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Items: 1 to 50 of 304

1.

H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.

Hasumi H, Hasumi Y, Baba M, Nishi H, Furuya M, Vocke CD, Lang M, Irie N, Esumi C, Merino MJ, Kawahara T, Isono Y, Makiyama K, Warner AC, Haines DC, Wei MH, Zbar B, Hagenau H, Feigenbaum L, Kondo K, Nakaigawa N, Yao M, Metwalli AR, Marston Linehan W, Schmidt LS.

Hum Mol Genet. 2017 Jan 15;26(2):354-366. doi: 10.1093/hmg/ddw392.

2.

Somatic alterations contributing to metastasis of a castration-resistant prostate cancer.

Nickerson ML, Im KM, Misner KJ, Tan W, Lou H, Gold B, Wells DW, Bravo HC, Fredrikson KM, Harkins TT, Milos P, Zbar B, Linehan WM, Yeager M, Andresson T, Dean M, Bova GS.

Hum Mutat. 2013 Sep;34(9):1231-41. doi: 10.1002/humu.22346. Epub 2013 Jun 3.

3.

Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.

Ricketts CJ, Shuch B, Vocke CD, Metwalli AR, Bratslavsky G, Middelton L, Yang Y, Wei MH, Pautler SE, Peterson J, Stolle CA, Zbar B, Merino MJ, Schmidt LS, Pinto PA, Srinivasan R, Pacak K, Linehan WM.

J Urol. 2012 Dec;188(6):2063-71. doi: 10.1016/j.juro.2012.08.030. Epub 2012 Oct 18.

4.

Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors.

Nickerson ML, Jaeger E, Shi Y, Durocher JA, Mahurkar S, Zaridze D, Matveev V, Janout V, Kollarova H, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, Mukeria A, Holcatova I, Schmidt LS, Toro JR, Karami S, Hung R, Gerard GF, Linehan WM, Merino M, Zbar B, Boffetta P, Brennan P, Rothman N, Chow WH, Waldman FM, Moore LE.

Clin Cancer Res. 2008 Aug 1;14(15):4726-34. doi: 10.1158/1078-0432.CCR-07-4921.

5.

Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.

Baba M, Furihata M, Hong SB, Tessarollo L, Haines DC, Southon E, Patel V, Igarashi P, Alvord WG, Leighty R, Yao M, Bernardo M, Ileva L, Choyke P, Warren MB, Zbar B, Linehan WM, Schmidt LS.

J Natl Cancer Inst. 2008 Jan 16;100(2):140-54. doi: 10.1093/jnci/djm288. Epub 2008 Jan 8.

6.

Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer.

Grubb RL 3rd, Franks ME, Toro J, Middelton L, Choyke L, Fowler S, Torres-Cabala C, Glenn GM, Choyke P, Merino MJ, Zbar B, Pinto PA, Srinivasan R, Coleman JA, Linehan WM.

J Urol. 2007 Jun;177(6):2074-9; discussion 2079-80.

PMID:
17509289
7.

Lung cysts, spontaneous pneumothorax, and genetic associations in 89 families with Birt-Hogg-Dubé syndrome.

Toro JR, Pautler SE, Stewart L, Glenn GM, Weinreich M, Toure O, Wei MH, Schmidt LS, Davis L, Zbar B, Choyke P, Steinberg SM, Nguyen DM, Linehan WM.

Am J Respir Crit Care Med. 2007 May 15;175(10):1044-53. Epub 2007 Feb 22.

8.

Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics.

Linehan WM, Pinto PA, Srinivasan R, Merino M, Choyke P, Choyke L, Coleman J, Toro J, Glenn G, Vocke C, Zbar B, Schmidt LS, Bottaro D, Neckers L.

Clin Cancer Res. 2007 Jan 15;13(2 Pt 2):671s-679s. Review.

9.

Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma development.

Zbar B, Glenn G, Merino M, Middelton L, Peterson J, Toro J, Coleman J, Pinto P, Schmidt LS, Choyke P, Linehan WM.

J Urol. 2007 Feb;177(2):461-5; discussion 465.

PMID:
17222609
10.

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.

