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Items: 1 to 50 of 454

1.

Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-β.

Goulart E, de Caires-Junior LC, Telles-Silva KA, Araujo BHS, Kobayashi GS, Musso CM, Assoni AF, Oliveira D, Caldini E, Gerstenhaber JA, Raia S, Lelkes PI, Zatz M.

Stem Cell Res Ther. 2019 Aug 15;10(1):258. doi: 10.1186/s13287-019-1367-x.

2.

Alterations in visual acuity and visual development in infants 1-24 months old either exposed to or infected by Zika virus during gestation, with and without microcephaly.

Portnoi Baran LC, Fernades da Costa M, Summer Vidal K, Damico FM, Telles Salgueiro Barboni M, da Silva Lima D, de Cássia Rodrigues de Matos França V, Gomes Martins CM, Segundo Tabares H, Leonardo Dias S, Aparecido Silva L, Decleva D, Hamer RD, Zatz M, A P Bertozzi AP, Gazeta RE, Duarte Passos S, Fix Ventura D.

J AAPOS. 2019 Jun 20. pii: S1091-8531(19)30137-5. doi: 10.1016/j.jaapos.2019.03.005. [Epub ahead of print]

PMID:
31229606
3.

The Role of Pericytes in Amyotrophic Lateral Sclerosis.

Coatti GC, Cavaçana N, Zatz M.

Adv Exp Med Biol. 2019;1147:137-146. doi: 10.1007/978-3-030-16908-4_6.

PMID:
31147876
4.

Barriers Pushed Aside: Insights on Career and Family Success from Women Leaders in Academic Otolaryngology.

Meyer TK, Bergmark R, Zatz M, Sardesai MG, Litvack JR, Starks Acosta A.

Otolaryngol Head Neck Surg. 2019 Aug;161(2):257-264. doi: 10.1177/0194599819841608. Epub 2019 Apr 16.

PMID:
30987521
5.

A population-based study of inter-generational attitudes towards consanguineous marriages in north-eastern Brazil.

Lima SOA, Farias AA, Albino VA, Marques-Alves YK, Olinda R, Santos-Silva TA, Alves LU, Zatz M, Santos S.

J Biosoc Sci. 2019 Sep;51(5):683-697. doi: 10.1017/S0021932018000433. Epub 2019 Mar 13.

PMID:
30862325
6.

Loss-of-function mutation in inositol monophosphatase 1 (IMPA1) results in abnormal synchrony in resting-state EEG.

Walker CP, Pessoa ALS, Figueiredo T, Rafferty M, Melo US, Nóbrega PR, Murphy N, Kok F, Zatz M, Santos S, Cho RY.

Orphanet J Rare Dis. 2019 Jan 7;14(1):3. doi: 10.1186/s13023-018-0977-1.

7.

Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations.

de Farias AA, Nunes K, Lemes RB, Moura R, Fernandes GR, Melo US, Zatz M, Kok F, Santos S.

Sci Rep. 2018 Nov 8;8(1):16552. doi: 10.1038/s41598-018-35022-1.

8.

10q23.31 microduplication encompassing PTEN decreases mTOR signalling activity and is associated with autosomal dominant primary microcephaly.

Oliveira D, Leal GF, Sertié AL, Caires LC Jr, Goulart E, Musso CM, Oliveira JRM, Krepischi ACV, Vianna-Morgante AM, Zatz M.

J Med Genet. 2019 Aug;56(8):543-547. doi: 10.1136/jmedgenet-2018-105471. Epub 2018 Oct 9.

PMID:
30301738
9.

Clinical aspects of hereditary spastic paraplegia 76 and novel CAPN1 mutations.

Melo US, Freua F, Lynch DS, Ripa BD, Tenorio RB, Saute JAM, de Souza Leite F, Kitajima J, Houlden H, Zatz M, Kok F.

Clin Genet. 2018 Nov;94(5):482-483. doi: 10.1111/cge.13428. Epub 2018 Sep 10. No abstract available.

PMID:
30198554
10.

Careers in Science and Grant Administration: View from the National Institutes of Health.

