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Items: 35

1.

Dissecting Therapeutic Resistance to ERK Inhibition.

Jha S, Morris EJ, Hruza A, Mansueto MS, Schroeder GK, Arbanas J, McMasters D, Restaino CR, Dayananth P, Black S, Elsen NL, Mannarino A, Cooper A, Fawell S, Zawel L, Jayaraman L, Samatar AA.

Mol Cancer Ther. 2016 Apr;15(4):548-59. doi: 10.1158/1535-7163.MCT-15-0172. Epub 2016 Feb 1.

2.

Novel Anti-TM4SF1 Antibody-Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature.

Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder WB, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC.

Mol Cancer Ther. 2015 Aug;14(8):1868-76. doi: 10.1158/1535-7163.MCT-15-0188. Epub 2015 Jun 18.

3.

MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.

Booher RN, Hatch H, Dolinski BM, Nguyen T, Harmonay L, Al-Assaad AS, Ayers M, Nebozhyn M, Loboda A, Hirsch HA, Zhang T, Shi B, Merkel CE, Angagaw MH, Wang Y, Long BJ, Lennon XQ, Miselis N, Pucci V, Monahan JW, Lee J, Kondic AG, Im EK, Mauro D, Blanchard R, Gilliland G, Fawell SE, Zawel L, Schuller AG, Strack P.

PLoS One. 2014 Oct 7;9(10):e108371. doi: 10.1371/journal.pone.0108371. eCollection 2014.

4.

Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.

Stoeck A, Lejnine S, Truong A, Pan L, Wang H, Zang C, Yuan J, Ware C, MacLean J, Garrett-Engele PW, Kluk M, Laskey J, Haines BB, Moskaluk C, Zawel L, Fawell S, Gilliland G, Zhang T, Kremer BE, Knoechel B, Bernstein BE, Pear WS, Liu XS, Aster JC, Sathyanarayanan S.

Cancer Discov. 2014 Oct;4(10):1154-67. doi: 10.1158/2159-8290.CD-13-0830. Epub 2014 Aug 7.

5.

Evaluating TBK1 as a therapeutic target in cancers with activated IRF3.

Muvaffak A, Pan Q, Yan H, Fernandez R, Lim J, Dolinski B, Nguyen TT, Strack P, Wu S, Chung R, Zhang W, Hulton C, Ripley S, Hirsch H, Nagashima K, Wong KK, Jánne PA, Seidel-Dugan C, Zawel L, Kirschmeier PT, Middleton RE, Morris EJ, Wang Y.

Mol Cancer Res. 2014 Jul;12(7):1055-66. doi: 10.1158/1541-7786.MCR-13-0642. Epub 2014 Apr 21.

6.

Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy.

Guertin AD, Li J, Liu Y, Hurd MS, Schuller AG, Long B, Hirsch HA, Feldman I, Benita Y, Toniatti C, Zawel L, Fawell SE, Gilliland DG, Shumway SD.

Mol Cancer Ther. 2013 Aug;12(8):1442-52. doi: 10.1158/1535-7163.MCT-13-0025. Epub 2013 May 22.

7.

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Morris EJ, Jha S, Restaino CR, Dayananth P, Zhu H, Cooper A, Carr D, Deng Y, Jin W, Black S, Long B, Liu J, Dinunzio E, Windsor W, Zhang R, Zhao S, Angagaw MH, Pinheiro EM, Desai J, Xiao L, Shipps G, Hruza A, Wang J, Kelly J, Paliwal S, Gao X, Babu BS, Zhu L, Daublain P, Zhang L, Lutterbach BA, Pelletier MR, Philippar U, Siliphaivanh P, Witter D, Kirschmeier P, Bishop WR, Hicklin D, Gilliland DG, Jayaraman L, Zawel L, Fawell S, Samatar AA.

Cancer Discov. 2013 Jul;3(7):742-50. doi: 10.1158/2159-8290.CD-13-0070. Epub 2013 Apr 24.

8.

Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors.

Zhang W, Haines BB, Efferson C, Zhu J, Ware C, Kunii K, Tammam J, Angagaw M, Hinton MC, Keilhack H, Paweletz CP, Zhang T, Winter C, Sathyanarayanan S, Cheng J, Zawel L, Fawell S, Gilliland G, Majumder PK.

Transl Oncol. 2012 Dec;5(6):422-9. Epub 2012 Dec 1.

9.

A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo.

Ziegler DS, Keating J, Kesari S, Fast EM, Zawel L, Ramakrishna N, Barnes J, Kieran MW, Veldhuijzen van Zanten SE, Kung AL.

Neuro Oncol. 2011 Aug;13(8):820-9. doi: 10.1093/neuonc/nor066. Epub 2011 Jul 1.

10.

P3Kα: a driver of tumor metastasis?

Zawel L.

Oncotarget. 2010 Sep;1(5):315-6. No abstract available.

11.

Smac mimetics: implications for enhancement of targeted therapies in leukemia.

Weisberg E, Ray A, Barrett R, Nelson E, Christie AL, Porter D, Straub C, Zawel L, Daley JF, Lazo-Kallanian S, Stone R, Galinsky I, Frank D, Kung AL, Griffin JD.

Leukemia. 2010 Dec;24(12):2100-9. doi: 10.1038/leu.2010.212. Epub 2010 Sep 16. Erratum in: Leukemia. 2011 Jul;25(7):1221.

12.

IAP inhibitors enhance co-stimulation to promote tumor immunity.

Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G.

J Exp Med. 2010 Sep 27;207(10):2195-206. doi: 10.1084/jem.20101123. Epub 2010 Sep 13.

13.

A histone deacetylase inhibitor LBH589 downregulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL.

