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Items: 45


Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition.

Emami A, Shojaei S, da Silva Rosa SC, Aghaei M, Samiei E, Vosoughi AR, Kalantari F, Kawalec P, Thliveris J, Sharma P, Zeki AA, Akbari M, Gordon JW, Ghavami S.

Eur J Pharmacol. 2019 Nov 5;862:172616. doi: 10.1016/j.ejphar.2019.172616. Epub 2019 Aug 23.


Viruses and non-allergen environmental triggers in asthma.

Chau-Etchepare F, Hoerger JL, Kuhn BT, Zeki AA, Haczku A, Louie S, Kenyon NJ, Davis CE, Schivo M.

J Investig Med. 2019 Oct;67(7):1029-1041. doi: 10.1136/jim-2019-001000. Epub 2019 Jul 27. Review.


Targeting cholesterol metabolism in glioblastoma: a new therapeutic approach in cancer therapy.

Pirmoradi L, Seyfizadeh N, Ghavami S, Zeki AA, Shojaei S.

J Investig Med. 2019 Apr;67(4):715-719. doi: 10.1136/jim-2018-000962. Epub 2019 Feb 14.


A 51-Year-Old Man With Unresolved Pulmonary Infiltrates Following Streptococcus pneumoniae Pneumonia.

Pugashetti JV, Adams JY, Zeki AA, Kuhn BT.

Chest. 2019 Feb;155(2):e47-e50. doi: 10.1016/j.chest.2018.08.1064.


A burning need to redefine airways disease: Biomass smoke exposure identified as a unique risk factor for asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries.

Zeki AA, Flayer CH, Haczku A.

J Allergy Clin Immunol. 2019 Apr;143(4):1339-1341. doi: 10.1016/j.jaci.2018.11.020. Epub 2018 Dec 5. No abstract available.


Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay.

Alizadeh J, Shojaei S, da Silva Rosa S, Rezaei Moghadam A, Zeki AA, Hashemi M, Los MJ, Gordon JW, Ghavami S.

J Vis Exp. 2018 Nov 11;(141). doi: 10.3791/57646.


Asthma Control During Pregnancy: Avoiding Frequent Pitfalls.

Alqalyoobi S, Zeki AA, Louie S.

Consultant. 2017 Nov;57(11):662-665. No abstract available.


Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.

Bratt JM, Chang KY, Rabowsky M, Franzi LM, Ott SP, Filosto S, Goldkorn T, Arif M, Last JA, Kenyon NJ, Zeki AA.

J Immunol. 2018 Jun 1;200(11):3840-3856. doi: 10.4049/jimmunol.1601317. Epub 2018 Apr 27.


Innovations in asthma therapy: is there a role for inhaled statins?

Zeki AA, Elbadawi-Sidhu M.

Expert Rev Respir Med. 2018 Jun;12(6):461-473. doi: 10.1080/17476348.2018.1457437. Epub 2018 May 3. Review.


Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability.

Pecic S, Zeki AA, Xu X, Jin GY, Zhang S, Kodani S, Halim M, Morisseau C, Hammock BD, Deng SX.

Prostaglandins Other Lipid Mediat. 2018 May;136:90-95. doi: 10.1016/j.prostaglandins.2018.02.004. Epub 2018 Mar 20.


Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts.

Ghavami S, Yeganeh B, Zeki AA, Shojaei S, Kenyon NJ, Ott S, Samali A, Patterson J, Alizadeh J, Moghadam AR, Dixon IMC, Unruh H, Knight DA, Post M, Klonisch T, Halayko AJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L493-L504. doi: 10.1152/ajplung.00372.2017. Epub 2017 Oct 26.


Medical Management of Hospitalized Patients with Asthma or Chronic Obstructive Pulmonary Disease.

Duong TN, Zeki AA, Louie S.

Hosp Med Clin. 2017 Oct;6(4):437-455. doi: 10.1016/j.ehmc.2017.05.002. Epub 2017 Sep 15. No abstract available.


Eosinophilic and Noneosinophilic Asthma.

Carr TF, Zeki AA, Kraft M.

Am J Respir Crit Care Med. 2018 Jan 1;197(1):22-37. doi: 10.1164/rccm.201611-2232PP. Review. No abstract available.


Editorial: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part II).

Zeki AA, Yeganeh B, Kenyon NJ, Ghavami S.