Zatz M, Dupere S.

Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9). pii: a032847. doi: 10.1101/cshperspect.a032847. Review.

PMID:
30181194
11.

Helping our country as women scientists.

Zatz M.

Nat Cell Biol. 2018 Sep;20(9):1012. doi: 10.1038/s41556-018-0161-9. No abstract available.

PMID:
30154566
12.

Human Adipose-Derived CD146+ Stem Cells Increase Life Span of a Muscular Dystrophy Mouse Model More Efficiently than Mesenchymal Stromal Cells.

Gomes JP, Coatti GC, Valadares MC, Assoni AF, Pelatti MV, Secco M, Zatz M.

DNA Cell Biol. 2018 Sep;37(9):798-804. doi: 10.1089/dna.2018.4158. Epub 2018 Jul 30.

PMID:
30059260
13.

Development of a comprehensive noninvasive prenatal test.

Malcher C, Yamamoto GL, Burnham P, Ezquina SAM, Lourenço NCV, Balkassmi S, Antonio DSM, Hsia GSP, Gollop T, Pavanello RC, Lopes MA, Bakker E, Zatz M, Bertola D, Vlaminck I, Passos-Bueno MR.

Genet Mol Biol. 2018 Jul/Sept.;41(3):545-554. doi: 10.1590/1678-4685-GMB-2017-0177. Epub 2018 Jul 16.

14.

A fast method to reprogram and CRISPR/Cas9 gene editing from erythroblasts.

Melo US, de Souza Leite F, Costa S, Rosenberg C, Zatz M.

Stem Cell Res. 2018 Aug;31:52-54. doi: 10.1016/j.scr.2018.07.002. Epub 2018 Jul 4.

15.

Complexity of the 5' Untranslated Region of EIF4A3, a Critical Factor for Craniofacial and Neural Development.

Hsia GSP, Musso CM, Alvizi L, Brito LA, Kobayashi GS, Pavanello RCM, Zatz M, Gardham A, Wakeling E, Zechi-Ceide RM, Bertola D, Passos-Bueno MR.

Front Genet. 2018 Apr 25;9:149. doi: 10.3389/fgene.2018.00149. eCollection 2018.

16.

Efficient exon skipping of SGCG mutations mediated by phosphorodiamidate morpholino oligomers.

Wyatt EJ, Demonbreun AR, Kim EY, Puckelwartz MJ, Vo AH, Dellefave-Castillo LM, Gao QQ, Vainzof M, Pavanello RCM, Zatz M, McNally EM.

JCI Insight. 2018 May 3;3(9). pii: 99357. doi: 10.1172/jci.insight.99357.

17.

Zika Virus Selectively Kills Aggressive Human Embryonal CNS Tumor Cells In Vitro and In Vivo.

Kaid C, Goulart E, Caires-Júnior LC, Araujo BHS, Soares-Schanoski A, Bueno HMS, Telles-Silva KA, Astray RM, Assoni AF, Júnior AFR, Ventini DC, Puglia ALP, Gomes RP, Zatz M, Okamoto OK.

Cancer Res. 2018 Jun 15;78(12):3363-3374. doi: 10.1158/0008-5472.CAN-17-3201. Epub 2018 Apr 26.

18.

Publisher Correction: Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.

Caires-Júnior LC, Goulart E, Melo US, Araujo BHS, Alvizi L, Soares-Schanoski A, de Oliveira DF, Kobayashi GS, Griesi-Oliveira K, Musso CM, Amaral MS, daSilva LF, Astray RM, Suárez-Patiño SF, Ventini DC, da Silva SG, Yamamoto GL, Ezquina S, Naslavsky MS, Telles-Silva KA, Weinmann K, van der Linden V, van der Linden H, de Oliveira JRM, Arrais NMR, Melo A, Figueiredo T, Santos S, Meira JGC, Passos SD, de Almeida RP, Bispo AJB, Cavalheiro EA, Kalil J, Cunha-Neto E, Nakaya H, Andreata-Santos R, de Souza Ferreira LC, Verjovski-Almeida S, Ho PL, Passos-Bueno MR, Zatz M.

