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Items: 1 to 50 of 119

1.

C3HeB/FeJ Mice mimic many aspects of gene expression and pathobiological features of human hepatocellular carcinoma.

Zavadil JA, Herzig MCS, Hildreth K, Foroushani A, Boswell W, Walter R, Reddick R, White H, Zare H, Walter CA.

Mol Carcinog. 2018 Oct 26. doi: 10.1002/mc.22929. [Epub ahead of print]

PMID:
30365185
2.

Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice.

Viarisio D, Müller-Decker K, Accardi R, Robitaille A, Dürst M, Beer K, Jansen L, Flechtenmacher C, Bozza M, Harbottle R, Voegele C, Ardin M, Zavadil J, Caldeira S, Gissmann L, Tommasino M.

PLoS Pathog. 2018 Jan 11;14(1):e1006783. doi: 10.1371/journal.ppat.1006783. eCollection 2018 Jan.

3.

Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors.

Huang MN, Yu W, Teoh WW, Ardin M, Jusakul A, Ng AWT, Boot A, Abedi-Ardekani B, Villar S, Myint SS, Othman R, Poon SL, Heguy A, Olivier M, Hollstein M, Tan P, Teh BT, Sabapathy K, Zavadil J, Rozen SG.

Genome Res. 2017 Sep;27(9):1475-1486. doi: 10.1101/gr.220038.116. Epub 2017 Jul 24.

4.

Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing.

Huskova H, Ardin M, Weninger A, Vargova K, Barrin S, Villar S, Olivier M, Stopka T, Herceg Z, Hollstein M, Zavadil J, Korenjak M.

Oncogene. 2017 Oct 26;36(43):6041-6048. doi: 10.1038/onc.2017.215. Epub 2017 Jul 10.

5.

Comparison of the miRNA expression profiles in fresh frozen and formalin-fixed paraffin-embedded tonsillar tumors.

Vojtechova Z, Zavadil J, Klozar J, Grega M, Tachezy R.

PLoS One. 2017 Jun 23;12(6):e0179645. doi: 10.1371/journal.pone.0179645. eCollection 2017.

6.

Corrigendum: Modelling mutational landscapes of human cancers in vitro.

Olivier M, Weninger A, Ardin M, Huskova H, Castells X, Vallée MP, McKay J, Nedelko T, Muehlbauer KR, Marusawa H, Alexander J, Hazelwood L, Byrnes G, Hollstein M, Zavadil J.

Sci Rep. 2017 Jan 16;7:40898. doi: 10.1038/srep40898. No abstract available.

7.

Modelling Mutation Spectra of Human Carcinogens Using Experimental Systems.

Zhivagui M, Korenjak M, Zavadil J.

Basic Clin Pharmacol Toxicol. 2017 Sep;121 Suppl 3:16-22. doi: 10.1111/bcpt.12690. Epub 2017 Feb 3. Review.

8.

Differential expression, localization and activity of MARCKS between mantle cell lymphoma and chronic lymphocytic leukemia.

Vargova J, Vargova K, Dusilkova N, Kulvait V, Pospisil V, Zavadil J, Trneny M, Klener P, Stopka T.

Blood Cancer J. 2016 Sep 23;6(9):e475. doi: 10.1038/bcj.2016.80. No abstract available.

9.

Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones.

Vojtechova Z, Sabol I, Salakova M, Smahelova J, Zavadil J, Turek L, Grega M, Klozar J, Prochazka B, Tachezy R.

BMC Cancer. 2016 Jul 4;16:382. doi: 10.1186/s12885-016-2430-y.

10.

TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data.

Bouaoun L, Sonkin D, Ardin M, Hollstein M, Byrnes G, Zavadil J, Olivier M.

Hum Mutat. 2016 Sep;37(9):865-76. doi: 10.1002/humu.23035. Epub 2016 Jul 8.

PMID:
27328919
11.

Base changes in tumour DNA have the power to reveal the causes and evolution of cancer.

Hollstein M, Alexandrov LB, Wild CP, Ardin M, Zavadil J.

Oncogene. 2017 Jan 12;36(2):158-167. doi: 10.1038/onc.2016.192. Epub 2016 Jun 6. Review.

12.

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.

He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A.

Development. 2016 Jun 1;143(11):1937-47. doi: 10.1242/dev.135285.

13.

MutSpec: a Galaxy toolbox for streamlined analyses of somatic mutation spectra in human and mouse cancer genomes.

Ardin M, Cahais V, Castells X, Bouaoun L, Byrnes G, Herceg Z, Zavadil J, Olivier M.

BMC Bioinformatics. 2016 Apr 18;17:170. doi: 10.1186/s12859-016-1011-z.

14.

