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Items: 1 to 50 of 59

1.

The thyroid hormone activating enzyme, type 2 deiodinase, induces myogenic differentiation by regulating mitochondrial metabolism and reducing oxidative stress.

Sagliocchi S, Cicatiello AG, Di Cicco E, Ambrosio R, Miro C, Di Girolamo D, Nappi A, Mancino G, De Stefano MA, Luongo C, Raia M, Ogawa-Wong AN, Zavacki AM, Paladino S, Salvatore D, Dentice M.

Redox Biol. 2019 Jun;24:101228. doi: 10.1016/j.redox.2019.101228. Epub 2019 May 22.

2.

A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice.

Carmody C, Ogawa-Wong AN, Martin C, Luongo C, Zuidwijk M, Sager B, Petersen T, Roginski Guetter A, Janssen R, Wu EY, Bogaards S, Neumann NM, Hau K, Marsili A, Boelen A, Silva JE, Dentice M, Salvatore D, Wagers AJ, Larsen PR, Simonides WS, Zavacki AM.

Endocrinology. 2019 May 1;160(5):1205-1222. doi: 10.1210/en.2019-00088.

PMID:
30951174
3.

T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells.

Aguayo-Mazzucato C, Lee TB Jr, Matzko M, DiIenno A, Rezanejad H, Ramadoss P, Scanlan T, Zavacki AM, Larsen PR, Hollenberg A, Colton C, Sharma A, Bonner-Weir S.

Diabetes. 2018 Jul;67(7):1322-1331. doi: 10.2337/db18-0030. Epub 2018 Apr 6.

4.

Quantitative Analysis of the Benefits and Risk of Thyroid Nodule Evaluation in Patients ≥70 Years Old.

Wang Z, Vyas CM, Van Benschoten O, Nehs MA, Moore FD Jr, Marqusee E, Krane JF, Kim MI, Heller HT, Gawande AA, Frates MC, Doubilet PM, Doherty GM, Cho NL, Cibas ES, Benson CB, Barletta JA, Zavacki AM, Larsen PR, Alexander EK, Angell TE.

Thyroid. 2018 Apr;28(4):465-471. doi: 10.1089/thy.2017.0655. Epub 2018 Apr 2.

PMID:
29608439
5.

Differential Growth Rates of Benign vs. Malignant Thyroid Nodules.

Angell TE, Vyas CM, Medici M, Wang Z, Barletta JA, Benson CB, Cibas ES, Cho NL, Doherty GM, Doubilet PM, Frates MC, Gawande AA, Heller HT, Kim MI, Krane JF, Marqusee E, Moore FD Jr, Nehs MA, Zavacki AM, Larsen PR, Alexander EK.

J Clin Endocrinol Metab. 2017 Dec 1;102(12):4642-4647. doi: 10.1210/jc.2017-01832.

PMID:
29040691
6.

Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice.

Akinrotimi O, Riessen R, VanDuyne P, Park JE, Lee YK, Wong LJ, Zavacki AM, Schoonjans K, Anakk S.

Hepatology. 2017 Dec;66(6):1854-1865. doi: 10.1002/hep.29305. Epub 2017 Oct 30.

7.

Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.

Wassner AJ, Jugo RH, Dorfman DM, Padera RF, Maynard MA, Zavacki AM, Jay PY, Huang SA.

Thyroid. 2017 May;27(5):732-737. doi: 10.1089/thy.2016.0570. Epub 2017 Apr 5.

8.

The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism.

Luongo C, Martin C, Vella K, Marsili A, Ambrosio R, Dentice M, Harney JW, Salvatore D, Zavacki AM, Larsen PR.

Endocrinology. 2015 Feb;156(2):745-54. doi: 10.1210/en.2014-1698. Epub 2014 Dec 2.

9.

Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.

Bohinc BN, Michelotti G, Xie G, Pang H, Suzuki A, Guy CD, Piercy D, Kruger L, Swiderska-Syn M, Machado M, Pereira T, Zavacki AM, Abdelmalek M, Diehl AM.