Curr Mol Pharmacol. 2017;10(2):74-76. doi: 10.2174/187446721002170301204357. No abstract available.


Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.

Alizadeh J, Zeki AA, Mirzaei N, Tewary S, Rezaei Moghadam A, Glogowska A, Nagakannan P, Eftekharpour E, Wiechec E, Gordon JW, Xu FY, Field JT, Yoneda KY, Kenyon NJ, Hashemi M, Hatch GM, Hombach-Klonisch S, Klonisch T, Ghavami S.

Sci Rep. 2017 Mar 27;7:44841. doi: 10.1038/srep44841.


Paradigms in chronic obstructive pulmonary disease: phenotypes, immunobiology, and therapy with a focus on vascular disease.

Schivo M, Albertson TE, Haczku A, Kenyon NJ, Zeki AA, Kuhn BT, Louie S, Avdalovic MV.

J Investig Med. 2017 Aug;65(6):953-963. doi: 10.1136/jim-2016-000358. Epub 2017 Mar 3. Review.


The Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome: A New Take on an Old Concept.

Zeki AA, Jarjour NN.

Ann Am Thorac Soc. 2016 Sep;13(9):1440-2. doi: 10.1513/AnnalsATS.201606-493ED. No abstract available.


Update on the spider and the fly: An extended commentary on "Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-Oxidase activation".

Cross CE, Zeki AA.

Free Radic Biol Med. 2016 Jul;96:462-4. doi: 10.1016/j.freeradbiomed.2016.03.034. Epub 2016 Apr 1. No abstract available.


Editorial (Thematic Issue: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part I)).

Ghavami S, Kenyon NJ, Yeganeh B, Zeki AA.

Curr Mol Pharmacol. 2017;10(1):3-5. doi: 10.2174/1874467209999160114145952. No abstract available.


The combination of fluticasone furoate and vilanterol trifenatate in the management of asthma: clinical trial evidence and experience.

Albertson TE, Richards JR, Zeki AA.

Ther Adv Respir Dis. 2016 Feb;10(1):43-56. doi: 10.1177/1753465815619136. Epub 2015 Dec 14. Review.


Vocal Hoarseness and a Subglottic Mass: An Uncommon Diagnosis for a Common Complaint.

Rafizadeh S, Yoneda K, Zeki AA.

J Investig Med High Impact Case Rep. 2015 May 19;3(2):2324709615587528. doi: 10.1177/2324709615587528. eCollection 2015 Apr-Jun.


Autophagy in airway diseases: a new frontier in human asthma?

Zeki AA, Yeganeh B, Kenyon NJ, Post M, Ghavami S.

Allergy. 2016 Jan;71(1):5-14. doi: 10.1111/all.12761. Epub 2015 Oct 20. Review.


Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins.

Zeki AA, Bratt JM, Chang KY, Franzi LM, Ott S, Silveria M, Fiehn O, Last JA, Kenyon NJ.

Physiol Rep. 2015 May 11;3(5). pii: e12352. doi: 10.14814/phy2.12352.


Automatic lung segmentation using control feedback system: morphology and texture paradigm.

Noor NM, Than JC, Rijal OM, Kassim RM, Yunus A, Zeki AA, Anzidei M, Saba L, Suri JS.

J Med Syst. 2015 Mar;39(3):22. doi: 10.1007/s10916-015-0214-6. Epub 2015 Feb 10.


Novel therapeutic strategies for adult obese asthmatics.

Linderholm AL, Bratt JM, Schuster GU, Zeki AA, Kenyon NJ.

Immunol Allergy Clin North Am. 2014 Nov;34(4):809-23. doi: 10.1016/j.iac.2014.07.006. Epub 2014 Aug 29. Review.


Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice.

Yang J, Bratt J, Franzi L, Liu JY, Zhang G, Zeki AA, Vogel CF, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NJ, Hammock BD.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):46-55. doi: 10.1165/rcmb.2013-0440OC.


Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy.

Zeki AA.

Eur Respir J. 2014 Apr;43(4):1211-2. doi: 10.1183/09031936.00015314. No abstract available.


Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.

Yeganeh B, Wiechec E, Ande SR, Sharma P, Moghadam AR, Post M, Freed DH, Hashemi M, Shojaei S, Zeki AA, Ghavami S.

