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Items: 1 to 50 of 55

1.

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2.

Duncan CJA, Thompson BJ, Chen R, Rice GI, Gothe F, Young DF, Lovell SC, Shuttleworth VG, Brocklebank V, Corner B, Skelton AJ, Bondet V, Coxhead J, Duffy D, Fourrage C, Livingston JH, Pavaine J, Cheesman E, Bitetti S, Grainger A, Acres M, Innes BA, Mikulasova A, Sun R, Hussain R, Wright R, Wynn R, Zarhrate M, Zeef LAH, Wood K, Hughes SM, Harris CL, Engelhardt KR, Crow YJ, Randall RE, Kavanagh D, Hambleton S, Briggs TA.

Sci Immunol. 2019 Dec 13;4(42). pii: eaav7501. doi: 10.1126/sciimmunol.aav7501.

PMID:
31836668
2.

Cognitive dysfunction in diabetic rats is prevented by pyridoxamine treatment. A multidisciplinary investigation.

Kassab S, Begley P, Church SJ, Rotariu SM, Chevalier-Riffard C, Dowsey AW, Phillips AM, Zeef LAH, Grayson B, Neill JC, Cooper GJS, Unwin RD, Gardiner NJ.

Mol Metab. 2019 Oct;28:107-119. doi: 10.1016/j.molmet.2019.08.003. Epub 2019 Aug 5.

3.

Overactivity or blockade of transforming growth factor-β each generate a specific ureter malformation.

Lopes FM, Roberts NA, Zeef LA, Gardiner NJ, Woolf AS.

J Pathol. 2019 Dec;249(4):472-484. doi: 10.1002/path.5335. Epub 2019 Oct 1.

4.

Publisher Correction: SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis.

Athwal VS, Pritchett J, Martin K, Llewellyn J, Scott J, Harvey E, Zaitoun AM, Mullan AF, Zeef LAH, Friedman SL, Irving WL, Hanley NA, Guha IN, Piper Hanley K.

Sci Rep. 2019 Aug 6;9(1):11547. doi: 10.1038/s41598-019-47715-2.

5.

Infection-Induced Resistance to Experimental Cerebral Malaria Is Dependent Upon Secreted Antibody-Mediated Inhibition of Pathogenic CD8+ T Cell Responses.

Shaw TN, Inkson CA, Villegas-Mendez A, Pattinson DJ, Strangward P, Else KJ, Draper SJ, Zeef LAH, Couper KN.

Front Immunol. 2019 Feb 19;10:248. doi: 10.3389/fimmu.2019.00248. eCollection 2019.

6.

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

Rice GI, Meyzer C, Bouazza N, Hully M, Boddaert N, Semeraro M, Zeef LAH, Rozenberg F, Bondet V, Duffy D, Llibre A, Baek J, Sambe MN, Henry E, Jolaine V, Barnerias C, Barth M, Belot A, Cances C, Debray FG, Doummar D, Frémond ML, Kitabayashi N, Lepelley A, Levrat V, Melki I, Meyer P, Nougues MC, Renaldo F, Rodero MP, Rodriguez D, Roubertie A, Seabra L, Uggenti C, Abdoul H, Treluyer JM, Desguerre I, Blanche S, Crow YJ.

N Engl J Med. 2018 Dec 6;379(23):2275-7. doi: 10.1056/NEJMc1810983. No abstract available.

7.

SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis.

Athwal VS, Pritchett J, Martin K, Llewellyn J, Scott J, Harvey E, Zaitoun AM, Mullan AF, Zeef LAH, Friedman SL, Irving WL, Hanley NA, Guha IN, Piper Hanley K.

Sci Rep. 2018 Dec 17;8(1):17905. doi: 10.1038/s41598-018-36037-4. Erratum in: Sci Rep. 2019 Aug 6;9(1):11547.

8.

Human notochordal cell transcriptome unveils potential regulators of cell function in the developing intervertebral disc.

Rodrigues-Pinto R, Ward L, Humphreys M, Zeef LAH, Berry A, Hanley KP, Hanley N, Richardson SM, Hoyland JA.

Sci Rep. 2018 Aug 27;8(1):12866. doi: 10.1038/s41598-018-31172-4.

9.

Changes in S100 Proteins Identified in Healthy Skin following Electrical Stimulation: Relevance for Wound Healing.

Lallyett C, Yeung CC, Nielson RH, Zeef LAH, Chapman-Jones D, Kjaer M, Kadler KE.

Adv Skin Wound Care. 2018 Jul;31(7):322-327. doi: 10.1097/01.ASW.0000533722.06780.03.

PMID:
29923902
10.

Functional molecules in mesothelial-to-mesenchymal transition revealed by transcriptome analyses.

