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Items: 28


Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch.

Papadopoulos DK, Skouloudaki K, Engström Y, Terenius L, Rigler R, Zechner C, Vukojević V, Tomancak P.

Development. 2019 Jan 25;146(12). pii: dev168179. doi: 10.1242/dev.168179.


Selected-node stochastic simulation algorithm.

Duso L, Zechner C.

J Chem Phys. 2018 Apr 28;148(16):164108. doi: 10.1063/1.5021242.


The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.

Song P, Zechner C, Hernandez G, Cánovas J, Xie Y, Sondhi V, Wagner M, Stadlbauer V, Horvath A, Leber B, Hu MC, Moe OW, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2018 Jun 5;27(6):1338-1347.e4. doi: 10.1016/j.cmet.2018.04.001. Epub 2018 Apr 12.


Uniform gene expression in embryos is achieved by temporal averaging of transcription noise.

Stapel LC, Zechner C, Vastenhouw NL.

Genes Dev. 2017 Aug 15;31(16):1635-1640. doi: 10.1101/gad.302935.117. Epub 2017 Sep 13.


Parameter inference for stochastic single-cell dynamics from lineage tree data.

Kuzmanovska I, Milias-Argeitis A, Mikelson J, Zechner C, Khammash M.

BMC Syst Biol. 2017 Apr 26;11(1):52. doi: 10.1186/s12918-017-0425-1.


Sensitivity estimation for stochastic models of biochemical reaction networks in the presence of extrinsic variability.

Ruess J, Koeppl H, Zechner C.

J Chem Phys. 2017 Mar 28;146(12):124122. doi: 10.1063/1.4978940.


Design of a Synthetic Integral Feedback Circuit: Dynamic Analysis and DNA Implementation.

Briat C, Zechner C, Khammash M.

ACS Synth Biol. 2016 Oct 21;5(10):1108-1116. Epub 2016 Jul 8.


Reconstructing dynamic molecular states from single-cell time series.

Huang L, Pauleve L, Zechner C, Unger M, Hansen AS, Koeppl H.

J R Soc Interface. 2016 Sep;13(122). pii: 20160533. doi: 10.1098/rsif.2016.0533.


Molecular circuits for dynamic noise filtering.

Zechner C, Seelig G, Rullan M, Khammash M.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4729-34. doi: 10.1073/pnas.1517109113. Epub 2016 Apr 12.


Digital Quantification of Proteins and mRNA in Single Mammalian Cells.

Albayrak C, Jordi CA, Zechner C, Lin J, Bichsel CA, Khammash M, Tay S.

Mol Cell. 2016 Mar 17;61(6):914-24. doi: 10.1016/j.molcel.2016.02.030.


Systemic Mastocytosis With Decreased Bone Density and Fractures.

Zechner C, Gruntmanis U.

Mayo Clin Proc. 2015 Jun;90(6):843-4. doi: 10.1016/j.mayocp.2014.10.014. No abstract available.


Bayesian inference of reaction kinetics from single-cell recordings across a heterogeneous cell population.

Bronstein L, Zechner C, Koeppl H.

Methods. 2015 Sep 1;85:22-35. doi: 10.1016/j.ymeth.2015.05.012. Epub 2015 May 15. Review.


Uncoupled analysis of stochastic reaction networks in fluctuating environments.

Zechner C, Koeppl H.

PLoS Comput Biol. 2014 Dec 4;10(12):e1003942. doi: 10.1371/journal.pcbi.1003942. eCollection 2014 Dec.


Autocrine signaling is a key regulatory element during osteoclastogenesis.

Kopesky P, Tiedemann K, Alkekhia D, Zechner C, Millard B, Schoeberl B, Komarova SV.

Biol Open. 2014 Jul 25;3(8):767-76. doi: 10.1242/bio.20148128.


Scalable inference of heterogeneous reaction kinetics from pooled single-cell recordings.

