Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 283


Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).

Mitchell SM, Milan AM, Mitchell CJ, Gillies NA, D'Souza RF, Zeng N, Ramzan F, Sharma P, Knowles SO, Roy NC, Sjödin A, Wagner KH, Zeisel SH, Cameron-Smith D.

Nutrients. 2019 Sep 12;11(9). pii: E2207. doi: 10.3390/nu11092207.


Perspective: Dietary Biomarkers of Intake and Exposure—Exploration with Omics Approaches

Maruvada P, Lampe JW, Wishart DS, Barupal D, Chester DN, Dodd D, Djoumbou-Feunang Y, Dorrestein PC, Dragsted LO, Draper J, Duffy LC, Dwyer JT, Emenaker NJ, Fiehn O, Gerszten RE, B Hu F, Karp RW, Klurfeld DM, Laughlin MR, Little AR, Lynch CJ, Moore SC, Nicastro HL, O'Brien DM, Ordovás JM, Osganian SK, Playdon M, Prentice R, Raftery D, Reisdorph N, Roche HM, Ross SA, Sang S, Scalbert A, Srinivas PR, Zeisel SH.

Adv Nutr. 2019 Aug 6. pii: nmz075. doi: 10.1093/advances/nmz075. [Epub ahead of print]


Choline: The Neurocognitive Essential Nutrient of Interest to Obstetricians and Gynecologists.

Wallace TC, Blusztajn JK, Caudill MA, Klatt KC, Zeisel SH.

J Diet Suppl. 2019 Aug 6:1-20. doi: 10.1080/19390211.2019.1639875. [Epub ahead of print]


Low availability of choline in utero disrupts development and function of the retina.

Trujillo-Gonzalez I, Friday WB, Munson CA, Bachleda A, Weiss ER, Alam NM, Sha W, Zeisel SH, Surzenko N.

FASEB J. 2019 Aug;33(8):9194-9209. doi: 10.1096/fj.201900444R. Epub 2019 May 15.


A Conceptual Framework for Studying and Investing in Precision Nutrition.

Zeisel SH.

Front Genet. 2019 Mar 18;10:200. doi: 10.3389/fgene.2019.00200. eCollection 2019.


Choline: The Underconsumed and Underappreciated Essential Nutrient.

Wallace TC, Blusztajn JK, Caudill MA, Klatt KC, Natker E, Zeisel SH, Zelman KM.

Nutr Today. 2018 Nov-Dec;53(6):240-253. doi: 10.1097/NT.0000000000000302. Epub 2018 Nov 13.


Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study.

Han P, Bidulescu A, Barber JR, Zeisel SH, Joshu CE, Prizment AE, Vitolins MZ, Platz EA.

Cancer Causes Control. 2019 Apr;30(4):343-354. doi: 10.1007/s10552-019-01148-4. Epub 2019 Mar 1.


Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.

Partearroyo T, Murillo-Cuesta S, Vallecillo N, Bermúdez-Muñoz JM, Rodríguez-de la Rosa L, Mandruzzato G, Celaya AM, Zeisel SH, Pajares MA, Varela-Moreiras G, Varela-Nieto I.

FASEB J. 2019 May;33(5):5942-5956. doi: 10.1096/fj.201801533R. Epub 2019 Feb 12.


MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex.

Trujillo-Gonzalez I, Wang Y, Friday WB, Vickers KC, Toth CL, Molina-Torres L, Surzenko N, Zeisel SH.

FASEB J. 2019 Mar;33(3):3601-3612. doi: 10.1096/fj.201801094RR. Epub 2018 Dec 6.


Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Jacobson SW, Carter RC, Molteno CD, Stanton ME, Herbert JS, Lindinger NM, Lewis CE, Dodge NC, Hoyme HE, Zeisel SH, Meintjes EM, Duggan CP, Jacobson JL.

Alcohol Clin Exp Res. 2018 Jul;42(7):1327-1341. doi: 10.1111/acer.13769. Epub 2018 Jun 15.


Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Jacobson SW, Carter RC, Molteno CD, Meintjes EM, Senekal MS, Lindinger NM, Dodge NC, Zeisel SH, Duggan CP, Jacobson JL.

