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Items: 1 to 50 of 120

1.

Distinct cellular phenotype linked to defective DNA interstrand crosslink repair and homologous recombination.

Gorniewska AM, Kluzek K, Gackowska L, Kubiszewska I, Zdzienicka MZ, Bialkowska A.

Mol Med Rep. 2017 Aug;16(2):1885-1899. doi: 10.3892/mmr.2017.6781. Epub 2017 Jun 15.

2.

[The role of the Fanconi anemia pathway in DNA repair and maintenance of genome stability].

Koczorowska AM, Białkowska A, Kluzek K, Zdzienicka MZ.

Postepy Hig Med Dosw (Online). 2014 May 8;68:459-72. doi: 10.5604/17322693.1101567. Review. Polish.

3.

[Poly(ADP-ribose) polymerase (PARP) inhibitors in BRCA1/2 cancer therapy].

Kluzek K, Białkowska A, Koczorowska A, Zdzienicka MZ.

Postepy Hig Med Dosw (Online). 2012 Jun 15;66:372-84. Review. Polish.

4.

Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.

Sultana R, McNeill DR, Abbotts R, Mohammed MZ, Zdzienicka MZ, Qutob H, Seedhouse C, Laughton CA, Fischer PM, Patel PM, Wilson DM 3rd, Madhusudan S.

Int J Cancer. 2012 Nov 15;131(10):2433-44. doi: 10.1002/ijc.27512. Epub 2012 Mar 28.

5.

FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.

Kondo N, Takahashi A, Mori E, Noda T, Zdzienicka MZ, Thompson LH, Helleday T, Suzuki M, Kinashi Y, Masunaga S, Ono K, Hasegawa M, Ohnishi T.

PLoS One. 2011 May 9;6(5):e19659. doi: 10.1371/journal.pone.0019659. Erratum in: PLoS One. 2011;6(6). doi:10.1371/annotation/c6be24d1-bc23-43b4-ae01-b86dad174069.

6.

Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage.

Noda T, Takahashi A, Kondo N, Mori E, Okamoto N, Nakagawa Y, Ohnishi K, Zdzienicka MZ, Thompson LH, Helleday T, Asada H, Ohnishi T.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):206-10. doi: 10.1016/j.bbrc.2010.11.094. Epub 2010 Nov 25.

PMID:
21111709
7.

Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability.

Smeenk G, de Groot AJ, Romeijn RJ, van Buul PP, Zdzienicka MZ, Mullenders LH, Pastink A, Godthelp BC.

Mutat Res. 2010 Jul 7;689(1-2):50-8. doi: 10.1016/j.mrfmmm.2010.05.001. Epub 2010 May 13.

PMID:
20471405
8.

Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1.

van der Lelij P, Chrzanowska KH, Godthelp BC, Rooimans MA, Oostra AB, Stumm M, Zdzienicka MZ, Joenje H, de Winter JP.

Am J Hum Genet. 2010 Feb 12;86(2):262-6. doi: 10.1016/j.ajhg.2010.01.008. Epub 2010 Feb 4.

9.

A novel radiosensitive SCID patient with a pronounced G(2)/M sensitivity.

Wiegant WW, Meyers M, Verkaik NS, van der Burg M, Darroudi F, Romeijn R, Bernatowska E, Wolska-Kusnierz B, Mikoluc B, Jaspers NG, Vreeken C, Ijspeert H, Esveldt-van Lange RE, Friedl AA, de Villartay JP, Mullenders LH, van Dongen JJ, van Gent DC, Pastink A, Zdzienicka MZ.

DNA Repair (Amst). 2010 Apr 4;9(4):365-73. doi: 10.1016/j.dnarep.2009.12.004. Epub 2010 Jan 15.

PMID:
20079696
10.

A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining.

van der Burg M, Ijspeert H, Verkaik NS, Turul T, Wiegant WW, Morotomi-Yano K, Mari PO, Tezcan I, Chen DJ, Zdzienicka MZ, van Dongen JJ, van Gent DC.

J Clin Invest. 2009 Jan;119(1):91-8. doi: 10.1172/JCI37141. Epub 2008 Dec 15.

11.

Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.

Roos WP, Nikolova T, Quiros S, Naumann SC, Kiedron O, Zdzienicka MZ, Kaina B.

DNA Repair (Amst). 2009 Jan 1;8(1):72-86. doi: 10.1016/j.dnarep.2008.09.003. Epub 2008 Oct 21.

PMID:
18840549
12.

Artesunate derived from traditional Chinese medicine induces DNA damage and repair.

Li PC, Lam E, Roos WP, Zdzienicka MZ, Kaina B, Efferth T.

Cancer Res. 2008 Jun 1;68(11):4347-51. doi: 10.1158/0008-5472.CAN-07-2970.

13.

A homologous recombination defect affects replication-fork progression in mammalian cells.

Daboussi F, Courbet S, Benhamou S, Kannouche P, Zdzienicka MZ, Debatisse M, Lopez BS.

J Cell Sci. 2008 Jan 15;121(Pt 2):162-6. Epub 2007 Dec 18.