Namvar S, Woolf AS, Zeef LA, Wilm T, Wilm B, Herrick SE.

J Pathol. 2018 Aug;245(4):491-501. doi: 10.1002/path.5101. Epub 2018 Jul 4.

11.

Acute psychosocial stress downregulates N-methyl-d-aspartate receptors in healthy human skin.

Hunter HJA, Morsman E, Mellody KT, Ogden SK, Zeef LAH, Hayes A, Griffiths CEM, Kleyn CE.

Br J Dermatol. 2018 Jun;178(6):1458-1459. doi: 10.1111/bjd.16466. Epub 2018 May 9. No abstract available.

PMID:
29451693
12.

Type I interferon-mediated autoinflammation due to DNase II deficiency.

Rodero MP, Tesser A, Bartok E, Rice GI, Della Mina E, Depp M, Beitz B, Bondet V, Cagnard N, Duffy D, Dussiot M, Frémond ML, Gattorno M, Guillem F, Kitabayashi N, Porcheray F, Rieux-Laucat F, Seabra L, Uggenti C, Volpi S, Zeef LAH, Alyanakian MA, Beltrand J, Bianco AM, Boddaert N, Brouzes C, Candon S, Caorsi R, Charbit M, Fabre M, Faletra F, Girard M, Harroche A, Hartmann E, Lasne D, Marcuzzi A, Neven B, Nitschke P, Pascreau T, Pastore S, Picard C, Picco P, Piscianz E, Polak M, Quartier P, Rabant M, Stocco G, Taddio A, Uettwiller F, Valencic E, Vozzi D, Hartmann G, Barchet W, Hermine O, Bader-Meunier B, Tommasini A, Crow YJ.

Nat Commun. 2017 Dec 19;8(1):2176. doi: 10.1038/s41467-017-01932-3.

13.

Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1.

McCaffrey JC, Webb NJ, Poolman TM, Fresquet M, Moxey C, Zeef LAH, Donaldson IJ, Ray DW, Lennon R.

Sci Rep. 2017 Jul 27;7(1):6725. doi: 10.1038/s41598-017-06810-y.

14.

Whole Transcriptome Analysis of Pre-invasive and Invasive Early Squamous Lung Carcinoma in Archival Laser Microdissected Samples.

Koper A, Zeef LA, Joseph L, Kerr K, Gosney J, Lindsay MA, Booton R.

Respir Res. 2017 Jan 10;18(1):12. doi: 10.1186/s12931-016-0496-3.

15.

Regulation of the BMP Signaling-Responsive Transcriptional Network in the Drosophila Embryo.

Deignan L, Pinheiro MT, Sutcliffe C, Saunders A, Wilcockson SG, Zeef LA, Donaldson IJ, Ashe HL.

PLoS Genet. 2016 Jul 5;12(7):e1006164. doi: 10.1371/journal.pgen.1006164. eCollection 2016 Jul.

16.

PSR1 Is a Global Transcriptional Regulator of Phosphorus Deficiency Responses and Carbon Storage Metabolism in Chlamydomonas reinhardtii.

Bajhaiya AK, Dean AP, Zeef LA, Webster RE, Pittman JK.

Plant Physiol. 2016 Mar;170(3):1216-34. doi: 10.1104/pp.15.01907. Epub 2015 Dec 24.

17.

Chick tendon fibroblast transcriptome and shape depend on whether the cell has made its own collagen matrix.

Yeung CY, Zeef LA, Lallyett C, Lu Y, Canty-Laird EG, Kadler KE.

Sci Rep. 2015 Sep 4;5:13555. doi: 10.1038/srep13555.

18.

Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome.

Kasher PR, Jenkinson EM, Briolat V, Gent D, Morrissey C, Zeef LA, Rice GI, Levraud JP, Crow YJ.

J Immunol. 2015 Mar 15;194(6):2819-25. doi: 10.4049/jimmunol.1403157. Epub 2015 Feb 11.

19.

Mutations in CECR1 associated with a neutrophil signature in peripheral blood.

Belot A, Wassmer E, Twilt M, Lega JC, Zeef LA, Oojageer A, Kasher PR, Mathieu AL, Malcus C, Demaret J, Fabien N, Collardeau-Frachon S, Mechtouff L, Derex L, Walzer T, Rice GI, Durieu I, Crow YJ.

Pediatr Rheumatol Online J. 2014 Sep 24;12:44. doi: 10.1186/1546-0096-12-44. eCollection 2014.

20.

Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers.

Yeung CY, Taylor SH, Garva R, Holmes DF, Zeef LA, Soininen R, Boot-Handford RP, Kadler KE.

PLoS One. 2014 Sep 11;9(9):e107036. doi: 10.1371/journal.pone.0107036. eCollection 2014.

