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Items: 1 to 50 of 218

1.

Lipokine 5-PAHSA is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for de novo Lipogenesis in Mice.

Paluchova V, Oseeva M, Brezinova M, Cajka T, Bardova K, Adamcova K, Zacek P, Brejchova K, Balas L, Chodounska H, Kudova E, Schreiber R, Zechner R, Durand T, Rossmeisl M, Abumrad NA, Kopecky J, Kuda O.

Diabetes. 2019 Dec 5. pii: db190494. doi: 10.2337/db19-0494. [Epub ahead of print]

PMID:
31806624
2.

CD8+ T cells induce cachexia during chronic viral infection.

Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A.

Nat Immunol. 2019 Jun;20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20.

3.

Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons.

Ruiz-Calvo A, Bajo-Grañeras R, Maroto IB, Zian D, Grabner GF, García-Taboada E, Resel E, Zechner R, Zimmermann R, Ortega-Gutiérrez S, Galve-Roperh I, Bellocchio L, Guzmán M.

Neuropharmacology. 2019 May 15;150:134-144. doi: 10.1016/j.neuropharm.2019.03.027. Epub 2019 Mar 23.

PMID:
30914306
4.

Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans.

Grabner GF, Fawzy N, Pribasnig MA, Trieb M, Taschler U, Holzer M, Schweiger M, Wolinski H, Kolb D, Horvath A, Breinbauer R, Rülicke T, Rabl R, Lass A, Stadlbauer V, Hutter-Paier B, Stauber RE, Fickert P, Zechner R, Marsche G, Eichmann TO, Zimmermann R.

J Lipid Res. 2019 May;60(5):1020-1031. doi: 10.1194/jlr.M093351. Epub 2019 Mar 20.

5.

Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G0/G1 switch gene 2 (G0S2).

Zhang X, Xie X, Heckmann BL, Saarinen AM, Gu H, Zechner R, Liu J.

FASEB J. 2019 May;33(5):6655-6666. doi: 10.1096/fj.201802502R. Epub 2019 Feb 25.

PMID:
30802154
6.

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice.

Heine M, Fischer AW, Schlein C, Jung C, Straub LG, Gottschling K, Mangels N, Yuan Y, Nilsson SK, Liebscher G, Chen O, Schreiber R, Zechner R, Scheja L, Heeren J.

Cell Metab. 2018 Oct 2;28(4):644-655.e4. doi: 10.1016/j.cmet.2018.06.020. Epub 2018 Jul 19.

7.

Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase.

Parajuli N, Takahara S, Matsumura N, Kim TT, Ferdaoussi M, Migglautsch AK, Zechner R, Breinbauer R, Kershaw EE, Dyck JRB.

Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H879-H884. doi: 10.1152/ajpheart.00308.2018. Epub 2018 Jun 22.

8.

Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation.

Kotzbeck P, Giordano A, Mondini E, Murano I, Severi I, Venema W, Cecchini MP, Kershaw EE, Barbatelli G, Haemmerle G, Zechner R, Cinti S.

J Lipid Res. 2018 May;59(5):784-794. doi: 10.1194/jlr.M079665. Epub 2018 Mar 29.

9.

Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase.

Padmanabha Das KM, Wechselberger L, Liziczai M, De la Rosa Rodriguez M, Grabner GF, Heier C, Viertlmayr R, Radler C, Lichtenegger J, Zimmermann R, Borst JW, Zechner R, Kersten S, Oberer M.

J Lipid Res. 2018 Mar;59(3):531-541. doi: 10.1194/jlr.M082388. Epub 2018 Jan 11.

10.

Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue.

Schreiber R, Diwoky C, Schoiswohl G, Feiler U, Wongsiriroj N, Abdellatif M, Kolb D, Hoeks J, Kershaw EE, Sedej S, Schrauwen P, Haemmerle G, Zechner R.

Cell Metab. 2017 Nov 7;26(5):753-763.e7. doi: 10.1016/j.cmet.2017.09.004. Epub 2017 Oct 5.

11.

The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain.

Heier C, Kien B, Huang F, Eichmann TO, Xie H, Zechner R, Chang PA.

J Biol Chem. 2017 Nov 17;292(46):19087-19098. doi: 10.1074/jbc.M117.792978. Epub 2017 Sep 7.

12.

Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.

Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ.

Cell Metab. 2017 Sep 5;26(3):509-522.e6. doi: 10.1016/j.cmet.2017.08.006.