Endocrinology. 2014 Nov;155(11):4591-601. doi: 10.1210/en.2014-1302. Epub 2014 Aug 14.

10.

Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders.

Khan A, Harney JW, Zavacki AM, Sajdel-Sulkowska EM.

J Physiol Pharmacol. 2014 Apr;65(2):257-72.

11.

Thyroid hormones and skeletal muscle--new insights and potential implications.

Salvatore D, Simonides WS, Dentice M, Zavacki AM, Larsen PR.

Nat Rev Endocrinol. 2014 Apr;10(4):206-14. doi: 10.1038/nrendo.2013.238. Epub 2013 Dec 10. Review.

12.

RTHα, a newly recognized phenotype of the resistance to thyroid hormone (RTH) syndrome in patients with THRA gene mutations.

Zavacki AM, Larsen PR.

J Clin Endocrinol Metab. 2013 Jul;98(7):2684-6. doi: 10.1210/jc.2013-2475. No abstract available.

13.

Effects of perinatal lipopolysaccharide (LPS) exposure on the developing rat brain; modeling the effect of maternal infection on the developing human CNS.

Xu M, Sulkowski ZL, Parekh P, Khan A, Chen T, Midha S, Iwasaki T, Shimokawa N, Koibuchi N, Zavacki AM, Sajdel-Sulkowska EM.

Cerebellum. 2013 Aug;12(4):572-86. doi: 10.1007/s12311-013-0465-z.

PMID:
23475384
14.

Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA.

Aguayo-Mazzucato C, Zavacki AM, Marinelarena A, Hollister-Lock J, El Khattabi I, Marsili A, Weir GC, Sharma A, Larsen PR, Bonner-Weir S.

Diabetes. 2013 May;62(5):1569-80. doi: 10.2337/db12-0849. Epub 2013 Jan 10.

15.

Sex-dependent changes in cerebellar thyroid hormone-dependent gene expression following perinatal exposure to thimerosal in rats.

Khan A, Sulkowski ZL, Chen T, Zavacki AM, Sajdel-Sulkowska EM.

J Physiol Pharmacol. 2012 Jun;63(3):277-83.

16.

A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons.

Kalló I, Mohácsik P, Vida B, Zeöld A, Bardóczi Z, Zavacki AM, Farkas E, Kádár A, Hrabovszky E, Arrojo E Drigo R, Dong L, Barna L, Palkovits M, Borsay BA, Herczeg L, Lechan RM, Bianco AC, Liposits Z, Fekete C, Gereben B.

PLoS One. 2012;7(6):e37860. doi: 10.1371/journal.pone.0037860. Epub 2012 Jun 18.

17.

Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation.

Zhu B, Shrivastava A, Luongo C, Chen T, Harney JW, Marsili A, Tran TV, Bhadouria A, Mopala R, Steen AI, Larsen PR, Zavacki AM.

J Endocrinol. 2012 Jul;214(1):87-94. doi: 10.1530/JOE-11-0459. Epub 2012 Apr 27.

18.
19.

Maternal thimerosal exposure results in aberrant cerebellar oxidative stress, thyroid hormone metabolism, and motor behavior in rat pups; sex- and strain-dependent effects.

Sulkowski ZL, Chen T, Midha S, Zavacki AM, Sajdel-Sulkowska EM.

Cerebellum. 2012 Jun;11(2):575-86. doi: 10.1007/s12311-011-0319-5.

PMID:
22015705
20.

The arrestin domain-containing 3 protein regulates body mass and energy expenditure.

Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen PR, Zavacki AM, Fong LG, Young SG, Lee RT.

Cell Metab. 2011 Nov 2;14(5):671-83. doi: 10.1016/j.cmet.2011.08.011. Epub 2011 Oct 6.

21.

Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.

Marsili A, Sanchez E, Singru P, Harney JW, Zavacki AM, Lechan RM, Larsen PR.

J Endocrinol. 2011 Oct;211(1):73-8. doi: 10.1530/JOE-11-0248. Epub 2011 Jul 25.

22.

Type II iodothyronine deiodinase provides intracellular 3,5,3'-triiodothyronine to normal and regenerating mouse skeletal muscle.

