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Items: 43

1.

Dynamics of human telomerase recruitment depend on template- telomere base pairing.

Schmidt JC, Zaug AJ, Kufer R, Cech TR.

Mol Biol Cell. 2018 Jan 31. pii: mbc.E17-11-0637. doi: 10.1091/mbc.E17-11-0637. [Epub ahead of print]

2.

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.

Lim CJ, Zaug AJ, Kim HJ, Cech TR.

Nat Commun. 2017 Oct 20;8(1):1075. doi: 10.1038/s41467-017-01313-w.

3.

Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.

Schmidt JC, Zaug AJ, Cech TR.

Cell. 2016 Aug 25;166(5):1188-1197.e9. doi: 10.1016/j.cell.2016.07.033. Epub 2016 Aug 11.

4.

A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.

Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR.

Genome Biol. 2015 Nov 10;16:231. doi: 10.1186/s13059-015-0791-1.

5.

Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer.

Borah S, Xi L, Zaug AJ, Powell NM, Dancik GM, Cohen SB, Costello JC, Theodorescu D, Cech TR.

Science. 2015 Feb 27;347(6225):1006-10. doi: 10.1126/science.1260200. Epub 2015 Feb 5.

6.

Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.

Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, Zaug AJ, Liu D, Zhao Y, Cech TR, Ma W, Songyang Z.

J Cell Sci. 2015 Jan 15;128(2):331-41. doi: 10.1242/jcs.159467. Epub 2014 Nov 21.

7.

Many disease-associated variants of hTERT retain high telomerase enzymatic activity.

Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR.

Nucleic Acids Res. 2013 Oct;41(19):8969-78. doi: 10.1093/nar/gkt653. Epub 2013 Jul 30.

8.

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.

Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR.

Nature. 2012 Dec 13;492(7428):285-9. doi: 10.1038/nature11648. Epub 2012 Oct 24.

9.

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera RA, Artandi SE.

Nature. 2011 May 22;474(7351):399-402. doi: 10.1038/nature10084.

10.

Functional interaction between telomere protein TPP1 and telomerase.

Zaug AJ, Podell ER, Nandakumar J, Cech TR.

Genes Dev. 2010 Mar 15;24(6):613-22. doi: 10.1101/gad.1881810.

11.

Mutation in TERT separates processivity from anchor-site function.

Zaug AJ, Podell ER, Cech TR.

Nat Struct Mol Biol. 2008 Aug;15(8):870-2. doi: 10.1038/nsmb.1462. Epub 2008 Jul 20.

12.

The POT1-TPP1 telomere complex is a telomerase processivity factor.

Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M.

Nature. 2007 Feb 1;445(7127):506-10. Epub 2007 Jan 21.

13.

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.

Zaug AJ, Podell ER, Cech TR.

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10864-9. Epub 2005 Jul 25.

14.

Switching human telomerase on and off with hPOT1 protein in vitro.

Lei M, Zaug AJ, Podell ER, Cech TR.

J Biol Chem. 2005 May 27;280(21):20449-56. Epub 2005 Mar 24.

15.

A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.

Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR.

RNA. 2003 Nov;9(11):1323-32.

16.

Yeast telomerase is specialized for C/A-rich RNA templates.

Förstemann K, Zaug AJ, Cech TR, Lingner J.

Nucleic Acids Res. 2003 Mar 15;31(6):1646-55.

17.
18.

Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle.

Seto AG, Zaug AJ, Sobel SG, Wolin SL, Cech TR.

Nature. 1999 Sep 9;401(6749):177-80. Erratum in: Nature 1999 Dec 23-30;402(6764):898.

PMID:
10490028
19.

Polyadenylation of telomerase RNA in budding yeast.

Chapon C, Cech TR, Zaug AJ.

RNA. 1997 Nov;3(11):1337-51.

20.

Method for determining RNA 3' ends and application to human telomerase RNA.

Zaug AJ, Linger J, Cech TR.

Nucleic Acids Res. 1996 Feb 1;24(3):532-3. No abstract available.

21.

Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy.

Nakamura TM, Wang YH, Zaug AJ, Griffith JD, Cech TR.

EMBO J. 1995 Oct 2;14(19):4849-59.

23.

Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu).

Zaug AJ, Dávila-Aponte JA, Cech TR.

Biochemistry. 1994 Dec 13;33(49):14935-47.

PMID:
7527660
24.
25.

Aminoacyl esterase activity of the Tetrahymena ribozyme.

Piccirilli JA, McConnell TS, Zaug AJ, Noller HF, Cech TR.

Science. 1992 Jun 5;256(5062):1420-4.

PMID:
1604316
26.

The intervening sequence RNA of Tetrahymena is an enzyme. 1986.

Zaug AJ, Cech TR.

Biotechnology. 1992;24:57-62. No abstract available.

PMID:
1422070
27.

Self-splicing and enzymatic cleavage of RNA by a group I intervening sequence.

Latham JA, Zaug AJ, Cech TR.

Methods Enzymol. 1990;181:558-69. No abstract available.

PMID:
2199766
29.

Self-splicing RNA and an RNA enzyme in Tetrahymena.

Zaug AJ, Cech TR.

J Protozool. 1987 Nov;34(4):416-7. Review.

PMID:
3323479
30.

Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity.

Been MD, Barfod ET, Burke JM, Price JV, Tanner NK, Zaug AJ, Cech TR.

Cold Spring Harb Symp Quant Biol. 1987;52:147-57. No abstract available.

PMID:
3454258
31.

The Tetrahymena ribozyme acts like an RNA restriction endonuclease.

Zaug AJ, Been MD, Cech TR.

Nature. 1986 Dec 4-10;324(6096):429-33. Erratum in: Nature 1987 Feb 12-18;325(6105):646.

PMID:
3537808
32.
33.

Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor.

Burke JM, Irvine KD, Kaneko KJ, Kerker BJ, Oettgen AB, Tierney WM, Williamson CL, Zaug AJ, Cech TR.

Cell. 1986 Apr 25;45(2):167-76.

PMID:
2421916
34.

The intervening sequence RNA of Tetrahymena is an enzyme.

Zaug AJ, Cech TR.

Science. 1986 Jan 31;231(4737):470-5.

PMID:
3941911
36.

Oligomerization of intervening sequence RNA molecules in the absence of proteins.

Zaug AJ, Cech TR.

Science. 1985 Sep 13;229(4718):1060-4.

PMID:
2412290
37.

A labile phosphodiester bond at the ligation junction in a circular intervening sequence RNA.

Zaug AJ, Kent JR, Cech TR.

Science. 1984 May 11;224(4649):574-8.

PMID:
6200938
38.

Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage-ligation reaction.

Zaug AJ, Grabowski PJ, Cech TR.

Nature. 1983 Feb 17-23;301(5901):578-83.

PMID:
6186917
39.

Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.

Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR.

Cell. 1982 Nov;31(1):147-57.

PMID:
6297745
42.
43.

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