13.

Cytosolic lipolysis and lipophagy: two sides of the same coin.

Zechner R, Madeo F, Kratky D.

Nat Rev Mol Cell Biol. 2017 Nov;18(11):671-684. doi: 10.1038/nrm.2017.76. Epub 2017 Aug 30. Review.

PMID:
28852221
14.

Corrigendum: Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.

Schweiger M, Romauch M, Schreiber R, Grabner GF, Hütter S, Kotzbeck P, Benedikt P, Eichmann TO, Yamada S, Knittelfelder O, Diwoky C, Doler C, Mayer N, De Cecco W, Breinbauer R, Zimmermann R, Zechner R.

Nat Commun. 2017 Apr 25;8:15490. doi: 10.1038/ncomms15490. No abstract available.

15.

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.

Schweiger M, Romauch M, Schreiber R, Grabner GF, Hütter S, Kotzbeck P, Benedikt P, Eichmann TO, Yamada S, Knittelfelder O, Diwoky C, Doler C, Mayer N, De Cecco W, Breinbauer R, Zimmermann R, Zechner R.

Nat Commun. 2017 Mar 22;8:14859. doi: 10.1038/ncomms14859.

16.

Liver X receptor α mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression.

Heckmann BL, Zhang X, Saarinen AM, Schoiswohl G, Kershaw EE, Zechner R, Liu J.

JCI Insight. 2017 Feb 23;2(4):e88735. doi: 10.1172/jci.insight.88735.

17.

Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.

Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV Jr, Walther TC.

J Lipid Res. 2017 Jan;58(1):226-235. doi: 10.1194/jlr.M072538. Epub 2016 Nov 11.

18.

PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides.

Grond S, Eichmann TO, Dubrac S, Kolb D, Schmuth M, Fischer J, Crumrine D, Elias PM, Haemmerle G, Zechner R, Lass A, Radner FPW.

J Invest Dermatol. 2017 Feb;137(2):394-402. doi: 10.1016/j.jid.2016.08.036. Epub 2016 Oct 14.

19.

Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation.

Grond S, Radner FPW, Eichmann TO, Kolb D, Grabner GF, Wolinski H, Gruber R, Hofer P, Heier C, Schauer S, Rülicke T, Hoefler G, Schmuth M, Elias PM, Lass A, Zechner R, Haemmerle G.

J Invest Dermatol. 2017 Feb;137(2):403-413. doi: 10.1016/j.jid.2016.09.025. Epub 2016 Oct 7.

20.

Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation.

Lord CC, Ferguson D, Thomas G, Brown AL, Schugar RC, Burrows A, Gromovsky AD, Betters J, Neumann C, Sacks J, Marshall S, Watts R, Schweiger M, Lee RG, Crooke RM, Graham MJ, Lathia JD, Sakaguchi TF, Lehner R, Haemmerle G, Zechner R, Brown JM.

Cell Rep. 2016 Jul 26;16(4):939-949. doi: 10.1016/j.celrep.2016.06.049. Epub 2016 Jul 7.

21.

Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover.

Grumet L, Eichmann TO, Taschler U, Zierler KA, Leopold C, Moustafa T, Radovic B, Romauch M, Yan C, Du H, Haemmerle G, Zechner R, Fickert P, Kratky D, Zimmermann R, Lass A.

J Biol Chem. 2016 Aug 19;291(34):17977-87. doi: 10.1074/jbc.M116.724054. Epub 2016 Jun 27.

22.

Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.

Al-Zoughbi W, Pichler M, Gorkiewicz G, Guertl-Lackner B, Haybaeck J, Jahn SW, Lackner C, Liegl-Atzwanger B, Popper H, Schauer S, Nusshold E, Kindt AS, Trajanoski Z, Speicher MR, Haemmerle G, Zimmermann R, Zechner R, Vesely PW, Hoefler G.

Oncotarget. 2016 Jun 7;7(23):33832-40. doi: 10.18632/oncotarget.9418.

23.

Monoacylglycerol Lipases Act as Evolutionarily Conserved Regulators of Non-oxidative Ethanol Metabolism.

Heier C, Taschler U, Radulovic M, Aschauer P, Eichmann TO, Grond S, Wolinski H, Oberer M, Zechner R, Kohlwein SD, Zimmermann R.

J Biol Chem. 2016 May 27;291(22):11865-75. doi: 10.1074/jbc.M115.705541. Epub 2016 Mar 31.