Mitral valve prolapse is associated with altered extracellular matrix gene expression patterns.

Greenhouse DG, Murphy A, Mignatti P, Zavadil J, Galloway AC, Balsam LB.

Gene. 2016 Jul 15;586(1):56-61. doi: 10.1016/j.gene.2016.04.004. Epub 2016 Apr 6.

PMID:
27063507
15.

DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status.

Herzig MC, Zavadil JA, Street K, Hildreth K, Drinkwater NR, Reddick T, Herbert DC, Hanes MA, McMahan CA, Reddick RL, Walter CA.

Cancer Prev Res (Phila). 2016 Mar;9(3):245-52. doi: 10.1158/1940-6207.CAPR-15-0251. Epub 2015 Dec 14.

16.

Circulating free DNA concentration is an independent prognostic biomarker in lung cancer.

Tissot C, Toffart AC, Villar S, Souquet PJ, Merle P, Moro-Sibilot D, Pérol M, Zavadil J, Brambilla C, Olivier M, Couraud S.

Eur Respir J. 2015 Dec;46(6):1773-80. doi: 10.1183/13993003.00676-2015. Epub 2015 Oct 22.

17.

Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid.

Castells X, Karanović S, Ardin M, Tomić K, Xylinas E, Durand G, Villar S, Forey N, Le Calvez-Kelm F, Voegele C, Karlović K, Mišić M, Dittrich D, Dolgalev I, McKay J, Shariat SF, Sidorenko VS, Fernandes A, Heguy A, Dickman KG, Olivier M, Grollman AP, Jelaković B, Zavadil J.

Cancer Epidemiol Biomarkers Prev. 2015 Dec;24(12):1873-81. doi: 10.1158/1055-9965.EPI-15-0553. Epub 2015 Sep 17.

18.

Revealing the Molecular Portrait of Triple Negative Breast Tumors in an Understudied Population through Omics Analysis of Formalin-Fixed and Paraffin-Embedded Tissues.

Vaca-Paniagua F, Alvarez-Gomez RM, Maldonado-Martínez HA, Pérez-Plasencia C, Fragoso-Ontiveros V, Lasa-Gonsebatt F, Herrera LA, Cantú D, Bargallo-Rocha E, Mohar A, Durand G, Forey N, Voegele C, Vallée M, Le Calvez-Kelm F, McKay J, Ardin M, Villar S, Zavadil J, Olivier M.

PLoS One. 2015 May 11;10(5):e0126762. doi: 10.1371/journal.pone.0126762. eCollection 2015.

19.

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity.

Vanpouille-Box C, Diamond JM, Pilones KA, Zavadil J, Babb JS, Formenti SC, Barcellos-Hoff MH, Demaria S.

Cancer Res. 2015 Jun 1;75(11):2232-42. doi: 10.1158/0008-5472.CAN-14-3511. Epub 2015 Apr 9.

20.

Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal disease.

Jhawar S, Singh P, Torres D, Ramirez-Valle F, Kassem H, Banerjee T, Dolgalev I, Heguy A, Zavadil J, Lowenstein J.

PLoS One. 2015 Mar 26;10(3):e0118703. doi: 10.1371/journal.pone.0118703. eCollection 2015.

21.

Cancer risk: role of chance overstated.

Wild C, Brennan P, Plummer M, Bray F, Straif K, Zavadil J.

Science. 2015 Feb 13;347(6223):728. doi: 10.1126/science.aaa6799. Epub 2015 Feb 5. No abstract available.

PMID:
25656657
22.

Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid.

Jelaković B, Castells X, Tomić K, Ardin M, Karanović S, Zavadil J.

Int J Cancer. 2015 Jun 15;136(12):2967-72. doi: 10.1002/ijc.29338. Epub 2014 Dec 10.

23.

Variation in genomic landscape of clear cell renal cell carcinoma across Europe.

Scelo G, Riazalhosseini Y, Greger L, Letourneau L, Gonzàlez-Porta M, Wozniak MB, Bourgey M, Harnden P, Egevad L, Jackson SM, Karimzadeh M, Arseneault M, Lepage P, How-Kit A, Daunay A, Renault V, Blanché H, Tubacher E, Sehmoun J, Viksna J, Celms E, Opmanis M, Zarins A, Vasudev NS, Seywright M, Abedi-Ardekani B, Carreira C, Selby PJ, Cartledge JJ, Byrnes G, Zavadil J, Su J, Holcatova I, Brisuda A, Zaridze D, Moukeria A, Foretova L, Navratilova M, Mates D, Jinga V, Artemov A, Nedoluzhko A, Mazur A, Rastorguev S, Boulygina E, Heath S, Gut M, Bihoreau MT, Lechner D, Foglio M, Gut IG, Skryabin K, Prokhortchouk E, Cambon-Thomsen A, Rung J, Bourque G, Brennan P, Tost J, Banks RE, Brazma A, Lathrop GM.

