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Items: 31


Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression.

Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K.

Sci Transl Med. 2018 Sep 12;10(458). pii: eaan0724. doi: 10.1126/scitranslmed.aan0724.


High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis.

Xu X, Tan X, Tampe B, Wilhelmi T, Hulshoff MS, Saito S, Moser T, Kalluri R, Hasenfuss G, Zeisberg EM, Zeisberg M.

Nat Commun. 2018 Aug 29;9(1):3509. doi: 10.1038/s41467-018-05766-5.


Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure.

Tampe B, Tampe D, Nyamsuren G, Klöpper F, Rapp G, Kauffels A, Lorf T, Zeisberg EM, Müller GA, Kalluri R, Hakroush S, Zeisberg M.

J Clin Invest. 2018 Jul 2;128(7):3053-3070. doi: 10.1172/JCI89632. Epub 2018 Jun 11.


Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury-to-chronic kidney disease progression.

Tampe B, Steinle U, Tampe D, Carstens JL, Korsten P, Zeisberg EM, Müller GA, Kalluri R, Zeisberg M.

Kidney Int. 2017 Jan;91(1):157-176. doi: 10.1016/j.kint.2016.07.042. Epub 2016 Sep 28.


Differentiation of functional endothelial cells from human induced pluripotent stem cells: A novel, highly efficient and cost effective method.

Liu X, Qi J, Xu X, Zeisberg M, Guan K, Zeisberg EM.

Differentiation. 2016 Oct - Nov;92(4):225-236. doi: 10.1016/j.diff.2016.05.004. Epub 2016 Jun 4.


Hypoxia-induced endothelial-mesenchymal transition is associated with RASAL1 promoter hypermethylation in human coronary endothelial cells.

Xu X, Tan X, Hulshoff MS, Wilhelmi T, Zeisberg M, Zeisberg EM.

FEBS Lett. 2016 Apr;590(8):1222-33. doi: 10.1002/1873-3468.12158. Epub 2016 Apr 21.


DNMT1 and HDAC2 Cooperate to Facilitate Aberrant Promoter Methylation in Inorganic Phosphate-Induced Endothelial-Mesenchymal Transition.

Tan X, Xu X, Zeisberg M, Zeisberg EM.

PLoS One. 2016 Jan 27;11(1):e0147816. doi: 10.1371/journal.pone.0147816. eCollection 2016.


High inorganic phosphate causes DNMT1 phosphorylation and subsequent fibrotic fibroblast activation.

Tan X, Xu X, Zeisberg EM, Zeisberg M.

Biochem Biophys Res Commun. 2016 Apr 8;472(3):459-64. doi: 10.1016/j.bbrc.2016.01.077. Epub 2016 Jan 14.


Hepatic Interferon-λ3 (IFNL3) Gene Expression Reveals Not to Be Attenuated in Non-Favorable IFNL3 rs4803217 or IFNL4 rs368234815 Minor Allele Carriers in Chronic Hepatitis C.

Amanzada A, Reinhardt L, Fey D, Zeisberg EM, Mihm S.

PLoS One. 2015 Nov 25;10(11):e0143783. doi: 10.1371/journal.pone.0143783. eCollection 2015.


Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies.

Zeisberg M, Zeisberg EM.

Fibrogenesis Tissue Repair. 2015 Sep 1;8:16. doi: 10.1186/s13069-015-0033-x. eCollection 2015.


Evidence for antifibrotic incretin-independent effects of the DPP-4 inhibitor linagliptin.

Zeisberg M, Zeisberg EM.

Kidney Int. 2015 Sep;88(3):429-31. doi: 10.1038/ki.2015.175.


Association of circulating angiogenesis inhibitors and asymmetric dimethyl arginine with coronary plaque burden.

Charytan DM, Cinelli A, Zeisberg EM.

Fibrogenesis Tissue Repair. 2015 Jul 21;8:13. doi: 10.1186/s13069-015-0029-6. eCollection 2015.


Snail Is a Direct Target of Hypoxia-inducible Factor 1α (HIF1α) in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells.

Xu X, Tan X, Tampe B, Sanchez E, Zeisberg M, Zeisberg EM.

J Biol Chem. 2015 Jul 3;290(27):16653-64. doi: 10.1074/jbc.M115.636944. Epub 2015 May 13.


Association of activated vitamin D use with myocardial fibrosis and capillary supply: results of an autopsy study.

Charytan DM, Padera RF, Helfand AM, Zeisberg EM.

Ren Fail. 2015 Jul;37(6):1067-9. doi: 10.3109/0886022X.2015.1040704. Epub 2015 May 8. No abstract available.


Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease.