24.

Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.

Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27.

25.

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae.

Weinert BT, Iesmantavicius V, Moustafa T, Schölz C, Wagner SA, Magnes C, Zechner R, Choudhary C.

Mol Syst Biol. 2015 Oct 26;11(10):833. doi: 10.15252/msb.156513. No abstract available.

26.

Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions.

Weinert BT, Moustafa T, Iesmantavicius V, Zechner R, Choudhary C.

EMBO J. 2015 Nov 3;34(21):2620-32. doi: 10.15252/embj.201591271. Epub 2015 Sep 9.

27.

Structure of a CGI-58 motif provides the molecular basis of lipid droplet anchoring.

Boeszoermenyi A, Nagy HM, Arthanari H, Pillip CJ, Lindermuth H, Luna RE, Wagner G, Zechner R, Zangger K, Oberer M.

J Biol Chem. 2015 Oct 30;290(44):26361-72. doi: 10.1074/jbc.M115.682203. Epub 2015 Sep 8.

28.

G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.

Heier C, Radner FP, Moustafa T, Schreiber R, Grond S, Eichmann TO, Schweiger M, Schmidt A, Cerk IK, Oberer M, Theussl HC, Wojciechowski J, Penninger JM, Zimmermann R, Zechner R.

J Biol Chem. 2015 Oct 23;290(43):26141-50. doi: 10.1074/jbc.M115.671842. Epub 2015 Sep 8.

29.

ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6.

Eichmann TO, Grumet L, Taschler U, Hartler J, Heier C, Woblistin A, Pajed L, Kollroser M, Rechberger G, Thallinger GG, Zechner R, Haemmerle G, Zimmermann R, Lass A.

J Lipid Res. 2015 Oct;56(10):1972-84. doi: 10.1194/jlr.M062372. Epub 2015 Aug 31.

30.

Breaking the Barrier--Chaperone-Mediated Autophagy of Perilipins Regulates the Lipolytic Degradation of Fat.

Schweiger M, Zechner R.

Cell Metab. 2015 Jul 7;22(1):60-1. doi: 10.1016/j.cmet.2015.06.017.

31.

Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling.

Hofer P, Boeszoermenyi A, Jaeger D, Feiler U, Arthanari H, Mayer N, Zehender F, Rechberger G, Oberer M, Zimmermann R, Lass A, Haemmerle G, Breinbauer R, Zechner R, Preiss-Landl K.

J Biol Chem. 2015 Jul 24;290(30):18438-53. doi: 10.1074/jbc.M114.628958. Epub 2015 May 7.

32.

Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58.

Das SK, Stadelmeyer E, Schauer S, Schwarz A, Strohmaier H, Claudel T, Zechner R, Hoefler G, Vesely PW.

Int J Mol Sci. 2015 Apr 16;16(4):8555-68. doi: 10.3390/ijms16048555.

33.

Structure-activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL).

Mayer N, Schweiger M, Melcher MC, Fledelius C, Zechner R, Zimmermann R, Breinbauer R.

Bioorg Med Chem. 2015 Jun 15;23(12):2904-16. doi: 10.1016/j.bmc.2015.02.051. Epub 2015 Mar 5.

34.

Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids.

Jaeger D, Schoiswohl G, Hofer P, Schreiber R, Schweiger M, Eichmann TO, Pollak NM, Poecher N, Grabner GF, Zierler KA, Eder S, Kolb D, Radner FP, Preiss-Landl K, Lass A, Zechner R, Kershaw EE, Haemmerle G.

J Hepatol. 2015 Aug;63(2):437-45. doi: 10.1016/j.jhep.2015.02.035. Epub 2015 Feb 27.

35.

Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells.

Taschler U, Schreiber R, Chitraju C, Grabner GF, Romauch M, Wolinski H, Haemmerle G, Breinbauer R, Zechner R, Lass A, Zimmermann R.

Biochim Biophys Acta. 2015 Jul;1851(7):937-45. doi: 10.1016/j.bbalip.2015.02.017. Epub 2015 Feb 27.

36.

FAT FLUX: enzymes, regulators, and pathophysiology of intracellular lipolysis.

Zechner R.

EMBO Mol Med. 2015 Apr;7(4):359-62. doi: 10.15252/emmm.201404846. Review.

37.

The tissue distribution of lipoprotein lipase determines where chylomicrons bind.