Nat Commun. 2018 Mar 13;9(1):1114. doi: 10.1038/s41467-018-03497-1.

19.

Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.

Caires-Júnior LC, Goulart E, Melo US, Araujo BHS, Alvizi L, Soares-Schanoski A, de Oliveira DF, Kobayashi GS, Griesi-Oliveira K, Musso CM, Amaral MS, daSilva LF, Astray RM, Suárez-Patiño SF, Ventini DC, Gomes da Silva S, Yamamoto GL, Ezquina S, Naslavsky MS, Telles-Silva KA, Weinmann K, van der Linden V, van der Linden H, de Oliveira JRM, Arrais NMR, Melo A, Figueiredo T, Santos S, Meira JGC, Passos SD, de Almeida RP, Bispo AJB, Cavalheiro EA, Kalil J, Cunha-Neto E, Nakaya H, Andreata-Santos R, de Souza Ferreira LC, Verjovski-Almeida S, Ho PL, Passos-Bueno MR, Zatz M.

Nat Commun. 2018 Feb 2;9(1):475. doi: 10.1038/s41467-017-02790-9. Erratum in: Nat Commun. 2018 Mar 13;9(1):1114.

20.

Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice.

Nunes BG, Loures FV, Bueno HMS, Cangussu EB, Goulart E, Coatti GC, Caldini EG, Condino-Neto A, Zatz M.

Eur J Hum Genet. 2017 Dec;25(12):1388-1396. doi: 10.1038/s41431-017-0017-y. Epub 2017 Oct 27.

21.

Down Syndrome iPSC-Derived Astrocytes Impair Neuronal Synaptogenesis and the mTOR Pathway In Vitro.

Araujo BHS, Kaid C, De Souza JS, Gomes da Silva S, Goulart E, Caires LCJ, Musso CM, Torres LB, Ferrasa A, Herai R, Zatz M, Okamoto OK, Cavalheiro EA.

Mol Neurobiol. 2018 Jul;55(7):5962-5975. doi: 10.1007/s12035-017-0818-6. Epub 2017 Nov 11.

PMID:
29128905
22.

Paracoccidioidomycosis Associated With a Heterozygous STAT4 Mutation and Impaired IFN-γ Immunity.

Schimke LF, Hibbard J, Martinez-Barricarte R, Khan TA, de Souza Cavalcante R, Borges de Oliveira Junior E, Takahashi França T, Iqbal A, Yamamoto G, Arslanian C, Feriotti C, Costa TA, Bustamante J, Boisson-Dupuis S, Casanova JL, Marzagao Barbuto JA, Zatz M, Poncio Mendes R, Garcia Calich VL, Ochs HD, Torgerson TR, Cabral-Marques O, Condino-Neto A.

J Infect Dis. 2017 Dec 19;216(12):1623-1634. doi: 10.1093/infdis/jix522.

PMID:
29029192
23.

Diabetes is Not Associated with Alzheimer's Disease Neuropathology.

Dos Santos Matioli MNP, Suemoto CK, Rodriguez RD, Farias DS, da Silva MM, Leite REP, Ferretti-Rebustini REL, Farfel JM, Pasqualucci CA, Jacob Filho W, Arvanitakis Z, Naslavsky MS, Zatz M, Grinberg LT, Nitrini R.

J Alzheimers Dis. 2017;60(3):1035-1043. doi: 10.3233/JAD-170179.

24.

Deepening a Simple Question: Can MSCs Be Used to Treat Cancer?

Gomes JPA, Assoni AF, Pelatti M, Coatti G, Okamoto OK, Zatz M.

Anticancer Res. 2017 Sep;37(9):4747-4758. Review.

PMID:
28870893
25.

Pericytes Extend Survival of ALS SOD1 Mice and Induce the Expression of Antioxidant Enzymes in the Murine Model and in IPSCs Derived Neuronal Cells from an ALS Patient.

