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Items: 25


HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice.

Luo H, Zhu G, Xu J, Lai Q, Yan B, Guo Y, Fung TK, Zeisig BB, Cui Y, Zha J, Cogle C, Wang F, Xu B, Yang FC, Li W, So CWE, Qiu Y, Xu M, Huang S.

Cancer Cell. 2019 Dec 9;36(6):645-659.e8. doi: 10.1016/j.ccell.2019.10.011. Epub 2019 Nov 27.


MLL-AF4, a double-edged sword for iPSC respecification into HSPCs.

Zeisig BB, So CWE.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):1964-1966. doi: 10.1073/pnas.1800622115. Epub 2018 Feb 14. No abstract available.


Transcriptional memory of cells of origin overrides β-catenin requirement of MLL cancer stem cells.

Siriboonpiputtana T, Zeisig BB, Zarowiecki M, Fung TK, Mallardo M, Tsai CT, Lau PNI, Hoang QC, Veiga P, Barnes J, Lynn C, Wilson A, Lenhard B, So CWE.

EMBO J. 2017 Nov 2;36(21):3139-3155. doi: 10.15252/embj.201797994. Epub 2017 Oct 4.


Combinatorial Tethering: A Novel Mode to Recruit Non-canonical PRC1 for Normal and Malignant GC B Cell Development.

Zeisig BB, So CWE.

Cancer Cell. 2016 Aug 8;30(2):185-187. doi: 10.1016/j.ccell.2016.07.014.


Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.

Cheung N, Fung TK, Zeisig BB, Holmes K, Rane JK, Mowen KA, Finn MG, Lenhard B, Chan LC, So CW.

Cancer Cell. 2016 Jan 11;29(1):32-48. doi: 10.1016/j.ccell.2015.12.007.


Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.

Qiu JJ, Zeisig BB, Li S, Liu W, Chu H, Song Y, Giordano A, Schwaller J, Gronemeyer H, Dong S, So CW.

Leukemia. 2015 May;29(5):1153-62. doi: 10.1038/leu.2014.334. Epub 2014 Dec 16.


A knockout Combo: eradicating AML Stem Cells with TKI plus SIRT1 inhibition.

Zeisig BB, So CWE.

Cell Stem Cell. 2014 Oct 2;15(4):395-397. doi: 10.1016/j.stem.2014.09.006.


Linking MLL Leukemia with Integrin Signaling.

Zeisig BB, So CW.

Cancer Cell. 2013 Jul 8;24(1):5-7. doi: 10.1016/j.ccr.2013.06.011.


Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation.

Martin N, Popov N, Aguilo F, O'Loghlen A, Raguz S, Snijders AP, Dharmalingam G, Li S, Thymiakou E, Carroll T, Zeisig BB, So CW, Peters G, Episkopou V, Walsh MJ, Gil J.

EMBO J. 2013 Apr 3;32(7):982-95. doi: 10.1038/emboj.2013.37. Epub 2013 Mar 1.


SnapShot: Acute myeloid leukemia.

Zeisig BB, Kulasekararaj AG, Mufti GJ, So CW.

Cancer Cell. 2012 Nov 13;22(5):698-698.e1. doi: 10.1016/j.ccr.2012.10.017. No abstract available.


Collaboration between PcG proteins and MLL fusions in Leukemogenesis: an emerging paradigm.

Zeisig BB, Arteaga MF, Thirant C, So CW.

Cancer Cell. 2011 Nov 15;20(5):551-3. doi: 10.1016/j.ccr.2011.10.031.


Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells.

Smith LL, Yeung J, Zeisig BB, Popov N, Huijbers I, Barnes J, Wilson AJ, Taskesen E, Delwel R, Gil J, Van Lohuizen M, So CW.

Cell Stem Cell. 2011 Jun 3;8(6):649-62. doi: 10.1016/j.stem.2011.05.004.


β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.

Yeung J, Esposito MT, Gandillet A, Zeisig BB, Griessinger E, Bonnet D, So CW.

Cancer Cell. 2010 Dec 14;18(6):606-18. doi: 10.1016/j.ccr.2010.10.032.


The role of CBFbeta in AML1-ETO's activity.

Kwok C, Zeisig BB, Dong S, So CW.

Blood. 2010 Apr 15;115(15):3176-7. doi: 10.1182/blood-2009-12-260570. No abstract available. Erratum in: Blood. 2010 Sep 2;116(9):1627.


Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.

Qiu JJ, Lu X, Zeisig BB, Ma Z, Cai X, Chen S, Gronemeyer H, Tweardy DJ, So CW, Dong S.

Blood. 2010 Jan 21;115(3):643-52. doi: 10.1182/blood-2009-07-232652. Epub 2009 Nov 17.


Retroviral/Lentiviral transduction and transformation assay.

Zeisig BB, So CW.

Methods Mol Biol. 2009;538:207-29. doi: 10.1007/978-1-59745-418-6_10.


Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes.

Kwok C, Zeisig BB, Qiu J, Dong S, So CW.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2853-8. doi: 10.1073/pnas.0810558106. Epub 2009 Feb 6.


Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia.

Zeisig BB, Cheung N, Yeung J, So CW.

Cancer Cell. 2008 Nov 4;14(5):345-7. doi: 10.1016/j.ccr.2008.10.008.


Recruitment of RXR by homotetrameric RARalpha fusion proteins is essential for transformation.

Zeisig BB, Kwok C, Zelent A, Shankaranarayanan P, Gronemeyer H, Dong S, So CW.

Cancer Cell. 2007 Jul;12(1):36-51.


Forced homo-oligomerization of RARalpha leads to transformation of primary hematopoietic cells.

Kwok C, Zeisig BB, Dong S, So CW.

Cancer Cell. 2006 Feb;9(2):95-108.


The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin.

Zeisig DT, Bittner CB, Zeisig BB, García-Cuéllar MP, Hess JL, Slany RK.

Oncogene. 2005 Aug 18;24(35):5525-32.


Direct physical and functional interaction of the NuA4 complex components Yaf9p and Swc4p.

Bittner CB, Zeisig DT, Zeisig BB, Slany RK.

Eukaryot Cell. 2004 Aug;3(4):976-83.


Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.

Zeisig BB, Milne T, García-Cuéllar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK.

Mol Cell Biol. 2004 Jan;24(2):617-28.


The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell.

Zeisig BB, García-Cuéllar MP, Winkler TH, Slany RK.

Oncogene. 2003 Mar 20;22(11):1629-37.


Transcriptional activation is a key function encoded by MLL fusion partners.

Zeisig BB, Schreiner S, García-Cuéllar MP, Slany RK.

Leukemia. 2003 Feb;17(2):359-65.


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