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Sinus surgery is associated with a decrease in aspirin-induced reaction severity in AERD patients.

Jerschow E, Edin ML, Chi Y, Hurst B, Abuzeid WM, Akbar NA, Gibber M, Fried MP, Han W, Pelletier T, Ren Z, Keskin T, Gottlieb GR, Lih FB, Gruzdev A, Bradbury JA, Schuster V, Spivack S, Rosenstreich D, Zeldin DC.

J Allergy Clin Immunol Pract. 2018 Dec 20. pii: S2213-2198(18)30836-5. doi: 10.1016/j.jaip.2018.12.014. [Epub ahead of print]


Prediagnostic Serum Levels of Fatty Acid Metabolites and Risk of Ovarian Cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.

Hada M, Edin ML, Hartge P, Lih FB, Wentzensen N, Zeldin DC, Trabert B.

Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):189-197. doi: 10.1158/1055-9965.EPI-18-0392. Epub 2018 Sep 27.


Bedroom Allergen Exposure Beyond House Dust Mites.

Salo PM, Cohn RD, Zeldin DC.

Curr Allergy Asthma Rep. 2018 Aug 20;18(10):52. doi: 10.1007/s11882-018-0805-7. Review.


NIEHS: Making a Mark on Translational Research Science.

Collman GW, Berridge BR, Hall JE, Woychik R, Zeldin DC, Birnbaum LS.

Environ Health Perspect. 2018 Aug 2;126(8):081001. doi: 10.1289/EHP4075. eCollection 2018 Aug. No abstract available.


Ablation of soluble epoxide hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo.

Liu L, Puri N, Raffaele M, Schragenheim J, Singh SP, Bradbury JA, Bellner L, Vanella L, Zeldin DC, Cao J, Abraham NG.

Prostaglandins Other Lipid Mediat. 2018 Sep;138:1-8. doi: 10.1016/j.prostaglandins.2018.07.004. Epub 2018 Jul 21. Review.


Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.

Lafite P, André F, Graves JP, Zeldin DC, Dansette PM, Mansuy D.

Int J Mol Sci. 2018 Jul 16;19(7). pii: E2066. doi: 10.3390/ijms19072066.


Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment".

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 May 11;122(10):e84-e85. doi: 10.1161/CIRCRESAHA.118.312976. No abstract available.


Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy.

Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD.

J Med Chem. 2018 May 10;61(9):4271. doi: 10.1021/acs.jmedchem.8b00582. Epub 2018 Apr 27. No abstract available.


Exposure and Sensitization to Pets Modify Endotoxin Association with Asthma and Wheeze.

Mendy A, Wilkerson J, Salo PM, Cohn RD, Zeldin DC, Thorne PS.

J Allergy Clin Immunol Pract. 2018 Nov - Dec;6(6):2006-2013.e4. doi: 10.1016/j.jaip.2018.04.009. Epub 2018 Apr 21.


Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis.

Olona A, Terra X, Ko JH, Grau-Bové C, Pinent M, Ardevol A, Diaz AG, Moreno-Moral A, Edin M, Bishop-Bailey D, Zeldin DC, Aitman TJ, Petretto E, Blay M, Behmoaras J.

Mol Metab. 2018 May;11:18-32. doi: 10.1016/j.molmet.2018.03.003. Epub 2018 Mar 9.


Commercial scale production of RvD4 opens the resolving door to new research.

Edin ML, Zeldin DC.

J Leukoc Biol. 2018 Mar 30. doi: 10.1002/JLB.3CE0118-032R. [Epub ahead of print] No abstract available.


House Dust Endotoxin Association with Chronic Bronchitis and Emphysema.

Mendy A, Salo PM, Cohn RD, Wilkerson J, Zeldin DC, Thorne PS.

Environ Health Perspect. 2018 Mar 23;126(3):037007. doi: 10.1289/EHP2452.