Baba M, Hong SB, Sharma N, Warren MB, Nickerson ML, Iwamatsu A, Esposito D, Gillette WK, Hopkins RF 3rd, Hartley JL, Furihata M, Oishi S, Zhen W, Burke TR Jr, Linehan WM, Schmidt LS, Zbar B.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15552-7. Epub 2006 Oct 6.

11.

Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis.

Hong SB, Furihata M, Baba M, Zbar B, Schmidt LS.

Lab Invest. 2006 Jul;86(7):664-75. Epub 2006 May 1.

12.

The Drosophila homolog of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance.

Singh SR, Zhen W, Zheng Z, Wang H, Oh SW, Liu W, Zbar B, Schmidt LS, Hou SX.

Oncogene. 2006 Sep 28;25(44):5933-41. Epub 2006 Apr 24.

PMID:
16636660
13.

Fumarate hydratase enzyme activity in lymphoblastoid cells and fibroblasts of individuals in families with hereditary leiomyomatosis and renal cell cancer.

Pithukpakorn M, Wei MH, Toure O, Steinbach PJ, Glenn GM, Zbar B, Linehan WM, Toro JR.

J Med Genet. 2006 Sep;43(9):755-62. Epub 2006 Apr 5.

14.

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L.

Cancer Cell. 2005 Aug;8(2):143-53.

15.

High frequency of somatic frameshift BHD gene mutations in Birt-Hogg-Dubé-associated renal tumors.

Vocke CD, Yang Y, Pavlovich CP, Schmidt LS, Nickerson ML, Torres-Cabala CA, Merino MJ, Walther MM, Zbar B, Linehan WM.

J Natl Cancer Inst. 2005 Jun 15;97(12):931-5. Erratum in: J Natl Cancer Inst. 2005 Jul 20;97(14):1096.

PMID:
15956655
16.

Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer.

Wei MH, Toure O, Glenn GM, Pithukpakorn M, Neckers L, Stolle C, Choyke P, Grubb R, Middelton L, Turner ML, Walther MM, Merino MJ, Zbar B, Linehan WM, Toro JR.

J Med Genet. 2006 Jan;43(1):18-27. Epub 2005 Jun 3.

17.

Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome.

Schmidt LS, Nickerson ML, Warren MB, Glenn GM, Toro JR, Merino MJ, Turner ML, Choyke PL, Sharma N, Peterson J, Morrison P, Maher ER, Walther MM, Zbar B, Linehan WM.

Am J Hum Genet. 2005 Jun;76(6):1023-33. Epub 2005 Apr 25.

18.

Evaluation and management of renal tumors in the Birt-Hogg-Dubé syndrome.

Pavlovich CP, Grubb RL 3rd, Hurley K, Glenn GM, Toro J, Schmidt LS, Torres-Cabala C, Merino MJ, Zbar B, Choyke P, Walther MM, Linehan WM.

J Urol. 2005 May;173(5):1482-6. Erratum in: J Urol. 2005 Aug;174(2):796.

PMID:
15821464
19.

The genetic basis of cancer of kidney cancer: implications for gene-specific clinical management.

Linehan WM, Grubb RL, Coleman JA, Zbar B, Walther MM.

BJU Int. 2005 Mar;95 Suppl 2:2-7. Review. No abstract available.

20.

Genetic basis of cancer of the kidney: disease-specific approaches to therapy.

Linehan WM, Vasselli J, Srinivasan R, Walther MM, Merino M, Choyke P, Vocke C, Schmidt L, Isaacs JS, Glenn G, Toro J, Zbar B, Bottaro D, Neckers L.

Clin Cancer Res. 2004 Sep 15;10(18 Pt 2):6282S-9S. Review.

21.

Focus on kidney cancer.

Linehan WM, Zbar B.

Cancer Cell. 2004 Sep;6(3):223-8. Review. No abstract available. Erratum in: Cancer Cell. 2004 Oct;6(4):423.

22.

Early onset hereditary papillary renal carcinoma: germline missense mutations in the tyrosine kinase domain of the met proto-oncogene.

Schmidt LS, Nickerson ML, Angeloni D, Glenn GM, Walther MM, Albert PS, Warren MB, Choyke PL, Torres-Cabala CA, Merino MJ, Brunet J, Bérez V, Borràs J, Sesia G, Middelton L, Phillips JL, Stolle C, Zbar B, Pautler SE, Linehan WM.