Nat Commun. 2014 Oct 29;5:5135. doi: 10.1038/ncomms6135.

PMID:
25351205
24.

MicroRNA-21 in glomerular injury.

Lai JY, Luo J, O'Connor C, Jing X, Nair V, Ju W, Randolph A, Ben-Dov IZ, Matar RN, Briskin D, Zavadil J, Nelson RG, Tuschl T, Brosius FC 3rd, Kretzler M, Bitzer M.

J Am Soc Nephrol. 2015 Apr;26(4):805-16. doi: 10.1681/ASN.2013121274. Epub 2014 Aug 21.

25.

Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function.

Mariga A, Zavadil J, Ginsberg SD, Chao MV.

Dev Neurobiol. 2015 Feb;75(2):173-92. doi: 10.1002/dneu.22216. Epub 2014 Aug 25.

26.

Endemic (Balkan) nephropathy is aristolochic acid nephropathy.

Karanović S, Tomić K, Dittrich D, Borovečki F, Zavadil J, Vuković-Lela I, Karlović K, Knežević M, Jelaković B.

Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2014;35(1):43-6. Review.

PMID:
24798595
27.

Modelling mutational landscapes of human cancers in vitro.

Olivier M, Weninger A, Ardin M, Huskova H, Castells X, Vallée MP, McKay J, Nedelko T, Muehlbauer KR, Marusawa H, Alexander J, Hazelwood L, Byrnes G, Hollstein M, Zavadil J.

Sci Rep. 2014 Mar 27;4:4482. doi: 10.1038/srep04482. Erratum in: Sci Rep. 2017 Jan 16;7:40898.

28.

Global Reprogramming of the Cellular Translational Landscape Facilitates Cytomegalovirus Replication.

McKinney C, Zavadil J, Bianco C, Shiflett L, Brown S, Mohr I.

Cell Rep. 2014 Mar 27;6(6):1175. doi: 10.1016/j.celrep.2014.03.002. Epub 2014 Mar 27. No abstract available.

29.

Global reprogramming of the cellular translational landscape facilitates cytomegalovirus replication.

McKinney C, Zavadil J, Bianco C, Shiflett L, Brown S, Mohr I.

Cell Rep. 2014 Jan 16;6(1):9-17. doi: 10.1016/j.celrep.2013.11.045. Epub 2013 Dec 27.

30.

Analysis and meta-analysis of transcriptional profiling in human epidermis.

Mimoso C, Lee DD, Zavadil J, Tomic-Canic M, Blumenberg M.

Methods Mol Biol. 2014;1195:61-97. doi: 10.1007/7651_2013_60.

PMID:
24297317
31.

Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo.

O'Reilly KE, de Miera EV, Segura MF, Friedman E, Poliseno L, Han SW, Zhong J, Zavadil J, Pavlick A, Hernando E, Osman I.

Pharmaceuticals (Basel). 2013 Nov 11;6(11):1429-50. doi: 10.3390/ph6111429.

32.

Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer.

Wu X, Li Y, Wang J, Wen X, Marcus MT, Daniels G, Zhang DY, Ye F, Wang LH, Du X, Adams S, Singh B, Zavadil J, Lee P, Monaco ME.

PLoS One. 2013 Oct 14;8(10):e77060. doi: 10.1371/journal.pone.0077060. eCollection 2013.

33.

Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system.

Park DS, Tompkins RO, Liu F, Zhang J, Phoon CK, Zavadil J, Fishman GI.

Biol Open. 2013 Jul 31;2(9):968-78. doi: 10.1242/bio.20135785. eCollection 2013.

34.

Identification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiation.

Wolf L, Gao CS, Gueta K, Xie Q, Chevallier T, Podduturi NR, Sun J, Conte I, Zelenka PS, Ashery-Padan R, Zavadil J, Cvekl A.

G3 (Bethesda). 2013 Dec 9;3(12):2239-55. doi: 10.1534/g3.113.008698.

35.

In TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways.

Lynch SJ, Zavadil J, Pellicer A.

PLoS One. 2013 Jun 3;8(6):e63193. doi: 10.1371/journal.pone.0063193. Print 2014. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/f0d2b6b0-7d87-492e-8505-5159c4b5bdd5.

36.

Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.

Guijarro MV, Dahiya S, Danielson LS, Segura MF, Vales-Lara FM, Menendez S, Popiolek D, Mittal K, Wei JJ, Zavadil J, Cordon-Cardo C, Pandolfi PP, Hernando E.