Clinician Agreement, Self-Efficacy, and Adherence with the Guidelines for the Diagnosis and Management of Asthma.

Cloutier MM, Salo PM, Akinbami LJ, Cohn RD, Wilkerson JC, Diette GB, Williams S, Elward KS, Mazurek JM, Spinner JR, Mitchell TA, Zeldin DC.

J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):886-894.e4. doi: 10.1016/j.jaip.2018.01.018. Epub 2018 Feb 3.


Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia.

Edin ML, Hamedani BG, Gruzdev A, Graves JP, Lih FB, Arbes SJ 3rd, Singh R, Orjuela Leon AC, Bradbury JA, DeGraff LM, Hoopes SL, Arand M, Zeldin DC.

J Biol Chem. 2018 Mar 2;293(9):3281-3292. doi: 10.1074/jbc.RA117.000298. Epub 2018 Jan 3.


Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144. Epub 2018 Jan 3.


Conditional ablation of the RFX4 isoform 1 transcription factor: Allele dosage effects on brain phenotype.

Xu P, Morrison JP, Foley JF, Stumpo DJ, Ward T, Zeldin DC, Blackshear PJ.

PLoS One. 2018 Jan 3;13(1):e0190561. doi: 10.1371/journal.pone.0190561. eCollection 2018.


Endotoxin predictors and associated respiratory outcomes differ with climate regions in the U.S.

Mendy A, Wilkerson J, Salo PM, Cohn RD, Zeldin DC, Thorne PS.

Environ Int. 2018 Mar;112:218-226. doi: 10.1016/j.envint.2017.12.003. Epub 2017 Dec 23.


Mite-impermeable bedding casings and severe asthma exacerbations.

Salo PM, Zeldin DC.

J Pediatr. 2018 Jan;192:266-269. doi: 10.1016/j.jpeds.2017.10.058. No abstract available.


Bedroom allergen exposures in US households.

Salo PM, Wilkerson J, Rose KM, Cohn RD, Calatroni A, Mitchell HE, Sever ML, Gergen PJ, Thorne PS, Zeldin DC.

J Allergy Clin Immunol. 2018 May;141(5):1870-1879.e14. doi: 10.1016/j.jaci.2017.08.033. Epub 2017 Nov 30.


A Slippery Cause of a Slimy Problem: Mucin Induction by an Esterified Lipid.

Randell SH, Zeldin DC.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):633-634. doi: 10.1165/rcmb.2017-0275ED. No abstract available.


Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock.

Hagar JA, Edin ML, Lih FB, Thurlow LR, Koller BH, Cairns BA, Zeldin DC, Miao EA.

J Immunol. 2017 Nov 15;199(10):3634-3643. doi: 10.4049/jimmunol.1700820. Epub 2017 Oct 16.


It All Begins In Utero: Cord Blood Bacterial DNA and T Cell Immunity.

Silveyra P, Zeldin DC.

Am J Respir Cell Mol Biol. 2017 Oct;57(4):379-380. doi: 10.1165/rcmb.2017-0185ED. No abstract available.


WEC 2016 special issue editorial.

Panigrahy D, Zeldin DC.

Prostaglandins Other Lipid Mediat. 2017 Sep;132:1-2. doi: 10.1016/j.prostaglandins.2017.09.006. Epub 2017 Sep 18. No abstract available.


Reduced coronary reactive hyperemia in mice was reversed by the soluble epoxide hydrolase inhibitor (t-AUCB): Role of adenosine A2A receptor and plasma oxylipins.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Ledent C, Tilley SL, Nayeem MA.

Prostaglandins Other Lipid Mediat. 2017 Jul;131:83-95. doi: 10.1016/j.prostaglandins.2017.09.001. Epub 2017 Sep 7.


Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.

Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7545-E7553. doi: 10.1073/pnas.1620898114. Epub 2017 Aug 21.


Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia.