21.

The effect of type 1 IFN on human aortic endothelial cell function in vitro: relevance to systemic lupus erythematosus.

Reynolds JA, Ray DW, Zeef LA, O'Neill T, Bruce IN, Alexander MY.

J Interferon Cytokine Res. 2014 May;34(5):404-12. doi: 10.1089/jir.2013.0016. Epub 2014 Jan 20.

22.

Certolizumab pegol attenuates the pro-inflammatory state in endothelial cells in a manner that is atheroprotective.

Heathfield SK, Parker B, Zeef LA, Bruce IN, Alexander MY.

Clin Exp Rheumatol. 2013 Mar-Apr;31(2):225-33. Epub 2012 Dec 13.

PMID:
23295110
23.

A conserved function for the H2A.Z C terminus.

Wratting D, Thistlethwaite A, Harris M, Zeef LA, Millar CB.

J Biol Chem. 2012 Jun 1;287(23):19148-57. doi: 10.1074/jbc.M111.317990. Epub 2012 Apr 9.

24.

Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration.

Love NR, Chen Y, Bonev B, Gilchrist MJ, Fairclough L, Lea R, Mohun TJ, Paredes R, Zeef LA, Amaya E.

BMC Dev Biol. 2011 Nov 15;11:70. doi: 10.1186/1471-213X-11-70.

25.

The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.

Ji Z, Donaldson IJ, Liu J, Hayes A, Zeef LA, Sharrocks AD.

Mol Cell Biol. 2012 Jan;32(2):385-98. doi: 10.1128/MCB.05504-11. Epub 2011 Nov 14. Erratum in: Mol Cell Biol. 2014 May;34(10):1892.

26.

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.

Vascotto C, Bisetto E, Li M, Zeef LA, D'Ambrosio C, Domenis R, Comelli M, Delneri D, Scaloni A, Altieri F, Mavelli I, Quadrifoglio F, Kelley MR, Tell G.

Mol Biol Cell. 2011 Oct;22(20):3887-901. doi: 10.1091/mbc.E11-05-0391. Epub 2011 Aug 24.

27.

Absolute and relative quantification of mRNA expression (transcript analysis).

Hayes A, Rash BM, Zeef LA.

Methods Mol Biol. 2011;759:73-86. doi: 10.1007/978-1-61779-173-4_5.

PMID:
21863482
28.

Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated.

Castelli LM, Lui J, Campbell SG, Rowe W, Zeef LA, Holmes LE, Hoyle NP, Bone J, Selley JN, Sims PF, Ashe MP.

Mol Biol Cell. 2011 Sep;22(18):3379-93. doi: 10.1091/mbc.E11-02-0153. Epub 2011 Jul 27.

29.

Mutations in PRDM5 in brittle cornea syndrome identify a pathway regulating extracellular matrix development and maintenance.

Burkitt Wright EMM, Spencer HL, Daly SB, Manson FDC, Zeef LAH, Urquhart J, Zoppi N, Bonshek R, Tosounidis I, Mohan M, Madden C, Dodds A, Chandler KE, Banka S, Au L, Clayton-Smith J, Khan N, Biesecker LG, Wilson M, Rohrbach M, Colombi M, Giunta C, Black GCM.

Am J Hum Genet. 2011 Jun 10;88(6):767-777. doi: 10.1016/j.ajhg.2011.05.007. Erratum in: Am J Hum Genet. 2011 Aug 12;89(2):346.

30.

WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line.

Goodfellow SJ, Rebello MR, Toska E, Zeef LA, Rudd SG, Medler KF, Roberts SG.

Biochem J. 2011 Apr 1;435(1):113-25. doi: 10.1042/BJ20101734.

31.

Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature.

Briggs TA, Rice GI, Daly S, Urquhart J, Gornall H, Bader-Meunier B, Baskar K, Baskar S, Baudouin V, Beresford MW, Black GC, Dearman RJ, de Zegher F, Foster ES, Francès C, Hayman AR, Hilton E, Job-Deslandre C, Kulkarni ML, Le Merrer M, Linglart A, Lovell SC, Maurer K, Musset L, Navarro V, Picard C, Puel A, Rieux-Laucat F, Roifman CM, Scholl-Bürgi S, Smith N, Szynkiewicz M, Wiedeman A, Wouters C, Zeef LA, Casanova JL, Elkon KB, Janckila A, Lebon P, Crow YJ.

Nat Genet. 2011 Feb;43(2):127-31. doi: 10.1038/ng.748. Epub 2011 Jan 9.

32.

Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation.

Minogue BM, Richardson SM, Zeef LA, Freemont AJ, Hoyland JA.

Arthritis Rheum. 2010 Dec;62(12):3695-705. doi: 10.1002/art.27710.

