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Items: 25

1.

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain.

Heiland T, Zeitschel U, Puchades MA, Kuhn PH, Lichtenthaler SF, Bjaalie JG, Hartlage-Rübsamen M, Roßner S, Höfling C.

Glia. 2019 Feb;67(2):393-403. doi: 10.1002/glia.23550. Epub 2018 Nov 28.

2.

Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation.

Schlenzig D, Cynis H, Hartlage-Rübsamen M, Zeitschel U, Menge K, Fothe A, Ramsbeck D, Spahn C, Wermann M, Roßner S, Buchholz M, Schilling S, Demuth HU.

J Alzheimers Dis. 2018;66(1):359-375. doi: 10.3233/JAD-171183.

PMID:
30320570
3.

Pyroglutamate-Modified Amyloid β (11- 40) Fibrils Are More Toxic than Wildtype Fibrils but Structurally Very Similar.

Scheidt HA, Adler J, Zeitschel U, Höfling C, Korn A, Krueger M, Roßner S, Huster D.

Chemistry. 2017 Nov 7;23(62):15834-15838. doi: 10.1002/chem.201703909. Epub 2017 Oct 10.

PMID:
28857302
4.

Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies.

Höfling C, Morawski M, Zeitschel U, Zanier ER, Moschke K, Serdaroglu A, Canneva F, von Hörsten S, De Simoni MG, Forloni G, Jäger C, Kremmer E, Roßner S, Lichtenthaler SF, Kuhn PH.

Aging Cell. 2016 Oct;15(5):953-63. doi: 10.1111/acel.12508. Epub 2016 Jul 29.

5.

Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery.

Wagner L, Wolf R, Zeitschel U, Rossner S, Petersén Å, Leavitt BR, Kästner F, Rothermundt M, Gärtner UT, Gündel D, Schlenzig D, Frerker N, Schade J, Manhart S, Rahfeld JU, Demuth HU, von Hörsten S.

J Neurochem. 2015 Dec;135(5):1019-37. doi: 10.1111/jnc.13378. Epub 2015 Nov 16.

6.

Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons.

Morawski M, Nuytens K, Juhasz T, Zeitschel U, Seeger G, Waelkens E, Regal L, Schulz I, Arendt T, Szeltner Z, Creemers J, Rossner S.

Neuroscience. 2013 Jul 9;242:128-39. doi: 10.1016/j.neuroscience.2013.02.038. Epub 2013 Feb 26.

PMID:
23485813
7.

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.

Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF.

EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173.

8.

Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway.

Schulz I, Engel C, Niestroj AJ, Zeitschel U, Menge K, Kehlen A, Meyer A, Rossner S, Demuth HU.

J Neuroinflammation. 2011 Jul 29;8:86. doi: 10.1186/1742-2094-8-86.

9.

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms.

Hartlage-Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, Cynis H, Schilling S, Schliebs R, Demuth HU, Rossner S.

Acta Neuropathol. 2011 Jun;121(6):705-19. doi: 10.1007/s00401-011-0806-2. Epub 2011 Feb 8.

10.

Role of prolyl endopeptidase in intracellular transport and protein secretion.

Morawski M, Schulz I, Zeitschel U, Blosa M, Seeger G, Rossner S.

CNS Neurol Disord Drug Targets. 2011 May;10(3):327-32.

PMID:
21222628
11.

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.

Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF.

EMBO J. 2010 Sep 1;29(17):3020-32. doi: 10.1038/emboj.2010.167. Epub 2010 Jul 30.

12.

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, Lichtenthaler SF.

J Neurosci. 2010 Jun 30;30(26):8974-83. doi: 10.1523/JNEUROSCI.1199-10.2010.

13.

BACE1 is a newly discovered protein secreted by the pancreas which cleaves enteropeptidase in vitro.

Hoffmeister A, Dietz G, Zeitschel U, Mössner J, Rossner S, Stahl T.

JOP. 2009 Sep 4;10(5):501-6.

14.

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HU, Rossner S.

Nat Med. 2008 Oct;14(10):1106-11. doi: 10.1038/nm.1872. Epub 2008 Sep 28.

PMID:
18836460
15.

The transcription factor Yin Yang 1 is an activator of BACE1 expression.

Nowak K, Lange-Dohna C, Zeitschel U, Günther A, Lüscher B, Robitzki A, Perez-Polo R, Rossner S.

J Neurochem. 2006 Mar;96(6):1696-707.

16.

Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer's disease.

Rossner S, Schulz I, Zeitschel U, Schliebs R, Bigl V, Demuth HU.

Neurochem Res. 2005 Jun-Jul;30(6-7):695-702.

PMID:
16187206
17.

Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion.

Schulz I, Zeitschel U, Rudolph T, Ruiz-Carrillo D, Rahfeld JU, Gerhartz B, Bigl V, Demuth HU, Rossner S.

J Neurochem. 2005 Aug;94(4):970-9.

18.

Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme.

Rossner S, Lange-Dohna C, Zeitschel U, Perez-Polo JR.

J Neurochem. 2005 Jan;92(2):226-34. Review.

19.

Cloning and expression of the rat BACE1 promoter.

Lange-Dohna C, Zeitschel U, Gaunitz F, Perez-Polo JR, Bigl V, Rossner S.

J Neurosci Res. 2003 Jul 1;73(1):73-80.

PMID:
12815710
20.

Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent.

Hartlage-Rübsamen M, Zeitschel U, Apelt J, Gärtner U, Franke H, Stahl T, Günther A, Schliebs R, Penkowa M, Bigl V, Rossner S.

Glia. 2003 Jan 15;41(2):169-79.

PMID:
12509807
21.

Changes in activity and expression of phosphofructokinase in different rat brain regions after basal forebrain cholinergic lesion.

Zeitschel U, Schliebs R, Rossner S, Bigl V, Eschrich K, Bigl M.

J Neurochem. 2002 Oct;83(2):371-80.

22.
23.

Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons?

Rossner S, Bakinde N, Zeitschel U, Schliebs R, Bigl V.

Int J Dev Neurosci. 1998 Nov-Dec;16(7-8):669-73.

PMID:
10198815
24.

Cellular distribution of 6-phosphofructo-1-kinase isoenzymes in rat brain.

Zeitschel U, Bigl M, Eschrich K, Bigl V.

J Neurochem. 1996 Dec;67(6):2573-80.

PMID:
8931492
25.

Chymotrypsin-catalyzed peptide synthesis in an acetonitrile-water-system: studies on the efficiency of nucleophiles.

Fischer U, Zeitschel U, Jakubke HD.

Biomed Biochim Acta. 1991;50(10-11):S131-5.

PMID:
1820034

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