Zechner C, Unger M, Pelet S, Peter M, Koeppl H.

Nat Methods. 2014 Feb;11(2):197-202. doi: 10.1038/nmeth.2794. Epub 2014 Jan 12.


Structural insights into gene repression by the orphan nuclear receptor SHP.

Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):839-44. doi: 10.1073/pnas.1322827111. Epub 2013 Dec 30. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3895.


Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge.

Tarca AL, Lauria M, Unger M, Bilal E, Boue S, Kumar Dey K, Hoeng J, Koeppl H, Martin F, Meyer P, Nandy P, Norel R, Peitsch M, Rice JJ, Romero R, Stolovitzky G, Talikka M, Xiang Y, Zechner C; IMPROVER DSC Collaborators.

Bioinformatics. 2013 Nov 15;29(22):2892-9. doi: 10.1093/bioinformatics/btt492. Epub 2013 Aug 20.


Moment-based inference predicts bimodality in transient gene expression.

Zechner C, Ruess J, Krenn P, Pelet S, Peter M, Lygeros J, Koeppl H.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8340-5. doi: 10.1073/pnas.1200161109. Epub 2012 May 7.


Regularized variational Bayesian learning of echo state networks with delay&sum readout.

Shutin D, Zechner C, Kulkarni SR, Poor HV.

Neural Comput. 2012 Apr;24(4):967-95. doi: 10.1162/NECO_a_00253. Epub 2011 Dec 14.


Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity.

Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW, Collia D, Chen Z, Wozniak DF, Leone TC, Kelly DP.

Cell Metab. 2010 Dec 1;12(6):633-42. doi: 10.1016/j.cmet.2010.11.008. Erratum in: Cell Metab. 2011 Jan 5;13(1):114.


Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation.

Bugger H, Guzman C, Zechner C, Palmeri M, Russell KS, Russell RR 3rd.

Cancer Chemother Pharmacol. 2011 Jun;67(6):1381-8. doi: 10.1007/s00280-010-1441-7. Epub 2010 Aug 31.


Functional protein expression of multiple sodium channel alpha- and beta-subunit isoforms in neonatal cardiomyocytes.

Kaufmann SG, Westenbroek RE, Zechner C, Maass AH, Bischoff S, Muck J, Wischmeyer E, Scheuer T, Maier SK.

J Mol Cell Cardiol. 2010 Jan;48(1):261-9. doi: 10.1016/j.yjmcc.2009.04.017. Epub 2009 May 5.


Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.

Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP, Medeiros DM, Kovacs A, Kelly DP.

Genes Dev. 2008 Jul 15;22(14):1948-61. doi: 10.1101/gad.1661708.


A role for the transcriptional coactivator PGC-1alpha in muscle refueling.

Wende AR, Schaeffer PJ, Parker GJ, Zechner C, Han DH, Chen MM, Hancock CR, Lehman JJ, Huss JM, McClain DA, Holloszy JO, Kelly DP.

J Biol Chem. 2007 Dec 14;282(50):36642-51. Epub 2007 Oct 11.


Hyperglycemia during cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery.

Doenst T, Wijeysundera D, Karkouti K, Zechner C, Maganti M, Rao V, Borger MA.

J Thorac Cardiovasc Surg. 2005 Oct;130(4):1144.


Discrepancy between GLUT4 translocation and glucose uptake after ischemia.

Zaha V, Nitschke R, Göbel H, Fischer-Rasokat U, Zechner C, Doenst T.

Mol Cell Biochem. 2005 Oct;278(1-2):129-37.


AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury.

Russell RR 3rd, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ, Young LH.

J Clin Invest. 2004 Aug;114(4):495-503.


The role of calcium in the regulation of glucose uptake in isolated working rat heart.

Zechner C, Beyersdorf F, Doenst T.

Mol Cell Biochem. 2002 Mar;232(1-2):75-80.


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