Bettaieb A, Koike S, Hsu MF, Ito Y, Chahed S, Bachaalany S, Gruzdev A, Calvo-Rubio M, Lee KSS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2758-2765. doi: 10.1016/j.bbagen.2017.07.021. Epub 2017 Jul 27.


Sensitization and Exposure to Pets: The Effect on Asthma Morbidity in the US Population.

Gergen PJ, Mitchell HE, Calatroni A, Sever ML, Cohn RD, Salo PM, Thorne PS, Zeldin DC.

J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):101-107.e2. doi: 10.1016/j.jaip.2017.05.019. Epub 2017 Jul 8.


House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies.

Fessler MB, Carnes MU, Salo PM, Wilkerson J, Cohn RD, King D, Hoppin JA, Sandler DP, Travlos G, London SJ, Thorne PS, Zeldin DC.

Environ Health Perspect. 2017 May 31;125(5):057010. doi: 10.1289/EHP661.


NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.

Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, Matsui EC.

J Allergy Clin Immunol. 2017 Oct;140(4):933-949. doi: 10.1016/j.jaci.2017.04.024. Epub 2017 May 10.


Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury.

Bettaieb A, Koike S, Chahed S, Zhao Y, Bachaalany S, Hashoush N, Graham J, Fatima H, Havel PJ, Gruzdev A, Zeldin DC, Hammock BD, Haj FG.

FEBS J. 2017 Jul;284(13):1970-1986. doi: 10.1111/febs.14100. Epub 2017 May 29. Erratum in: FEBS J. 2018 Feb;285(3):629-632.


Characterization of the Tissue Distribution of the Mouse Cyp2c Subfamily by Quantitative PCR Analysis.

Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Edin ML, Zeldin DC.

Drug Metab Dispos. 2017 Jul;45(7):807-816. doi: 10.1124/dmd.117.075697. Epub 2017 Apr 27.


Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis.

Hu J, Geyer A, Dziumbla S, Awwad K, Zeldin DC, Schunck WH, Popp R, Frömel T, Fleming I.

Prostaglandins Other Lipid Mediat. 2017 Nov;133:93-102. doi: 10.1016/j.prostaglandins.2017.04.002. Epub 2017 Apr 23.


Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

Hoopes SL, Gruzdev A, Edin ML, Graves JP, Bradbury JA, Flake GP, Lih FB, DeGraff LM, Zeldin DC.

PLoS One. 2017 Apr 6;12(4):e0175348. doi: 10.1371/journal.pone.0175348. eCollection 2017.


Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Nayeem MA.

PLoS One. 2017 Mar 22;12(3):e0174137. doi: 10.1371/journal.pone.0174137. eCollection 2017.


20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension.

Garcia V, Gilani A, Shkolnik B, Pandey V, Zhang FF, Dakarapu R, Gandham SK, Reddy NR, Graves JP, Gruzdev A, Zeldin DC, Capdevila JH, Falck JR, Schwartzman ML.

Circ Res. 2017 May 26;120(11):1776-1788. doi: 10.1161/CIRCRESAHA.116.310525. Epub 2017 Mar 21.


Plasma 15-Hydroxyeicosatetraenoic Acid Predicts Treatment Outcomes in Aspirin-Exacerbated Respiratory Disease.

Jerschow E, Edin ML, Pelletier T, Abuzeid WM, Akbar NA, Gibber M, Fried M, Lih FB, Gruzdev A, Bradbury JA, Han W, Hudes G, Keskin T, Schuster VL, Spivack S, Zeldin DC, Rosenstreich D.

J Allergy Clin Immunol Pract. 2017 Jul - Aug;5(4):998-1007.e2. doi: 10.1016/j.jaip.2016.11.021. Epub 2017 Jan 31.


The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases.

Xu X, Li R, Chen G, Hoopes SL, Zeldin DC, Wang DW.

Adv Nutr. 2016 Nov 15;7(6):1122-1128. doi: 10.3945/an.116.012245. Print 2016 Nov. Review.


Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice.

House JS, Nichols CE, Li H, Brandenberger C, Virgincar RS, DeGraff LM, Driehuys B, Zeldin DC, London SJ.

Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L520-L530. doi: 10.1152/ajplung.00495.2016. Epub 2017 Jan 27.


Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Nayeem MA.

PLoS One. 2017 Jan 5;12(1):e0169584. doi: 10.1371/journal.pone.0169584. eCollection 2017.


Racial/ethnic and socioeconomic differences in self-reported food allergy among food-sensitized children in National Health and Nutrition Examination Survey III.

McGowan EC, Matsui EC, Peng R, Salo PM, Zeldin DC, Keet CA.

Ann Allergy Asthma Immunol. 2016 Nov;117(5):570-572.e3. doi: 10.1016/j.anai.2016.08.034. Epub 2016 Oct 24. No abstract available.


Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis.

Gong Y, Shao Z, Fu Z, Edin ML, Sun Y, Liegl RG, Wang Z, Liu CH, Burnim SB, Meng SS, Lih FB, SanGiovanni JP, Zeldin DC, Hellström A, Smith LEH.

EBioMedicine. 2016 Nov;13:201-211. doi: 10.1016/j.ebiom.2016.09.025. Epub 2016 Sep 30.


Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD.

FASEB J. 2016 Dec;30(12):4256-4266. Epub 2016 Sep 15.


Effect of Soluble Epoxide Hydrolase on the Modulation of Coronary Reactive Hyperemia: Role of Oxylipins and PPARγ.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Nayeem MA.

PLoS One. 2016 Sep 1;11(9):e0162147. doi: 10.1371/journal.pone.0162147. eCollection 2016.


Deletion of soluble epoxide hydrolase enhances coronary reactive hyperemia in isolated mouse heart: role of oxylipins and PPARγ.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Nayeem MA.

Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311(4):R676-R688. doi: 10.1152/ajpregu.00237.2016. Epub 2016 Aug 3.


Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization.

Gong Y, Fu Z, Edin ML, Liu CH, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellström A, Hammock BD, Zeldin DC, Smith LE.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1919-27. doi: 10.1161/ATVBAHA.116.307558. Epub 2016 Jul 14.


Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.

Johnson AR, Qin Y, Cozzo AJ, Freemerman AJ, Huang MJ, Zhao L, Sampey BP, Milner JJ, Beck MA, Damania B, Rashid N, Galanko JA, Lee DP, Edin ML, Zeldin DC, Fueger PT, Dietz B, Stahl A, Wu Y, Mohlke KL, Makowski L.

Mol Metab. 2016 Apr 23;5(7):506-526. doi: 10.1016/j.molmet.2016.04.005. eCollection 2016 Jul.


Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.

Wells MA, Vendrov KC, Edin ML, Ferslew BC, Zha W, Nguyen BK, Church RJ, Lih FB, DeGraff LM, Brouwer KL, Barritt AS 4th, Zeldin DC, Lee CR.

Prostaglandins Other Lipid Mediat. 2016 Sep;125:19-29. doi: 10.1016/j.prostaglandins.2016.07.002. Epub 2016 Jul 9.


CYP450-derived oxylipins mediate inflammatory resolution.

Gilroy DW, Edin ML, De Maeyer RP, Bystrom J, Newson J, Lih FB, Stables M, Zeldin DC, Bishop-Bailey D.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3240-9. doi: 10.1073/pnas.1521453113. Epub 2016 May 25.


Changes in Food-Specific IgE Over Time in the National Health and Nutrition Examination Survey (NHANES).

McGowan EC, Peng RD, Salo PM, Zeldin DC, Keet CA.

J Allergy Clin Immunol Pract. 2016 Jul-Aug;4(4):713-20. doi: 10.1016/j.jaip.2016.01.017. Epub 2016 Apr 25.

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