J Urol. 2004 Oct;172(4 Pt 1):1256-61.

PMID:
15371818
23.

Expression of Birt-Hogg-Dubé gene mRNA in normal and neoplastic human tissues.

Warren MB, Torres-Cabala CA, Turner ML, Merino MJ, Matrosova VY, Nickerson ML, Ma W, Linehan WM, Zbar B, Schmidt LS.

Mod Pathol. 2004 Aug;17(8):998-1011.

24.

A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer.

Okimoto K, Sakurai J, Kobayashi T, Mitani H, Hirayama Y, Nickerson ML, Warren MB, Zbar B, Schmidt LS, Hino O.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2023-7. Epub 2004 Feb 9.

25.

Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location.

Maranchie JK, Afonso A, Albert PS, Kalyandrug S, Phillips JL, Zhou S, Peterson J, Ghadimi BM, Hurley K, Riss J, Vasselli JR, Ried T, Zbar B, Choyke P, Walther MM, Klausner RD, Linehan WM.

Hum Mutat. 2004 Jan;23(1):40-6.

PMID:
14695531
26.

The genetic basis of cancer of the kidney.

Linehan WM, Walther MM, Zbar B.

J Urol. 2003 Dec;170(6 Pt 1):2163-72. Review.

PMID:
14634372
27.

A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog.

Lingaas F, Comstock KE, Kirkness EF, Sørensen A, Aarskaug T, Hitte C, Nickerson ML, Moe L, Schmidt LS, Thomas R, Breen M, Galibert F, Zbar B, Ostrander EA.

Hum Mol Genet. 2003 Dec 1;12(23):3043-53. Epub 2003 Oct 7.

PMID:
14532326
28.

Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene.

Ma W, Tessarollo L, Hong SB, Baba M, Southon E, Back TC, Spence S, Lobe CG, Sharma N, Maher GW, Pack S, Vortmeyer AO, Guo C, Zbar B, Schmidt LS.

Cancer Res. 2003 Sep 1;63(17):5320-8.

29.

Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America.

Toro JR, Nickerson ML, Wei MH, Warren MB, Glenn GM, Turner ML, Stewart L, Duray P, Tourre O, Sharma N, Choyke P, Stratton P, Merino M, Walther MM, Linehan WM, Schmidt LS, Zbar B.

Am J Hum Genet. 2003 Jul;73(1):95-106. Epub 2003 May 22.

30.

Studying cancer families to identify kidney cancer genes.

Zbar B, Klausner R, Linehan WM.

Annu Rev Med. 2003;54:217-33. Epub 2001 Dec 3. Review.

PMID:
12525673
31.

Facial papules, spontaneous pneumothorax, and renal tumors.

Toro JR, Glenn G, Hou L, Duray P, Clark B, Merino M, Zbar B, Linehan M, Turner ML.

J Am Acad Dermatol. 2003 Jan;48(1):111-4. No abstract available.

PMID:
12522379
32.

Hereditary renal cancers.

Choyke PL, Glenn GM, Walther MM, Zbar B, Linehan WM.

Radiology. 2003 Jan;226(1):33-46. Review.

PMID:
12511666
33.

Renal tumors in the Birt-Hogg-Dubé syndrome.

Pavlovich CP, Walther MM, Eyler RA, Hewitt SM, Zbar B, Linehan WM, Merino MJ.

Am J Surg Pathol. 2002 Dec;26(12):1542-52.

PMID:
12459621
34.

Effects of different fixatives on beta-galactosidase activity.

Ma W, Rogers K, Zbar B, Schmidt L.

J Histochem Cytochem. 2002 Oct;50(10):1421-4.

PMID:
12364575
35.

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome.

Nickerson ML, Warren MB, Toro JR, Matrosova V, Glenn G, Turner ML, Duray P, Merino M, Choyke P, Pavlovich CP, Sharma N, Walther M, Munroe D, Hill R, Maher E, Greenberg C, Lerman MI, Linehan WM, Zbar B, Schmidt LS.