Savonen R, Hiden M, Hultin M, Zechner R, Levak-Frank S, Olivecrona G, Olivecrona T.

J Lipid Res. 2015 Mar;56(3):588-98. doi: 10.1194/jlr.M056028. Epub 2015 Jan 14.

38.

Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.

Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC.

Science. 2015 Jan 2;347(6217):83-6. doi: 10.1126/science.1258857.

39.

The interplay of protein kinase A and perilipin 5 regulates cardiac lipolysis.

Pollak NM, Jaeger D, Kolleritsch S, Zimmermann R, Zechner R, Lass A, Haemmerle G.

J Biol Chem. 2015 Jan 16;290(3):1295-306. doi: 10.1074/jbc.M114.604744. Epub 2014 Nov 22.

40.

The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets.

Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV Jr, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M.

J Biol Chem. 2014 Dec 26;289(52):35770-80. doi: 10.1074/jbc.M114.587816. Epub 2014 Nov 7.

41.

Lipolysis meets inflammation: arachidonic acid mobilization from fat.

Schreiber R, Zechner R.

J Lipid Res. 2014 Dec;55(12):2447-9. doi: 10.1194/jlr.C055673. Epub 2014 Oct 20. No abstract available.

42.

Role of the ubiquitin-proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice.

Mussbacher M, Stessel H, Wölkart G, Haemmerle G, Zechner R, Mayer B, Schrammel A.

J Mol Cell Cardiol. 2014 Dec;77:11-9. doi: 10.1016/j.yjmcc.2014.09.028. Epub 2014 Oct 5.

43.

A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase.

Cerk IK, Salzburger B, Boeszoermenyi A, Heier C, Pillip C, Romauch M, Schweiger M, Cornaciu I, Lass A, Zimmermann R, Zechner R, Oberer M.

J Biol Chem. 2014 Nov 21;289(47):32559-70. doi: 10.1074/jbc.M114.602599. Epub 2014 Sep 25.

44.

Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis.

Brahma MK, Adam RC, Pollak NM, Jaeger D, Zierler KA, Pöcher N, Schreiber R, Romauch M, Moustafa T, Eder S, Ruelicke T, Preiss-Landl K, Lass A, Zechner R, Haemmerle G.

J Lipid Res. 2014 Nov;55(11):2229-41. doi: 10.1194/jlr.M044784. Epub 2014 Aug 31.

45.

Hormone-sensitive lipase deficiency in humans.

Zechner R, Langin D.

Cell Metab. 2014 Aug 5;20(2):199-201. doi: 10.1016/j.cmet.2014.07.018.

46.

A switch from white to brown fat increases energy expenditure in cancer-associated cachexia.

Petruzzelli M, Schweiger M, Schreiber R, Campos-Olivas R, Tsoli M, Allen J, Swarbrick M, Rose-John S, Rincon M, Robertson G, Zechner R, Wagner EF.

Cell Metab. 2014 Sep 2;20(3):433-47. doi: 10.1016/j.cmet.2014.06.011. Epub 2014 Jul 17.

47.

Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion.

Mattijssen F, Georgiadi A, Andasarie T, Szalowska E, Zota A, Krones-Herzig A, Heier C, Ratman D, De Bosscher K, Qi L, Zechner R, Herzig S, Kersten S.

J Biol Chem. 2014 Jul 11;289(28):19279-93. doi: 10.1074/jbc.M114.570044. Epub 2014 May 29.

48.

Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation.

Tsoli M, Schweiger M, Vanniasinghe AS, Painter A, Zechner R, Clarke S, Robertson G.

PLoS One. 2014 Mar 25;9(3):e92966. doi: 10.1371/journal.pone.0092966. eCollection 2014.

49.

Endothelial dysfunction in adipose triglyceride lipase deficiency.

Schrammel A, Mussbacher M, Wölkart G, Stessel H, Pail K, Winkler S, Schweiger M, Haemmerle G, Al Zoughbi W, Höfler G, Lametschwandtner A, Zechner R, Mayer B.

Biochim Biophys Acta. 2014 Jun;1841(6):906-17. doi: 10.1016/j.bbalip.2014.03.005. Epub 2014 Mar 21.

50.

Angiopoietin-like 4: An endogenous break of intestinal lipid digestion.

Kotzbeck P, Zechner R.

Mol Metab. 2014 Jan 21;3(2):88-9. doi: 10.1016/j.molmet.2014.01.009. eCollection 2014 Apr. No abstract available.

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