Alcohol Clin Exp Res. 2018 Jul;42(7):1315-1326. doi: 10.1111/acer.13768. Epub 2018 Jun 13.


Dietary Modulation of the Epigenome.

Ideraabdullah FY, Zeisel SH.

Physiol Rev. 2018 Apr 1;98(2):667-695. doi: 10.1152/physrev.00010.2017. Review.



Zeisel SH, Klatt KC, Caudill MA.

Adv Nutr. 2018 Jan 1;9(1):58-60. doi: 10.1093/advances/nmx004. No abstract available.


Contribution of Dietary Supplements to Nutritional Adequacy by Socioeconomic Subgroups in Adults of the United States.

Blumberg JB, Frei B, Fulgoni VL, Weaver CM, Zeisel SH.

Nutrients. 2017 Dec 22;10(1). pii: E4. doi: 10.3390/nu10010004.


Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups.

Blumberg JB, Frei B, Fulgoni VL, Weaver CM, Zeisel SH.

Nutrients. 2017 Dec 6;9(12). pii: E1325. doi: 10.3390/nu9121325.


Contribution of Dietary Supplements to Nutritional Adequacy in Race/Ethnic Population Subgroups in the United States.

Blumberg JB, Frei B, Fulgoni VL III, Weaver CM, Zeisel SH.

Nutrients. 2017 Nov 28;9(12). pii: E1295. doi: 10.3390/nu9121295.


CASAnova: a multiclass support vector machine model for the classification of human sperm motility patterns.

Goodson SG, White S, Stevans AM, Bhat S, Kao CY, Jaworski S, Marlowe TR, Kohlmeier M, McMillan L, Zeisel SH, O'Brien DA.

Biol Reprod. 2017 Nov 1;97(5):698-708. doi: 10.1093/biolre/iox120.


Impact of Frequency of Multi-Vitamin/Multi-Mineral Supplement Intake on Nutritional Adequacy and Nutrient Deficiencies in U.S. Adults.

Blumberg JB, Frei BB, Fulgoni VL, Weaver CM, Zeisel SH.

Nutrients. 2017 Aug 9;9(8). pii: E849. doi: 10.3390/nu9080849.


Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.

Zeisel SH, Warrier M.

Annu Rev Nutr. 2017 Aug 21;37:157-181. doi: 10.1146/annurev-nutr-071816-064732. Epub 2017 Jul 17. Review.


Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.

Prieur EAK, Pjetri E, Zeisel SH, Jadavji NM.

Appl Physiol Nutr Metab. 2017 Nov;42(11):1228-1231. doi: 10.1139/apnm-2017-0182. Epub 2017 Jul 17.


Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation.

McClatchie T, Meredith M, Ouédraogo MO, Slow S, Lever M, Mann MRW, Zeisel SH, Trasler JM, Baltz JM.

J Biol Chem. 2017 Aug 18;292(33):13784-13794. doi: 10.1074/jbc.M117.803080. Epub 2017 Jun 29.


Deletion of one allele of Mthfd1 (methylenetetrahydrofolate dehydrogenase 1) impairs learning in mice.

Pjetri E, Zeisel SH.

Behav Brain Res. 2017 Aug 14;332:71-74. doi: 10.1016/j.bbr.2017.05.051. Epub 2017 May 27.


Astronaut ophthalmic syndrome.

Zwart SR, Gibson CR, Gregory JF, Mader TH, Stover PJ, Zeisel SH, Smith SM.

FASEB J. 2017 Sep;31(9):3746-3756. doi: 10.1096/fj.201700294. Epub 2017 May 25.


Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults.

Roe AJ, Zhang S, Bhadelia RA, Johnson EJ, Lichtenstein AH, Rogers GT, Rosenberg IH, Smith CE, Zeisel SH, Scott TM.

Am J Clin Nutr. 2017 Jun;105(6):1283-1290. doi: 10.3945/ajcn.116.137158. Epub 2017 Mar 29.


Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.

Lupu DS, Orozco LD, Wang Y, Cullen JM, Pellegrini M, Zeisel SH.

FASEB J. 2017 May;31(5):2090-2103. doi: 10.1096/fj.201601169R. Epub 2017 Feb 8.


