2016 Oct 1;197(7):2646-52. doi: 10.4049/jimmunol.1600250. Epub 2016 Aug 17.


Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.

Bergstrom K, Liu X, Zhao Y, Gao N, Wu Q, Song K, Cui Y, Li Y, McDaniel JM, McGee S, Chen W, Huycke MM, Houchen CW, Zenewicz LA, West CM, Chen H, Braun J, Fu J, Xia L.

Gastroenterology. 2016 Jul;151(1):152-164.e11. doi: 10.1053/j.gastro.2016.03.039. Epub 2016 Apr 6.


Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.

Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA.

Nature. 2016 Feb 25;530(7591):504. doi: 10.1038/nature16074. Epub 2015 Nov 25. No abstract available.


IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic.

Zenewicz LA, Yin X, Wang G, Elinav E, Hao L, Zhao L, Flavell RA.

J Immunol. 2013 May 15;190(10):5306-12. doi: 10.4049/jimmunol.1300016. Epub 2013 Apr 12.


Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis.

Ishigame H, Zenewicz LA, Sanjabi S, Licona-Limón P, Nakayama M, Leonard WJ, Flavell RA.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6961-6. doi: 10.1073/pnas.1304498110. Epub 2013 Apr 8.


IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.

Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA.

Nature. 2012 Nov 8;491(7423):259-63. doi: 10.1038/nature11535. Epub 2012 Oct 17.


IL-22 signaling contributes to West Nile encephalitis pathogenesis.

Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E.

PLoS One. 2012;7(8):e44153. doi: 10.1371/journal.pone.0044153. Epub 2012 Aug 28.


NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.

Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA.

Nature. 2012 Apr 25;484(7395):510-3. doi: 10.1038/nature11012. Erratum in: Nature. 2016 Feb 25;530(7591):504.


Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.

Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG.

Immunity. 2012 Feb 24;36(2):276-87. doi: 10.1016/j.immuni.2011.12.011. Epub 2012 Feb 2.


Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology.

Kamanaka M, Huber S, Zenewicz LA, Gagliani N, Rathinam C, O'Connor W Jr, Wan YY, Nakae S, Iwakura Y, Hao L, Flavell RA.

J Exp Med. 2011 May 9;208(5):1027-40. doi: 10.1084/jem.20102149. Epub 2011 Apr 25.


Recent advances in IL-22 biology.

Zenewicz LA, Flavell RA.

Int Immunol. 2011 Mar;23(3):159-63. doi: 10.1093/intimm/dxr001. Review.


The dual nature of T(H)17 cells: shifting the focus to function.

O'Connor W Jr, Zenewicz LA, Flavell RA.

Nat Immunol. 2010 Jun;11(6):471-6. doi: 10.1038/ni.1882. Epub 2010 May 18.


Unraveling the genetics of autoimmunity.

Zenewicz LA, Abraham C, Flavell RA, Cho JH.

Cell. 2010 Mar 19;140(6):791-7. doi: 10.1016/j.cell.2010.03.003.


Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.

Kinnebrew MA, Ubeda C, Zenewicz LA, Smith N, Flavell RA, Pamer EG.

J Infect Dis. 2010 Feb 15;201(4):534-43. doi: 10.1086/650203. Erratum in: J Infect Dis. 2010 Apr 15;201(8):1278.


RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells.

Priatel JJ, Chen X, Huang YH, Chow MT, Zenewicz LA, Coughlin JJ, Shen H, Stone JC, Tan R, Teh HS.

J Immunol. 2010 Jan 15;184(2):666-76. doi: 10.4049/jimmunol.0803521. Epub 2009 Dec 9.


Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity.

Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA.

Curr Opin Pharmacol. 2009 Aug;9(4):447-53. doi: 10.1016/j.coph.2009.04.008. Epub 2009 May 29. Review.


CD4 T-cell differentiation and inflammatory bowel disease.

Zenewicz LA, Antov A, Flavell RA.

Trends Mol Med. 2009 May;15(5):199-207. doi: 10.1016/j.molmed.2009.03.002. Epub 2009 Apr 8. Review.


Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.

Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA.

Immunity. 2008 Dec 19;29(6):947-57. doi: 10.1016/j.immuni.2008.11.003.


IL-22 and inflammation: leukin' through a glass onion.

Zenewicz LA, Flavell RA.

Eur J Immunol. 2008 Dec;38(12):3265-8. doi: 10.1002/eji.200838655. Review.


Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.

Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA.

Immunity. 2007 Oct;27(4):647-59. Epub 2007 Oct 4.


Innate and adaptive immune responses to Listeria monocytogenes: a short overview.

Zenewicz LA, Shen H.

Microbes Infect. 2007 Aug;9(10):1208-15. Epub 2007 May 7. Review.


Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion.

Priatel JJ, Chen X, Zenewicz LA, Shen H, Harder KW, Horwitz MS, Teh HS.

J Immunol. 2007 Aug 15;179(4):2143-52.


Characterization of Listeria monocytogenes expressing anthrolysin O and phosphatidylinositol-specific phospholipase C from Bacillus anthracis.

Wei Z, Schnupf P, Poussin MA, Zenewicz LA, Shen H, Goldfine H.

Infect Immun. 2005 Oct;73(10):6639-46.


Listeria monocytogenes phosphatidylinositol-specific phospholipase C has evolved for virulence by greatly reduced activity on GPI anchors.

Wei Z, Zenewicz LA, Goldfine H.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12927-31. Epub 2005 Aug 23.


Sugar-coated regulation of T cells.

Eynon EE, Zenewicz LA, Flavell RA.

Cell. 2005 Jul 15;122(1):2-4. Review.


Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune response.

Zenewicz LA, Wei Z, Goldfine H, Shen H.

J Immunol. 2005 Jun 15;174(12):8011-6.


Listeria monocytogenes virulence proteins induce surface expression of Fas ligand on T lymphocytes.

Zenewicz LA, Skinner JA, Goldfine H, Shen H.

Mol Microbiol. 2004 Mar;51(5):1483-92.


Activation of antigen-specific CD8 T cells results in minimal killing of bystander bacteria.

Jiang J, Zenewicz LA, San Mateo LR, Lau LL, Shen H.

J Immunol. 2003 Dec 1;171(11):6032-8.


Nonsecreted bacterial proteins induce recall CD8 T cell responses but do not serve as protective antigens.

Zenewicz LA, Foulds KE, Jiang J, Fan X, Shen H.

J Immunol. 2002 Nov 15;169(10):5805-12.


Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses.

Foulds KE, Zenewicz LA, Shedlock DJ, Jiang J, Troy AE, Shen H.

J Immunol. 2002 Feb 15;168(4):1528-32.


Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor.

Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1433-7.

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