Marsili A, Tang D, Harney JW, Singh P, Zavacki AM, Dentice M, Salvatore D, Larsen PR.

Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E818-24. doi: 10.1152/ajpendo.00292.2011. Epub 2011 Jul 19.

23.

Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity.

Marsili A, Aguayo-Mazzucato C, Chen T, Kumar A, Chung M, Lunsford EP, Harney JW, Van-Tran T, Gianetti E, Ramadan W, Chou C, Bonner-Weir S, Larsen PR, Silva JE, Zavacki AM.

PLoS One. 2011;6(6):e20832. doi: 10.1371/journal.pone.0020832. Epub 2011 Jun 16.

24.

Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice.

Ramadan W, Marsili A, Larsen PR, Zavacki AM, Silva JE.

Endocrinology. 2011 Aug;152(8):3093-102. doi: 10.1210/en.2011-0139. Epub 2011 Jun 7.

25.

Physiological role and regulation of iodothyronine deiodinases: a 2011 update.

Marsili A, Zavacki AM, Harney JW, Larsen PR.

J Endocrinol Invest. 2011 May;34(5):395-407. doi: 10.3275/7615. Epub 2011 Mar 21. Review.

26.

Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism.

Marsili A, Ramadan W, Harney JW, Mulcahey M, Castroneves LA, Goemann IM, Wajner SM, Huang SA, Zavacki AM, Maia AL, Dentice M, Salvatore D, Silva JE, Larsen PR.

Endocrinology. 2010 Dec;151(12):5952-60. doi: 10.1210/en.2010-0631. Epub 2010 Sep 29.

27.

Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells.

Freitas BC, Gereben B, Castillo M, Kalló I, Zeöld A, Egri P, Liposits Z, Zavacki AM, Maciel RM, Jo S, Singru P, Sanchez E, Lechan RM, Bianco AC.

J Clin Invest. 2010 Jun;120(6):2206-17. doi: 10.1172/JCI41977. Epub 2010 May 10.

28.

Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway.

Christoffolete MA, Doleschall M, Egri P, Liposits Z, Zavacki AM, Bianco AC, Gereben B.

J Endocrinol. 2010 May;205(2):179-86. doi: 10.1677/JOE-09-0448. Epub 2010 Feb 22.

29.

Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat.

Simmen FA, Mercado CP, Zavacki AM, Huang SA, Greenway AD, Kang P, Bowman MT, Prior RL.

J Nutr Biochem. 2010 Nov;21(11):1106-13. doi: 10.1016/j.jnutbio.2009.09.008. Epub 2009 Dec 3.

PMID:
19962299
30.

Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells.

Aerts G, Arrojo E Drigo R, Van Herck SL, Sammels E, Mirebeau-Prunier D, Gereben B, Zeöld A, Harney JW, Huang SA, Mulcahey MA, Van der Geyten S, Van den Bergh G, Arckens L, Darras VM, Zavacki AM.

Endocrinology. 2009 Nov;150(11):5171-80. doi: 10.1210/en.2009-0702. Epub 2009 Oct 9.

31.

The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase.

Zavacki AM, Arrojo E Drigo R, Freitas BC, Chung M, Harney JW, Egri P, Wittmann G, Fekete C, Gereben B, Bianco AC.

Mol Cell Biol. 2009 Oct;29(19):5339-47. doi: 10.1128/MCB.01498-08. Epub 2009 Aug 3.

32.

Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice.

Isganaitis E, Jimenez-Chillaron J, Woo M, Chow A, DeCoste J, Vokes M, Liu M, Kasif S, Zavacki AM, Leshan RL, Myers MG, Patti ME.

Diabetes. 2009 May;58(5):1192-200. doi: 10.2337/db08-1266. Epub 2009 Feb 10.

33.

Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.

Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeöld A, Bianco AC.

Endocr Rev. 2008 Dec;29(7):898-938. doi: 10.1210/er.2008-0019. Epub 2008 Sep 24. Review.

34.

Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus.

Sánchez E, Singru PS, Acharya R, Bodria M, Fekete C, Zavacki AM, Bianco AC, Lechan RM.