Coatti GC, Frangini M, Valadares MC, Gomes JP, Lima NO, Cavaçana N, Assoni AF, Pelatti MV, Birbrair A, de Lima ACP, Singer JM, Rocha FMM, Da Silva GL, Mantovani MS, Macedo-Souza LI, Ferrari MFR, Zatz M.

Stem Cell Rev Rep. 2017 Oct;13(5):686-698. doi: 10.1007/s12015-017-9752-2.

PMID:
28710685
26.

Repression of phosphatidylinositol transfer protein α ameliorates the pathology of Duchenne muscular dystrophy.

Vieira NM, Spinazzola JM, Alexander MS, Moreira YB, Kawahara G, Gibbs DE, Mead LC, Verjovski-Almeida S, Zatz M, Kunkel LM.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6080-6085. doi: 10.1073/pnas.1703556114. Epub 2017 May 22.

27.

Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study.

Suemoto CK, Ferretti-Rebustini RE, Rodriguez RD, Leite RE, Soterio L, Brucki SM, Spera RR, Cippiciani TM, Farfel JM, Chiavegatto Filho A, Naslavsky MS, Zatz M, Pasqualucci CA, Jacob-Filho W, Nitrini R, Grinberg LT.

PLoS Med. 2017 Mar 28;14(3):e1002267. doi: 10.1371/journal.pmed.1002267. eCollection 2017 Mar.

28.

Exomic variants of an elderly cohort of Brazilians in the ABraOM database.

Naslavsky MS, Yamamoto GL, de Almeida TF, Ezquina SAM, Sunaga DY, Pho N, Bozoklian D, Sandberg TOM, Brito LA, Lazar M, Bernardo DV, Amaro E Jr, Duarte YAO, Lebrão ML, Passos-Bueno MR, Zatz M.

Hum Mutat. 2017 Jul;38(7):751-763. doi: 10.1002/humu.23220. Epub 2017 May 3.

PMID:
28332257
29.

Targeted molecular investigation in patients within the clinical spectrum of Auriculocondylar syndrome.

Romanelli Tavares VL, Zechi-Ceide RM, Bertola DR, Gordon CT, Ferreira SG, Hsia GS, Yamamoto GL, Ezquina SA, Kokitsu-Nakata NM, Vendramini-Pittoli S, Freitas RS, Souza J, Raposo-Amaral CA, Zatz M, Amiel J, Guion-Almeida ML, Passos-Bueno MR.

Am J Med Genet A. 2017 Apr;173(4):938-945. doi: 10.1002/ajmg.a.38101.

PMID:
28328130
30.

Myocardial Fibrosis Progression in Duchenne and Becker Muscular Dystrophy: A Randomized Clinical Trial.

Silva MC, Magalhães TA, Meira ZM, Rassi CH, Andrade AC, Gutierrez PS, Azevedo CF, Gurgel-Giannetti J, Vainzof M, Zatz M, Kalil-Filho R, Rochitte CE.

JAMA Cardiol. 2017 Feb 1;2(2):190-199. doi: 10.1001/jamacardio.2016.4801.

PMID:
27926769
31.

Different Donors Mesenchymal Stromal Cells Secretomes Reveal Heterogeneous Profile of Relevance for Therapeutic Use.

Assoni A, Coatti G, Valadares MC, Beccari M, Gomes J, Pelatti M, Mitne-Neto M, Carvalho VM, Zatz M.

Stem Cells Dev. 2017 Feb 1;26(3):206-214. doi: 10.1089/scd.2016.0218. Epub 2016 Oct 20.

PMID:
27762666
32.

Neuromuscular disorders: genes, genetic counseling and therapeutic trials.

Zatz M, Passos-Bueno MR, Vainzof M.

Genet Mol Biol. 2016 Jul-Sep;39(3):339-48. doi: 10.1590/1678-4685-GMB-2016-0019.

33.

Dystrophin Is Required for Proper Functioning of Luminance and Red-Green Cone Opponent Mechanisms in the Human Retina.

Barboni MT, Martins CM, Nagy BV, Tsai T, Damico FM, da Costa MF, de Cassia R, Pavanello M, Lourenço NC, de Cerqueira AM, Zatz M, Kremers J, Ventura DF.

Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3581-7. doi: 10.1167/iovs.16-19287.

PMID:
27388051
34.

Transplantation of Human Adipose Mesenchymal Stem Cells in Non-Immunosuppressed GRMD Dogs is a Safe Procedure.

Pelatti MV, Gomes JP, Vieira NM, Cangussu E, Landini V, Andrade T, Sartori M, Petrus L, Zatz M.

Stem Cell Rev Rep. 2016 Aug;12(4):448-53. doi: 10.1007/s12015-016-9659-3.

PMID:
27193781
35.

Concordant utrophin upregulation in phenotypically discordant DMD/BMD brothers.

Vainzof M, Feitosa L, Canovas M, Ayub-Guerrieri D, Pavanello Rde C, Zatz M.

Neuromuscul Disord. 2016 Mar;26(3):197-200. doi: 10.1016/j.nmd.2016.01.001. Epub 2016 Jan 25.

PMID:
26851826
36.

Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype.

Vieira NM, Elvers I, Alexander MS, Moreira YB, Eran A, Gomes JP, Marshall JL, Karlsson EK, Verjovski-Almeida S, Lindblad-Toh K, Kunkel LM, Zatz M.

Cell. 2015 Nov 19;163(5):1204-1213. doi: 10.1016/j.cell.2015.10.049. Epub 2015 Nov 12.

37.

A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability.

Figueiredo T, Melo US, Pessoa AL, Nobrega PR, Kitajima JP, Rusch H, Vaz F, Lucato LT, Zatz M, Kok F, Santos S.

Mol Psychiatry. 2016 Aug;21(8):1125-9. doi: 10.1038/mp.2015.150. Epub 2015 Sep 29.

PMID:
26416544
38.

Correction: Human Tubal-Derived Mesenchymal Stromal Cells Associated with Low Level Laser Therapy Significantly Reduces Cigarette Smoke-Induced COPD in C57BL/6 mice.

Peron JP, de Brito AA, Pelatti M, Brandão WN, Vitoretti LB, Greiffo FR, da Silveira EC, Oliveira-Junior MC, Maluf M, Evangelista L, Halpern S, Nisenbaum MG, Perin P, Czeresnia CE, Câmara NO, Aimbire F, de Paula Vieira R, Zatz M, de Oliveira AP.

PLoS One. 2015 Sep 25;10(9):e0139294. doi: 10.1371/journal.pone.0139294. eCollection 2015. No abstract available.

39.

Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome.

Melo US, Macedo-Souza LI, Figueiredo T, Muotri AR, Gleeson JG, Coux G, Armas P, Calcaterra NB, Kitajima JP, Amorim S, Olávio TR, Griesi-Oliveira K, Coatti GC, Rocha CR, Martins-Pinheiro M, Menck CF, Zaki MS, Kok F, Zatz M, Santos S.

Hum Mol Genet. 2015 Dec 15;24(24):6877-85. doi: 10.1093/hmg/ddv388. Epub 2015 Sep 18.

40.

Human Tubal-Derived Mesenchymal Stromal Cells Associated with Low Level Laser Therapy Significantly Reduces Cigarette Smoke-Induced COPD in C57BL/6 mice.

Peron JP, de Brito AA, Pelatti M, Brandão WN, Vitoretti LB, Greiffo FR, da Silveira EC, Oliveira-Junior MC, Maluf M, Evangelista L, Halpern S, Nisenbaum MG, Perin P, Czeresnia CE, Câmara NO, Aimbire F, Vieira RP, Zatz M, de Oliveira AP.

PLoS One. 2015 Aug 31;10(8):e0136942. doi: 10.1371/journal.pone.0136942. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0139294.

41.

Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate.

Brito LA, Yamamoto GL, Melo S, Malcher C, Ferreira SG, Figueiredo J, Alvizi L, Kobayashi GS, Naslavsky MS, Alonso N, Felix TM, Zatz M, Seruca R, Passos-Bueno MR.

Hum Mutat. 2015 Nov;36(11):1029-33. doi: 10.1002/humu.22827. Epub 2015 Aug 3.

