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Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent.

Kanev K, Wu M, Drews A, Roelli P, Wurmser C, von Hösslin M, Zehn D.

Proc Natl Acad Sci U S A. 2019 Sep 17. pii: 201902701. doi: 10.1073/pnas.1902701116. [Epub ahead of print]


Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts.

Schaeuble K, Cannelle H, Favre S, Huang HY, Oberle SG, Speiser DE, Zehn D, Luther SA.

PLoS Biol. 2019 Jul 15;17(7):e3000072. doi: 10.1371/journal.pbio.3000072. eCollection 2019 Jul.


TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, von Hoesslin M, Cullen JG, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen CJ, Thimme R, Youngblood B, Zehn D.

Nature. 2019 Jul;571(7764):265-269. doi: 10.1038/s41586-019-1326-9. Epub 2019 Jun 17.


Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.

Puleston DJ, Buck MD, Klein Geltink RI, Kyle RL, Caputa G, O'Sullivan D, Cameron AM, Castoldi A, Musa Y, Kabat AM, Zhang Y, Flachsmann LJ, Field CS, Patterson AE, Scherer S, Alfei F, Baixauli F, Austin SK, Kelly B, Matsushita M, Curtis JD, Grzes KM, Villa M, Corrado M, Sanin DE, Qiu J, Pällman N, Paz K, Maccari ME, Blazar BR, Mittler G, Buescher JM, Zehn D, Rospert S, Pearce EJ, Balabanov S, Pearce EL.

Cell Metab. 2019 Aug 6;30(2):352-363.e8. doi: 10.1016/j.cmet.2019.05.003. Epub 2019 May 23.


Acetate Promotes T Cell Effector Function during Glucose Restriction.

Qiu J, Villa M, Sanin DE, Buck MD, O'Sullivan D, Ching R, Matsushita M, Grzes KM, Winkler F, Chang CH, Curtis JD, Kyle RL, Van Teijlingen Bakker N, Corrado M, Haessler F, Alfei F, Edwards-Hicks J, Maggi LB Jr, Zehn D, Egawa T, Bengsch B, Klein Geltink RI, Jenuwein T, Pearce EJ, Pearce EL.

Cell Rep. 2019 May 14;27(7):2063-2074.e5. doi: 10.1016/j.celrep.2019.04.022.


MicroRNA-155 Expression Is Enhanced by T-cell Receptor Stimulation Strength and Correlates with Improved Tumor Control in Melanoma.

Martinez-Usatorre A, Sempere LF, Carmona SJ, Carretero-Iglesia L, Monnot G, Speiser DE, Rufer N, Donda A, Zehn D, Jandus C, Romero P.

Cancer Immunol Res. 2019 Jun;7(6):1013-1024. doi: 10.1158/2326-6066.CIR-18-0504. Epub 2019 May 1.


Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells.

Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, Wagner I, Kreutzfeldt M, Di Liberto G, Vincenti I, Lingner T, Salinas G, Brück W, Simons M, Murr R, Kaye J, Zehn D, Pinschewer DD, Merkler D.

Immunity. 2019 Mar 19;50(3):763. doi: 10.1016/j.immuni.2019.02.011. No abstract available.


Leveraging TCR Affinity in Adoptive Immunotherapy against Shared Tumor/Self-Antigens.

Miller AM, Bahmanof M, Zehn D, Cohen EEW, Schoenberger SP.

Cancer Immunol Res. 2019 Jan;7(1):40-49. doi: 10.1158/2326-6066.CIR-18-0371. Epub 2018 Nov 27.


Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis.

Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W.

Nat Commun. 2018 Nov 15;9(1):4805. doi: 10.1038/s41467-018-07213-x.


PD-1 Blockade Unleashes Effector Potential of Both High- and Low-Affinity Tumor-Infiltrating T Cells.

Martínez-Usatorre A, Donda A, Zehn D, Romero P.

J Immunol. 2018 Jul 15;201(2):792-803. doi: 10.4049/jimmunol.1701644. Epub 2018 Jun 6.


Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells.

Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, Wagner I, Kreutzfeldt M, Di Liberto G, Vincenti I, Lingner T, Salinas G, Brück W, Simons M, Murr R, Kaye J, Zehn D, Pinschewer DD, Merkler D.

Immunity. 2018 May 15;48(5):937-950.e8. doi: 10.1016/j.immuni.2018.04.005. Erratum in: Immunity. 2019 Mar 19;50(3):763.


Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells.

Drobek A, Moudra A, Mueller D, Huranova M, Horkova V, Pribikova M, Ivanek R, Oberle S, Zehn D, McCoy KD, Draber P, Stepanek O.

EMBO J. 2018 Jul 13;37(14). pii: e98518. doi: 10.15252/embj.201798518. Epub 2018 May 11.


Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo.

Rota G, Niogret C, Dang AT, Barros CR, Fonta NP, Alfei F, Morgado L, Zehn D, Birchmeier W, Vivier E, Guarda G.

Cell Rep. 2018 Apr 3;23(1):39-49. doi: 10.1016/j.celrep.2018.03.026.


Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.

Man K, Gabriel SS, Liao Y, Gloury R, Preston S, Henstridge DC, Pellegrini M, Zehn D, Berberich-Siebelt F, Febbraio MA, Shi W, Kallies A.

Immunity. 2017 Dec 19;47(6):1129-1141.e5. doi: 10.1016/j.immuni.2017.11.021. Epub 2017 Dec 12.


Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.

Brownlie RJ, Garcia C, Ravasz M, Zehn D, Salmond RJ, Zamoyska R.

Nat Commun. 2017 Nov 7;8(1):1343. doi: 10.1038/s41467-017-01427-1.


T Cell Exhaustion: An Epigenetically Imprinted Phenotypic and Functional Makeover.

Alfei F, Zehn D.

Trends Mol Med. 2017 Sep;23(9):769-771. doi: 10.1016/j.molmed.2017.07.006. Epub 2017 Aug 7.


TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation.

Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M, Thimme R.

Nat Commun. 2017 May 3;8:15050. doi: 10.1038/ncomms15050.


Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis.

Rossi M, Castiglioni P, Hartley MA, Eren RO, Prével F, Desponds C, Utzschneider DT, Zehn D, Cusi MG, Kuhlmann FM, Beverley SM, Ronet C, Fasel N.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):4987-4992. doi: 10.1073/pnas.1621447114. Epub 2017 Apr 24.


Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid.

Castiglioni P, Hartley MA, Rossi M, Prevel F, Desponds C, Utzschneider DT, Eren RO, Zangger H, Brunner L, Collin N, Zehn D, Kuhlmann FM, Beverley SM, Fasel N, Ronet C.

PLoS Negl Trop Dis. 2017 Jan 18;11(1):e0005240. doi: 10.1371/journal.pntd.0005240. eCollection 2017 Jan.


pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion.

Ozga AJ, Moalli F, Abe J, Swoger J, Sharpe J, Zehn D, Kreutzfeldt M, Merkler D, Ripoll J, Stein JV.

J Exp Med. 2016 Nov 14;213(12):2811-2829. Epub 2016 Oct 31.


A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire.

Oberle SG, Hanna-El-Daher L, Chennupati V, Enouz S, Scherer S, Prlic M, Zehn D.

Cell Rep. 2016 Oct 11;17(3):627-635. doi: 10.1016/j.celrep.2016.09.072.


T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.

Utzschneider DT, Charmoy M, Chennupati V, Pousse L, Ferreira DP, Calderon-Copete S, Danilo M, Alfei F, Hofmann M, Wieland D, Pradervand S, Thimme R, Zehn D, Held W.

Immunity. 2016 Aug 16;45(2):415-27. doi: 10.1016/j.immuni.2016.07.021.


High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival.

Utzschneider DT, Alfei F, Roelli P, Barras D, Chennupati V, Darbre S, Delorenzi M, Pinschewer DD, Zehn D.

J Exp Med. 2016 Aug 22;213(9):1819-34. doi: 10.1084/jem.20150598. Epub 2016 Jul 25.


Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells.

Chennupati V, Koch U, Coutaz M, Scarpellino L, Tacchini-Cottier F, Luther SA, Radtke F, Zehn D, MacDonald HR.

J Immunol. 2016 Aug 1;197(3):771-82. doi: 10.4049/jimmunol.1501675. Epub 2016 Jun 20.


Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection.

Margaroli C, Oberle S, Lavanchy C, Scherer S, Rosa M, Strasser A, Pellegrini M, Zehn D, Acha-Orbea H, Ehirchiou D.

Eur J Immunol. 2016 Jun;46(6):1427-37. doi: 10.1002/eji.201545857.


Target Density, Not Affinity or Avidity of Antigen Recognition, Determines Adoptive T Cell Therapy Outcomes in a Mouse Lymphoma Model.

Segal G, Prato S, Zehn D, Mintern JD, Villadangos JA.

J Immunol. 2016 May 1;196(9):3935-42. doi: 10.4049/jimmunol.1502187. Epub 2016 Apr 1.


NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions.

Ludigs K, Jandus C, Utzschneider DT, Staehli F, Bessoles S, Dang AT, Rota G, Castro W, Zehn D, Vivier E, Held W, Romero P, Guarda G.

Nat Commun. 2016 Feb 10;7:10554. doi: 10.1038/ncomms10554.


Immune-surveillance through exhausted effector T-cells.

Zehn D, Utzschneider DT, Thimme R.

Curr Opin Virol. 2016 Feb;16:49-54. doi: 10.1016/j.coviro.2016.01.002. Epub 2016 Jan 29. Review.


Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner.

Zhang L, Tschumi BO, Lopez-Mejia IC, Oberle SG, Meyer M, Samson G, Rüegg MA, Hall MN, Fajas L, Zehn D, Mach JP, Donda A, Romero P.

Cell Rep. 2016 Feb 9;14(5):1206-1217. doi: 10.1016/j.celrep.2015.12.095. Epub 2016 Jan 21.


Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model.

Zehn D, Wherry EJ.

Adv Exp Med Biol. 2015;850:137-52. doi: 10.1007/978-3-319-15774-0_10. Review.


Optimal T-cell receptor affinity for inducing autoimmunity.

Koehli S, Naeher D, Galati-Fournier V, Zehn D, Palmer E.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17248-53. doi: 10.1073/pnas.1402724111. Epub 2014 Nov 19.


Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation.

Keck S, Schmaler M, Ganter S, Wyss L, Oberle S, Huseby ES, Zehn D, King CG.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14852-7. doi: 10.1073/pnas.1403271111. Epub 2014 Sep 29.


T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?

Speiser DE, Utzschneider DT, Oberle SG, Münz C, Romero P, Zehn D.

Nat Rev Immunol. 2014 Nov;14(11):768-74. doi: 10.1038/nri3740. Epub 2014 Sep 26.


Differences in the transduction of canonical Wnt signals demarcate effector and memory CD8 T cells with distinct recall proliferation capacity.

Boudousquié C, Danilo M, Pousse L, Jeevan-Raj B, Angelov GS, Chennupati V, Zehn D, Held W.

J Immunol. 2014 Sep 15;193(6):2784-91. doi: 10.4049/jimmunol.1400465. Epub 2014 Aug 15.


PTPN2 restrains CD8⁺ T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice.

Wiede F, Ziegler A, Zehn D, Tiganis T.

J Autoimmun. 2014 Sep;53:105-14. doi: 10.1016/j.jaut.2014.05.008. Epub 2014 Jul 2.


Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.

Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N.

PLoS One. 2014 Feb 3;9(2):e86677. doi: 10.1371/journal.pone.0086677. eCollection 2014.


Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells.

Legat A, Speiser DE, Pircher H, Zehn D, Fuertes Marraco SA.

Front Immunol. 2013 Dec 19;4:455. doi: 10.3389/fimmu.2013.00455. eCollection 2013.


Inflammation and TCR signal strength determine the breadth of the T cell response in a bim-dependent manner.