Endocrinology. 2008 Sep;149(9):4329-35. doi: 10.1210/en.2008-0411. Epub 2008 May 8.

35.

Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.

Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14466-71. Epub 2007 Aug 24.

36.

Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.

Sagar GD, Gereben B, Callebaut I, Mornon JP, Zeöld A, da Silva WS, Luongo C, Dentice M, Tente SM, Freitas BC, Harney JW, Zavacki AM, Bianco AC.

Mol Cell Biol. 2007 Jul;27(13):4774-83. Epub 2007 Apr 23.

37.

Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations.

Christoffolete MA, Arrojo e Drigo R, Gazoni F, Tente SM, Goncalves V, Amorim BS, Larsen PR, Bianco AC, Zavacki AM.

Endocrinology. 2007 Mar;148(3):954-60. Epub 2006 Nov 30.

PMID:
17138654
38.

LXRs regulate the balance between fat storage and oxidation.

Kalaany NY, Gauthier KC, Zavacki AM, Mammen PP, Kitazume T, Peterson JA, Horton JD, Garry DJ, Bianco AC, Mangelsdorf DJ.

Cell Metab. 2005 Apr;1(4):231-44.

39.

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.

Dentice M, Bandyopadhyay A, Gereben B, Callebaut I, Christoffolete MA, Kim BW, Nissim S, Mornon JP, Zavacki AM, Zeöld A, Capelo LP, Curcio-Morelli C, Ribeiro R, Harney JW, Tabin CJ, Bianco AC.

Nat Cell Biol. 2005 Jul;7(7):698-705. Epub 2005 Jun 19.

40.

CARs and drugs: a risky combination.

Zavacki AM, Larsen PR.

Endocrinology. 2005 Mar;146(3):992-4. No abstract available.

PMID:
15713940
41.

Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.

Zavacki AM, Ying H, Christoffolete MA, Aerts G, So E, Harney JW, Cheng SY, Larsen PR, Bianco AC.

Endocrinology. 2005 Mar;146(3):1568-75. Epub 2004 Dec 9.

PMID:
15591136
42.

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.

Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM.

Cell. 2004 Oct 1;119(1):121-35.

43.

Antioxidant function of a novel selenoprotein in Drosophila melanogaster.

Morozova N, Forry EP, Shahid E, Zavacki AM, Harney JW, Kraytsberg Y, Berry MJ.

Genes Cells. 2003 Dec;8(12):963-71.

44.

Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.

Kim BW, Zavacki AM, Curcio-Morelli C, Dentice M, Harney JW, Larsen PR, Bianco AC.

Mol Endocrinol. 2003 Dec;17(12):2603-12. Epub 2003 Aug 21.

PMID:
12933904
45.

Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.

Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC.

J Clin Invest. 2003 Jul;112(2):189-96.

46.

Coupled tRNA(Sec)-dependent assembly of the selenocysteine decoding apparatus.

Zavacki AM, Mansell JB, Chung M, Klimovitsky B, Harney JW, Berry MJ.

Mol Cell. 2003 Mar;11(3):773-81.

47.

In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases.

Curcio-Morelli C, Gereben B, Zavacki AM, Kim BW, Huang S, Harney JW, Larsen PR, Bianco AC.

Endocrinology. 2003 Mar;144(3):937-46.

PMID:
12586771
48.

FOR, a novel orphan nuclear receptor related to farnesoid X receptor.

Seo YW, Sanyal S, Kim HJ, Won DH, An JY, Amano T, Zavacki AM, Kwon HB, Shi YB, Kim WS, Kang H, Moore DD, Choi HS.

J Biol Chem. 2002 May 17;277(20):17836-44. Epub 2002 Feb 26.

49.

Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor.

Laffitte BA, Kast HR, Nguyen CM, Zavacki AM, Moore DD, Edwards PA.

J Biol Chem. 2000 Apr 7;275(14):10638-47.

50.

Bile acids: natural ligands for an orphan nuclear receptor.

Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM.

Science. 1999 May 21;284(5418):1365-8.

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