Pharmacol Ther. 2014 Jul;143(1):87-110. doi: 10.1016/j.pharmthera.2014.02.007. Epub 2014 Feb 26. Review.


Statins and asthma: where we stand, and the next critical steps in research.

Zeki AA.

Curr Med Res Opin. 2014 Jun;30(6):1051-4. doi: 10.1185/03007995.2014.881794. Epub 2014 Jan 30.


Immunobiology of the critical asthma syndrome.

Harper RW, Zeki AA.

Clin Rev Allergy Immunol. 2015 Feb;48(1):54-65. doi: 10.1007/s12016-013-8407-6. Review.


Definition of critical asthma syndromes.

Kenyon N, Zeki AA, Albertson TE, Louie S.

Clin Rev Allergy Immunol. 2015 Feb;48(1):1-6. doi: 10.1007/s12016-013-8395-6. Review.


Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation.

Kenyon NJ, Bratt JM, Lee J, Luo J, Franzi LM, Zeki AA, Lam KS.

PLoS One. 2013 Oct 25;8(10):e77730. doi: 10.1371/journal.pone.0077730. eCollection 2013.


A 40-year-old woman with cough and dyspnea 2 months after a motorcycle accident.

Hoffman PJ, Cooke DT, Zeki AA, Black H.

Chest. 2013 Nov;144(5):1720-1723. doi: 10.1378/chest.13-0471. No abstract available.


Statin use and asthma control in patients with severe asthma.

Zeki AA, Oldham J, Wilson M, Fortenko O, Goyal V, Last M, Last A, Patel A, Last JA, Kenyon NJ.

BMJ Open. 2013 Aug 13;3(8). pii: e003314. doi: 10.1136/bmjopen-2013-003314.


The pharmacological approach to the elderly COPD patient.

Albertson TE, Schivo M, Zeki AA, Louie S, Sutter ME, Avdalovic M, Chan AL.

Drugs Aging. 2013 Jul;30(7):479-502. doi: 10.1007/s40266-013-0080-1. Review.


The asthma-chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations.

Louie S, Zeki AA, Schivo M, Chan AL, Yoneda KY, Avdalovic M, Morrissey BM, Albertson TE.

Expert Rev Clin Pharmacol. 2013 Mar;6(2):197-219. doi: 10.1586/ecp.13.2. Review.


Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy.

Davis BB, Zeki AA, Bratt JM, Wang L, Filosto S, Walby WF, Kenyon NJ, Goldkorn T, Schelegle ES, Pinkerton KE.

Eur Respir J. 2013 Aug;42(2):350-61. doi: 10.1183/09031936.00042512. Epub 2012 Nov 22.


The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly.

Zeki AA, Schivo M, Chan A, Albertson TE, Louie S.

J Allergy (Cairo). 2011;2011:861926. doi: 10.1155/2011/861926. Epub 2011 Oct 30.


Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.

Bratt JM, Zeki AA, Last JA, Kenyon NJ.

J Biomed Res. 2011 Sep;25(5):299-308. doi: 10.1016/S1674-8301(11)60041-9.


The adult asthmatic.

Zeki AA, Kenyon NJ, Yoneda K, Louie S.

Clin Rev Allergy Immunol. 2012 Aug;43(1-2):138-55. doi: 10.1007/s12016-011-8260-4. Review.


Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research.

Zeki AA, Kenyon NJ, Goldkorn T.

Drug Metab Lett. 2011 Jan;5(1):40-4. Review.


Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?

Zeki AA, Bratt JM, Rabowsky M, Last JA, Kenyon NJ.

Transl Res. 2010 Dec;156(6):335-49. doi: 10.1016/j.trsl.2010.09.003.


Geoepidemiology of COPD and idiopathic pulmonary fibrosis.

Zeki AA, Schivo M, Chan AL, Hardin KA, Kenyon NJ, Albertson TE, Rosenquist GL, Louie S.

J Autoimmun. 2010 May;34(3):J327-38. doi: 10.1016/j.jaut.2009.11.004. Epub 2009 Dec 16. Review.


Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond.

Zeki AA, Franzi L, Last J, Kenyon NJ.

Am J Respir Crit Care Med. 2009 Oct 15;180(8):731-40. doi: 10.1164/rccm.200901-0018OC. Epub 2009 Jul 16.

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