Zehn D, Roepke S, Weakly K, Bevan MJ, Prlic M.

J Immunol. 2014 Jan 1;192(1):200-5. doi: 10.4049/jimmunol.1302289. Epub 2013 Nov 22.


Molecular insights for optimizing T cell receptor specificity against cancer.

Hebeisen M, Oberle SG, Presotto D, Speiser DE, Zehn D, Rufer N.

Front Immunol. 2013 Jun 19;4:154. doi: 10.3389/fimmu.2013.00154. eCollection 2013.


IL-12-mediated STAT4 signaling and TCR signal strength cooperate in the induction of CD40L in human and mouse CD8+ T cells.

Stark R, Hartung A, Zehn D, Frentsch M, Thiel A.

Eur J Immunol. 2013 Jun;43(6):1511-7. doi: 10.1002/eji.201243218.


T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.

Utzschneider DT, Legat A, Fuertes Marraco SA, Carrié L, Luescher I, Speiser DE, Zehn D.

Nat Immunol. 2013 Jun;14(6):603-10. doi: 10.1038/ni.2606. Epub 2013 May 5.


The effect of vaccines based on ovalbumin coupled to gas-filled microbubbles for reducing infection by ovalbumin-expressing Listeria monocytogenes.

Bioley G, Zehn D, Lassus A, Terrettaz J, Tranquart F, Corthésy B.

Biomaterials. 2013 Jul;34(21):5423-30. doi: 10.1016/j.biomaterials.2013.04.005. Epub 2013 Apr 22.


MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.

Dudda JC, Salaun B, Ji Y, Palmer DC, Monnot GC, Merck E, Boudousquie C, Utzschneider DT, Escobar TM, Perret R, Muljo SA, Hebeisen M, Rufer N, Zehn D, Donda A, Restifo NP, Held W, Gattinoni L, Romero P.

Immunity. 2013 Apr 18;38(4):742-53. doi: 10.1016/j.immuni.2012.12.006.


Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner.

Chu T, Tyznik AJ, Roepke S, Berkley AM, Woodward-Davis A, Pattacini L, Bevan MJ, Zehn D, Prlic M.

Cell Rep. 2013 Mar 28;3(3):701-8. doi: 10.1016/j.celrep.2013.02.020. Epub 2013 Mar 21.


Functional avidity: a measure to predict the efficacy of effector T cells?

Viganò S, Utzschneider DT, Perreau M, Pantaleo G, Zehn D, Harari A.

Clin Dev Immunol. 2012;2012:153863. doi: 10.1155/2012/153863. Epub 2012 Nov 20. Review.


T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology.

King CG, Koehli S, Hausmann B, Schmaler M, Zehn D, Palmer E.

Immunity. 2012 Oct 19;37(4):709-20. doi: 10.1016/j.immuni.2012.06.021.


Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection.

Enouz S, Carrié L, Merkler D, Bevan MJ, Zehn D.

J Exp Med. 2012 Sep 24;209(10):1769-79. Epub 2012 Sep 17.


TCR signaling requirements for activating T cells and for generating memory.

Zehn D, King C, Bevan MJ, Palmer E.

Cell Mol Life Sci. 2012 May;69(10):1565-75. doi: 10.1007/s00018-012-0965-x. Epub 2012 Apr 19. Review.


Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.

Siegert S, Huang HY, Yang CY, Scarpellino L, Carrie L, Essex S, Nelson PJ, Heikenwalder M, Acha-Orbea H, Buckley CD, Marsland BJ, Zehn D, Luther SA.

PLoS One. 2011;6(11):e27618. doi: 10.1371/journal.pone.0027618. Epub 2011 Nov 14.


One naive T cell, multiple fates in CD8+ T cell differentiation.

Gerlach C, van Heijst JW, Swart E, Sie D, Armstrong N, Kerkhoven RM, Zehn D, Bevan MJ, Schepers K, Schumacher TN.

J Exp Med. 2010 Jun 7;207(6):1235-46. doi: 10.1084/jem.20091175. Epub 2010 May 17.

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