Symanowski J, Vogelzang N, Zawel L, Atadja P, Pass H, Sharma S.

J Thorac Oncol. 2009 Feb;4(2):149-60. doi: 10.1097/JTO.0b013e318194f991.

14.

Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins.

Ziegler DS, Wright RD, Kesari S, Lemieux ME, Tran MA, Jain M, Zawel L, Kung AL.

J Clin Invest. 2008 Sep;118(9):3109-22. doi: 10.1172/JCI34120.

15.

A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling.

Gaither A, Porter D, Yao Y, Borawski J, Yang G, Donovan J, Sage D, Slisz J, Tran M, Straub C, Ramsey T, Iourgenko V, Huang A, Chen Y, Schlegel R, Labow M, Fawell S, Sellers WR, Zawel L.

Cancer Res. 2007 Dec 15;67(24):11493-8.

16.

Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells.

Weisberg E, Kung AL, Wright RD, Moreno D, Catley L, Ray A, Zawel L, Tran M, Cools J, Gilliland G, Mitsiades C, McMillin DW, Jiang J, Hall-Meyers E, Griffin JD.

Mol Cancer Ther. 2007 Jul;6(7):1951-61.

17.

Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).

Chauhan D, Neri P, Velankar M, Podar K, Hideshima T, Fulciniti M, Tassone P, Raje N, Mitsiades C, Mitsiades N, Richardson P, Zawel L, Tran M, Munshi N, Anderson KC.

Blood. 2007 Feb 1;109(3):1220-7. Epub 2006 Oct 10.

18.

Development of Peptidomimetics Targeting IAPs.

Sharma SK, Straub C, Zawel L.

Int J Pept Res Ther. 2006 Mar;12(1):21-32. Epub 2006 Mar 3.

19.

Teaching cancer cells to die.

Zawel L.

J Cell Biochem. 2004 Jul 1;92(4):651-5. Review.

PMID:
15211563
20.

DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities.

Zawel L, Yu J, Torrance CJ, Markowitz S, Kinzler KW, Vogelstein B, Zhou S.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2848-53.

21.

Analysis of human transcriptomes.

Velculescu VE, Madden SL, Zhang L, Lash AE, Yu J, Rago C, Lal A, Wang CJ, Beaudry GA, Ciriello KM, Cook BP, Dufault MR, Ferguson AT, Gao Y, He TC, Hermeking H, Hiraldo SK, Hwang PM, Lopez MA, Luderer HF, Mathews B, Petroziello JM, Polyak K, Zawel L, Kinzler KW, et al.

Nat Genet. 1999 Dec;23(4):387-8. No abstract available.

PMID:
10581018
22.

The RNA polymerase II general transcription factors: past, present, and future.

Reinberg D, Orphanides G, Ebright R, Akoulitchev S, Carcamo J, Cho H, Cortes P, Drapkin R, Flores O, Ha I, Inostroza JA, Kim S, Kim TK, Kumar P, Lagrange T, LeRoy G, Lu H, Ma DM, Maldonado E, Merino A, Mermelstein F, Olave I, Sheldon M, Shiekhattar R, Zawel L, et al.

Cold Spring Harb Symp Quant Biol. 1998;63:83-103. Review. No abstract available.

PMID:
10384273
23.

Identification of c-MYC as a target of the APC pathway.

He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW.

Science. 1998 Sep 4;281(5382):1509-12.

24.

Characterization of human FAST-1, a TGF beta and activin signal transducer.

Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B.

Mol Cell. 1998 Jul;2(1):121-7.

25.

Human Smad3 and Smad4 are sequence-specific transcription activators.

Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B, Kern SE.

Mol Cell. 1998 Mar;1(4):611-7.

26.

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.

Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL, Kern SE, Kinzler KW, Vogelstein B.

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2412-6.

27.

Recycling of the general transcription factors during RNA polymerase II transcription.

Zawel L, Kumar KP, Reinberg D.

Genes Dev. 1995 Jun 15;9(12):1479-90.

28.

Visualization of TBP oligomers binding and bending the HIV-1 and adeno promoters.

Griffith JD, Makhov A, Zawel L, Reinberg D.

J Mol Biol. 1995 Mar 10;246(5):576-84.

PMID:
7533216
29.

Common themes in assembly and function of eukaryotic transcription complexes.

Zawel L, Reinberg D.

Annu Rev Biochem. 1995;64:533-61. Review.

PMID:
7574492
30.

Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II.

Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D.

Nature. 1994 Apr 21;368(6473):769-72.

PMID:
8152490
31.

Identification of a minimal set of proteins that is sufficient for accurate initiation of transcription by RNA polymerase II.

Tyree CM, George CP, Lira-DeVito LM, Wampler SL, Dahmus ME, Zawel L, Kadonaga JT.

Genes Dev. 1993 Jul;7(7A):1254-65.

32.

Initiation of transcription by RNA polymerase II: a multi-step process.

Zawel L, Reinberg D.

Prog Nucleic Acid Res Mol Biol. 1993;44:67-108. No abstract available.

PMID:
8434126
33.

The cycling of RNA polymerase II during transcription.

Zawel L, Lu H, Cisek LJ, Corden JL, Reinberg D.

Cold Spring Harb Symp Quant Biol. 1993;58:187-98. No abstract available.

PMID:
7956029
34.

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II.

Lu H, Zawel L, Fisher L, Egly JM, Reinberg D.

Nature. 1992 Aug 20;358(6388):641-5.

PMID:
1495560
35.

Advances in RNA polymerase II transcription.

Zawel L, Reinberg D.

Curr Opin Cell Biol. 1992 Jun;4(3):488-95. Review.

PMID:
1497921

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