Cancer Cell. 2002 Aug;2(2):157-64.

36.

Dysregulation of Met receptor tyrosine kinase activity in invasive tumors.

Danilkovitch-Miagkova A, Zbar B.

J Clin Invest. 2002 Apr;109(7):863-7. Review. No abstract available.

37.

Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-Dubé syndrome.

Zbar B, Alvord WG, Glenn G, Turner M, Pavlovich CP, Schmidt L, Walther M, Choyke P, Weirich G, Hewitt SM, Duray P, Gabril F, Greenberg C, Merino MJ, Toro J, Linehan WM.

Cancer Epidemiol Biomarkers Prev. 2002 Apr;11(4):393-400.

38.

Disruption of a novel MFS transporter gene, DIRC2, by a familial renal cell carcinoma-associated t(2;3)(q35;q21).

Bodmer D, Eleveld M, Kater-Baats E, Janssen I, Janssen B, Weterman M, Schoenmakers E, Nickerson M, Linehan M, Zbar B, van Kessel AG.

Hum Mol Genet. 2002 Mar 15;11(6):641-9.

PMID:
11912179
39.

Birt-Hogg-Dubé syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2.

Schmidt LS, Warren MB, Nickerson ML, Weirich G, Matrosova V, Toro JR, Turner ML, Duray P, Merino M, Hewitt S, Pavlovich CP, Glenn G, Greenberg CR, Linehan WM, Zbar B.

Am J Hum Genet. 2001 Oct;69(4):876-82. Epub 2001 Aug 30.

40.

Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway.

Danilkovitch-Miagkova A, Miagkov A, Skeel A, Nakaigawa N, Zbar B, Leonard EJ.

Mol Cell Biol. 2001 Sep;21(17):5857-68.

41.

The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis.

Dreijerink K, Braga E, Kuzmin I, Geil L, Duh FM, Angeloni D, Zbar B, Lerman MI, Stanbridge EJ, Minna JD, Protopopov A, Li J, Kashuba V, Klein G, Zabarovsky ER.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7504-9. Epub 2001 Jun 5.

42.

Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies.

Miller M, Ginalski K, Lesyng B, Nakaigawa N, Schmidt L, Zbar B.

Proteins. 2001 Jul 1;44(1):32-43.

PMID:
11354004
43.
44.

Clinical and genetic analysis of patients with pancreatic neuroendocrine tumors associated with von Hippel-Lindau disease.

Libutti SK, Choyke PL, Alexander HR, Glenn G, Bartlett DL, Zbar B, Lubensky I, McKee SA, Maher ER, Linehan WM, Walther MM.

Surgery. 2000 Dec;128(6):1022-7;discussion 1027-8.

PMID:
11114638
45.

Histopathology and molecular genetics of multiple cysts and microcystic (serous) adenomas of the pancreas in von Hippel-Lindau patients.

Mohr VH, Vortmeyer AO, Zhuang Z, Libutti SK, Walther MM, Choyke PL, Zbar B, Linehan WM, Lubensky IA.

Am J Pathol. 2000 Nov;157(5):1615-21.

46.

A novel germ line juxtamembrane Met mutation in human gastric cancer.

Lee JH, Han SU, Cho H, Jennings B, Gerrard B, Dean M, Schmidt L, Zbar B, Vande Woude GF.

Oncogene. 2000 Oct 12;19(43):4947-53.

47.

Inherited epithelial tumors of the kidney: old and new diseases.

Zbar B.

Semin Cancer Biol. 2000 Aug;10(4):313-8. Review.

PMID:
10966853
48.

Signature-based analysis of MET proto-oncogene mutations using DHPLC.

Nickerson ML, Weirich G, Zbar B, Schmidt LS.

Hum Mutat. 2000;16(1):68-76.

PMID:
10874308
49.

Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src.

Nakaigawa N, Weirich G, Schmidt L, Zbar B.

Oncogene. 2000 Jun 15;19(26):2996-3002.

50.

Negligent care and malpractice claiming behavior in Utah and Colorado.

Studdert DM, Thomas EJ, Burstin HR, Zbar BI, Orav EJ, Brennan TA.

Med Care. 2000 Mar;38(3):250-60.

PMID:
10718350

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