33.

Colonic transcriptional profiling in resistance and susceptibility to trichuriasis: phenotyping a chronic colitis and lessons for iatrogenic helminthosis.

Levison SE, McLaughlin JT, Zeef LA, Fisher P, Grencis RK, Pennock JL.

Inflamm Bowel Dis. 2010 Dec;16(12):2065-79. doi: 10.1002/ibd.21326.

PMID:
20687192
34.

Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes.

Minogue BM, Richardson SM, Zeef LA, Freemont AJ, Hoyland JA.

Arthritis Res Ther. 2010;12(1):R22. doi: 10.1186/ar2929. Epub 2010 Feb 11.

35.

Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell.

D'Elia R, DeSchoolmeester ML, Zeef LA, Wright SH, Pemberton AD, Else KJ.

BMC Genomics. 2009 Oct 24;10:492. doi: 10.1186/1471-2164-10-492.

36.

Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates.

Bivi N, Bereszczak JZ, Romanello M, Zeef LA, Delneri D, Quadrifoglio F, Moro L, Brancia FL, Tell G.

J Proteome Res. 2009 Mar;8(3):1131-42. doi: 10.1021/pr8005606.

PMID:
19226166
37.

Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.

Vascotto C, Cesaratto L, Zeef LA, Deganuto M, D'Ambrosio C, Scaloni A, Romanello M, Damante G, Taglialatela G, Delneri D, Kelley MR, Mitra S, Quadrifoglio F, Tell G.

Proteomics. 2009 Feb;9(4):1058-74. doi: 10.1002/pmic.200800638.

38.

5alpha-dihydrotestosterone (DHT) retards wound closure by inhibiting re-epithelialization.

Gilliver SC, Ruckshanthi JP, Hardman MJ, Zeef LA, Ashcroft GS.

J Pathol. 2009 Jan;217(1):73-82. doi: 10.1002/path.2444.

PMID:
18855875
39.

Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a(-/-) mice.

Collett A, Higgs NB, Gironella M, Zeef LA, Hayes A, Salmo E, Haboubi N, Iovanna JL, Carlson GL, Warhurst G.

Inflamm Bowel Dis. 2008 May;14(5):620-31. doi: 10.1002/ibd.20375.

PMID:
18275070
40.

Growth control of the eukaryote cell: a systems biology study in yeast.

Castrillo JI, Zeef LA, Hoyle DC, Zhang N, Hayes A, Gardner DC, Cornell MJ, Petty J, Hakes L, Wardleworth L, Rash B, Brown M, Dunn WB, Broadhurst D, O'Donoghue K, Hester SS, Dunkley TP, Hart SR, Swainston N, Li P, Gaskell SJ, Paton NW, Lilley KS, Kell DB, Oliver SG.

J Biol. 2007;6(2):4. doi: 10.1186/jbiol54.

41.

Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes.

Price SA, Gardiner NJ, Duran-Jimenez B, Zeef LA, Obrosova IG, Tomlinson DR.

Brain Res. 2006 Oct 20;1116(1):206-14. Epub 2006 Aug 30.

PMID:
16938273
42.

Identification of changes in gene expression in dorsal root ganglia in diabetic neuropathy: correlation with functional deficits.

Price SA, Zeef LA, Wardleworth L, Hayes A, Tomlinson DR.

J Neuropathol Exp Neurol. 2006 Jul;65(7):722-32.

PMID:
16825959
43.

Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics.

Brown DM, Zeef LA, Ellis J, Goodacre R, Turner SR.

Plant Cell. 2005 Aug;17(8):2281-95. Epub 2005 Jun 24.

44.

Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death.

Vickers ER, Kasza A, Kurnaz IA, Seifert A, Zeef LA, O'donnell A, Hayes A, Sharrocks AD.

Mol Cell Biol. 2004 Dec;24(23):10340-51.

45.

The ETS domain transcription factor Elk-1 regulates the expression of its partner protein, SRF.

Kasza A, O'Donnell A, Gascoigne K, Zeef LA, Hayes A, Sharrocks AD.

J Biol Chem. 2005 Jan 14;280(2):1149-55. Epub 2004 Nov 4.

46.

Characterization of nutrient-induced dispersion in Pseudomonas aeruginosa PAO1 biofilm.

Sauer K, Cullen MC, Rickard AH, Zeef LA, Davies DG, Gilbert P.

J Bacteriol. 2004 Nov;186(21):7312-26.

47.
48.
49.

A revised bacterial polypeptide chain elongation cycle with a stepwise increase in restriction of unwanted ternary complexes by the ribosome.

Bosch L, Vijgenboom E, Zeef LA.

Biochemistry. 1996 Oct 1;35(39):12647-51. No abstract available.

PMID:
8841107
50.

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