14.

Role of Artemis in DSB repair and guarding chromosomal stability following exposure to ionizing radiation at different stages of cell cycle.

Darroudi F, Wiegant W, Meijers M, Friedl AA, van der Burg M, Fomina J, van Dongen JJ, van Gent DC, Zdzienicka MZ.

Mutat Res. 2007 Feb 3;615(1-2):111-24. Epub 2006 Dec 12.

PMID:
17169382
15.

Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2.

Godthelp BC, van Buul PP, Jaspers NG, Elghalbzouri-Maghrani E, van Duijn-Goedhart A, Arwert F, Joenje H, Zdzienicka MZ.

Mutat Res. 2006 Oct 10;601(1-2):191-201. Epub 2006 Aug 21.

PMID:
16920162
16.

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.

McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S, Giavara S, O'Connor MJ, Tutt AN, Zdzienicka MZ, Smith GC, Ashworth A.

Cancer Res. 2006 Aug 15;66(16):8109-15.

17.

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.

Saeki H, Siaud N, Christ N, Wiegant WW, van Buul PP, Han M, Zdzienicka MZ, Stark JM, Jasin M.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8768-73. Epub 2006 May 26.

18.

[Complex role of the FA proteins in providing genome stability].

Kluzek K, Zdzienicka MZ.

Postepy Biochem. 2005;51(4):387-94. Review. Polish.

PMID:
16676573
19.

Inhibition of DNA synthesis by ionizing radiation: a marker for an S-phase checkpoint.

Jaspers NG, Zdzienicka MZ.

Methods Mol Biol. 2006;314:51-9.

PMID:
16673873
20.
21.

Chinese hamster cell mutant, V-C8, a model for analysis of Brca2 function.

Wiegant WW, Overmeer RM, Godthelp BC, van Buul PP, Zdzienicka MZ.

Mutat Res. 2006 Aug 30;600(1-2):79-88. Epub 2006 Apr 27.

PMID:
16643964
23.

A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation.

van der Burg M, van Veelen LR, Verkaik NS, Wiegant WW, Hartwig NG, Barendregt BH, Brugmans L, Raams A, Jaspers NG, Zdzienicka MZ, van Dongen JJ, van Gent DC.

J Clin Invest. 2006 Jan;116(1):137-45. Epub 2005 Dec 15.

24.

Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2.

Godthelp BC, Wiegant WW, Waisfisz Q, Medhurst AL, Arwert F, Joenje H, Zdzienicka MZ.

Mutat Res. 2006 Feb 22;594(1-2):39-48. Epub 2005 Sep 8.

PMID:
16154163
25.

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J.

Levitus M, Waisfisz Q, Godthelp BC, de Vries Y, Hussain S, Wiegant WW, Elghalbzouri-Maghrani E, Steltenpool J, Rooimans MA, Pals G, Arwert F, Mathew CG, Zdzienicka MZ, Hiom K, De Winter JP, Joenje H.

Nat Genet. 2005 Sep;37(9):934-5. Epub 2005 Aug 21.

PMID:
16116423
26.

Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52.

van Veelen LR, Essers J, van de Rakt MW, Odijk H, Pastink A, Zdzienicka MZ, Paulusma CC, Kanaar R.

Mutat Res. 2005 Jul 1;574(1-2):34-49. Epub 2005 Apr 9.

PMID:
15914205
27.
28.

Cellular response to pulsed low-dose rate irradiation in X-ray sensitive hamster mutant cell lines.

Kreder NC, ten Cate R, Rodermond HM, van Bree C, Franken NA, Zdzienicka MZ, Haveman J.

J Radiat Res. 2004 Sep;45(3):385-91.

29.

Spontaneous homologous recombination is decreased in Rad51C-deficient hamster cells.

Drexler GA, Rogge S, Beisker W, Eckardt-Schupp F, Zdzienicka MZ, Fritz E.

DNA Repair (Amst). 2004 Oct 5;3(10):1335-43.

PMID:
15336628
30.

The XRCC genes: expanding roles in DNA double-strand break repair.

Thacker J, Zdzienicka MZ.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1081-90. Review. Erratum in: DNA Repair (Amst). 2005 Feb 3;4(2):303-4.

PMID:
15279796
31.

Cellular response of X-ray sensitive hamster mutant cell lines to gemcitabine, cisplatin and 5-fluorouracil.

Haveman J, Castro Kreder N, Rodermond HM, van Bree C, Franken NA, Stalpers LJ, Zdzienicka MZ, Peters GJ.

Oncol Rep. 2004 Jul;12(1):187-92.

PMID:
15201982
32.

Brca2 (XRCC11) deficiency results in enhanced mutagenesis.

Kraakman-van der Zwet M, Wiegant WW, Zdzienicka MZ.

Mutagenesis. 2003 Nov;18(6):521-5.

PMID:
14614187
33.

Selective targeting of homologous DNA recombination repair by gemcitabine.

Wachters FM, van Putten JW, Maring JG, Zdzienicka MZ, Groen HJ, Kampinga HH.