Metabolomic Approaches to Explore Chemical Diversity of Human Breast-Milk, Formula Milk and Bovine Milk.

Qian L, Zhao A, Zhang Y, Chen T, Zeisel SH, Jia W, Cai W.

Int J Mol Sci. 2016 Dec 17;17(12). pii: E2128. doi: 10.3390/ijms17122128.


Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).

Meyer KA, Benton TZ, Bennett BJ, Jacobs DR Jr, Lloyd-Jones DM, Gross MD, Carr JJ, Gordon-Larsen P, Zeisel SH.

J Am Heart Assoc. 2016 Oct 21;5(10). pii: e003970.


Vitamin and Mineral Intake Is Inadequate for Most Americans: What Should We Advise Patients About Supplements?

Blumberg JB, Frei B, Fulgoni VL 3rd, Weaver CM, Zeisel SH.

J Fam Pract. 2016 Sep;65(9 Suppl):S1-S8.


Maternal dietary intake of choline in mice regulates development of the cerebral cortex in the offspring.

Wang Y, Surzenko N, Friday WB, Zeisel SH.

FASEB J. 2016 Apr;30(4):1566-78. doi: 10.1096/fj.15-282426. Epub 2015 Dec 23.


Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial.

Wozniak JR, Fuglestad AJ, Eckerle JK, Fink BA, Hoecker HL, Boys CJ, Radke JP, Kroupina MG, Miller NC, Brearley AM, Zeisel SH, Georgieff MK.

Am J Clin Nutr. 2015 Nov;102(5):1113-25. doi: 10.3945/ajcn.114.099168. Epub 2015 Oct 7.


Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes.

Zwart SR, Gregory JF, Zeisel SH, Gibson CR, Mader TH, Kinchen JM, Ueland PM, Ploutz-Snyder R, Heer MA, Smith SM.

FASEB J. 2016 Jan;30(1):141-8. doi: 10.1096/fj.15-278457. Epub 2015 Aug 27.


Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells.

Orena S, Owen J, Jin F, Fabian M, Gillitt ND, Zeisel SH.

J Nutr. 2015 Sep;145(9):2006-11. doi: 10.3945/jn.115.216705. Epub 2015 Jul 29.


Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency.

Strauss KA, Ferreira C, Bottiglieri T, Zhao X, Arning E, Zhang S, Zeisel SH, Escolar ML, Presnick N, Puffenberger EG, Vugrek O, Kovacevic L, Wagner C, Mazariegos GV, Mudd SH, Soltys K.

Mol Genet Metab. 2015 Sep-Oct;116(1-2):44-52. doi: 10.1016/j.ymgme.2015.06.005. Epub 2015 Jun 19.


Rapid LC-MRM-MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N-oxide, and creatinine in human plasma and urine.

Zhao X, Zeisel SH, Zhang S.

Electrophoresis. 2015 Sep;36(18):2207-2214. doi: 10.1002/elps.201500055. Epub 2015 Aug 13.


Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.

Silver MJ, Corbin KD, Hellenthal G, da Costa KA, Dominguez-Salas P, Moore SE, Owen J, Prentice AM, Hennig BJ, Zeisel SH.

FASEB J. 2015 Aug;29(8):3426-35. doi: 10.1096/fj.15-271056. Epub 2015 Apr 28.


Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice.

Tsuchiya H, da Costa KA, Lee S, Renga B, Jaeschke H, Yang Z, Orena SJ, Goedken MJ, Zhang Y, Kong B, Lebofsky M, Rudraiah S, Smalling R, Guo G, Fiorucci S, Zeisel SH, Wang L.

Gastroenterology. 2015 May;148(5):1012-1023.e14. doi: 10.1053/j.gastro.2015.01.045. Epub 2015 Feb 19.


Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts.

Schenkel LC, Singh RK, Michel V, Zeisel SH, da Costa KA, Johnson AR, Mudd HS, Bakovic M.

FASEB J. 2015 May;29(5):1663-75. doi: 10.1096/fj.14-258566. Epub 2014 Dec 2.


Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.