Tampe B, Tampe D, Zeisberg EM, Müller GA, Bechtel-Walz W, Koziolek M, Kalluri R, Zeisberg M.

EBioMedicine. 2015 Jan;2(1):19-36.


Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice.

Gogiraju R, Xu X, Bochenek ML, Steinbrecher JH, Lehnart SE, Wenzel P, Kessel M, Zeisberg EM, Dobbelstein M, Schäfer K.

J Am Heart Assoc. 2015 Feb 24;4(2). pii: e001770. doi: 10.1161/JAHA.115.001770.


Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis.

Xu X, Tan X, Tampe B, Nyamsuren G, Liu X, Maier LS, Sossalla S, Kalluri R, Zeisberg M, Hasenfuss G, Zeisberg EM.

Cardiovasc Res. 2015 Mar 1;105(3):279-91. doi: 10.1093/cvr/cvv015. Epub 2015 Jan 23.


Endocardial fibroelastosis is caused by aberrant endothelial to mesenchymal transition.

Xu X, Friehs I, Zhong Hu T, Melnychenko I, Tampe B, Alnour F, Iascone M, Kalluri R, Zeisberg M, Del Nido PJ, Zeisberg EM.

Circ Res. 2015 Feb 27;116(5):857-66. doi: 10.1161/CIRCRESAHA.116.305629. Epub 2015 Jan 13.


Thrombospondin-1 deficiency causes a shift from fibroproliferative to inflammatory kidney disease and delays onset of renal failure.

Zeisberg M, Tampe B, LeBleu V, Tampe D, Zeisberg EM, Kalluri R.

Am J Pathol. 2014 Oct;184(10):2687-98. doi: 10.1016/j.ajpath.2014.06.014. Epub 2014 Aug 10.


Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease.

Charytan DM, Padera R, Helfand AM, Zeisberg M, Xu X, Liu X, Himmelfarb J, Cinelli A, Kalluri R, Zeisberg EM.

Int J Cardiol. 2014 Sep;176(1):99-109. doi: 10.1016/j.ijcard.2014.06.062. Epub 2014 Jul 6.


Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis.

Tampe B, Tampe D, Müller CA, Sugimoto H, LeBleu V, Xu X, Müller GA, Zeisberg EM, Kalluri R, Zeisberg M.

J Am Soc Nephrol. 2014 May;25(5):905-12. doi: 10.1681/ASN.2013070723. Epub 2014 Jan 30.


The role of promoter hypermethylation in fibroblast activation and fibrogenesis.

Zeisberg EM, Zeisberg M.

J Pathol. 2013 Jan;229(2):264-73. doi: 10.1002/path.4120. Review.


Circulating endoglin concentration is not elevated in chronic kidney disease.

Charytan DM, Helfand AM, MacDonald BA, Cinelli A, Kalluri R, Zeisberg EM.

PLoS One. 2011;6(8):e23718. doi: 10.1371/journal.pone.0023718. Epub 2011 Aug 19.


Origins of cardiac fibroblasts.

Zeisberg EM, Kalluri R.

Circ Res. 2010 Nov 26;107(11):1304-12. doi: 10.1161/CIRCRESAHA.110.231910. Review.


The origin of fibroblasts and mechanism of cardiac fibrosis.

Krenning G, Zeisberg EM, Kalluri R.

J Cell Physiol. 2010 Nov;225(3):631-7. doi: 10.1002/jcp.22322. Review.


Methylation determines fibroblast activation and fibrogenesis in the kidney.

Bechtel W, McGoohan S, Zeisberg EM, Müller GA, Kalbacher H, Salant DJ, Müller CA, Kalluri R, Zeisberg M.

Nat Med. 2010 May;16(5):544-50. doi: 10.1038/nm.2135. Epub 2010 Apr 25.


Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition.

Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R.

J Am Soc Nephrol. 2008 Dec;19(12):2282-7. doi: 10.1681/ASN.2008050513. Epub 2008 Nov 5.


Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis.

Tanjore H, Zeisberg EM, Gerami-Naini B, Kalluri R.

Dev Dyn. 2008 Jan;237(1):75-82.


Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts.

Zeisberg EM, Potenta S, Xie L, Zeisberg M, Kalluri R.

Cancer Res. 2007 Nov 1;67(21):10123-8.


Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.

Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R.

Nat Med. 2007 Aug;13(8):952-61. Epub 2007 Jul 29.


Morphogenesis of the right ventricle requires myocardial expression of Gata4.

Zeisberg EM, Ma Q, Juraszek AL, Moses K, Schwartz RJ, Izumo S, Pu WT.

J Clin Invest. 2005 Jun;115(6):1522-31. Epub 2005 May 12.

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