Int J Radiat Oncol Biol Phys. 2003 Oct 1;57(2):553-62.

PMID:
12957269
34.

The mammalian XRCC genes: their roles in DNA repair and genetic stability.

Thacker J, Zdzienicka MZ.

DNA Repair (Amst). 2003 Jun 11;2(6):655-72. Review.

PMID:
12767346
35.

Defective Brca2 influences topoisomerase I activity in mammalian cells.

Rahden-Staroń I, Szumiło M, Grosicka E, Kraakman van der Zwet M, Zdzienicka MZ.

Acta Biochim Pol. 2003;50(1):139-44.

36.

A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.

Woods T, Wang W, Convery E, Errami A, Zdzienicka MZ, Meek K.

Nucleic Acids Res. 2002 Dec 1;30(23):5120-8.

37.

Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow.

Noordzij JG, Verkaik NS, van der Burg M, van Veelen LR, de Bruin-Versteeg S, Wiegant W, Vossen JM, Weemaes CM, de Groot R, Zdzienicka MZ, van Gent DC, van Dongen JJ.

Blood. 2003 Feb 15;101(4):1446-52. Epub 2002 Oct 24.

PMID:
12406895
38.

Breast cancer and Fanconi anemia: what are the connections?

Zdzienicka MZ, Arwert F.

Trends Mol Med. 2002 Oct;8(10):458-60.

PMID:
12383764
39.

Differing responses of Nijmegen breakage syndrome and ataxia telangiectasia cells to ionizing radiation.

Little JB, Nagasawa H, Dahlberg WK, Zdzienicka MZ, Burma S, Chen DJ.

Radiat Res. 2002 Sep;158(3):319-26.

PMID:
12175309
40.

Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1.

Godthelp BC, Artwert F, Joenje H, Zdzienicka MZ.

Oncogene. 2002 Jul 25;21(32):5002-5.

41.

Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability.

Godthelp BC, Wiegant WW, van Duijn-Goedhart A, Schärer OD, van Buul PP, Kanaar R, Zdzienicka MZ.

Nucleic Acids Res. 2002 May 15;30(10):2172-82.

42.

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells.

Verkaik NS, Esveldt-van Lange RE, van Heemst D, Brüggenwirth HT, Hoeijmakers JH, Zdzienicka MZ, van Gent DC.

Eur J Immunol. 2002 Mar;32(3):701-9.

43.

Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard.

Becker R, Ritter A, Eichhorn U, Lips J, Bertram B, Wiessler M, Zdzienicka MZ, Kaina B.

Br J Cancer. 2002 Jan 7;86(1):130-5.

44.

Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice.

Koomen M, Cheng NC, van de Vrugt HJ, Godthelp BC, van der Valk MA, Oostra AB, Zdzienicka MZ, Joenje H, Arwert F.

Hum Mol Genet. 2002 Feb 1;11(3):273-81.

PMID:
11823446
45.

The relationship between the RBE of alpha particles and the radiosensitivity of different mutations of Chinese hamster cells.

Zyuzikov NA, Prise KM, Zdzienicka MZ, Newman HC, Michael BD, Trott KR.

Radiat Environ Biophys. 2001 Sep;40(3):243-8.

PMID:
11783854
46.

Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.

Kraakman-van der Zwet M, Overkamp WJ, van Lange RE, Essers J, van Duijn-Goedhart A, Wiggers I, Swaminathan S, van Buul PP, Errami A, Tan RT, Jaspers NG, Sharan SK, Kanaar R, Zdzienicka MZ.

Mol Cell Biol. 2002 Jan;22(2):669-79.

47.

Restoration of nucleotide excision repair in a helicase-deficient XPD mutant from intragenic suppression by a trichothiodystrophy mutation.

George JW, Salazar EP, Vreeswijk MP, Lamerdin JE, Reardon JT, Zdzienicka MZ, Sancar A, Kadkhodayan S, Tebbs RS, Mullenders LH, Thompson LH.

Mol Cell Biol. 2001 Nov;21(21):7355-65.

48.

Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line.

Steenbergen RD, Kramer D, Meijer CJ, Walboomers JM, Trott DA, Cuthbert AP, Newbold RF, Overkamp WJ, Zdzienicka MZ, Snijders PJ.

J Natl Cancer Inst. 2001 Jun 6;93(11):865-72.

PMID:
11390536
49.

Complementation of chromosomal aberrations in AT/NBS hybrids: inadequacy of RDS as an endpoint in complementation studies with immortal NBS cells.

Kraakman-van der Zwet M, Overkamp WJ, Jaspers NG, Natarajan AT, Lohman PH, Zdzienicka MZ.

Mutat Res. 2001 Apr 4;485(3):177-85.

PMID:
11267829
50.

Differential responses of Chinese hamster mutagen sensitive cell lines to low and high concentrations of calicheamicin and neocarzinostatin.

van Duijn-Goedhart A, Zdzienicka MZ, Sankaranarayanan K, van Buul PP.

Mutat Res. 2000 Nov 20;471(1-2):95-105.

PMID:
11080665

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