PMID:
26123647
42.

Human Mesenchymal Stromal Cells Transplantation May Enhance or Inhibit 4T1 Murine Breast Adenocarcinoma through Different Approaches.

Jazedje T, Ribeiro AL, Pellati M, de Siqueira Bueno HM, Nagata G, Trierveiler M, Rodrigues EG, Zatz M.

Stem Cells Int. 2015;2015:796215. doi: 10.1155/2015/796215. Epub 2015 Apr 27.

43.

Muscular dystrophy in a family of Labrador Retrievers with no muscle dystrophin and a mild phenotype.

Vieira NM, Guo LT, Estrela E, Kunkel LM, Zatz M, Shelton GD.

Neuromuscul Disord. 2015 May;25(5):363-70. doi: 10.1016/j.nmd.2015.02.012. Epub 2015 Mar 3.

PMID:
25813339
44.

Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome.

Yamamoto GL, Aguena M, Gos M, Hung C, Pilch J, Fahiminiya S, Abramowicz A, Cristian I, Buscarilli M, Naslavsky MS, Malaquias AC, Zatz M, Bodamer O, Majewski J, Jorge AA, Pereira AC, Kim CA, Passos-Bueno MR, Bertola DR.

J Med Genet. 2015 Jun;52(6):413-21. doi: 10.1136/jmedgenet-2015-103018. Epub 2015 Mar 20.

PMID:
25795793
45.

Response to: Milder course in Duchenne patients with nonsense mutations and no muscle dystrophin.

Zatz M.

Neuromuscul Disord. 2015 May;25(5):444. doi: 10.1016/j.nmd.2015.02.010. Epub 2015 Feb 23. No abstract available.

PMID:
25777492
46.

A normal life without muscle dystrophin.

Zatz M, Vieira NM, Zucconi E, Pelatti M, Gomes J, Vainzof M, Martins-Bach AB, Garcia Otaduy MC, Bento dos Santos G, Amaro E Jr, Landini V, Andrade T.

Neuromuscul Disord. 2015 May;25(5):371-4. doi: 10.1016/j.nmd.2015.02.007. Epub 2015 Feb 24.

PMID:
25770920
47.

Schinzel-Giedion syndrome in two Brazilian patients: Report of a novel mutation in SETBP1 and literature review of the clinical features.

Carvalho E, Honjo R, Magalhães M, Yamamoto G, Rocha K, Naslavsky M, Zatz M, Passos-Bueno MR, Kim C, Bertola D.

Am J Med Genet A. 2015 May;167A(5):1039-46. doi: 10.1002/ajmg.a.36789. Epub 2015 Feb 7.

PMID:
25663181
48.

Stem cells for amyotrophic lateral sclerosis modeling and therapy: myth or fact?

Coatti GC, Beccari MS, Olávio TR, Mitne-Neto M, Okamoto OK, Zatz M.

Cytometry A. 2015 Mar;87(3):197-211. doi: 10.1002/cyto.a.22630. Epub 2015 Feb 2. Review.

49.

Homozygous missense mutation in MED25 segregates with syndromic intellectual disability in a large consanguineous family.

Figueiredo T, Melo US, Pessoa AL, Nobrega PR, Kitajima JP, Correa I, Zatz M, Kok F, Santos S.

J Med Genet. 2015 Feb;52(2):123-7. doi: 10.1136/jmedgenet-2014-102793. Epub 2014 Dec 19.

PMID:
25527630
50.

Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility.

Toledo RA, Hatakana R, Lourenço DM Jr, Lindsey SC, Camacho CP, Almeida M, Lima JV Jr, Sekiya T, Garralda E, Naslavsky MS, Yamamoto GL, Lazar M, Meirelles O, Sobreira TJ, Lebrao ML, Duarte YA, Blangero J, Zatz M, Cerutti JM, Maciel RM, Toledo SP.

Endocr Relat Cancer. 2015 Feb;22(1):65-76. doi: 10.1530/ERC-14-0491. Epub 2014 Nov 25.

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