Martínez-Vega R, Garrido F, Partearroyo T, Cediel R, Zeisel SH, Martínez-Álvarez C, Varela-Moreiras G, Varela-Nieto I, Pajares MA.

FASEB J. 2015 Feb;29(2):418-32. doi: 10.1096/fj.14-259283. Epub 2014 Nov 10.


Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study.

Miller CA, Corbin KD, da Costa KA, Zhang S, Zhao X, Galanko JA, Blevins T, Bennett BJ, O'Connor A, Zeisel SH.

Am J Clin Nutr. 2014 Sep;100(3):778-86. doi: 10.3945/ajcn.114.087692. Epub 2014 Jun 18.


Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.

Dominguez-Salas P, Moore SE, Baker MS, Bergen AW, Cox SE, Dyer RA, Fulford AJ, Guan Y, Laritsky E, Silver MJ, Swan GE, Zeisel SH, Innis SM, Waterland RA, Prentice AM, Hennig BJ.

Nat Commun. 2014 Apr 29;5:3746. doi: 10.1038/ncomms4746.


Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.

da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH.

FASEB J. 2014 Jul;28(7):2970-8. doi: 10.1096/fj.14-249557. Epub 2014 Mar 26.


Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability.

Wozniak JR, Fuglestad AJ, Eckerle JK, Kroupina MG, Miller NC, Boys CJ, Brearley AM, Fink BA, Hoecker HL, Zeisel SH, Georgieff MK.

Nutr Res. 2013 Nov;33(11):897-904. doi: 10.1016/j.nutres.2013.08.005. Epub 2013 Sep 16.


A targeted metabolomic protocol for short-chain fatty acids and branched-chain amino acids.

Zheng X, Qiu Y, Zhong W, Baxter S, Su M, Li Q, Xie G, Ore BM, Qiao S, Spencer MD, Zeisel SH, Zhou Z, Zhao A, Jia W.

Metabolomics. 2013 Aug 1;9(4):818-827.


Inadequate intake of nutrients essential for neurodevelopment in children with fetal alcohol spectrum disorders (FASD).

Fuglestad AJ, Fink BA, Eckerle JK, Boys CJ, Hoecker HL, Kroupina MG, Zeisel SH, Georgieff MK, Wozniak JR.

Neurotoxicol Teratol. 2013 Sep-Oct;39:128-32. doi: 10.1016/ Epub 2013 Jul 17.


Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption.

Xie G, Zhong W, Li H, Li Q, Qiu Y, Zheng X, Chen H, Zhao X, Zhang S, Zhou Z, Zeisel SH, Jia W.

FASEB J. 2013 Sep;27(9):3583-93. doi: 10.1096/fj.13-231860. Epub 2013 May 24.


Nutrition in pregnancy: the argument for including a source of choline.

Zeisel SH.

Int J Womens Health. 2013 Apr 22;5:193-9. doi: 10.2147/IJWH.S36610. Print 2013.


DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.

Dominguez-Salas P, Moore SE, Cole D, da Costa KA, Cox SE, Dyer RA, Fulford AJ, Innis SM, Waterland RA, Zeisel SH, Prentice AM, Hennig BJ.

Am J Clin Nutr. 2013 Jun;97(6):1217-27. doi: 10.3945/ajcn.112.048462. Epub 2013 Apr 10.


Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.

Mehedint MG, Zeisel SH.

Curr Opin Clin Nutr Metab Care. 2013 May;16(3):339-45. doi: 10.1097/MCO.0b013e3283600d46. Review.


Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.

Corbin KD, Abdelmalek MF, Spencer MD, da Costa KA, Galanko JA, Sha W, Suzuki A, Guy CD, Cardona DM, Torquati A, Diehl AM, Zeisel SH.

FASEB J. 2013 Apr;27(4):1674-89. doi: 10.1096/fj.12-219097. Epub 2013 Jan 4.


Spectral deconvolution for gas chromatography mass spectrometry-based metabolomics: current status and future perspectives.

Du X, Zeisel SH.

Comput Struct Biotechnol J. 2013 Jun 28;4:e201301013. doi: 10.5936/csbj.201301013. eCollection 2013. Review.

Supplemental Content

Loading ...
Support Center