Am J Pathol. 2013 Jun;182(6):2015-27. doi: 10.1016/j.ajpath.2013.02.035.

37.

Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.

Lu X, Wontakal SN, Kavi H, Kim BJ, Guzzardo PM, Emelyanov AV, Xu N, Hannon GJ, Zavadil J, Fyodorov DV, Skoultchi AI.

Science. 2013 Apr 5;340(6128):78-81. doi: 10.1126/science.1234654.

38.

Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144.

Ramírez CM, Rotllan N, Vlassov AV, Dávalos A, Li M, Goedeke L, Aranda JF, Cirera-Salinas D, Araldi E, Salerno A, Wanschel A, Zavadil J, Castrillo A, Kim J, Suárez Y, Fernández-Hernando C.

Circ Res. 2013 Jun 7;112(12):1592-601. doi: 10.1161/CIRCRESAHA.112.300626. Epub 2013 Mar 21.

39.

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia.

Meyer JA, Wang J, Hogan LE, Yang JJ, Dandekar S, Patel JP, Tang Z, Zumbo P, Li S, Zavadil J, Levine RL, Cardozo T, Hunger SP, Raetz EA, Evans WE, Morrison DJ, Mason CE, Carroll WL.

Nat Genet. 2013 Mar;45(3):290-4. doi: 10.1038/ng.2558. Epub 2013 Feb 3.

40.

Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain.

Xie Q, Yang Y, Huang J, Ninkovic J, Walcher T, Wolf L, Vitenzon A, Zheng D, Götz M, Beebe DC, Zavadil J, Cvekl A.

PLoS One. 2013;8(1):e54507. doi: 10.1371/journal.pone.0054507. Epub 2013 Jan 14.

41.

DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs.

Badura M, Braunstein S, Zavadil J, Schneider RJ.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18767-72. doi: 10.1073/pnas.1203853109. Epub 2012 Oct 29.

42.

Antibiotics in early life alter the murine colonic microbiome and adiposity.

Cho I, Yamanishi S, Cox L, Methé BA, Zavadil J, Li K, Gao Z, Mahana D, Raju K, Teitler I, Li H, Alekseyenko AV, Blaser MJ.

Nature. 2012 Aug 30;488(7413):621-6. doi: 10.1038/nature11400.

43.

Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer.

Clancy HA, Sun H, Passantino L, Kluz T, Muñoz A, Zavadil J, Costa M.

Metallomics. 2012 Aug;4(8):784-93. doi: 10.1039/c2mt20074k. Epub 2012 Jun 19.

44.

Histology-specific microRNA alterations in melanoma.

Poliseno L, Haimovic A, Segura MF, Hanniford D, Christos PJ, Darvishian F, Wang J, Shapiro RL, Pavlick AC, Berman RS, Hernando E, Zavadil J, Osman I.

J Invest Dermatol. 2012 Jul;132(7):1860-8. doi: 10.1038/jid.2011.451. Epub 2012 May 3.

45.

Aristolochic acid-associated urothelial cancer in Taiwan.

Chen CH, Dickman KG, Moriya M, Zavadil J, Sidorenko VS, Edwards KL, Gnatenko DV, Wu L, Turesky RJ, Wu XR, Pu YS, Grollman AP.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8241-6. doi: 10.1073/pnas.1119920109. Epub 2012 Apr 9.

46.

Quantitative analysis of miRNA expression in epithelial cells and tissues.

Bitzer M, Ju W, Jing X, Zavadil J.

Methods Mol Biol. 2012;820:55-70. doi: 10.1007/978-1-61779-439-1_4. Review.

PMID:
22131025
47.

Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage.

Seo E, Basu-Roy U, Zavadil J, Basilico C, Mansukhani A.

Mol Cell Biol. 2011 Nov;31(22):4593-608. doi: 10.1128/MCB.05798-11. Epub 2011 Sep 19.

48.

Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation.

Pospisil V, Vargova K, Kokavec J, Rybarova J, Savvulidi F, Jonasova A, Necas E, Zavadil J, Laslo P, Stopka T.

EMBO J. 2011 Sep 6;30(21):4450-64. doi: 10.1038/emboj.2011.317.

49.

Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.

Zamparini AL, Davis MY, Malone CD, Vieira E, Zavadil J, Sachidanandam R, Hannon GJ, Lehmann R.

Development. 2011 Sep;138(18):4039-50. doi: 10.1242/dev.069187. Epub 2011 Aug 10.

50.

Wild type N-ras displays anti-malignant properties, in part by downregulating decorin.

Benet M, Dulman RY, Suzme R, de Miera EV, Vega ME, Nguyen T, Zavadil J, Pellicer A.

J Cell Physiol. 2012 Jun;227(6):2341-51. doi: 10.1002/jcp.22969.

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